LOCUS Y16535 4197 bp DNA linear HUM 11-FEB-2000
DEFINITION Homo sapiens NEU2 gene.
ACCESSION Y16535
VERSION Y16535.1
KEYWORDS NEU2 gene; neuraminidase; sialidase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Monti E., Preti A., Rossi E., Ballabio A., Borsani G.
TITLE Cloning and characterization of NEU2, a human gene homologous to
rodent soluble sialidases
JOURNAL Genomics 57(1), 137-143(1999).
PUBMED 10191093
REFERENCE 2 (bases 1 to 4197)
AUTHORS Monti E.
JOURNAL Submitted (10-FEB-1998) to the INSDC. E. Monti, Dept. Biomedical
Science and, Biotechnology, University of Brescia, Tigem, Telethon
Institute of Genetics, and Medicine, Via Valsabbina 19,25123
BRESCIA, ITALY
REFERENCE 3
AUTHORS Bassi M.T., Sperandeo M.P., Incerti B., Bulfone A., Pepe A.,
Surace E.M., Gattuso C., de Grandi A., Buoninconti A., Riboni M.,
Manzoni M., Andria G., Ballabio A., Borsani G., Sebastio G.
TITLE SLC7A8, a gene mapping within the lysinuric protein intolerance
critical region, encodes a new member of the
glycoprotein-associated amino acid transporter family
JOURNAL Genomics 62(2), 297-303(1999).
PUBMED 10610726
FEATURES Location/Qualifiers
source 1..4197
/organism="Homo sapiens"
/chromosome="2"
/map="q37"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
regulatory 249..254
/gene="NEU2"
/note="CAXXTG E-box"
/regulatory_class="other"
regulatory 324..329
/gene="NEU2"
/note="CAXXTG E-box"
/regulatory_class="other"
regulatory 549..553
/gene="NEU2"
/regulatory_class="CAAT_signal"
regulatory 596..601
/gene="NEU2"
/note="CAXXTG E-box"
/regulatory_class="other"
regulatory 606..611
/gene="NEU2"
/note="CAXXTG E-box"
/regulatory_class="other"
regulatory 1013..1021
/gene="NEU2"
/regulatory_class="TATA_box"
CDS join(1435..1635,2878..3819)
/gene="NEU2"
/product="neuraminidase"
/product="sialidase"
/EC_number="3.2.1.18"
/db_xref="GOA:Q9Y3R4"
/db_xref="HGNC:HGNC:7759"
/db_xref="InterPro:IPR011040"
/db_xref="InterPro:IPR026856"
/db_xref="InterPro:IPR026945"
/db_xref="InterPro:IPR036278"
/db_xref="PDB:1SNT"
/db_xref="PDB:1SO7"
/db_xref="PDB:1VCU"
/db_xref="PDB:2F0Z"
/db_xref="PDB:2F10"
/db_xref="PDB:2F11"
/db_xref="PDB:2F12"
/db_xref="PDB:2F13"
/db_xref="PDB:2F24"
/db_xref="PDB:2F25"
/db_xref="PDB:2F26"
/db_xref="PDB:2F27"
/db_xref="PDB:2F28"
/db_xref="PDB:2F29"
/db_xref="PDB:4NC5"
/db_xref="PDB:4NCS"
/db_xref="UniProtKB/Swiss-Prot:Q9Y3R4"
/protein_id="CAB41449.1"
/translation="MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASK
KDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFF
IAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVG
PGHCLQLNDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLE
CQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSV
ISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAY
SDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ"
exon 1435..1635
/gene="NEU2"
/note="number 1"
intron 1636..2877
/gene="NEU2"
/note="number 1"
exon 2878..3819
/gene="NEU2"
/note="number 2"
BASE COUNT 879 a 1198 c 1146 g 974 t
ORIGIN
1 aaagcatagc ctcccgatac ctatcaaggc tgtgtccctt ggattataat ttggtgattc
61 ttatcaccaa gccatgaatc tcccaccgaa gttcagggaa tagcacattt tttccttgtg
121 cagcttttgc ccttctcagt tttattttct cacatcgtcc taatattaac gttcactgtg
181 gttgaatgaa agactgatag attacattta tttctcaaag aagctaagtt ttaaatagat
241 aacgcatgca tgtggtagaa aaatgagagc agtacaaaag ggtgcacaaa ggcaaacctt
301 gcccctcttg ctggcctctt gcccacttgc cctctgcaaa ggctgtgtct cagacggggt
361 gcccaggacg ccggctctga cacggagacc cacggcaggc aagagcctct gggggaaagg
421 gaggagcagc agagaaagag gcggctgtaa tgcagtctca gggaaggccc agccgcccgg
481 agggagctcc ggagccgcac tgttcctggt caggagttca ggaagagggt cttcaggctc
541 tgagtggacc aatcatcaag cagcccttct tgggtatgac ctggggcaga ttcttcatct
601 gggaacaact ggcccatcct ccccaggcca gggccctgca gccaacactc cccagagctg
661 cgggatgcat cctcctaaag ggacctaggc agcttagccc gaaaatcact gtcacccact
721 gtccccaagt tacctctgtc ccctccctac cctttttagc tgaagactta tttttaattg
781 ttattttctt agacctctgg agcaccccac gcccccagcc tgggttagct gtcaggagcc
841 cctgtctctt cctttcccac tgcagcgccg ccccctcgct gcctcagggg gagcccacgc
901 agcagcgggg gcaggacggg cctcagcctc aggcagcctg gggagcagag cccttagaag
961 ccatgctttt tctttttcct tttctttgaa acaactttct agggctctgg agttataaaa
1021 agctcccatg tgtcactttc tggcatttgg gcagctgccg aatgccaccc ggcctgcact
1081 gctgtcctcc cgaggtttgc ccctggattg atgggctggg tttggcaaaa gcagctggag
1141 gttatcgaaa atccgttgta aggagcattg ttaacttaga ataaaaatcg aatccaaaac
1201 acgcttttgc aataccccct cccgatatcc accgaggcaa aggcagaatt aagaagcagg
1261 gtcttgagat gtaggaaagg agaatgaacc ccacgcggga agaggacagg ccgccctgac
1321 tttggtccac tcagccaggg ggtgagcacc acctgtcttg gtgaatgact ctgagcccat
1381 ctcaggtgtg gctgcaggtg acacatcttc tcttcctgtc caccccccag ccccatggcg
1441 tcccttcctg tcctgcagaa ggagagcgtg ttccagtcgg gagcccatgc ctacagaatc
1501 cctgccctgc tctacctgcc tgggcagcag tccctgctgg ccttcgcgga acagcgggca
1561 agcaagaagg atgagcacgc agagctgatt gtcctgcgca gaggagacta cgacgcaccc
1621 acccaccagg ttcaggtgag gcaggaggtg tctgcactgg ctccccaggg ctctgccaca
1681 ccctttgctg ctgtgatcag gggccagtcc tggatctcaa gaaatacagg gacaacttta
1741 tccctcaatg gctgtactcc ggaggagaga tagagcagag aaagtgcccc taatggttcc
1801 ctggacctct gggttcactg tgaattagtc cagctggcct ccatctgttt tcatgaaaga
1861 ttgaatgagt tgcccagcat ccgtgatgac ctcacggagg aatagttcag tgttgcataa
1921 tggagggttg tgtcctttga gtaaaattaa cttggggact tggggtgggg tgatggcttg
1981 tgtcctaaag tcccatttta tagattaaat aattaatcct gatgacagca cccaaggctg
2041 gctgatcata tttgaagagt ttaatattat tatcattcct ttgtggtcat tactacacag
2101 ctgttcaaag catgggattt gaagcagatg gacctgggtt caagtcctgg ttccgccact
2161 gaccacagat gtggcctagg caactcctcc tccctgtcgc ggtctcttgc tcactgtaat
2221 aatggagcta ctaacacctg ttccctgggg attgaggcat tagatgagac catggatgtt
2281 agacttttgg tgctgtgtct gtgcttagaa ttgcccaatg ggggtagctg ttaataaatg
2341 gggacagaca gcacatgtga catagacttg gggattctgg aagctcaatg tgactcctcc
2401 ttggctacat gagtaggata tggagtgtag aaggtgagag gtgaccgtca cattctgtct
2461 tgtactggtc aggttattgc accttccgcc agggctttgc tattcaagga tggtgagctg
2521 gactggggtg ggaagtggag gaaccaggat gaagttggga atggctcatg cacgagtcat
2581 cttcatatct gtggtctggc aggtgggtgt tctgtaaatg catattgatg gcaatggaag
2641 gaacagaatc actcagccga gtgtggctgc cttggagggg tgaggtggca ccctgggccc
2701 cgcagctctg gggaaacgtt gcaaggagga tatgagtgtt gggtgaagag ttcttctcga
2761 tgacttttga ctctaacccg ggagacacac ccgtgcccac ccctcccact catgcagctc
2821 ctggcaccat ccccagctgt ttcaaggctg ccttcttctt tctctctccc tactcagtgg
2881 caagctcagg aggtggtggc ccaggcccgg ctggatggcc accggtccat gaacccatgc
2941 cccttgtatg acgcgcagac ggggaccctc ttcctcttct tcattgccat ccctgggcaa
3001 gtcacggagc aacagcagct gcagaccagg gccaatgtga cgcggctgtg ccaagtcacc
3061 agcactgacc acgggaggac ctggagctcc cccagagacc tcactgatgc ggccatcggc
3121 ccagcctacc gggagtggtc cacctttgca gtgggcccgg ggcattgttt gcagcttaac
3181 gacagggccc ggagcctggt ggtgcccgcc tacgcctacc ggaaacttca ccccatccaa
3241 aggccgatcc cctctgcctt ctgcttcctc agccatgacc atgggcgcac gtgggcgcga
3301 gggcactttg tggcccagga caccctggag tgccaggtgg ccgaagtcga gactggggag
3361 cagagggtgg tgaccctcaa cgcgagaagc cacctccgag ccagggtcca ggcccagagc
3421 accaatgacg ggcttgattt ccaggagtct cagctggtga agaagctggt ggagccgccg
3481 ccccagggct gccaggggag cgtcatcagc ttccccagcc cccgctcggg gcctggctcc
3541 ccagcccagt ggctgctcta cactcacccc acacactcct ggcagagggc cgacctgggt
3601 gcctacctca acccgcgacc tccagcccct gaggcctggt cagagccggt actgctggcc
3661 aagggcagct gtgcctactc agacctccag agcatgggca ccggccctga tgggtccccc
3721 ttgtttgggt gtctgtacga agccaatgat tacgaggaga ttgtctttct catgttcacc
3781 ctgaagcaag ccttcccagc tgagtacctg cctcagtgag cctgtggtgc ccacctcaag
3841 ggcctgcctt tcacctgcac acccagctcg gaggctctgc ggctgcctct ccttcccgtg
3901 gcccctggac gtgggggcca ctctgggctc ccttcggcgc ccgtgtgtgg agagaggtgc
3961 acctcttgct cttttcctcc tgcgtggttc cagtcttccc aaaaggttct attttcagcc
4021 cagaaaccaa aagtgtctgg cttcccatag cccctccata gggaaggcgt ggagggtcct
4081 gcagcgcagc tgtcaccttg tctgcctgtc ccctaccccc agctttgtgt aggtcttgac
4141 aaatttctaa gttcaactcc ttccttcttg ggaaccattc cttatgttcc tggggga
//