LOCUS Y19209 9681 bp DNA linear HUM 14-NOV-2006 DEFINITION Homo sapiens KRTHB4 gene for type II hair keratin 4, exons 1 to 10. ACCESSION Y19209 VERSION Y19209.1 KEYWORDS HB4 gene; KRTHB4 gene; type II hair keratin 4. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J. TITLE Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain JOURNAL J. Invest. Dermatol. 114(3), 464-472(2000). PUBMED 10692104 REFERENCE 2 (bases 1 to 9681) AUTHORS Schweizer J. JOURNAL Submitted (31-AUG-1999) to the INSDC. J. Schweizer, German Cancer Research Center, Research Program 2 (b0501), Im Neuenheimer Feld 280, 69120 Heidelberg, GERMANY FEATURES Location/Qualifiers source 1..9681 /organism="Homo sapiens" /chromosome="12" /map="12q13" /mol_type="genomic DNA" /clone_lib="PAC" /db_xref="taxon:9606" regulatory 539..543 /gene="KRTHB4" /regulatory_class="TATA_box" mRNA join(590..1183,2428..2636,3161..3221,3694..3789, 4701..4865,5021..5146,5643..5863,6319..6350,7846..8459, 8693..8978) /gene="KRTHB4" exon 590..1183 /gene="KRTHB4" /number=1 CDS join(638..1183,2428..2636,3161..3221,3694..3789, 4701..4865,5021..5146,5643..5863,6319..6350,7846..8192) /gene="KRTHB4" /product="type II hair keratin 3" /note="formerly HB4 gene" /db_xref="GOA:Q9NSB2" /db_xref="HGNC:HGNC:6461" /db_xref="InterPro:IPR003054" /db_xref="InterPro:IPR018039" /db_xref="InterPro:IPR032444" /db_xref="InterPro:IPR039008" /db_xref="InterPro:IPR042180" /db_xref="UniProtKB/Swiss-Prot:Q9NSB2" /protein_id="CAB76829.1" /translation="MSCRSYRVSSGHRVGNFSSCSAMTPQNLNRFRANSVSCWSGPGF RGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVGLGPRADSC VGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQR VKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYI TNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDA AFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGII AEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLK AEIEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLREYQE LMNAKLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLS RGGVTFSGSSSVCATSGVLASCGPSLGGARVAPATGDLLSTGTRSGSMLISEACVPSV PCPLPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY" exon 2428..2636 /gene="KRTHB4" /number=2 exon 3161..3221 /gene="KRTHB4" /number=3 exon 3694..3789 /gene="KRTHB4" /number=4 exon 4701..4865 /gene="KRTHB4" /number=5 exon 5021..5146 /gene="KRTHB4" /number=6 exon 5643..5863 /gene="KRTHB4" /number=7 exon 6319..6350 /gene="KRTHB4" /number=8 exon 7846..8459 /gene="KRTHB4" /number=9 exon 8693..8978 /gene="KRTHB4" /number=10 regulatory 8959..8964 /gene="KRTHB4" /regulatory_class="polyA_signal_sequence" BASE COUNT 2434 a 2429 c 2495 g 2323 t ORIGIN 1 gctttactgt agattcaact cttgtatact aaacagccat attggataaa acatggcaga 61 aggttttttg atgatttaat tgatttgcag aaatgcaaca aactgtattt tctccatatc 121 acttcttact tggagatgtg cacacactcc cacctcttta gggggttata tcttcatgga 181 tgcatcccat gtgagcctct tgctggagct gtcgccatcc taactttctg gtggttagcc 241 acactcacag tgaaaaaacc tattgcattt atgaccaaag caaattaatg tccccttaat 301 ggcaattgtg gtagacttat agggaaaaaa aagactataa tgtttatatg tttatgtgtt 361 tttaatgttt attggtttgc tgttacagcc ctcatcccaa tgagactagg tgtgtctgag 421 ttaactcatt gtcaaggagg ttataggcat gcagagtttc tgctaactac ccaagctcat 481 aaatgcctgc aaatggattt tttcattttt atggggccaa gcctcagatc accacacaca 541 taaaaggggt gcaagggttc cactggcctc agagggactc ccagctccag ctcacccatt 601 ctacacttgc tcttttgctc ccaaccagga agccatcatg tcttgccgct cctaccgagt 661 cagctctggt caccgggtgg gcaacttcag ctcttgttca gcaatgacac cacagaacct 721 gaatcgcttc cgggccaact ctgtctcctg ttggagtggg cctggattcc ggggccttgg 781 cagctttggt agtcggagtg tcatcacctt tggatcgtac tcaccccgga tagcagctgt 841 aggctctcgg cccatccact gtggagtccg ctttggtgct ggctgtggga tgggttttgg 901 tgatgggaga ggtgttggtc tggggcctag ggctgacagc tgtgttggtc tgggctttgg 961 agctggcagt ggcattggct atggctttgg tggccctggc tttggttaca gagttggagg 1021 ggttggagtc ccagcagccc catctatcac agctgtgact gtgaacaaga gcctactgac 1081 ccccctcaac ctggagattg accccaatgc ccagagggtg aagaaggatg agaaggagca 1141 aatcaagacc ctcaacaaca agtttgcctc cttcattgac aaggtaccta tgatagctga 1201 atctctgggt ctaggaatat tacagccaaa atgcactaga gtgctctttc ccttaaaaag 1261 aactggcccg gttctgggga cttgaccttg acctcagatc tttcaagtgc ctacctcagg 1321 cattgtggta tgctttatgg gttgctctgc tgcagagcaa ggccaagcca gaggacgagc 1381 tgcatggtgg gatagattcc gacagtgttg atatcttctg gaggacagag gagcatccag 1441 ccaaactcga gggcatctcg acaaactaag atgttgcatc tggtcactta gaaatgtctc 1501 tgaaacaggc tggaaacact gggactttag ccaggtgttg gctggtatat gcttaagagg 1561 ttttattctt tgagatcctt ttgttcctta tgaagttttc atagtttctg aggctgagtg 1621 gcctcatcta ttcaggctta gaaaagtaga gaatggagtt gagtaattaa aaaaagaaga 1681 agaattcata cccccacatg gggtatcaaa attcggccaa gttgcctaga ttcagggaaa 1741 ttgtagggaa tgaccactgg tagtcactgg cttccaggca gatgagtggg aacagtgatg 1801 tggataaccc aaaagaactg acatcccaca caccatgtct atgtggagat ggaatggtta 1861 tgtctgagaa tgaaggataa cctctgtaag ttttgggttc ttcctctcta aaatgagggg 1921 ctggggtaaa gggtctgtaa gttctcttcc agctctacac atctcagcca atggaatatc 1981 tgcgatgttg gataggactt acaatctgag aattcctacc tcccagtacc atatcccacc 2041 ccaaatgtag tttactctgc tccccattct ctgccaggga tgcctggcat cagttttcag 2101 atataggcaa accagagctt aaatagaatc aacccttcca acttcctgat gtaccagtgt 2161 acagctttct tagagactgg ataggggaat ggtactgaag tgctatggtt caaaacccca 2221 tactggtaac taggcctagc cgagcacaag gagggagtca caacctgccc ttccagcttc 2281 tgctgagtta gtggaggaat gaaagtcagc agaggagaga accctgtcga catgtggtca 2341 agtcatcgct ggccatctca agagcttggt caaggcatga accctatcaa gcacttcaaa 2401 tgccatttct gtgccctgtg gatttaggtt cggttcctag agcagcagaa taagctccta 2461 gagaccaagt ggagcttcct ccaagagcag aaatgtatca ggagcaatct ggagccactc 2521 ttcgagagct acatcaccaa cctgcggagg cagttggagg tgctggtcag tgatcaggcc 2581 cggctccagg ctgagaggaa ccacctgcag gatgtcctag agggcttcaa gaagaagtga 2641 gtgacatctg agctgcacag accagtgaca ggccaggcct ggccccagaa ttagctgcca 2701 agctcagatg agagcagctg gaaggatcag ggttgaatgc tggttaccac atcaagcctg 2761 gggaggtggg ggtgggtaga gatatgtgaa cagagaagag gaggccctcc tgaggaaaaa 2821 ggtgcccatg ttcagtatct ttttcagttg ggccctactt gctctatagt caaatgcaat 2881 gatcctacat tatttctgtc agaggaacat agcaatagac caggttttca gatcccaaac 2941 ccacattaag aaagtggaag ggatttggag aaactgagag gcactggctt atgaaaggtc 3001 ataaagatga gacagagggg atgatgttat agcattcaga tagcaatagg gaaccatgat 3061 cctgcacaga ctgagagatc ttgcaaggtt cactggggag ttgggagtaa ctgcctctca 3121 gttcagagta agcactcacc ctcttaacct ttatcatcag gtatgaagag gaagtggtat 3181 gtcgggccaa tgctgagaat gagtttgtgg ctctgaagaa ggtaaggggg aaccacagac 3241 caggccaact tctcctctgg accggcaaat gttctcaaga ctccccagga aactgctcag 3301 gcagccctgt ggagtctggg actactcaca ccaagacagt ggagacagtg gaatctcaga 3361 gataacaaga gatttcctac aaagttcagg ttcagcctca gattctttag gattgggtca 3421 catgtgagca gaggtatgaa aaggtgacct aagtatcttg gattatctag attttctttg 3481 cctctaactg aacatcagga aatgtccagc agcccctggg ggaatgttgg cattgtaata 3541 gggaaatgag caaaagttgc tgagcttcac ttctacccag cgaccttacc atctgtggga 3601 agtggctgcc tctttgcacc catctccaga cacaggtggg aaggtgaaac agtgcccagg 3661 cgatgagtat ttatccttct ctgttttata caggatgtgg atgcagcttt catgaacaag 3721 tctgatctcg aggccaacgt ggatacccta actcaggaaa ttgactttct aaaaacgctt 3781 tacatggagg tgagggttca tcttctctag ggcacccaag gagatcaatg cttggcctgg 3841 actccctgaa tgcttagcct gggctagcat attttcaaac atttgctatc atatatcttt 3901 cctctcactc aaatctgtat gctatatatg ccaatatgtc ttcaaatggg gaagggaagg 3961 tgagcaggct tttcagcagc ctgatgcaag tcaaactcct tggatctatg atccaactcc 4021 ttatttacca atttaaagac tgggatctag aaatgtcact tcctgtgtac tgacaagaag 4081 actgaaaaat tgatttgcca ggagaggtaa gaaaaaatgt gtttgaccta attagccaaa 4141 ccagctgtct tttgcttcat aaacaatctg tccagtctgg tataggccca gccagagctg 4201 aattgctagc tctaagtgaa gaggctgagg aaagcctcct ctggaactct ctttgcaggc 4261 cagtcccaag cccctcagtt cttctattaa gggcttggga tataggaatt cctagaccac 4321 catgtgctaa aatattgtca ggtctcaacg gtctgtgacc agcccagcca ctttgtagat 4381 aatctaagaa aagtttaagc cctagagtgg ctcccacttt cttccaccat gttcttagat 4441 ccccatggtt ttaatactta ctgagcaaag tagtgtgtta aagggatgtt tctgagtaga 4501 tcacaagagc tctaaagtca gcctgagatg gttctcagac atgtcttttt ctttatcatc 4561 aatttagatg gtcttgcttt tttatgaacc aatgagtgat gctctctgcc cctggcacca 4621 cttcctgggc cccctgtggc agagtcccag ctactaaatg agactctaag cacatctgtc 4681 tccccaatcc tccaacacag gaaatccagt tgctgcagtc gcacatctca gagacgtcgg 4741 tcattgtgaa gatggacaac agccgtgacc tgaaccttga tgggatcatt gctgaggtca 4801 aggcccagta tgaggaggtg gccaggcgca gccgggctga tgctgaggcc tggtaccaga 4861 ccaaggtggg cagtggaggc tggggaaggg atgtaggcag ctctgggaat gactcatata 4921 taacagatca ggcccaggga ggtttgaagc ccccaactca gtgggggctg tgatcctgac 4981 ctgacctccg aaccctcaaa ataccctcct ctctccgcag tatgaagaga tgcaggtgac 5041 agctggccaa cactgtgaca acctgcgcaa catacggaac gagatcaacg aactgacccg 5101 cctgatccag aggcttaagg cagagattga gcacgccaag gctcaggtgg gcaaaggaaa 5161 ggagggaaag cctcagatga gggagaacca gggcctcagg ctttgggaac ccccaagtct 5221 aatgaggtga gggagaccat caagacccag aaaccaagga atggagggat cagtccagga 5281 aggctttctg gaggataaaa atatggaagg gaaggagagc ttcccacata gaagtaaagg 5341 gctagagcag acccagcagg gaaggtggta cagaaagaat aaatttaccc tctagatgcc 5401 atgactctgg ggcagctgaa atcagcagtg acaaagtcag tggggatgga aacaacagca 5461 atgccctacc ccatagtgac atcaaactac aggatctcca gtgcctggga aagcagccac 5521 catggggtcc atccctgcct tggccccagg ctatgttccc actaagaggg gccgtgtttc 5581 taacccaacc tggggatgcc ctggcactgc cgaagcctac ctgcaaactg ccttccctgc 5641 agcgtgccaa gttggaggct gcagtggccg aggccgagca gcagggcgag gcgaccctca 5701 gtgatgccaa atgcaagctg gcagatctgg agtgtgccct gcagcaggcc aagcaggaca 5761 tggcgcggca gctgcgcgag taccaggagc tgatgaatgc caagctgggc ctggacatcg 5821 agatcgccac ctacaggcgc ctgctggagg gcgaggagag ccggtgagta ctctcagtcc 5881 agcaggagag tgaagtcaga cttaggcatc tagaaagact aaggaagaga aggggacagt 5941 gaagaactgc agaaatacat agtctttaaa gatgacaata ccttctctgc aaacattagt 6001 tgcattgccc ttgtcaggga atcagaagaa ggctctagac ctgtgattct caaatgcaag 6061 tctagataag ctgcaccaga atcattagta attttgctaa aattactact aatgataaat 6121 ttccttaaat attttaatct aatggttttg ggatagggtc taagaacgtg tttttcaacg 6181 ctccccagat gtgtgtataa ccaggggtga gaactactgc tccacagatc tactcaaaca 6241 agaaagccct ttttatggca aataggtttt caggaaacaa tagtgcatgt gaaatgattt 6301 gtttcttccc ctttccaggc tctgtgaagg tgttggacca gtaaacatat gtaagaaact 6361 tgttttttcc tcttcacaca tttctctcct cttcaaactt cctttaaact caggctcaca 6421 ctggggtcag gaggcgtccg acatggccgg tctggccacg acagtcaggg gagctgggac 6481 catccagccc tggatgggga gcatcttctt agctgaggtc tgagatctcc ccagagcctg 6541 ccttccccag agcaaaacat tcataaaggt tttcaaggcc tccaaagtgg aggacagcca 6601 gcttttttgc tttgagcggc cttgtccttc aagggaactt agaaggactt agaaggactg 6661 ggacttagaa ggaatgggac gcctctgcca ggggagcctc tcatcccctg atggcaggga 6721 acgcaataag gccaaatgga agtctcccca ctgctgcagc cgaagcatgg gttgtaccca 6781 aagcacgcag ggcagtgtgc cgggcatggc agtctgggga cactggcaag gcaagaccca 6841 gcccacgctc tctagaaata gaatcttctt gagaagatga gtcctagcca ccatcaacct 6901 aacactggaa ggatccctgg ggagaaaagc ggatactggc atccctgttt tgcccactca 6961 gagaaagtac atgatttgcc agaacttaca aagcgaacca gatttcaaac ccagatttct 7021 gactccaaaa acacaaatga acactgacgt gtagtggaac cgagtgctaa actgggtggg 7081 tcagacagtc agagctacat gtacttggaa gacagtgtcc cttcccactc ccatggaggc 7141 ggtgagtggt caggggaagc cacaggcaat ggctttctgc aggaggtcaa gcttgagtga 7201 acatcatgga tggcaggaag gattctgggt aagatgaaag ggcaggaaag agtgtacccc 7261 tccatggatg gggctggtct agcaagctct tctgtggatt tgagtcctga ggcatggagt 7321 tgtgtccaag ggagagcaga gggctacaga gcacagccac cagtgggtca ggagagaggc 7381 gacaagggac tagtgttgga ggggtttcct gtgtgctggg ctaggggaaa tgtggagacc 7441 accaaggggc ataatacaac tggaagagaa aaggcccatg gctttgtgga agctgctgtt 7501 ccagctgtct ggataatcca gctcactacc tacatctcac aacccaactt gactttagcc 7561 atatataaat gacagtcaac ctatggatgc atgcaaacat ctggggaatt ggatgaagtc 7621 gtcattttca tctgaatgtt tgattttaat gtagtcacag tctttgagcc atccagagag 7681 ggaaaaagtg tatactgact gtatagacaa tagggaccac ttccccagat gccacaaccc 7741 tgaccccact ccctccccac cagacccgga ggtgcagccc aggggtagca tggaggtgga 7801 gggccctggt gtcggcagcc tccctgatgc tttctttctc cgcagccgtc agcagctccc 7861 ggggcggcct ggtgtgcggg cctgagcctt tggttgccgg ctccaccctc tcccgcggcg 7921 gggtcacctt ctcaggtagc agcagcgtct gtgccaccag tggggtcctg gcttcctgtg 7981 gccccagcct gggtggagcc cgggtcgccc cggccactgg ggacctgctg agcactggca 8041 caaggagtgg ctccatgctc atcagcgagg cctgtgtccc cagcgtcccc tgccccctgc 8101 ccacccaggg gggcttcagc agctgcagcg gcggccgcag ctccagcgtc cgctttgtgt 8161 ccaccaccac ctcctgccgg accaagtact gagagcccag ccccagacag ctgctgccca 8221 gagaagaacc agctccacgg ctcctgcttc tgcccccagg gttcgtgggc tctgggcttg 8281 acggtctcca gctccccttt ctgccaggaa gccacccctt agcactcccc cgattattct 8341 gcctggcccc atgtcctctt ggaggatttt tctgccatgt agatgctcca ttagcagttc 8401 cagctaagct ggcttctccc tgcctcccaa tttctgtcct ttggatcact cctctccctg 8461 tcagcaacag cctggagaaa tgcacattcc gtgcaataac aacaatccac ccagtgccct 8521 caccacccgt ggctttgggt taatttggag aatggagttg accgtccaca ctgcaggcat 8581 ccttaactcc acatccttca cttccttctt cttcctttct ctggtaggag aaggttcttt 8641 ccttctctcc ctgatgaagg ggatcccagt ccttggtggc cccaggctcc ctaaaccccg 8701 agatggcttt tctcccagtg gcttctctcc ggctgtttct cttcctgggt tgttggtgta 8761 actccagcat gcaagtccac gaggtggggt gcaggcggac aggcgggctt tgcaatgatc 8821 cccgtactcc tgcccctgct cgtggtgtga ggcccagccc tgtccactgc agggttgtgt 8881 ctgcaagctc caaggaggcc tgggggttgg gtggggtggg ctgcctgtgt gcactactct 8941 ttgtgttcct gggttttcaa taaacttgcc aagctcacct cacagggact ctggcctctc 9001 cttctggatc acactggggt tggaggagtt gcctcctaga ctccaccaga tcacagcctg 9061 cctagctgag gtagggcaga gactggtgtc ctgggcacag ggaaggcact gaggaaagag 9121 ggcccaggcc attcgctgga gggactgaca gttctgcagg gcataggaga ggtagcaaag 9181 gctccaaaaa caagtggcag ccagcccact gcccacttcc ccccaccact gggaatagcc 9241 ttgtgctcag aggcaccctc ccctgaccaa agtgaaccct gccatctgtt gctccccagg 9301 tctcacccac cctcagttcc cccagttcat cagttcatat aggtccttcc tggtctttct 9361 gttcccactc gtgtctccat ccaactcatt catcacgatg ctgctagaaa ggcctttctc 9421 acataaaaaa ctgactgtgg ttccccgcag ctcatatcct tcggtagctc cccgttgcct 9481 cccagaaata gcccaagctc cttaacatgg catacaagcc ctgtgtgatc tgcccgtaga 9541 cttccacccc cagccatccc ctccacacag cccactgccc acctctcatc ttttgtctat 9601 tcatccaaca aacatttgag aagtgcctac cacataccag gcatgatgct gggaaaatgg 9661 taattgacaa gattcaattc c //