LOCUS Y13367 5061 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for phosphoinositide 3-kinase.
ACCESSION Y13367
VERSION Y13367.1
KEYWORDS phosphoinositide 3-kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Domin J., Pages F., Volinia S., Rittenhouse S.E., Zvelebil M.J.,
Stein R.C., Waterfield M.D.
TITLE Cloning of a human phosphoinositide 3-kinase with a C2 domain which
displays reduced sensitivity to the inhibitor wortmannin
JOURNAL Biochem. J. 326, 139-147(1997).
PUBMED 9337861
REFERENCE 2 (bases 1 to 5061)
AUTHORS Domin J.
JOURNAL Submitted (23-MAY-1997) to the INSDC. J. Domin, Ludwig Institute
for Cancer Research Receptor Studies, 91 Riding House St, London,
W1P 8BT, UK
FEATURES Location/Qualifiers
source 1..5061
/db_xref="H-InvDB:HIT000325770"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="U937"
/cell_type="histiocytic lymphoma"
/db_xref="taxon:9606"
CDS 1..5061
/product="phosphoinositide 3-kinase"
/db_xref="GOA:O00443"
/db_xref="H-InvDB:HIT000325770.14"
/db_xref="HGNC:HGNC:8971"
/db_xref="InterPro:IPR000008"
/db_xref="InterPro:IPR000341"
/db_xref="InterPro:IPR000403"
/db_xref="InterPro:IPR001263"
/db_xref="InterPro:IPR001683"
/db_xref="InterPro:IPR002420"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR015433"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR018936"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR035892"
/db_xref="InterPro:IPR036871"
/db_xref="InterPro:IPR036940"
/db_xref="InterPro:IPR037705"
/db_xref="InterPro:IPR042133"
/db_xref="InterPro:IPR042236"
/db_xref="PDB:2AR5"
/db_xref="PDB:2IWL"
/db_xref="PDB:2REA"
/db_xref="PDB:2RED"
/db_xref="PDB:6BTY"
/db_xref="PDB:6BTZ"
/db_xref="PDB:6BU0"
/db_xref="PDB:6BUB"
/db_xref="UniProtKB/Swiss-Prot:O00443"
/protein_id="CAA73797.1"
/translation="MAQIFSNSGFKECPFSHPEPTRAKDVDKEEALQMEAEALAKLQK
DRQVTDNQRGFELSSSTRKKAQVYNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEK
LLLDDSFETKKTPVLPVTPILSPSFSAQLYFRPTIQRGQWPPGLPGPSTYALPSIYPS
TYSKQAAFQNGFNPRMPTFPSTEPIYLSLPGQSPYFSYPLTPATPFHPQGSLPIYRPV
VSTDMAKLFDKIASTSEFLKNGKARTDLEITDSKVSNLQVSPKSEDISKFDWLDLDPL
SKPKVDNVEVLDHEEEKNVSSLLAKDPWDAVLLEERSTANCHLERKVNGKSLSVATVT
RSQSLNIRTTQLAKAQGHISQKDPNGTSSLPTGSSLLQEVEVQNEEMAAFCRSITKLK
TKFPYTNHRTNPGYLLSPVTAQRNICGENASVKVSIDIEGFQLPVTFTCDVSSTVEII
IMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIRLQLL
TFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCKEAMTRHPVEELLDSYHNQVELALQ
IENQHRAVDQVIKAVRKICSALDGVETLAITESVKKLKRAVNLPRSKTADVTSLFGGE
DTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHANSGRSPTDCAQSSKSVKEAWTT
TEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIK
WDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLPLCDF
RRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDR
SIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWEKRYYCFKHPNCLPKILA
SAPNWKWGNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRSLAVTWIEAISDDELT
DLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDVQFSTRYEHV
LGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQRSMERVQSFFQK
NKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPLGEEINVMFKVGEDLRQD
MLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQVEYGVTG
SFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTG
HMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY
NLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESS
LGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKY
NPDKHYIYVVRILWEGQIEPSFVFRTFVEFQELHNKLSIIFPLWKLPGFPNRMVLGRT
HIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSADAGSF
SPTPGQIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSKR
KTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDF
NLSKETVKWYQLTAATYL"
BASE COUNT 1634 a 991 c 1002 g 1434 t
ORIGIN
1 atggctcaga tatttagcaa cagcggattt aaagaatgtc cattttcaca tccggaacca
61 acaagagcaa aagatgtgga caaagaagaa gcattacaga tggaagcaga ggctttagca
121 aaactgcaaa aggatagaca agtgactgac aatcagagag gctttgagtt gtcaagcagc
181 accagaaaaa aagcacaggt ttataacaag caggattatg atctcatggt gtttcctgaa
241 tcagattccc aaaaaagagc attagatatt gatgtagaaa agctcaccca agctgaactt
301 gagaaactat tgctggatga cagtttcgag actaaaaaaa cacctgtatt accagttact
361 cctattctga gcccttcctt ttcagcacag ctctatttta gacctactat tcagagagga
421 cagtggccac ctggattacc tgggccttcc acttatgctt taccttctat ttatccttct
481 acttacagta aacaggctgc attccaaaat ggcttcaatc caagaatgcc cacttttcca
541 tctacagaac ctatatattt aagtcttccg ggacaatctc catatttctc atatcctttg
601 acacctgcca caccctttca tccacaagga agcttaccta tctatcgtcc agtagtcagt
661 actgacatgg caaaactatt tgacaaaata gctagtacat cagaattttt aaaaaatggg
721 aaagcaagga ctgatttgga gataacagat tcaaaagtca gcaatctaca ggtatctcca
781 aagtctgagg atatcagtaa atttgactgg ttagacttgg atcctctaag taagcctaag
841 gtggataatg tggaggtatt agaccatgag gaagagaaaa atgtttcaag tttgctagca
901 aaggatcctt gggatgctgt tcttcttgaa gagagatcga cagcaaattg tcatcttgaa
961 agaaaggtga atggaaaatc cctttctgtg gcaactgtta caagaagcca gtctttaaat
1021 attcgaacaa ctcagcttgc aaaagcccag ggccatatat ctcagaaaga cccaaatggg
1081 accagtagtt tgccaactgg aagttctctt cttcaagaag ttgaagtaca gaatgaggag
1141 atggcagctt tttgtcgatc cattacaaaa ttgaagacca aatttccata taccaatcac
1201 cgcacaaacc caggctattt gttaagtcca gtcacagcgc aaagaaacat atgcggagaa
1261 aatgctagtg tgaaggtctc cattgacatt gaaggatttc agctaccagt tacttttacg
1321 tgtgatgtga gttctactgt agaaatcatt ataatgcaag ccctttgctg ggtacatgat
1381 gacttgaatc aagtagatgt tggcagctat gttctaaaag tttgtggtca agaggaagtg
1441 ctgcagaata atcattgcct tggaagtcat gagcatattc aaaactgtcg aaaatgggac
1501 acagaaatta gactacaact cttgaccttc agtgcaatgt gtcaaaatct ggcccgaaca
1561 gcagaagatg atgaaacacc cgtggattta aacaaacacc tgtatcaaat agaaaaacct
1621 tgcaaagaag ccatgacgag acaccctgtt gaagaactct tagattctta tcacaaccaa
1681 gtagaactgg ctcttcaaat tgaaaaccaa caccgagcag tagatcaagt aattaaagct
1741 gtaagaaaaa tctgtagtgc tttagatggt gtcgagactc ttgccattac agaatcagta
1801 aagaagctaa agagagcagt taatcttcca aggagtaaaa ctgctgatgt gacttctttg
1861 tttggaggag aagacactag caggagttca actaggggct cacttaatcc tgaaaatcct
1921 gttcaagtaa gcataaacca attaactgca gcaatttatg atcttctcag actccatgca
1981 aattctggta ggagtcctac agactgtgcc caaagtagca agagtgtcaa ggaagcatgg
2041 actacaacag agcagctcca gtttactatt tttgctgctc atggaatttc aagtaattgg
2101 gtatcaaatt atgaaaaata ctacttgata tgttcactgt ctcacaatgg aaaggatctt
2161 tttaaaccta ttcaatcaaa gaaggttggc acttacaaga atttcttcta tcttattaaa
2221 tgggatgaac taatcatttt tcctatccag atatcacaat tgccattaga atcagttctt
2281 caccttactc tttttggaat tttaaatcag agcagtggaa gttcccctga ttctaataag
2341 cagagaaagg gaccagaagc tttgggcaaa gtttctttac ctctttgtga ctttagacgg
2401 tttttaacat gtggaactaa acttctatat ctttggactt catcacatac aaattctgtt
2461 cctggaacag ttaccaaaaa aggatatgtc atggaaagaa tagtgctaca ggttgatttt
2521 ccttctcctg catttgatat tatttataca actcctcaag ttgacagaag cattatacag
2581 caacataact tagaaacact agagaatgat ataaaaggga aacttcttga tattcttcat
2641 aaagactcat cacttggact ttctaaagaa gataaagctt ttttatggga gaaacgttat
2701 tattgcttca aacacccaaa ttgtcttcct aaaatattag caagcgcccc aaactggaaa
2761 tggggtaatc ttgccaaaac ttactcattg cttcaccagt ggcctgcatt gtacccacta
2821 attgcattgg aacttcttga ttcaaaattt gctgatcagg aagtaagatc cctagctgtg
2881 acctggattg aggccattag tgatgatgag ctaacagatc ttcttccaca gtttgtacaa
2941 gctttgaaat atgaaattta cttgaatagt tcattagtgc aattcctttt gtccagggca
3001 ttgggaaata tccagatagc acacaattta tattggcttc tcaaagatgc cctgcatgat
3061 gtacagttta gtacccgata cgaacatgtt ttgggtgctc tcctgtcagt aggaggaaaa
3121 cgacttagag aagaacttct aaaacagacg aaacttgtac agcttttagg aggagtagca
3181 gaaaaagtaa ggcaggctag tggatcagcc agacaggttg ttctccaaag aagtatggaa
3241 cgagtacagt ccttttttca gaaaaataaa tgccgtctcc ctctcaagcc aagtctagtg
3301 gcaaaagaat taaatattaa gtcgtgttcc ttcttcagtt ctaatgctgt ccccctaaaa
3361 gtcacaatgg tgaatgctga ccctctggga gaagaaatta atgtcatgtt taaggttggt
3421 gaagatcttc ggcaagatat gttagcttta cagatgataa agattatgga taagatctgg
3481 cttaaagaag gactagatct gaggatggta attttcaaat gtctctcaac tggcagagat
3541 cgaggcatgg tggagctggt tcctgcttcc gataccctca ggaaaatcca agtggaatat
3601 ggtgtgacag gatcctttaa agataaacca cttgcagagt ggctaaggaa atacaatccc
3661 tctgaagaag aatatgaaaa ggcttcagag aactttatct attcctgtgc tggatgctgt
3721 gtagccacct atgttttagg catctgtgat cgacacaatg acaatataat gcttcgaagc
3781 acgggacaca tgtttcacat tgactttgga aagtttttgg gacatgcaca gatgtttggc
3841 agcttcaaaa gggatcgggc tccttttgtg ctgacctctg atatggcata tgtcattaat
3901 gggggtgaaa agcccaccat tcgttttcag ttgtttgtgg acctctgctg tcaggcctac
3961 aacttgataa gaaagcagac aaaccttttt cttaacctcc tttcactgat gattccttca
4021 gggttaccag aacttacaag tattcaagat ttgaaatacg ttagagatgc acttcaaccc
4081 caaactacag acgcagaagc tacaattttc tttactaggc ttattgaatc aagtttggga
4141 agcattgcca caaagtttaa cttcttcatt cacaaccttg ctcagcttcg tttttctggt
4201 cttccttcta atgatgagcc catcctttca ttttcaccta aaacatactc ctttagacaa
4261 gatggtcgaa tcaaggaagt ctctgttttt acatatcata agaaatacaa cccagataaa
4321 cattatattt atgtagtccg aattttgtgg gaaggacaga ttgaaccatc atttgtcttc
4381 cgaacatttg tcgaatttca ggaacttcac aataagctca gtattatttt tccactttgg
4441 aagttaccag gctttcctaa taggatggtt ctaggaagaa cacacataaa agatgtagca
4501 gccaaaagga aaattgagtt aaacagttac ttacagagtt tgatgaatgc ttcaacggat
4561 gtagcagagt gtgatcttgt ttgtactttc ttccaccctt tacttcgtga tgagaaagct
4621 gaagggatag ctaggtctgc agatgcaggt tccttcagtc ctactccagg ccaaatagga
4681 ggagctgtga aattatccat ctcttaccga aatggtactc ttttcatcat ggtgatgcat
4741 atcaaagatc ttgttactga agatggagct gacccaaatc catatgtcaa aacataccta
4801 cttccagata accacaaaac atccaaacgt aaaaccaaaa tttcacgaaa aacgaggaat
4861 ccgacattca atgaaatgct tgtatacagt ggatatagca aagaaaccct aagacagcga
4921 gaacttcaac taagtgtact cagtgcagaa tctctgcggg agaatttttt cttgggtgga
4981 gtaaccctgc ctttgaaaga tttcaacttg agcaaagaga cggttaaatg gtatcagctg
5041 actgcggcaa catacttgta a
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