LOCUS       Y19209                  9681 bp    DNA     linear   HUM 14-NOV-2006
DEFINITION  Homo sapiens KRTHB4 gene for type II hair keratin 4, exons 1 to 10.
ACCESSION   Y19209
VERSION     Y19209.1
KEYWORDS    HB4 gene; KRTHB4 gene; type II hair keratin 4.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.
  TITLE     Characterization of a 300 kbp region of human DNA containing the
            type II hair keratin gene domain
  JOURNAL   J. Invest. Dermatol. 114(3), 464-472(2000).
   PUBMED   10692104
REFERENCE   2  (bases 1 to 9681)
  AUTHORS   Schweizer J.
  JOURNAL   Submitted (31-AUG-1999) to the INSDC. J. Schweizer, German Cancer
            Research Center, Research Program 2 (b0501), Im Neuenheimer Feld
            280, 69120 Heidelberg, GERMANY
FEATURES             Location/Qualifiers
     source          1..9681
                     /organism="Homo sapiens"
                     /chromosome="12"
                     /map="12q13"
                     /mol_type="genomic DNA"
                     /clone_lib="PAC"
                     /db_xref="taxon:9606"
     regulatory      539..543
                     /gene="KRTHB4"
                     /regulatory_class="TATA_box"
     mRNA            join(590..1183,2428..2636,3161..3221,3694..3789,
                     4701..4865,5021..5146,5643..5863,6319..6350,7846..8459,
                     8693..8978)
                     /gene="KRTHB4"
     exon            590..1183
                     /gene="KRTHB4"
                     /number=1
     CDS             join(638..1183,2428..2636,3161..3221,3694..3789,
                     4701..4865,5021..5146,5643..5863,6319..6350,7846..8192)
                     /gene="KRTHB4"
                     /product="type II hair keratin 3"
                     /note="formerly HB4 gene"
                     /db_xref="GOA:Q9NSB2"
                     /db_xref="HGNC:HGNC:6461"
                     /db_xref="InterPro:IPR003054"
                     /db_xref="InterPro:IPR018039"
                     /db_xref="InterPro:IPR032444"
                     /db_xref="InterPro:IPR039008"
                     /db_xref="InterPro:IPR042180"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NSB2"
                     /protein_id="CAB76829.1"
                     /translation="MSCRSYRVSSGHRVGNFSSCSAMTPQNLNRFRANSVSCWSGPGF
                     RGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVGLGPRADSC
                     VGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQR
                     VKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYI
                     TNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDA
                     AFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGII
                     AEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLK
                     AEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLREYQE
                     LMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLS
                     RGGVTFSGSSSVCATSGVLASCGPSLGGARVAPATGDLLSTGTRSGSMLISEACVPSV
                     PCPLPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY"
     exon            2428..2636
                     /gene="KRTHB4"
                     /number=2
     exon            3161..3221
                     /gene="KRTHB4"
                     /number=3
     exon            3694..3789
                     /gene="KRTHB4"
                     /number=4
     exon            4701..4865
                     /gene="KRTHB4"
                     /number=5
     exon            5021..5146
                     /gene="KRTHB4"
                     /number=6
     exon            5643..5863
                     /gene="KRTHB4"
                     /number=7
     exon            6319..6350
                     /gene="KRTHB4"
                     /number=8
     exon            7846..8459
                     /gene="KRTHB4"
                     /number=9
     exon            8693..8978
                     /gene="KRTHB4"
                     /number=10
     regulatory      8959..8964
                     /gene="KRTHB4"
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT         2434 a         2429 c         2495 g         2323 t
ORIGIN      
        1 gctttactgt agattcaact cttgtatact aaacagccat attggataaa acatggcaga
       61 aggttttttg atgatttaat tgatttgcag aaatgcaaca aactgtattt tctccatatc
      121 acttcttact tggagatgtg cacacactcc cacctcttta gggggttata tcttcatgga
      181 tgcatcccat gtgagcctct tgctggagct gtcgccatcc taactttctg gtggttagcc
      241 acactcacag tgaaaaaacc tattgcattt atgaccaaag caaattaatg tccccttaat
      301 ggcaattgtg gtagacttat agggaaaaaa aagactataa tgtttatatg tttatgtgtt
      361 tttaatgttt attggtttgc tgttacagcc ctcatcccaa tgagactagg tgtgtctgag
      421 ttaactcatt gtcaaggagg ttataggcat gcagagtttc tgctaactac ccaagctcat
      481 aaatgcctgc aaatggattt tttcattttt atggggccaa gcctcagatc accacacaca
      541 taaaaggggt gcaagggttc cactggcctc agagggactc ccagctccag ctcacccatt
      601 ctacacttgc tcttttgctc ccaaccagga agccatcatg tcttgccgct cctaccgagt
      661 cagctctggt caccgggtgg gcaacttcag ctcttgttca gcaatgacac cacagaacct
      721 gaatcgcttc cgggccaact ctgtctcctg ttggagtggg cctggattcc ggggccttgg
      781 cagctttggt agtcggagtg tcatcacctt tggatcgtac tcaccccgga tagcagctgt
      841 aggctctcgg cccatccact gtggagtccg ctttggtgct ggctgtggga tgggttttgg
      901 tgatgggaga ggtgttggtc tggggcctag ggctgacagc tgtgttggtc tgggctttgg
      961 agctggcagt ggcattggct atggctttgg tggccctggc tttggttaca gagttggagg
     1021 ggttggagtc ccagcagccc catctatcac agctgtgact gtgaacaaga gcctactgac
     1081 ccccctcaac ctggagattg accccaatgc ccagagggtg aagaaggatg agaaggagca
     1141 aatcaagacc ctcaacaaca agtttgcctc cttcattgac aaggtaccta tgatagctga
     1201 atctctgggt ctaggaatat tacagccaaa atgcactaga gtgctctttc ccttaaaaag
     1261 aactggcccg gttctgggga cttgaccttg acctcagatc tttcaagtgc ctacctcagg
     1321 cattgtggta tgctttatgg gttgctctgc tgcagagcaa ggccaagcca gaggacgagc
     1381 tgcatggtgg gatagattcc gacagtgttg atatcttctg gaggacagag gagcatccag
     1441 ccaaactcga gggcatctcg acaaactaag atgttgcatc tggtcactta gaaatgtctc
     1501 tgaaacaggc tggaaacact gggactttag ccaggtgttg gctggtatat gcttaagagg
     1561 ttttattctt tgagatcctt ttgttcctta tgaagttttc atagtttctg aggctgagtg
     1621 gcctcatcta ttcaggctta gaaaagtaga gaatggagtt gagtaattaa aaaaagaaga
     1681 agaattcata cccccacatg gggtatcaaa attcggccaa gttgcctaga ttcagggaaa
     1741 ttgtagggaa tgaccactgg tagtcactgg cttccaggca gatgagtggg aacagtgatg
     1801 tggataaccc aaaagaactg acatcccaca caccatgtct atgtggagat ggaatggtta
     1861 tgtctgagaa tgaaggataa cctctgtaag ttttgggttc ttcctctcta aaatgagggg
     1921 ctggggtaaa gggtctgtaa gttctcttcc agctctacac atctcagcca atggaatatc
     1981 tgcgatgttg gataggactt acaatctgag aattcctacc tcccagtacc atatcccacc
     2041 ccaaatgtag tttactctgc tccccattct ctgccaggga tgcctggcat cagttttcag
     2101 atataggcaa accagagctt aaatagaatc aacccttcca acttcctgat gtaccagtgt
     2161 acagctttct tagagactgg ataggggaat ggtactgaag tgctatggtt caaaacccca
     2221 tactggtaac taggcctagc cgagcacaag gagggagtca caacctgccc ttccagcttc
     2281 tgctgagtta gtggaggaat gaaagtcagc agaggagaga accctgtcga catgtggtca
     2341 agtcatcgct ggccatctca agagcttggt caaggcatga accctatcaa gcacttcaaa
     2401 tgccatttct gtgccctgtg gatttaggtt cggttcctag agcagcagaa taagctccta
     2461 gagaccaagt ggagcttcct ccaagagcag aaatgtatca ggagcaatct ggagccactc
     2521 ttcgagagct acatcaccaa cctgcggagg cagttggagg tgctggtcag tgatcaggcc
     2581 cggctccagg ctgagaggaa ccacctgcag gatgtcctag agggcttcaa gaagaagtga
     2641 gtgacatctg agctgcacag accagtgaca ggccaggcct ggccccagaa ttagctgcca
     2701 agctcagatg agagcagctg gaaggatcag ggttgaatgc tggttaccac atcaagcctg
     2761 gggaggtggg ggtgggtaga gatatgtgaa cagagaagag gaggccctcc tgaggaaaaa
     2821 ggtgcccatg ttcagtatct ttttcagttg ggccctactt gctctatagt caaatgcaat
     2881 gatcctacat tatttctgtc agaggaacat agcaatagac caggttttca gatcccaaac
     2941 ccacattaag aaagtggaag ggatttggag aaactgagag gcactggctt atgaaaggtc
     3001 ataaagatga gacagagggg atgatgttat agcattcaga tagcaatagg gaaccatgat
     3061 cctgcacaga ctgagagatc ttgcaaggtt cactggggag ttgggagtaa ctgcctctca
     3121 gttcagagta agcactcacc ctcttaacct ttatcatcag gtatgaagag gaagtggtat
     3181 gtcgggccaa tgctgagaat gagtttgtgg ctctgaagaa ggtaaggggg aaccacagac
     3241 caggccaact tctcctctgg accggcaaat gttctcaaga ctccccagga aactgctcag
     3301 gcagccctgt ggagtctggg actactcaca ccaagacagt ggagacagtg gaatctcaga
     3361 gataacaaga gatttcctac aaagttcagg ttcagcctca gattctttag gattgggtca
     3421 catgtgagca gaggtatgaa aaggtgacct aagtatcttg gattatctag attttctttg
     3481 cctctaactg aacatcagga aatgtccagc agcccctggg ggaatgttgg cattgtaata
     3541 gggaaatgag caaaagttgc tgagcttcac ttctacccag cgaccttacc atctgtggga
     3601 agtggctgcc tctttgcacc catctccaga cacaggtggg aaggtgaaac agtgcccagg
     3661 cgatgagtat ttatccttct ctgttttata caggatgtgg atgcagcttt catgaacaag
     3721 tctgatctcg aggccaacgt ggatacccta actcaggaaa ttgactttct aaaaacgctt
     3781 tacatggagg tgagggttca tcttctctag ggcacccaag gagatcaatg cttggcctgg
     3841 actccctgaa tgcttagcct gggctagcat attttcaaac atttgctatc atatatcttt
     3901 cctctcactc aaatctgtat gctatatatg ccaatatgtc ttcaaatggg gaagggaagg
     3961 tgagcaggct tttcagcagc ctgatgcaag tcaaactcct tggatctatg atccaactcc
     4021 ttatttacca atttaaagac tgggatctag aaatgtcact tcctgtgtac tgacaagaag
     4081 actgaaaaat tgatttgcca ggagaggtaa gaaaaaatgt gtttgaccta attagccaaa
     4141 ccagctgtct tttgcttcat aaacaatctg tccagtctgg tataggccca gccagagctg
     4201 aattgctagc tctaagtgaa gaggctgagg aaagcctcct ctggaactct ctttgcaggc
     4261 cagtcccaag cccctcagtt cttctattaa gggcttggga tataggaatt cctagaccac
     4321 catgtgctaa aatattgtca ggtctcaacg gtctgtgacc agcccagcca ctttgtagat
     4381 aatctaagaa aagtttaagc cctagagtgg ctcccacttt cttccaccat gttcttagat
     4441 ccccatggtt ttaatactta ctgagcaaag tagtgtgtta aagggatgtt tctgagtaga
     4501 tcacaagagc tctaaagtca gcctgagatg gttctcagac atgtcttttt ctttatcatc
     4561 aatttagatg gtcttgcttt tttatgaacc aatgagtgat gctctctgcc cctggcacca
     4621 cttcctgggc cccctgtggc agagtcccag ctactaaatg agactctaag cacatctgtc
     4681 tccccaatcc tccaacacag gaaatccagt tgctgcagtc gcacatctca gagacgtcgg
     4741 tcattgtgaa gatggacaac agccgtgacc tgaaccttga tgggatcatt gctgaggtca
     4801 aggcccagta tgaggaggtg gccaggcgca gccgggctga tgctgaggcc tggtaccaga
     4861 ccaaggtggg cagtggaggc tggggaaggg atgtaggcag ctctgggaat gactcatata
     4921 taacagatca ggcccaggga ggtttgaagc ccccaactca gtgggggctg tgatcctgac
     4981 ctgacctccg aaccctcaaa ataccctcct ctctccgcag tatgaagaga tgcaggtgac
     5041 agctggccaa cactgtgaca acctgcgcaa catacggaac gagatcaacg aactgacccg
     5101 cctgatccag aggcttaagg cagagattga gcacgccaag gctcaggtgg gcaaaggaaa
     5161 ggagggaaag cctcagatga gggagaacca gggcctcagg ctttgggaac ccccaagtct
     5221 aatgaggtga gggagaccat caagacccag aaaccaagga atggagggat cagtccagga
     5281 aggctttctg gaggataaaa atatggaagg gaaggagagc ttcccacata gaagtaaagg
     5341 gctagagcag acccagcagg gaaggtggta cagaaagaat aaatttaccc tctagatgcc
     5401 atgactctgg ggcagctgaa atcagcagtg acaaagtcag tggggatgga aacaacagca
     5461 atgccctacc ccatagtgac atcaaactac aggatctcca gtgcctggga aagcagccac
     5521 catggggtcc atccctgcct tggccccagg ctatgttccc actaagaggg gccgtgtttc
     5581 taacccaacc tggggatgcc ctggcactgc cgaagcctac ctgcaaactg ccttccctgc
     5641 agcgtgccaa gttggaggct gcagtggccg aggccgagca gcagggcgag gcgaccctca
     5701 gtgatgccaa atgcaagctg gcagatctgg agtgtgccct gcagcaggcc aagcaggaca
     5761 tggcgcggca gctgcgcgag taccaggagc tgatgaatgc caagctgggc ctggacatcg
     5821 agatcgccac ctacaggcgc ctgctggagg gcgaggagag ccggtgagta ctctcagtcc
     5881 agcaggagag tgaagtcaga cttaggcatc tagaaagact aaggaagaga aggggacagt
     5941 gaagaactgc agaaatacat agtctttaaa gatgacaata ccttctctgc aaacattagt
     6001 tgcattgccc ttgtcaggga atcagaagaa ggctctagac ctgtgattct caaatgcaag
     6061 tctagataag ctgcaccaga atcattagta attttgctaa aattactact aatgataaat
     6121 ttccttaaat attttaatct aatggttttg ggatagggtc taagaacgtg tttttcaacg
     6181 ctccccagat gtgtgtataa ccaggggtga gaactactgc tccacagatc tactcaaaca
     6241 agaaagccct ttttatggca aataggtttt caggaaacaa tagtgcatgt gaaatgattt
     6301 gtttcttccc ctttccaggc tctgtgaagg tgttggacca gtaaacatat gtaagaaact
     6361 tgttttttcc tcttcacaca tttctctcct cttcaaactt cctttaaact caggctcaca
     6421 ctggggtcag gaggcgtccg acatggccgg tctggccacg acagtcaggg gagctgggac
     6481 catccagccc tggatgggga gcatcttctt agctgaggtc tgagatctcc ccagagcctg
     6541 ccttccccag agcaaaacat tcataaaggt tttcaaggcc tccaaagtgg aggacagcca
     6601 gcttttttgc tttgagcggc cttgtccttc aagggaactt agaaggactt agaaggactg
     6661 ggacttagaa ggaatgggac gcctctgcca ggggagcctc tcatcccctg atggcaggga
     6721 acgcaataag gccaaatgga agtctcccca ctgctgcagc cgaagcatgg gttgtaccca
     6781 aagcacgcag ggcagtgtgc cgggcatggc agtctgggga cactggcaag gcaagaccca
     6841 gcccacgctc tctagaaata gaatcttctt gagaagatga gtcctagcca ccatcaacct
     6901 aacactggaa ggatccctgg ggagaaaagc ggatactggc atccctgttt tgcccactca
     6961 gagaaagtac atgatttgcc agaacttaca aagcgaacca gatttcaaac ccagatttct
     7021 gactccaaaa acacaaatga acactgacgt gtagtggaac cgagtgctaa actgggtggg
     7081 tcagacagtc agagctacat gtacttggaa gacagtgtcc cttcccactc ccatggaggc
     7141 ggtgagtggt caggggaagc cacaggcaat ggctttctgc aggaggtcaa gcttgagtga
     7201 acatcatgga tggcaggaag gattctgggt aagatgaaag ggcaggaaag agtgtacccc
     7261 tccatggatg gggctggtct agcaagctct tctgtggatt tgagtcctga ggcatggagt
     7321 tgtgtccaag ggagagcaga gggctacaga gcacagccac cagtgggtca ggagagaggc
     7381 gacaagggac tagtgttgga ggggtttcct gtgtgctggg ctaggggaaa tgtggagacc
     7441 accaaggggc ataatacaac tggaagagaa aaggcccatg gctttgtgga agctgctgtt
     7501 ccagctgtct ggataatcca gctcactacc tacatctcac aacccaactt gactttagcc
     7561 atatataaat gacagtcaac ctatggatgc atgcaaacat ctggggaatt ggatgaagtc
     7621 gtcattttca tctgaatgtt tgattttaat gtagtcacag tctttgagcc atccagagag
     7681 ggaaaaagtg tatactgact gtatagacaa tagggaccac ttccccagat gccacaaccc
     7741 tgaccccact ccctccccac cagacccgga ggtgcagccc aggggtagca tggaggtgga
     7801 gggccctggt gtcggcagcc tccctgatgc tttctttctc cgcagccgtc agcagctccc
     7861 ggggcggcct ggtgtgcggg cctgagcctt tggttgccgg ctccaccctc tcccgcggcg
     7921 gggtcacctt ctcaggtagc agcagcgtct gtgccaccag tggggtcctg gcttcctgtg
     7981 gccccagcct gggtggagcc cgggtcgccc cggccactgg ggacctgctg agcactggca
     8041 caaggagtgg ctccatgctc atcagcgagg cctgtgtccc cagcgtcccc tgccccctgc
     8101 ccacccaggg gggcttcagc agctgcagcg gcggccgcag ctccagcgtc cgctttgtgt
     8161 ccaccaccac ctcctgccgg accaagtact gagagcccag ccccagacag ctgctgccca
     8221 gagaagaacc agctccacgg ctcctgcttc tgcccccagg gttcgtgggc tctgggcttg
     8281 acggtctcca gctccccttt ctgccaggaa gccacccctt agcactcccc cgattattct
     8341 gcctggcccc atgtcctctt ggaggatttt tctgccatgt agatgctcca ttagcagttc
     8401 cagctaagct ggcttctccc tgcctcccaa tttctgtcct ttggatcact cctctccctg
     8461 tcagcaacag cctggagaaa tgcacattcc gtgcaataac aacaatccac ccagtgccct
     8521 caccacccgt ggctttgggt taatttggag aatggagttg accgtccaca ctgcaggcat
     8581 ccttaactcc acatccttca cttccttctt cttcctttct ctggtaggag aaggttcttt
     8641 ccttctctcc ctgatgaagg ggatcccagt ccttggtggc cccaggctcc ctaaaccccg
     8701 agatggcttt tctcccagtg gcttctctcc ggctgtttct cttcctgggt tgttggtgta
     8761 actccagcat gcaagtccac gaggtggggt gcaggcggac aggcgggctt tgcaatgatc
     8821 cccgtactcc tgcccctgct cgtggtgtga ggcccagccc tgtccactgc agggttgtgt
     8881 ctgcaagctc caaggaggcc tgggggttgg gtggggtggg ctgcctgtgt gcactactct
     8941 ttgtgttcct gggttttcaa taaacttgcc aagctcacct cacagggact ctggcctctc
     9001 cttctggatc acactggggt tggaggagtt gcctcctaga ctccaccaga tcacagcctg
     9061 cctagctgag gtagggcaga gactggtgtc ctgggcacag ggaaggcact gaggaaagag
     9121 ggcccaggcc attcgctgga gggactgaca gttctgcagg gcataggaga ggtagcaaag
     9181 gctccaaaaa caagtggcag ccagcccact gcccacttcc ccccaccact gggaatagcc
     9241 ttgtgctcag aggcaccctc ccctgaccaa agtgaaccct gccatctgtt gctccccagg
     9301 tctcacccac cctcagttcc cccagttcat cagttcatat aggtccttcc tggtctttct
     9361 gttcccactc gtgtctccat ccaactcatt catcacgatg ctgctagaaa ggcctttctc
     9421 acataaaaaa ctgactgtgg ttccccgcag ctcatatcct tcggtagctc cccgttgcct
     9481 cccagaaata gcccaagctc cttaacatgg catacaagcc ctgtgtgatc tgcccgtaga
     9541 cttccacccc cagccatccc ctccacacag cccactgccc acctctcatc ttttgtctat
     9601 tcatccaaca aacatttgag aagtgcctac cacataccag gcatgatgct gggaaaatgg
     9661 taattgacaa gattcaattc c
//