LOCUS Y16241 8034 bp mRNA linear HUM 23-OCT-2008
DEFINITION Homo sapiens mRNA for nebulette.
ACCESSION Y16241
VERSION Y16241.1
KEYWORDS nebulette.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Millevoi S., Trombitas K., Kolmerer B., Kostin S., Schaper J.,
Pelin K., Granzier H., Labeit S.
TITLE Characterization of nebulette and nebulin and emerging concepts of
their roles for vertebrate Z-discs
JOURNAL J. Mol. Biol. 282(1), 111-123(1998).
PUBMED 9733644
REFERENCE 2 (bases 1 to 8034)
AUTHORS Millevoi S.
JOURNAL Submitted (15-JAN-1998) to the INSDC. S. Millevoi, EMBL Heidelberg,
Meyerhofstr. 1, 69117 Heidelberg, FRG
COMMENT Related sequence: U35276
FEATURES Location/Qualifiers
source 1..8034
/db_xref="H-InvDB:HIT000325928"
/organism="Homo sapiens"
/chromosome="10"
/map="p12"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="Stratagene #936208"
/tissue_type="heart muscle"
/db_xref="taxon:9606"
5'UTR 1..397
CDS 398..3442
/product="nebulette"
/db_xref="GOA:O76041"
/db_xref="H-InvDB:HIT000325928.15"
/db_xref="HGNC:HGNC:16932"
/db_xref="InterPro:IPR000900"
/db_xref="InterPro:IPR001452"
/db_xref="InterPro:IPR035631"
/db_xref="InterPro:IPR036028"
/db_xref="PDB:4F14"
/db_xref="UniProtKB/Swiss-Prot:O76041"
/protein_id="CAA76130.1"
/translation="MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARK
CTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLY
KRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSN
ISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEH
AVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNM
HDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQ
SQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLD
KTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYK
KDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDV
QRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEK
MLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSV
KYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQ
LSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKK
NQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFT
PVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDP
LEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVT
RPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDE
VSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN"
repeat_region 491..2902
/note="nebulin-like repeat region"
repeat_region 491..610
/note="repeat 1"
repeat_region 611..712
/note="repeat 2"
repeat_region 713..832
/note="repeat 3"
repeat_region 833..934
/note="repeat 4"
repeat_region 935..1036
/note="repeat 5"
repeat_region 1037..1138
/note="repeat 6"
repeat_region 1139..1246
/note="repeat 7"
repeat_region 1247..1360
/note="repeat 8"
repeat_region 1361..1468
/note="repeat 9"
repeat_region 1469..1579
/note="repeat 10"
repeat_region 1580..1690
/note="repeat 11"
repeat_region 1691..1801
/note="repeat 12"
repeat_region 1802..1912
/note="repeat 13"
repeat_region 1913..2032
/note="repeat 14"
repeat_region 2024..2128
/note="repeat 15"
repeat_region 2129..2221
/note="repeat 16"
repeat_region 2222..2314
/note="repeat 17"
repeat_region 2315..2407
/note="repeat 18"
repeat_region 2408..2500
/note="repeat 19"
repeat_region 2501..2593
/note="repeat 20"
repeat_region 2594..2698
/note="repeat 21"
repeat_region 2699..2806
/note="repeat 22"
repeat_region 2807..2902
/note="repeat 23"
3'UTR 3443..8034
regulatory 7375..7380
/regulatory_class="polyA_signal_sequence"
regulatory 8004..8009
/regulatory_class="polyA_signal_sequence"
polyA_site 8023
BASE COUNT 2681 a 1430 c 1658 g 2265 t
ORIGIN
1 cttgagtgtt agagctgagt agttttccca gaatctctaa gtccttttta tgctctttta
61 tgaatgaata gaattagtaa aagataaata aattttttct tttggatttc ttaaccagtg
121 gaaaaaatgt tgactttaaa agttcataaa atcaaatttt gcttaagaat atgttatttc
181 cacttgtgag gccagcctgg tagacctctg ggatcctttt ctgttcactc acacaccact
241 gagataagga gtgaagtgtg ggctaaatag ggctgaggct tgggcaaggg catttctgcc
301 agagcaccag agacgtcagc atctcaaggg cactgtggta tggaaaagga cgccacatga
361 gtaaatttta aaaatataaa tattttaaag ggtaaaaatg agggtccctg tatttgagga
421 tataaaagat gaaactgaag aagaaaagat aggggaagaa gaaaatgaag aagaccaggt
481 cttctataag cctgttattg aagacttaag catggaattg gccagaaaat gcacggaact
541 cattagcgat atccgttata aagaagagtt taaaaagtcc aaggataagt gtacatttgt
601 gactgacagt cctatgctaa accatgtaaa aaatatcggt gcttttattt ctgaggcaaa
661 atacaaaggc accattaaag ctgacctttc taattctctt tataagcgga tgccagccac
721 aattgacagt gtttttgcag gagaagttac acagctccag agtgaggtgg cctacaagca
781 gaaacatgat gctgccaaag gattctcaga ttatgcccac atgaaggagc cccctgaggt
841 taaacatgcc atggaggtca ataaacacca gagtaatatt tcttatagga aagacgtgca
901 ggacacccac acgtacagtg cagaacttga ccgaccagac atcaagatgg caacccagat
961 ctctaagatc ataagcaatg cagaatacaa gaaaggacaa ggaataatga ataaagagcc
1021 cgctgtaatt ggaagaccag attttgaaca tgccgtggaa gcttctaaac tttctagtca
1081 aattaaatac aaagaaaaat tcgataatga aatgaaggat aagaaacatc attacaatcc
1141 tcttgaaagt gcttctttta ggcagaatca gcttgctgct acactggcga gcaatgtgaa
1201 gtacaagaaa gacattcaaa atatgcatga tccagtttca gatctcccaa atttgttgtt
1261 tttagaccat gttttgaaag ccagcaaaat gctcagcggc cgagaatata aaaagctctt
1321 tgaggaaaac aaaggaatgt atcattttga tgcagatgct gtggaacatc tgcaccataa
1381 aggcaatgcc gtcctccaaa gtcaggtgaa atataaagaa gaatatgaga aaaataaggg
1441 aaagccaatg cttgaatttg ttgagacacc atcatatcaa gcttcaaagg aggctcaaaa
1501 gatgcaaagt gaaaaagttt acaaagagga ttttgagaag gagattaaag gaaggtcatc
1561 actggattta gacaagactc cagaattttt acatgtaaag tacatcacca accttctgag
1621 ggagaaagaa tataaaaaag atttggaaaa tgagataaaa gggaaaggaa tggaacttaa
1681 ttcagaagtt cttgatatcc aaagagcaaa gcgggcctct gaaatggcaa gtgagaaaga
1741 atacaagaaa gacctggagt caataattaa agggaaagga atgcaagctg gcactgacac
1801 ccttgaaatg cagcatgcca agaaggctgc agagatagcg agtgagaaag actataaaag
1861 agatctggag actgaaatta aagggaaagg gatgcaggtg agcacagaca ctcttgatgt
1921 ccagagagct aagaaagcat ccgagatggc cagccagaaa caatacaaga aggacttaga
1981 aaatgaaatt aaagggaaag gaatgcaagt gagcatggat atcccagata tccttcgagc
2041 caagaggaca tctgaaatct atagccagag aaagtataaa gatgaagcag agaagatgct
2101 ttctaactat tctaccatag cagatactcc tgaaattcag agaattaaga caactcaaca
2161 aaacattagt gcggtatttt ataagaaaga agtgggagct ggcactgcag tgaaagatag
2221 cccagagatc gaacgagtga agaaaaatca gcagaatatt agttcagtga aatacaaaga
2281 agagattaaa catgcaacag ccatttctga tcctccagaa ctaaagagag ttaaagaaaa
2341 ccagaagaac atcagcaatc tccagtataa agagcaaaac tacaaggcca ctccggtaag
2401 catgaccccg gagatagaga gagtgaggcg aaaccaggag cagctgagtg cggtaaaata
2461 taagggagaa cttcaacggg gaactgcaat ttctgatcca ccagagctga agagggcaaa
2521 agaaaaccag aaaaacatca gcaatgttta ttacagaggt cagctgggaa gagctaccac
2581 tttaagtgta actcctgaaa tggaaagagt gaagaagaat caagaaaata ttagctcggt
2641 aaaatatacc caggaccata aacagatgaa aggtagacca agtctgattt tagatacacc
2701 tgctatgaga catgttaaag aagcacaaaa tcatatttca atggtaaaat accatgaaga
2761 ttttgaaaaa acaaagggga gaggctttac tcccgtcgtg gacgatcctg tgacagagag
2821 agtgaggaag aacacccagg tggtcagcga tgctgcctat aaaggggtcc accctcacat
2881 cgtggagatg gacaggagac ctggaatcat tgttgacctc aaagtttggc gcacagatcc
2941 tggctccatc ttcgaccttg atcccctgga agacaatatt cagtctagaa gtctccatat
3001 gctctctgaa aaggcgagtc actataggcg acactggtct cgatcccatt ccagcagtac
3061 tttcggtaca ggtctcggag acgacaggtc agaaatctcc gagatttacc ctagcttttc
3121 atgctgcagt gaggtaacaa gaccgtctga tgaaggagca cctgttcttc ccggagccta
3181 tcagcaaagc cattcccaag gctatggcta catgcaccag accagtgtgt catccatgag
3241 atcaatgcag cattcaccaa atctaaggac ctaccgagcc atgtacgatt acagtgccca
3301 ggatgaagac gaggtctcct ttagagacgg cgactacatc gtcaacgtgc agcctattga
3361 cgatggctgg atgtacggca cagtgcagag aacagggaga acaggaatgc tcccagcgaa
3421 ttacattgag tttgttaatt aattatttct ccctgccctt tgagctttat tctaatgtat
3481 cccaaaccta atctttttaa aagatagaag atacttttaa gacaacttgg ccattatttt
3541 acaatgatgt atccttcctt tgacaattag acacacaggt accaggaaga aggaatgacc
3601 tctgggctga aaacagcagc attttcagta attcctacaa acaaaaatct ttgtgtctgg
3661 acgcctggtg ctgctaattg tgttcatggt ttcctttgat tggctattga acccttctgg
3721 gaaatgtatt tttgtagact ttaatagaga agttgattgt cccttaaatg tagcgtgtgt
3781 ttgaaacttc ttagctgtca ctttggaatc accccaagcc aattctctta actctgtaat
3841 gcagccaata atacaaaccc gttttgcttt tgagtcatga ggcaatttcc aatattagtg
3901 aaaattgccc aatataataa gtgtaaacag tggcagaagg acagtctggt taaaattata
3961 ttgactggtg gccttaggga tctagaaact tctactaaac agagaaattt ccttgttccc
4021 taggctgact ggtatctatt tatttctcat ttgtaccaag gcatctccta ctctccattt
4081 atattctatg gacccaagtc tatgctcagt tccacagaat gtcaggacca aataacttca
4141 cagctactct gcaaagggca aattataatg tcattgatat aatttcccta gtagcattta
4201 ccctgttgca tgtcatgtag attcaagctt ctgtaacata ggcagctgca ctgcgcgttc
4261 ctattattga agcaaaaagg gtgactgata cctaaaagcc ctttcttcct ctagtcgcca
4321 gctcatcaga aaaacatact ttgaaaagat gcttgagatt ttcctgctgc atcgcactct
4381 agtttggaag gatttacatc ttaggaaata acatgtatac tctagtaaat aagcgattta
4441 ggtgttccat tgaacagctt tgattaactt aatgccacca ttgatttcaa agtgaagaaa
4501 atgtaacaga agccagtgaa gcaatggaag ctggagtgtg actggaaaaa tactcagcaa
4561 acaaagttac caattccata cagagatgat ctggtgtctt cttttggaaa atggtattca
4621 aattctggaa tggaaatcta gccaccaaaa cgggttaatc aaaagacgtc cttttccgtt
4681 ttttttgctt ttattttcta aatcattttt aagggaatga aacaggaatg tcatcagaga
4741 ttttttagta caggcccaag agcctgtact ctaagaaaga aatttttgcc atgtatgaat
4801 tttcgaataa gtgactttgc aggcttttgc tagcccttgc tggtgggtct ggaaattaca
4861 tccagagtct gcagtccagg tcaccaagcc agcggcaccc gtcggcaacc ctgtgtttaa
4921 cggattgtgc cgtttactgt gacctgcaac ggggtggcat tcacttaggg tctgacttca
4981 cagctatgac aaaaccgaaa aagcaaaact gcgaggaagt gctaagatgt acgggtcttg
5041 gggatatctg ccttatatgt tatattcaag gaaattaacg aaacatcctg tgaaacatcg
5101 tttaaggaaa cgtttactag tccaaaggcc aaagctaatt tatttccact ttagaaaagt
5161 tagcacatgc ttttgaaaat ctgtgatttc attttattag gctaaaaggg taaataggct
5221 ttattacact gaagctgcat ctatatgtca ctgacataaa gttgaaaaaa taaatgcagg
5281 caaataacta gagacttctt ttaagggggt ttggctggtt tctctcactg aaatggccag
5341 tcgtgattaa agtgataaaa ccccatatct gttttggtat attgtacaca aacctacaaa
5401 aataaactga acttgcaata tttttgcaat aaaatctgtc gttaaaactg aggataaaat
5461 acctgctcaa ttttatttta ctaagtatat atttacattt cacccaggca ggccattttc
5521 ttttgtgatt ataagaaaga gtagttgttg attaaatttt cagactaaat ataggacagg
5581 tacaattttg gataaatagc agatttataa gaaccgcaat gaaaactgac ttgaaataat
5641 gcttgtaatc aggaaagtaa tttcatccac cgatttcaaa accagattca ctgagcataa
5701 aagtcaatac atatttgagg aataagtctc ctaaaatttt aagcttcacg taataatgtt
5761 tgcatagcaa aatatttctg cttcaagcct ttaggaatta agatctgatc agaatttaac
5821 taaagggtag ttgttttaca atgaagacta aaactgaaca agatgttgca tgcgcttagg
5881 ccataatttg gtagtgttgg cagttgttaa taaagcttgt caggatgtta agcatctcag
5941 gagaaatatt ggaaaattat atgtataaaa ccaaagtgct gtttttaaaa gcatcattta
6001 aaaaaaaatg acatgcctga acaacttttc cactttccac gtgcttccct cccacctttg
6061 gtttggcaac aggtatctcg tgcatgaagc tgacagctaa agaagatttt aaaaattgag
6121 ttaaagatga ctgtgtaaat gtccaagcac agagagcatg cacctgactt tctaaagttt
6181 gatgtgttct caagcctgac agaagcacaa ggaacagttt gatacacttt taaaaggttc
6241 tgaaaacaaa gctgtatagg gatcctctct ctcttgagca aagtatagca acagaatata
6301 ttgcttttgt tgtaagcttt tgtagtacat gtttttacta ataattcttg ttctctagaa
6361 agctttctat ttctaaccta tggcaaaatg aatccttcat gtcttcttgt tattgtttac
6421 acacttgcag tgtagcccag tttgaaatat ttatttggtt atcaactgcc catggaggag
6481 gctcttgatg atcccaggtc tcctcgacct ccatacacca cacaggcatt tgtaagcaca
6541 gtttccacaa gcaccttgta ggaatatgga taagattaga ccagcccctc tctgtccact
6601 gggtttattt cttgaagaag atgcagatct ggtttttcca atgtgccaca gtctttcctt
6661 atcctctcca tgctgagctt gacaacactc tgggaatgag gaacaagact ttttctaaaa
6721 agatagtgga agttcaaggg atgtacctcg ttttcaggtt catccatctc cagtggaatg
6781 ttttcaataa aagatgaaga aaatgtgtgt gatctttaat aacacatccc tatagaaagt
6841 ggataaaaga tataccaaaa ctgtaataca gatatataca aatataggtg cctttttgat
6901 tactcttgtt tgtctagtat gctcttggaa agaaaaccaa gcaagcaagt tgctgcctat
6961 tctatagtaa tattttatta cacatgattg atatttttgt ggtagggaag tgggatgctc
7021 ctcagatatt aaaggtgtta gctgattgta ttttatctct aaagatttag aactttagaa
7081 aatgccgact tcttccatct atttctgaaa ggttctttgt ggatttatat agagttgagc
7141 tatataaaca ttaactttag atttgggatt taaaatgcct attgtaagat agaataattg
7201 tgaggctgga ttcactacac aagatgaact tcacttcata aattaattat accttagcga
7261 tttgcttctg ataatctaaa agtggctaga ttgtggttgt tttggttaag gtgatatgga
7321 ggtgggagag cttttagtta agtaagaagc tatgtaaact gacaaggatg ctaaaataaa
7381 agtctctgaa gtattccatg ccttttggac cctttcctcg caactaactg tcaactgttg
7441 atcaaaaaag tcaaggcatt gtatgttgct tctgtggtta ttattctgtg atgcttagac
7501 tacttgaacc cataaacttg gaagaatctt tgagcaaatt ttctcagttg tctgtatgac
7561 ttcagtatat tcctgggaat gccataggat tttttgtgct tgatacatgg tatccagttt
7621 gcatagtatc acttctttgt aatccagttg ctgttaagaa tgatgtactt taaaggaaaa
7681 gagaaaactg catcacagtc ccattctcca gtgtccatgc aatgaattgc tgagcattta
7741 ggaagcagca ccaagtctat tacaggcatg gtgtgaaact tgatgtttga cctgtgatca
7801 aaattgaacc attgtacagt ttggcttctg tttgcttcaa aatatgtaga attgtggttg
7861 atgattaatt tgcgagacta actttgagag tgtaacagtt ttgaagaaaa cattgaatgt
7921 tttacaaatg aaggggcttc acggaatgtt acaatgttac taatataatt tggcttttgt
7981 tatgcaaatt gttaacacca gctattaaaa tatattttag tagaaaaaaa aaaa
//