LOCUS Y17224 1116 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for MHC class I antigen, allele A*1103.
ACCESSION Y17224
VERSION Y17224.1
KEYWORDS HLA-A gene; HLA-A*1103 allele; human leucocyte antigen; major
histocompatibility complex; MHC class I antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Tijssen H.J., Sistermans E.A., van den Beucken M., Krausa P.,
Joosten I.
TITLE Complete sequence analysis of the A*1103 allele
JOURNAL Tissue Antigens 55(1), 68-70(2000).
PUBMED 10703613
REFERENCE 2 (bases 1 to 1116)
AUTHORS Tijssen H.J.
JOURNAL Submitted (05-MAY-1998) to the INSDC. H.J. Tijssen, University
Hospital Nijmegen St. Raboud, Blood Transfusion service, Transplant
Serology Lab. P.O.Box 9101, 6500 HB Nijmegen, NETHERLANDS
REFERENCE 3
AUTHORS Tijssen H.J., Sistermans E.A., Joosten I.
TITLE A unique second donor splice site in the intron 5 sequence of the
HLA-A*11 alleles results in a class I transcript encoding a
molecule with an elongated cytoplasmic domain
JOURNAL Tissue Antigens 55(5), 422-428(2000).
PUBMED 10885562
FEATURES Location/Qualifiers
source 1..1116
/db_xref="H-InvDB:HIT000325995"
/organism="Homo sapiens"
/chromosome="6"
/map="6p21.3"
/isolate="MAD"
/mol_type="mRNA"
/clone="M1"
/clone="M3"
/clone="M12"
/clone="M13"
/cell_type="PBL"
/tissue_type="blood"
/db_xref="taxon:9606"
CDS join(1..73,74..343,344..619,620..895,896..1012,1031..1063,
1064..1111,1112..1116)
/gene="HLA-A"
/product="MHC class I antigen"
/note="A*1103 allele"
/note="short variant"
/db_xref="GOA:P13746"
/db_xref="H-InvDB:HIT000325995.14"
/db_xref="HGNC:HGNC:4931"
/db_xref="InterPro:IPR001039"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR010579"
/db_xref="InterPro:IPR011161"
/db_xref="InterPro:IPR011162"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR037055"
/db_xref="PDB:1Q94"
/db_xref="PDB:1QVO"
/db_xref="PDB:1X7Q"
/db_xref="PDB:2HN7"
/db_xref="PDB:4MJ5"
/db_xref="PDB:4MJ6"
/db_xref="PDB:4N8V"
/db_xref="PDB:4UQ2"
/db_xref="PDB:5GRD"
/db_xref="PDB:5GRG"
/db_xref="PDB:5GSD"
/db_xref="PDB:5WJL"
/db_xref="PDB:5WJN"
/db_xref="PDB:5WKF"
/db_xref="PDB:5WKH"
/db_xref="PDB:6ID4"
/db_xref="UniProtKB/Swiss-Prot:P13746"
/protein_id="CAB38056.1"
/translation="MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFYTSVSRPGRGEP
RFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDL
GTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAA
DMAAQITKRKWEAAREAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPI
SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSG
EEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRR
KSSDRKGGSYTQAASSDSAQGSDVSLTACKV"
CDS join(1..73,74..343,344..619,620..895,896..1030,1031..1063,
1064..1111,1112..1116)
/gene="HLA-A"
/product="MHC class I antigen"
/note="A*1103 allele"
/note="alternative, long variant"
/db_xref="GOA:P13746"
/db_xref="HGNC:HGNC:4931"
/db_xref="InterPro:IPR001039"
/db_xref="InterPro:IPR003006"
/db_xref="InterPro:IPR003597"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR010579"
/db_xref="InterPro:IPR011161"
/db_xref="InterPro:IPR011162"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR037055"
/db_xref="PDB:1Q94"
/db_xref="PDB:1QVO"
/db_xref="PDB:1X7Q"
/db_xref="PDB:2HN7"
/db_xref="PDB:4MJ5"
/db_xref="PDB:4MJ6"
/db_xref="PDB:4N8V"
/db_xref="PDB:4UQ2"
/db_xref="PDB:5GRD"
/db_xref="PDB:5GRG"
/db_xref="PDB:5GSD"
/db_xref="PDB:5WJL"
/db_xref="PDB:5WJN"
/db_xref="PDB:5WKF"
/db_xref="PDB:5WKH"
/db_xref="PDB:6ID4"
/db_xref="UniProtKB/Swiss-Prot:P13746"
/protein_id="CAB38057.1"
/translation="MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFYTSVSRPGRGEP
RFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDL
GTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAA
DMAAQITKRKWEAAREAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPI
SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSG
EEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRR
KSSGGEGVKDRKGGSYTQAASSDSAQGSDVSLTACKV"
exon 1..73
/gene="HLA-A"
/number=1
exon 74..343
/gene="HLA-A"
/number=2
exon 344..619
/gene="HLA-A"
/number=3
exon 620..895
/gene="HLA-A"
/number=4
exon 896..1012
/gene="HLA-A"
/number=5
/note="short variant"
exon 896..1030
/gene="HLA-A"
/number=5
/note="alternative, long variant"
exon 1031..1063
/gene="HLA-A"
/number=6
exon 1064..1111
/gene="HLA-A"
/number=7
exon 1112..1116
/gene="HLA-A"
/number=8
BASE COUNT 225 a 331 c 382 g 178 t
ORIGIN
1 atggccgtca tggcgccccg aaccctcctc ctgctactct cgggggccct ggccctgacc
61 cagacctggg cgggctccca ctccatgagg tatttctaca cctccgtgtc ccggcccggc
121 cgcggggagc cccgcttcat cgccgtgggc tacgtggacg acacgcagtt cgtgcggttc
181 gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggg
241 ccggagtatt gggaccagga gacacggaat gtgaaggccc agtcacagac tgaccgagtg
301 gacctgggga ccctgcgcgg ctactacaac cagagcgagg acggttctca caccatccag
361 ataatgtatg gctgcgacgt ggggccggac gggcgcttcc tccgcgggta ccggcaggac
421 gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcttg gaccgcggcg
481 gacatggcag ctcagatcac caagcgcaag tgggaggcgg cccgtgaggc ggagcagcag
541 agagcctacc tggagggccg gtgcgtggag tggctccgca gatacctgga gaacgggaag
601 gagacgctgc agcgcacgga cccccccaag acacatatga cccaccaccc catctctgac
661 catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc
721 tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca
781 ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaga ggagcagaga
841 tacacctgcc atgtgcagca tgagggtctg cccaagcccc tcaccctgag atgggagctg
901 tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ccttggagct
961 gtgatcactg gagctgtggt cgctgccgtg atgtggagga ggaagagctc aggtggagaa
1021 ggggtgaaag atagaaaagg agggagttac actcaggctg caagcagtga cagtgcccag
1081 ggctctgatg tgtctctcac agcttgtaaa gtgtga
//