LOCUS Y15065 7420 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for voltage gated potassium channel.
ACCESSION Y15065
VERSION Y15065.1
KEYWORDS KCNQ2; voltage-gated potassium channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Biervert C., Schroeder B.C., Kubisch C., Berkovic S.F.,
Propping P., Jentsch T.J., Steinlein O.K.
TITLE A potassium channel mutation in neonatal human epilepsy
JOURNAL Science, e1252229 279(5349), 403-406(1998).
PUBMED 9430594
REFERENCE 2 (bases 1 to 7420)
AUTHORS Steinlein O.K.
JOURNAL Submitted (09-OCT-1997) to the INSDC. O.K. Steinlein, Inst. of
Human Genetics, University of Bonn, Wilhelmstr. 31, 53111 Bonn, FRG
REMARK Revised by submitter 02-DEC-1997
COMMENT Related sequences D82343 to D82347
FEATURES Location/Qualifiers
source 1..7420
/db_xref="H-InvDB:HIT000325871"
/organism="Homo sapiens"
/chromosome="20"
/map="q13.3"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 43..2577
/gene="KCNQ2"
/product="voltage gated potassium channel"
/db_xref="GOA:O43526"
/db_xref="H-InvDB:HIT000325871.13"
/db_xref="HGNC:HGNC:6296"
/db_xref="InterPro:IPR003937"
/db_xref="InterPro:IPR003947"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR013821"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR020969"
/db_xref="InterPro:IPR028325"
/db_xref="PDB:5J03"
/db_xref="PDB:6FEG"
/db_xref="PDB:6FEH"
/db_xref="UniProtKB/Swiss-Prot:O43526"
/protein_id="CAA75348.1"
/translation="MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAG
SEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLL
VFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGR
LKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW
KLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLT
TIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRN
PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYRLIPPLNQLELLRNLKSKSG
LAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPS
KVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGL
KVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVG
RGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPP
TETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPV
QCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQ
EDTPGCRPPEGTLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAP
CAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK"
BASE COUNT 1366 a 2325 c 2354 g 1368 t
ORIGIN
1 gctgagcctg agcccgaccc ggggcgcctc ccgccaggca ccatggtgca gaagtcgcgc
61 aacggcggcg tataccccgg cccgagcggg gagaagaagc tgaaggtggg cttcgtgggg
121 ctggaccccg gcgcgcccga ctccacccgg gacggggcgc tgctgatcgc cggctccgag
181 gcccccaagc gcggcagcat cctcagcaaa cctcgcgcgg gcggcgcggg cgccgggaag
241 ccccccaagc gcaacgcctt ctaccgcaag ctgcagaatt tcctctacaa cgtgctggag
301 cggccgcgcg gctgggcgtt catctaccac gcctacgtgt tcctcctggt tttctcctgc
361 ctcgtgctgt ctgtgttttc caccatcaag gagtatgaga agagctcgga gggggccctc
421 tacatcctgg aaatcgtgac tatcgtggtg tttggcgtgg agtacttcgt gcggatctgg
481 gccgcaggct gctgctgccg gtaccgtggc tggagggggc ggctcaagtt tgcccggaaa
541 ccgttctgtg tgattgacat catggtgctc atcgcctcca ttgcggtgct ggccgccggc
601 tcccagggca acgtctttgc cacatctgcg ctccggagcc tgcgcttcct gcagattctg
661 cggatgatcc gcatggaccg gcggggaggc acctggaagc tgctgggctc tgtggtctat
721 gcccacagca aggagctggt cactgcctgg tacatcggct tcctttgtct catcctggcc
781 tcgttcctgg tgtacttggc agagaagggg gagaacgacc actttgacac ctacgcggat
841 gcactctggt ggggcctgat cacgctgacc accattggct acggggacaa gtacccccag
901 acctggaacg gcaggctcct tgcggcaacc ttcaccctca tcggtgtctc cttcttcgcg
961 ctgcctgcag gcatcttggg gtctgggttt gccctgaagg ttcaggagca gcacaggcag
1021 aagcactttg agaagaggcg gaacccggca gcaggcctga tccagtcggc ctggagattc
1081 tacgccacca acctctcgcg cacagacctg cactccacgt ggcagtacta cgagcgaacg
1141 gtcaccgtgc ccatgtacag acttatcccc ccgctgaacc agctggagct gctgaggaac
1201 ctcaagagta aatctggact cgctttcagg aaggaccccc cgccggagcc gtctccaagc
1261 cagaaggtca gtttgaaaga tcgtgtcttc tccagccccc gaggcgtggc tgccaagggg
1321 aaggggtccc cgcaggccca gactgtgagg cggtcaccca gcgccgacca gagcctcgag
1381 gacagcccca gcaaggtgcc caagagctgg agcttcgggg accgcagccg ggcacgccag
1441 gctttccgca tcaagggtgc cgcgtcacgg cagaactcag aagaagcaag cctccccgga
1501 gaggacattg tggatgacaa gagctgcccc tgcgagtttg tgaccgagga cctgaccccg
1561 ggcctcaaag tcagcatcag agccgtgtgt gtcatgcggt tcctggtgtc caagcggaag
1621 ttcaaggaga gcctgcggcc ctacgacgtg atggacgtca tcgagcagta ctcagccggc
1681 cacctggaca tgctgtcccg aattaagagc ctgcagtcca gagtggacca gatcgtgggg
1741 cggggcccag cgatcacgga caaggaccgc accaagggcc cggccgaggc ggagctgccc
1801 gaggacccca gcatgatggg acggctcggg aaggtggaga agcaggtctt gtccatggag
1861 aagaagctgg acttcctggt gaatatctac atgcagcgga tgggcatccc cccgacagag
1921 accgaggcct actttggggc caaagagccg gagccggcgc cgccgtacca cagcccggaa
1981 gacagccggg agcatgtcga caggcacggc tgcattgtca agatcgtgcg ctccagcagc
2041 tccacgggcc agaagaactt ctcggcgccc ccggccgcgc cccctgtcca gtgtccgccc
2101 tccacctcct ggcagccaca gagccacccg cgccagggcc acggcacctc ccccgtgggg
2161 gaccacggct ccctggtgcg catcccgccg ccgcctgccc acgagcggtc gctgtccgcc
2221 tacggcgggg gcaaccgcgc cagcatggag ttcctgcggc aggaggacac cccgggctgc
2281 aggccccccg aggggaccct gcgggacagc gacacgtcca tctccatccc gtccgtggac
2341 cacgaggagc tggagcgttc cttcagcggc ttcagcatct cccagtccaa ggagaacctg
2401 gatgctctca acagctgcta cgcggccgtg gcgccttgtg ccaaagtcag gccctacatt
2461 gcggagggag agtcagacac cgactccgac ctctgtaccc cgtgcgggcc cccgccacgc
2521 tcggccaccg gcgagggtcc ctttggtgac gtgggctggg ccgggcccag gaagtgaggc
2581 ggcgctgggc cagtggaccc gcccgcggcc ctcctcagca cggtgcctcc gaggttttga
2641 ggcgggaacc ctctggggcc cttttcttac agtaactgag tgtggcggga agggtgggcc
2701 ctggaggggc ccatgtgggc tgaaggatgg gggctcctgg cagtgacctt ttacaaaagt
2761 tattttccaa cagggcactc ccaggccctg tcgccattga ggtgcctccg ctgggctgtc
2821 tcctcacccc tccctgtgct ggagcctgtc ccaaaaaggt gccaactggg aggcctcgga
2881 agccactgtc caggctccca ctgcctgtct gctctgttcc caaaggcagc gtgtgtggcc
2941 tcgggccctg cggtggcatg aagcatccct tctggtgtgg gcatcgctac gtgttttggg
3001 ggcagcgttt cacggcggtg cccttgctgt ctcccttggg ctggctcgag cctggggtcc
3061 atgtcccttt gccgtcccgt catggggcag ggaatccata gcggggccca caggcagggg
3121 tatgagtgcg tcccacccaa cgcagcacca gccccggcca ccgctccccg tgtccccagt
3181 tccgtctcag ctacctggac tccaggaccc tggagaaggg agacctggca gtggagggag
3241 gctgtgctgt gtgtccccct gcaggtgtga ccccgcctgc tctttcctcc cccgccaggt
3301 gtggccccgc ctgctctttc ctcccccacc agtatggccc cacctgctct ttcctncccc
3361 cccaaggtgt ggccccacct gttctttcct cccctgccga ggtgtgaccc cacctgctct
3421 ttcctccctc ccagtatggc cccacctgct ctttcctccc ccgaggtgag gccccgcctg
3481 ctctttcctc ccatgggagc cgctgaggcg tgcgcacctg ggcacaggtt ggggctctgc
3541 aggatgagga agacaggcca atcccttccc tcccagaagc tggccgccca gcaggaggga
3601 ctgaggccag actcatgtcc agcaaggaac gtgtggtgtg tcccctggga agtctctggg
3661 ccctgggaag agggaaggtg cacgtcctgg gatggttgcg gggccctgtt ttgggagaca
3721 aaggggtaga gggtctgtct tgngcccccc cagactctag cccgagcagt gcagccacct
3781 actgccccac ctcagagaag tgcagcggga aggaggctgg aggtggtgcg gcgctgcctc
3841 gggtgtctgc gtgaatgagc gtggccaagg accagtgcca cctcatggca aagagctccc
3901 gcagtgtttg ttagagtgca catcctacgt gcccactggc acacacacgt gctcacatac
3961 angtcngngt acaggngtac acatgcangc ttgcacacat gcacacagac cacatagcac
4021 acatgtgcac tgaccacacc tgtatagacc atgcacagta cacatacgtg catacacatg
4081 cctgcataca ggcatacaca tgcacgctta catgtacacg tgcacagatc acacacatgc
4141 acacacgtgt agctcacaca cagtatacac atacacaagt gcacagacca cacacagcac
4201 taacacatgc acacacaaag tgcataggcc acacagcaca tgcacacagg tgcacagacc
4261 acacagcaca cacaagtgca cagagcacac tgcacacatg cacacacaca cgcgtgcatg
4321 cacactcctc gcacttccag ccttggagcc cttctgtctc tggtctttct ctttgaccct
4381 gctgagtgta agctgcctgg ggaggggcta caaggagtaa ttgtggcttt aggggtcgtg
4441 gtgatgctgg aatgtcaagc gccgtcgtgg ggtatccgac tgtccgggct cctggtccgc
4501 agtggcagag cgccaggcag agccaatcag ggtctcgtgc tgcccttccc ccccacagcc
4561 tggcagccat ccagaggagg ggctctacca gatgccaagg tgccccggtg tctgtatggg
4621 tgtccggttg ggtcctgtgt ttggtctgcc ctggaggtgg ctgggccctc ctgggatggg
4681 tggctcagcc tcgaatccca ggccccagcc caggcaggtg ctgctgcctg ttgtggtttc
4741 ctggcccagc ttctccttct ccctctgcat aaaatcacag tccgtgagtc ttccagctgc
4801 caccacggct gggacacgct gggggagggc tcctcccatg cctcctgcac acagccgtct
4861 gagcagggca ggtgccaaca ccccccaccg gagacacgct gcccctcagc gatgccccta
4921 ccttttgggg ggcctcgtct caagcccccc cttggaggct gaaatcaccc caggcactgt
4981 gagggcttct ccagggggac accctttgag ctgtgggtct gatcacccca agtcccgcac
5041 acggaggaga ggcacagcca gggcgtgtgg tttaatgttt gccccttcgg ggctggaggt
5101 ctcagtgttt ctagattcca gaccctgctg ccagagagac ctgctgccgg agagaagggg
5161 aggaggactc cagctgggct cggtccccca cagtcaggga cccccataaa ggacaccccc
5221 ttctctctag aaagagctgg gctctcagct atttctagtt gcttcccaga agccgaggag
5281 cagaaggagc tgtgagagct ttgcagaaac gcccttgtcc ccgccctcct gagctatgaa
5341 tgccgtacag agcagaggct ggggcattgg caagatcaca ggttgatgct gcacagcccc
5401 attgacacaa accctcaaag cagacgtgag agggacggtt cacaaagctt ggacctgccg
5461 tggagggtgc ccggcagacg tggcgtgaga gggacggctc acgaggcttg gacctgctgt
5521 ggagggtgcc cagcagacgt ggtgtgagag gaacggctca cgagacttgg acctggtgga
5581 gggtgcccag cagacgtggt gtgagaggga cggctcacag ggcttggacc ggagagagat
5641 ggctcatgag acttggacct gccgtggagg gtgcccagca gacgtggtat gagagggatg
5701 gctcacgagg cttggacctg gtggagggtg cccggcagac gtgtgagagg gacggttcac
5761 aaggcttgga cctgccatgg agggtgccca gcagacgtgg tgtgagaggg acagctcacg
5821 aggcttggac ctgccgtgga gggtgcccag cagggggctg agctctgagg ggtgggtgct
5881 cagtgcacgg gtgcccccag tgtcctctga tcctgtccgg tgcctccccc aacccccaca
5941 cccatgcaga actcccaggt cacatgcacg tatgtccagg gcatgggggt ggcgtgaaga
6001 ggcctggtca gggcctttag gggctgcagg acggaatggc cacctgggga gcctgtgtgg
6061 ctgtgccggg cagccatcct gcattcccac ccagcgcgca gtctccacct cggccccagc
6121 aaagcgctaa gcagccggag agacagccag ggcggcttcc tgaaggatgt gggatggtgg
6181 actccggggt cgagggaata cgcaggttcc tgtcctccgg gagacctaga gaagctgcac
6241 acccaggagc tttccatgac ccgggagcat gagtgaatgg ggggttccag tttgctgaac
6301 tttgctgtct tgtaagggtg ggggctgacg gccgaccctg ggaggaggtg acaccgcagg
6361 gggaggttgt gggcaacggt ggaggaggag agacgggagg ggaccatttg ggatggaggg
6421 gcctcttcag agttttaaaa ggcgtttgtg gggtggagtt gagtgtgctc tgggcttgga
6481 cacttgccgt ggtgcccctg gctggccgag gagactggct ctggccaggg ccccgtcctg
6541 agaggtcctc agcgtctgac tctcggccag gcgccagcaa ggaggggccg gtccccgggg
6601 ctaccaggca ggcacgtgca catcgccatc gccacacgcc aactccgcct gggttttaca
6661 aagtcgttgc cttaatgcat gtggacagga actccctgag gtcgccccat gccccctggc
6721 tgtgccaggt acggacgccc tggaccctgc gaacaggtgg ggcgggcgag gggcccaagg
6781 gacgggctcc agagacacgc gcagggcagg aggggtctca cggaggggtc tcgcactgag
6841 gcgcccagag ctggtggtcc cgctggacgc catccctctg cccgggatcc acacggccca
6901 cgtgtgcccg ccatgcccgc gccccacgcc attgcagtct tccatcctct ggccgtgacg
6961 gtggctgcag cttccccatt tgcgccgttg cctctggctg tctgcacttt tgttcatgct
7021 ccaaagaaca tttcataatg ccttcagtac cgacgtacac ttctgaccat tttgtatgtg
7081 tccttgtgcc gtagtgacca ggcctttttt tggtggatgt gttaccccgc acacttcaat
7141 ctcaactttg tgcaccgtcc attttctagg gatagacgcc cagggaatga actctagttt
7201 tctaacagat tagctgagat attaacttac tcacacggac aggttgatgc cagagccgta
7261 agaatgcgcc agtgcgggtt tgcgggggac ttcgggtgtg gggtcctgcg gccgcgatgg
7321 ccgtggaagg ttctggggat ccctgctgcc acggggacga gttcggacgc caggtggacc
7381 tgtgcactca gtaaaacgca gtgattcaaa aaaaaaaaaa
//