LOCUS Y14385 4743 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for inositol polyphosphate 5-phosphatase.
ACCESSION Y14385
VERSION Y14385.1
KEYWORDS inositol polyphosphate 5-phosphatase; SHIP2 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Pesesse X., Deleu S., De Smedt F., Drayer L., Erneux C.
TITLE Identification of a second SH2-domain-containing protein closely
related to the phosphatidylinositol polyphosphate 5-phosphatase
SHIP
JOURNAL Biochem. Biophys. Res. Commun. 239(3), 697-700(1997).
PUBMED 9367831
REFERENCE 2 (bases 1 to 4743)
AUTHORS Pesesse X.
JOURNAL Submitted (30-JUL-1997) to the INSDC. X. Pesesse, Interdisciplinary
Research Institute, Universite Libre de Bruxelles, Campus Erasme
Bldg. C, 808 Route de Lennik, 1070 Brussels, BELGIUM
FEATURES Location/Qualifiers
source 1..4743
/db_xref="H-InvDB:HIT000325818"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="hippocampus"
/db_xref="taxon:9606"
CDS 212..3988
/gene="SHIP2"
/product="inositol polyphosphate 5-phosphatase"
/note="putative"
/db_xref="GOA:O15357"
/db_xref="H-InvDB:HIT000325818.14"
/db_xref="HGNC:HGNC:6080"
/db_xref="InterPro:IPR000300"
/db_xref="InterPro:IPR000980"
/db_xref="InterPro:IPR001660"
/db_xref="InterPro:IPR005135"
/db_xref="InterPro:IPR013761"
/db_xref="InterPro:IPR036691"
/db_xref="InterPro:IPR036860"
/db_xref="PDB:2K4P"
/db_xref="PDB:2KSO"
/db_xref="PDB:2MK2"
/db_xref="PDB:3NR8"
/db_xref="PDB:4A9C"
/db_xref="PDB:5OKM"
/db_xref="PDB:5OKN"
/db_xref="PDB:5OKO"
/db_xref="PDB:5OKP"
/db_xref="UniProtKB/Swiss-Prot:O15357"
/protein_id="CAA74743.1"
/translation="MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSF
LVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLY
AQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPL
PAPETPTAPAAESAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRL
HSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLS
GIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTL
SVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKD
FIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKG
LGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNI
KVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGN
EKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYIS
RKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVR
TNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLS
KTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQW
SSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFL
SHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRS
GSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGV
AAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHR
HPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGP
PPPKAHPRPPLPPGPSPASTFLGEVGSGDDRSCSVLQMAKTLSEVDYAPAGPARSALL
PGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAW
LRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK"
misc_feature 276..561
/note="encodes SH2 domain"
misc_feature 1491..2428
/note="encodes 5-phosphatase catalytic domain"
BASE COUNT 939 a 1466 c 1448 g 890 t
ORIGIN
1 gaattcctga ggccggcgct gcaggcagcg gcggctgcgc ggtgaacgag gcggcctgcg
61 cggcggagtg ctgagtcccg atccccggct ctgtccggcc cacggatcct caagcccggg
121 ccccgggccc ggccccagcc tcagccctga gcgtctcggg gcggatggcg cggggcggcg
181 ggggcgggcg gtgctgagcc ctgcgcgggc catggcctcg gcctgcgggg cgccgggccc
241 ggggggcgcc ctgggcagcc aggccccctc ctggtaccac cgcgacctga gccgggcggc
301 cgcggaggag ctgctggccc gggcgggccg cgatggcagc ttcctggtcc gagacagcga
361 gagcgtggcg ggggccttcg cgctctgcgt cctgtatcag aagcatgtgc acacgtatcg
421 cattctgcct gatggagaag atttcttggc tgtgcagacc tcgcagggtg tgcctgtgcg
481 ccgcttccag accctgggtg agctcatcgg cctgtacgcc cagcccaacc agggccttgt
541 gtgcgccctg cttcttcctg tagagggtga gcgagagccg gacccaccgg atgaccggga
601 tgcctcagat ggggaggatg agaagccccc gctgcccccg cgctctggct ccaccagcat
661 ttctgccccc actgggccca gcagtcccct gccagctcct gagactccca cagctccagc
721 tgctgagagt gctcccaatg ggctgagcac cgtctcgcac gactacctga aaggcagcta
781 tgggctggac ctggaagctg tgaggggtgg agccagccac ctgccccacc tcacccgtac
841 cctcgctacc tcatgccgga ggctgcacag tgaggtggac aaggtcctgt caggcctgga
901 gatcctgtcc aaggtgtttg accagcagag ctcgcccatg gtgacccgcc ttttgcagca
961 gcagaacctg ccacagacag gggagcagga actagagagc ctggtgctga agctgtcagt
1021 gctaaaggac ttcctgtcag gcatccagaa gaaggccctg aaggccctac aggacatgag
1081 ctccacagca cccccagctc cgcagccatc cacacgtaag gccaagacca tccccgtgca
1141 ggcctttgag gtgaagctag atgtgaccct gggtgacctg accaagattg ggaagtcaca
1201 gaagttcacg ctgagcgtgg atgtggaggg tgggcggctg gtgctgctgc ggagacagcg
1261 ggactcccag gaggactgga ccaccttcac gcacgaccgc atccgccagc tcattaagtc
1321 ccagcgtgtc cagaacaagc tgggtgttgt gtttgagaag gagaaggacc ggactcagcg
1381 caaggacttc atctttgtca gtgcccggaa gcgggaggcc ttctgccagc tgttgcagct
1441 catgaagaac aagcactcca agcaggacga gcccgacatg atctcagtct tcataggcac
1501 ctggaacatg ggaagtgtac cacctccaaa aaacgtgaca tcctggttca catcgaaggg
1561 tctggggaag accctggacg aggtcacagt gaccataccc catgacatct atgtctttgg
1621 gacccaggag aactcagtgg gcgaccgcga gtggctggac ctactgcgcg ggggcctcaa
1681 ggagcttacg gatctggatt accgcccgat tgccatgcaa tcactgtgga atatcaaggt
1741 ggcagtgctg gtcaagccag agcacgagaa ccgtatcagc catgtcagta cgtccagtgt
1801 gaagactggc atcgccaaca ccctggggaa caagggggct gtgggcgtct ccttcatgtt
1861 taatggcacc tcatttggct ttgtgaattg tcacctcacc tcgggaaatg agaagacggc
1921 tcggaggaac caaaactact tggacatcct gcggctgctc tcgctgggcg accggcagct
1981 caatgccttt gacatctctc tgcgtttcac acacctcttc tggtttgggg acctcaacta
2041 ccgcctggac atggatatcc aggagatcct gaactacatc agcaggaaag agtttgagcc
2101 cctcctcagg gtggaccagc tcaacctgga gcgggagaag cacaaggtct tccttcgatt
2161 cagtgaggag gagatctcct tcccacccac ctaccgctat gagcggggtt cccgggacac
2221 atatgcctgg cacaagcaga agccaactgg ggtccggacc aatgtgccct catggtgtga
2281 ccggattctg tggaaatcct accctgaaac tcacatcatc tgcaattctt atggttgcac
2341 tgatgacatc gtcaccagcg accattcccc cgtgtttggg acatttgagg ttggagttac
2401 ctcccagttc atctccaaga aagggctctc aaagacttca gaccaggcct acattgagtt
2461 tgagagcatc gaggccattg tgaagacagc cagccgcacc aagttcttca tcgagttcta
2521 ctctacctgc ctggaggaat acaagaagag ctttgagaat gatgcccaga gcagtgacaa
2581 catcaacttc ctcaaagtgc agtggtcttc acgccagctg cccacgctca aaccaattct
2641 ggctgatatc gagtacctgc aggaccagca cctcctgctc acagtcaagt ccatggatgg
2701 ctatgaatcc tatggggagt gtgtggttgc actcaaatcc atgatcggca gcacggccca
2761 acagttcctg accttcctat cccaccgtgg cgaggagaca ggcaatatca gaggctccat
2821 gaaggtgcgg gtgcccacgg agcgcctggg cacccgtgag cggctctacg agtggatcag
2881 cattgataag gatgaggcag gagcaaagag caaagccccc tctgtgtccc gagggagcca
2941 ggagcccagg tcagggagcc gcaagccagc cttcacagag gcctcctgcc cgctctccag
3001 gttatttgaa gaaccagaga aaccgccacc aacggggagg cccccagccc caccccgagc
3061 agctccccgg gaggagccct tgacccccag gttgaagcca gagggagctc ctgaaccaga
3121 aggggtggcg gcccccccac ccaagaacag cttcaataac cctgcctact acgtccttga
3181 aggggtcccg caccagctgc tgcccccgga gccaccctcg cctgccaggg cccctgtccc
3241 atctgccacc aagaacaaag tggccattac agtgcctgct ccacagcttg ggcaccaccg
3301 gcaccctcgt gtgggagagg ggagttcttc agatgaggag tctggaggca cactgccccc
3361 tccagacttt ccacctccac cactgccgga ctcagccatc ttcctgcccc ccagcctgga
3421 tcctttacca gggccagtgg tccggggccg tggtggggct gaggcccgtg gcccaccacc
3481 tcccaaggcc catccaaggc ctccactgcc cccaggcccc tcaccagcca gcactttcct
3541 gggggaagtg ggcagtgggg atgaccggtc ctgctcggtg ctgcagatgg ccaagacgct
3601 gagcgaggtg gactatgccc ctgctgggcc tgcacgctca gcgctcctcc caggccccct
3661 ggagctgcag cccccccggg gactgccctc ggactatggc cggcccctca gcttccctcc
3721 accccgcatc cgggagagca tccaggaaga cctggcagag gaggctccgt gcctgcaggg
3781 cgggcgggcc agcgggctgg gcgaggcagg catgagtgcc tggctgcggg ccatcggctt
3841 ggagcgctat gaggagggcc tggtgcataa tggctgggac gacctggagt ttctcagtga
3901 catcaccgag gaggacttgg aggaggctgg ggtgcaggac ccggctcaca agcgcctcct
3961 tctggacacc ctgcagctca gcaagtgata gcggaggcac cacgaagctg tgaactcaga
4021 gcccctccct gctaccaagg cccagctatg gccccagggt tgaaaagtta tgagggtcag
4081 ggcagtatct ctctgcctat ttattggggt gcctatttat tggggatctg cattccccgc
4141 tgcccaatca tttgcaatgc cctaattagg gcatcctgcc cctcgccttt taggctcagg
4201 acggaaggtc agttgccatg gttaccgagg accctggtta ctctggtgct gtcctgtttt
4261 actggacccc gcctcccagc cccaggggtg cctgtggggg tccatttggg tacgtctggg
4321 cccccacttt caccagtttc tgcggccttc caccgggcct gaaccacagc ggaggagctc
4381 cgctaagacc tccccacccc cgctgggggt gggggcgggt gtccgtccgg aaatgaagga
4441 atagcccgag gaccgggctg gggtttattt aaactgttct gtgtgggtct ggggagggag
4501 agcaccttaa tattattggg gttggttggg gtggggcagg atctcagcca taaagtgcca
4561 gtttgcttag ttctcactgt ctcctggtct gtgctgccct gctctgggga tgcacggcgg
4621 cagggtgggg gagggaggtt cctcgcaggt ctcagcccgg gacagggtct tgcaagcagc
4681 ctcctgggca gtcgtaaggg ttgcggcgtg atgtcttcaa taaattaagt tttatttgga
4741 aaa
//