LOCUS Y14591 4618 bp mRNA linear VRL 21-OCT-2008
DEFINITION Viral-cellular fusion mRNA with Human papillomavirus type 68 E6 and
E7 genes, and Homo sapiens APM-1 gene.
ACCESSION Y14591
VERSION Y14591.1
KEYWORDS APM-1 gene; E6 gene; E7 gene; fusion.
SOURCE Human papillomavirus type 68
ORGANISM Human papillomavirus type 68
Viruses; Papillomaviridae; Firstpapillomavirinae;
Alphapapillomavirus.
REFERENCE 1
AUTHORS Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I.,
Kahn T., Delius H., Lichter P., Weitz S., Korn B., Schwarz E.
TITLE APM-1, a novel human gene, identified by aberrant co-transcription
with papillomavirus oncogenes in a cervical carcinoma cell line,
encodes a BTB/POZ-zinc finger protein with growth inhibitory
activity
JOURNAL EMBO J. 17(1), 215-222(1998).
PUBMED 9427755
REFERENCE 2 (bases 1 to 4618)
AUTHORS Delius H.
JOURNAL Submitted (13-AUG-1997) to the INSDC. H. Delius, Deutsches
Krebsforschungszentrum, Angewandte Tumorvirologie, Im Neuenheimer
Feld 242, D-69120 Heidelberg, FRG
REMARK Revised by author 18-DEC-97
REFERENCE 3 (bases 1 to 4618)
AUTHORS Reuter S., Delius H., Kahn T., Hofmann B., zur Hausen H.,
Schwarz E.
TITLE Characterization of a novel human papillomavirus DNA in the
cervical carcinoma cell line ME180
JOURNAL J. Virol. 65(10), 5564-5568(1991).
PUBMED 1716694
COMMENT Related sequence M73258
FEATURES Location/Qualifiers
source 1..839
/organism="Human papillomavirus type 68"
/focus
/mol_type="mRNA"
/db_xref="taxon:45240"
source 840..4618
/organism="Homo sapiens"
/chromosome="18"
/map="q21"
/mol_type="mRNA"
/cell_line="ME180"
/tissue_type="uterine cervix"
/db_xref="taxon:9606"
CDS 1..477
/gene="E6"
/product="E6 protein"
/db_xref="GOA:Q7KYK8"
/db_xref="InterPro:IPR001334"
/db_xref="InterPro:IPR038575"
/db_xref="UniProtKB/TrEMBL:Q7KYK8"
/protein_id="CAA74931.1"
/translation="MALFHNPEERPYKLPDLCRTLDTTLHDVTIDCVYCRRQLQRTEV
YEFAFGDLNVVYRDGVPLAACQSCIKFYAKIRELRYYSESVYATTLETITNTKLYDLS
IRCMCCLKPLSPAEKLRHLNSKRRFHKIAGNFTGQCRHCWTSKREDRRRTRQETQV"
CDS 485..817
/gene="E7"
/product="E7 protein"
/db_xref="GOA:O73452"
/db_xref="InterPro:IPR000148"
/db_xref="UniProtKB/TrEMBL:O73452"
/protein_id="CAA74932.1"
/translation="MHGPKPTVQEIVLELCPCNEIEPVDLVCHEQLGDSDDEIDEPDH
AVNHHQHQLLARRDEQQRHTIQCTCCKCNNLLQLVVEASRENLRKLELLFMDSLNFVC
PWCATETQ"
CDS 856..2715
/gene="APM-1"
/product="APM-1 protein"
/db_xref="GOA:A1YPR0"
/db_xref="HGNC:HGNC:31700"
/db_xref="InterPro:IPR000210"
/db_xref="InterPro:IPR011333"
/db_xref="InterPro:IPR013087"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR036236"
/db_xref="UniProtKB/Swiss-Prot:A1YPR0"
/protein_id="CAA74933.1"
/translation="MANDIDELIGIPFPNHSSEVLCSLNEQRHDGLLCDVLLVVQEQE
YRTHRSVLAACSKYFKKLFTAGTLASQPYVYEIDFVQPEALAAILEFAYTSTLTITAG
NVKHILNAARMLEIQCIVNVCLEIMEPGGDGGEEDDKEDDDDDEDDDDEEDEEEEEEE
EEDDDDDTEDFADQENLPDPQDISCHQSPSKTDHLTEKAYSDTPRDFPDSFQAGSPGH
LGVIRDFSIESLLRENLYPKANIPDRRPSLSPFAPDFFPHLWPGDFGAFAQLPEQPMD
SGPLDLVIKNRKIKEEEKEELPPPPPPPFPNDFFKDMFPDLPGGPLGPIKAENDYGAY
LNFLSATHLGGLFPPWPLVEERKLKPKASQQCPICHKVIMGAGKLPRHMRTHTGEKPY
MCTICEVRFTRQDKLKIHMRKHTGERPYLCIHCNAKFVHNYDLKNHMRIHTGVRPYQC
EFCYKSFTRSDHLHRHIKRQSCRMARPRRGRKPAAWRAASLLFGPGGPAPDKAAFVMP
PALGEVGGHLGGAAVCLPGPSPAKHFLAAPKGALSLQELERQFEETQMKLFGRAQLEA
ERNAGGLLAFALAENVAAARPYFPLPDPWAAGLAGLPGLAGLNHVASMSEANN"
BASE COUNT 1097 a 1361 c 1204 g 956 t
ORIGIN
1 atggcgctat ttcacaaccc tgaggaacgg ccatacaaat tgccagacct gtgcaggaca
61 ttggacacca cattgcatga cgttacaata gactgtgtct attgcagaag gcaactacaa
121 cggacagagg tatatgaatt tgcctttggt gacttaaatg tagtatatag ggacggggta
181 ccattagctg catgccaatc atgtattaaa ttttatgcga aaatacggga actacgatat
241 tactcagaat cggtgtatgc aacaacatta gaaaccataa ctaatacaaa gttatatgat
301 ttatcaataa ggtgcatgtg ttgcctgaaa ccattgagtc ctgctgaaaa actaaggcac
361 ctaaattcaa aacgaagatt tcataaaata gcaggaaact ttacaggaca gtgtcgccac
421 tgctggacca gtaaacgaga ggaccgcaga cgcacacggc aggaaacaca agtataaact
481 aactatgcat ggaccaaagc ccaccgtgca ggaaattgtg ttagagttat gtccatgcaa
541 tgaaatagag ccggtcgacc ttgtatgtca cgagcaatta ggagattcag acgatgaaat
601 agatgaaccc gaccatgcag ttaatcacca ccaacatcaa ctactagcca gacgggacga
661 acaacagcgt cacacaattc agtgtacgtg ttgtaagtgt aacaacctac tgcaactagt
721 agtagaagcg tcgcgggaga acctgcggaa gctagaactg ctgtttatgg actcactaaa
781 ttttgtgtgt ccgtggtgtg caacggaaac ccagtaatct gcaatggcca attgtgaagg
841 gctctggctg agaacatggc caatgacatt gatgagctca ttggcattcc cttccccaac
901 cacagcagtg aggtcctgtg cagcctcaat gagcaacggc acgatggcct gctgtgtgac
961 gtgctcctgg tggtgcagga gcaggagtat cggacccacc gctccgtcct ggctgcctgc
1021 agcaagtact tcaagaagct tttcacagcc ggcaccctag ccagccagcc ctacgtctat
1081 gagatcgact ttgtccagcc tgaggctctg gctgctatcc tggagttcgc ctacacctcc
1141 acgctcacca tcaccgctgg caatgtcaag cacatcctca acgcagccag gatgctggag
1201 atccagtgca tcgtgaacgt gtgcctggag atcatggagc ctggggggga cgggggggag
1261 gaggatgaca aggaggacga tgacgacgac gaagatgatg atgatgagga ggacgaagag
1321 gaggaggagg aagaggagga ggatgacgat gatgacacgg aggactttgc tgaccaagaa
1381 aacttgcctg acccccagga catcagctgc caccaaagcc cttccaagac agaccatctc
1441 acagagaagg cctattcaga cacccccagg gacttccctg actccttcca ggctggcagt
1501 cctggccatc tgggggtgat ccgggacttc tccatcgaat ctctgctaag ggagaacctg
1561 taccccaagg ccaacatccc cgacaggaga ccctccttgt ctccattcgc cccggacttc
1621 tttccacacc tctggccagg ggacttcggt gcctttgccc agctgcctga gcagcccatg
1681 gacagtgggc cactggatct ggtcatcaag aatcggaaga tcaaggagga ggagaaggag
1741 gagctgcccc cacccccacc gccacccttc cctaatgact tcttcaagga catgttccct
1801 gacctgccgg gggggcctct gggacccatc aaggcggaga acgactacgg tgcctatctc
1861 aacttcctga gtgccaccca cctgggaggc ctcttcccac cctggcccct ggtagaagag
1921 cgcaagctga agcccaaggc ctctcagcag tgccccatct gccacaaagt catcatgggg
1981 gccgggaagc tgccgcggca catgaggacc cataccgggg agaagccata catgtgcacc
2041 atctgcgagg tccgcttcac caggcaggac aagctgaaaa tccacatgcg gaagcacaca
2101 ggggagcggc cctacctgtg catccactgc aacgccaagt tcgtgcacaa ctacgacctc
2161 aagaaccaca tgcgcatcca cacgggcgtg cggccctacc agtgcgagtt ctgctacaag
2221 agcttcacgc gctctgacca cctgcaccgc cacatcaagc gccagagctg ccgcatggca
2281 cggccccgac gcggccgcaa gcctgctgcg tggagggccg ccagcctgct cttcgggccc
2341 ggcggcccgg cccccgacaa ggcggccttc gtgatgcccc ctgcgctggg cgaggtgggc
2401 ggccacctgg gcggcgcagc tgtgtgcctc ccgggcccca gccccgccaa gcacttcctg
2461 gcagcgccca agggcgccct gagcctgcaa gagctggagc ggcagttcga ggagacacag
2521 atgaagctgt tcgggcgcgc gcagctggag gctgagagga acgcgggggg cctcctggcc
2581 ttcgcgctgg ccgagaatgt ggcggcggcg cggccctact tcccgctgcc cgacccttgg
2641 gccgccggcc tggccggcct ccctgggctc gccggcctca accacgtggc ctccatgtcc
2701 gaagccaaca actaggctgg tccctgtcgg ctccagccca ccagccctcc agtccttctc
2761 cctccaggcc cactctaccc taccccatgg atctgaactt ttcattttaa aaacacaaag
2821 ggaaaatggg aaaataataa taatactatc agtgatggca ttttcccggg ctcctaaagc
2881 agctgcctcc ttttgctggt ctgagacggg catcttttcc caaaaggcca ggagcccggg
2941 cctccctccc tgtctctctg gctctcatat agaaacttgc accggcccat gccacaaaga
3001 actgggtgcc caggggcact taggagctgg gtgagtcatg aggggtcagg gggtggttgg
3061 cctggtgccc agccagccac agcaggagga ggtaggggct gggcatgcac cttggttaag
3121 ccccaccccc tatggcaaag tctctgccaa cactcctctg agggctcatt ttccagtctc
3181 cagtggcccc ggggtctttt tgagaactac ccacctgcca catagaaaga aatgctctgt
3241 tggcagggag gcctcctgga accagtcagg aaccaggctc tggaaggccc gggccatttc
3301 ttccctgacc tgtcctgtga ccttgacagg tcagccctct gtagctcagt gtcacctggc
3361 tatggaaggg gctggtaact gaggtttccg ccctccacct ctaaacacat acacacctat
3421 ccccccagag aatcacagag atggtagaag ctttgtactc cccaagtcca tggggaaaca
3481 gtttatcttt ctggacttag ttttatcaca tccagctcta tattagcata ttagcatagg
3541 tgagaaatat ggccagacta gacagagatc aggtcatcag gggagcttcc gagcttcagc
3601 aaagcccaca ggtagctctg cgaactcaga atgctaccct accttccctg caggccgctg
3661 ttcatgtctg gactcctggg ggcgctattt aatgtttacc cccatctcca gtgccccctc
3721 caaggctgtg cagtgtcttg gggctctcag ggccaacatc gaagagatgg gggccacctc
3781 ttaacacctg gcaacagtct cccctcatcc tgattcctga caacagacaa aacaccggtt
3841 tctagggttt atctgtttgt tttttgagtt gagggttcct cagggccttg gcattgctag
3901 tgatggtccc ctttgctgtg tgagaacccc ctcaacccct tcctcctccc tctggggatg
3961 aagtgggagt atttggctcc ccatttttga caaaagggct cagtgcaggg aggtggaggc
4021 ctctgaggtt tgaagggctc tgtgagttag agttgtcaca tgttctcctg gttcttgaat
4081 ttgcagcagg tcctgaaaag gaaggctctg ctggccccgt gccttcctga ccttctctct
4141 ccttccctcc cctctctttt cttgccaagt ttgctttggt ttctgagcag cccagagagg
4201 aggagggttc gtccccaggg agagcccagg gctggagtcc ccaatccctg tgctatgggc
4261 acaaagagac ttcagctctt cctgttgcct tggctttttc ctgagcaaaa acacaacaaa
4321 caaaaaggcc agagaagagc acagactctg tccctctcac aactctccag aagagacccc
4381 ctgattcttc acaccaccgg atgccactcc agccagcagg attgctacac acaccctctg
4441 ttctcagaag tcatctgcct gggcagccgc ctctcagatt cctgtcttcg tttcagacac
4501 ttttctctga agcatgccca tgtccaccag ccaacgtgcc cccgtgttcc cccccatcag
4561 ccaagtgatt ggggctgaac cagactttaa aagagaggaa aaaaaaaaaa aaaaaaaa
//