LOCUS Y13834 2966 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for farnesylated-proteins converting enzyme 1.
ACCESSION Y13834
VERSION Y13834.1
KEYWORDS face1 gene; farnesylated-proteins converting enzyme; gluzincin;
metalloproteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Freije J.M.P., Blay P., Pendas A.M., Caninanos J., Crespo P.,
Lopez-Otin C.
TITLE Identification and chromosomal location of two human genes encoding
enzymes potentially involved in proteolytic maturation of
farnesylated proteins
JOURNAL Genomics 58(3), 270-280(1999).
PUBMED 10373325
REFERENCE 2 (bases 1 to 2966)
AUTHORS Lopez-Otin C.
JOURNAL Submitted (13-JUN-1997) to the INSDC. C. Lopez-Otin, Universidad de
Oviedo, Dept. de Bioquimica y Biologia Molecular, Facultad de
Medicina, C/ Julian Claveria S/N, 33006-Oviedo, SPAIN
REFERENCE 3
AUTHORS Navarro C.L., De Sandre-Giovannoli A., Bernard R., Boccaccio I.,
Boyer A., Genevieve D., Hadj-Rabia S., Gaudy0-Marqueste C.,
Smitt H.S., Vabres P., Faivre L., Verloes A., Van Essen T.,
Flori E., Hennekam R., Beemer F.A., Laurent N., Le Merrer M.,
Cau P., Levy N.
TITLE Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization
and identify restrictive dermopathy as a lethal neonatal
laminopathy
JOURNAL Hum. Mol. Genet. 13(20), 2493-2503(2004).
PUBMED 15317753
FEATURES Location/Qualifiers
source 1..2966
/db_xref="H-InvDB:HIT000325802"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="LAMBDA DR2"
/clone="A-1.3a"
/tissue_type="ovary"
/db_xref="taxon:9606"
CDS 34..1461
/gene="face1"
/product="farnesylated-proteins converting enzyme 1"
/db_xref="GOA:O75844"
/db_xref="H-InvDB:HIT000325802.12"
/db_xref="HGNC:HGNC:12877"
/db_xref="InterPro:IPR001915"
/db_xref="InterPro:IPR027057"
/db_xref="InterPro:IPR032456"
/db_xref="PDB:2YPT"
/db_xref="PDB:4AW6"
/db_xref="PDB:5SYT"
/db_xref="PDB:6BH8"
/db_xref="UniProtKB/Swiss-Prot:O75844"
/protein_id="CAB46277.1"
/translation="MGMWASLDALWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRI
YKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYLW
RLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTL
GFFMKDAIKKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADY
IAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKR
IVLFDTLLEEYSVLNKDIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLG
HELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFAAFGFYDSQPTLIGLLIIF
QFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDW
LFSMWHYSHPPLLERLQALKTMKQH"
BASE COUNT 844 a 515 c 578 g 1029 t
ORIGIN
1 gcacgctgaa ggagccggcg gaaccgggtg gccatgggga tgtgggcatc gctggacgct
61 ttgtgggaga tgccggccga gaagcgtatc ttcggggccg tgctgctctt ttcctggaca
121 gtgtatcttt gggagacctt cctagcacag cggcagagaa ggatatataa aacaacaact
181 catgtaccac cggagttagg acagatcatg gattctgaaa catttgagaa atctcgactc
241 tatcaactgg ataaaagcac tttcagcttc tggtcaggac tctattcaga gactgaaggc
301 actcttattc ttctctttgg aggaatacct tatctctgga gactttctgg acggttctgt
361 ggttatgctg gctttggacc agaatatgag atcactcagt ccctggtgtt tctgctgttg
421 gctacacttt tcagtgcatt gactggtttg ccatggagtc tttataatac ttttgtgata
481 gaagaaaaac atggcttcaa tcaacagact ttggggttct tcatgaaaga tgcaatcaag
541 aaatttgttg tgactcagtg tattttgttg cctgtgtctt cacttctact ttacattatt
601 aaaattgggg gtgactattt ttttatttat gcctggctgt tcacattagt tgtgtctctg
661 gttcttgtca caatctatgc tgattatatt gcccctttat ttgacaaatt cacacctctg
721 cctgagggaa agcttaaaga agaaattgaa gtaatggcaa agagtattga ctttcctttg
781 acgaaggtgt atgttgtgga aggatctaaa cgctcttccc acagcaatgc ttatttttat
841 ggcttcttca agaacaagcg aatagttttg tttgacactc tactagaaga gtactctgta
901 ctaaacaaag acatccagga ggattctggc atggaacccc gcaatgagga agaagggaac
961 agtgaagaaa taaaagctaa agttaaaaat aagaaacaag gatgtaaaaa tgaggaggta
1021 ctcgctgtac taggccatga actggggcac tggaagttgg gacatacagt caaaaatatc
1081 attattagcc agatgaattc tttcctgtgt ttttttttat ttgctgtatt aattggtcga
1141 aaggagcttt ttgctgcatt tggtttttat gatagccaac ccactcttat tggactattg
1201 atcatcttcc agtttatttt ttcaccttac aatgaggttc tttctttttg cctaacagtc
1261 ctaagccgca gatttgagtt tcaagctgat gcatttgcca agaaacttgg gaaggctaaa
1321 gacttatatt ctgctttaat caaacttaac aaagataact tgggattccc tgtttctgac
1381 tggttgttct caatgtggca ttattctcat cctccactgc tagagagact tcaagctttg
1441 aaaactatga agcaacactg agatgtccag gatctgtgac tgaagacatt tctgattatt
1501 tctgtcctgg gcagcatgtt ccagctcttg atgtttttaa actttttttt agaagaaaaa
1561 ttaagtacag aaaagcccag atttaaatac atttaatatg tcattttaaa aatgatttta
1621 ataattcatt tcttaaaaca ctgaatgaat tttgaagctt aatgttttta aaggcatagt
1681 tttatctttg acatctaatt taccatcaag ttgtaaaatt atttggaaaa atacagaact
1741 cgttttattt gtatacttat atggaatctg catgtgaggt gtttgagggc atatgtttga
1801 aagagggagc atcaccacag gaatccttct gtgaggtgga aacagtggtc ctgaatcatt
1861 gtgctcacac ctaacttgaa atctggtctt actttcatgc tgttatgatt tcacctggtg
1921 aatcagtgtt ttaaataaga aaggtaatag ttggtaaggc caatgttatt taaatgaaag
1981 tagttagaaa aatgctctcc tattctacca aatttttaat ttctttcttc ccctttcttg
2041 ctacacagtg atcaagagtt tctcatagtg ctttgaagtt agaaattatg tataggatat
2101 tttaaatcat tgagttttgt ggggtttttt tgtttgtttg tttcttttgt tttttggaaa
2161 atccgtgtct ttatcttttt ttcccacgtg gtagatatga tcccattgga ggtaaattgt
2221 agcttcttct cattcatgca gtaaataata catcctttca ctcagcagag atggccatat
2281 taaacacgtt ttgctatgtt aaaagtggca gaacaggaaa gacgaattaa aaataacatt
2341 ttttaagcga cataaggatg aaatactgat gaatctctgt gacattacag ggaaaaaaat
2401 atagttttct atctctttca agggcagaag agttttcatt tttatttttg taattttatc
2461 tgtaagtcat aaatattact taatcaggcc tgattctact tttgaaaatt acagttcttg
2521 aaatgcagat aatgtttact ttgaaaacaa atgtcatgaa tgatttccag tttttaaagc
2581 tatatgtttc actgcttcat atctctgtcc actttctgaa tgagaactta ttttgtgcct
2641 agagctctca ctcactgata atgcttatta ccttctgggc atttattcca aagtgggatc
2701 aactgtacgc ctttggtatc tgaccataaa gtctttcctc cgctgacatt tgggtgatgt
2761 cttcacatgg aaatataata aaaataaaaa tctagtttaa tactgcatta tttattttcc
2821 taaggctaaa gaggagcagt cctatgcttt tattcagcat cctttatctg tgacttcatg
2881 ctctgataac tgcctttcct tccttctgtg cctttgaata caaatttcag ttctgcaaaa
2941 gtgaaacatt aaacattgcc aacgca
//