LOCUS Y11312 7654 bp mRNA linear HUM 07-OCT-2008 DEFINITION H.sapiens mRNA for phosphoinositide 3-kinase. ACCESSION Y11312 VERSION Y11312.1 KEYWORDS C2 domain; phosphoinositide 3-kinase; PI3K gene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Brown R.A., Ho L.K.F., Weber-Hall S., Shipley J.M., Fry M.J. TITLE Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K JOURNAL Biochem. Biophys. Res. Commun. 233(2), 537-544(1997). PUBMED 9144573 REFERENCE 2 AUTHORS Brown R.A. JOURNAL Submitted (17-FEB-1997) to the INSDC. R.A. Brown, Institute Of Cancer Research, Cell Biology And Experimental Pathology, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK REMARK revised by [3] REFERENCE 3 (bases 1 to 7654) AUTHORS Brown R.A. JOURNAL Submitted (19-JAN-1998) to the INSDC. R.A. Brown, Institute Of Cancer Research, Cell Biology And Experimental Pathology, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK FEATURES Location/Qualifiers source 1..7654 /db_xref="H-InvDB:HIT000325644" /organism="Homo sapiens" /chromosome="1" /map="q32" /mol_type="mRNA" /cell_line="MCF-7" /db_xref="taxon:9606" 5'UTR 1..515 /gene="C2-PI3K" CDS 516..5420 /gene="C2-PI3K" /product="phosphoinositide 3-kinase" /EC_number="2.7.1.137" /db_xref="GOA:O00750" /db_xref="H-InvDB:HIT000325644.13" /db_xref="HGNC:HGNC:8972" /db_xref="InterPro:IPR000008" /db_xref="InterPro:IPR000341" /db_xref="InterPro:IPR000403" /db_xref="InterPro:IPR001263" /db_xref="InterPro:IPR001683" /db_xref="InterPro:IPR002420" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR015433" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR018936" /db_xref="InterPro:IPR029071" /db_xref="InterPro:IPR035892" /db_xref="InterPro:IPR036871" /db_xref="InterPro:IPR036940" /db_xref="InterPro:IPR042134" /db_xref="InterPro:IPR042236" /db_xref="UniProtKB/Swiss-Prot:O00750" /inference="non-experimental evidence, no additional details recorded" /protein_id="CAA72168.1" /translation="MSSTQDNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDK EENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGP PNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLP PRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGG QGRLLGSVDYDGINDAITRLNLKSTYDVEMLRDATRGWKEGRGPLDFSKDTSGKPVAR SKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDE EVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALT FTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYC RKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLF DTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQ PKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEA CHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKDMCSPLQTRRAHFSKYLFH LIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPL FNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPP GDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLV LASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAE LLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQ YLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFF ALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDL RQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLK TTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCC QAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKI FHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGR SRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSD GTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQK TTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIR LRELDLAQEKTGWFALGSRSHGTL" 3'UTR 5421..7654 /gene="C2-PI3K" BASE COUNT 1693 a 2102 c 2031 g 1828 t ORIGIN 1 actcactata gggctcgagc ggccgcccgg gcaggtaaga atcagaagac atttgtgctt 61 tggggagcag aggccctcag ggtatagaga aggaagaaga gagaggttca ctgtagtcct 121 gaagcagaaa taagacctgt ggctgaagga agccttagca attcactcct tcctcttcct 181 gagaactctc tgtaggaagt ctcacctagc agaggcttca cagtatttca gagaagccaa 241 agattgtttg cctctttgga aactgttatc cttccatcat gactgtgtca ctcctgccac 301 tgttccacca tagagatggc gtcctttgca gcaaaccgta agttataagg atgagggaag 361 aagagtagag ggccaaaagg attccatttt gaggaaaaac tacagtttgc cttgccaggt 421 agaagaatca ggcgcccaga caccatgtca caaccctcca gaactgacgt tggcaggaag 481 tagagacttt gttgcctgtg tcccccatcc tcaccatgtc ttcgactcag gacaatgggg 541 aacactggaa gtccctggag tctgtgggca tcagccgcaa agaactagcg atggccgaag 601 ccctgcagat ggagtatgat gccctgtccc ggctccggca tgacaaggag gagaacagag 661 ccaagcagaa cgcagacccc tctctcatca gctgggatga gcctggggta gacttttaca 721 gcaagccagc aggaaggcgg accgacctca agctgttacg cggtctctct ggctctgatc 781 ctacccttaa ctacaactca ctatccccac aggaagggcc gcccaaccac tctacctccc 841 aagggccaca gcctggctca gatccctggc ccaaaggctc cctgtctgga gactatctct 901 acatttttga tggttcagat gggggagtct cttcgtcccc aggaccaggg gacatagagg 961 gctcttgcaa gaaactatcc ccacctcctc tgcctccccg agcttctatc tgggataccc 1021 ctcccctgcc tcccagaaag gggtccccct catcctccaa gatctcccag cccagtgaca 1081 tcaacacttt ctctttggtc gaacaattgc caggcaaact gctagagcat cggatcctag 1141 aagaggaaga ggtgctggga ggtgggggtc aggggcgcct actggggtct gtggactatg 1201 atggtatcaa tgatgcaatt actaggctca acttgaaatc gacctatgat gtggagatgt 1261 tgcgggatgc caccaggggc tggaaggagg gccgagggcc gctggacttc agcaaagaca 1321 cctctggaaa acccgtggcc aggagcaaga ctatgccccc tcaggtgccc ccccgcacct 1381 atgcctcccg ctatggcaac cgaaagaatg cgacgcctgg caagaaccgc cggatttctg 1441 cagccccggt gggctcccgg ccccacactg ttgccaatgg ccatgagttg tttgaggtct 1501 cagaagagag agatgaggag gttgctgcat tttgccacat gctggatatc cttcgatctg 1561 gctctgacat ccaagactac ttcctcactg gctatgtctg gagtgctgtc acccctagcc 1621 cagagcacct cggggatgag gtcaacctga aggtgactgt gttgtgtgac aggcttcaag 1681 aggcactcac tttcacctgc aactgttcct ccactgtaga cttgcttatc taccagaccc 1741 tgtgctacac ccatgatgac ctgaggaatg tggacgtggg tgactttgtg ctaaagccct 1801 gcgggctgga ggagttcctg cagaacaagc atgccttggg cagtcatgag tacatccaat 1861 actgccgcaa gtttgacatt gacattcggc tacagctgat ggagcagaag gttgtgcgca 1921 gtgacctggc ccggacggtg aatgatgacc agagcccctc caccttgaac tacctcgtcc 1981 atctccaaga gaggcctgtc aagcagacca tcagcaggca ggccctgagt cttctgttcg 2041 acacttacca caatgaggtg gatgccttcc tgctggctga tggagacttc ccactgaagg 2101 ctgacagggt ggtccagtcc gtcaaggcca tctgcaacgc cctggccgcc gtggaaaccc 2161 ctgagatcac cagtgctctc aaccagctgc ccccctgccc ctcccgcatg cagcctaaaa 2221 ttcagaagga tcccagtgtc ttggctgtga gggaaaaccg agagaaggtc gtggaagccc 2281 tgaccgctgc catcttggac ctggtggagc tgtactgcaa cacattcaac gcagacttcc 2341 agacggcagt gcccgggagc cgcaagcatg acctggtcca ggaggcctgc catttcgcca 2401 ggtccctggc cttcactgtc tatgccaccc accgcatccc catcatctgg gctaccagct 2461 atgaagattt ctacctctcc tgctccctca gccatggcgg caaggacatg tgcagccccc 2521 tgcagacccg aagagctcac ttctccaagt acctcttcca cctcatcgtc tgggaccagc 2581 agatctgctt cccagtgcag gtgaaccggc tgcctcggga gacactgctg tgtgccactc 2641 tctatgctct gcccatcccc ccaccgggga gctcctcaga ggccaataag cagcggcggg 2701 tgcctgaagc cctgggctgg gtcactaccc cactcttcaa cttcaggcag gtcctgacct 2761 gtggccggaa gcttctgggt ttgtggccag caacacagga aaatcccagc gcccgttgga 2821 gtgcacctaa tttccaccag ccagacagtg tcatcctgca gattgacttc cccacctcgg 2881 cctttgacat caagttcacc agcccccctg gagacaagtt cagcccccgc tatgagtttg 2941 gcagcctccg ggaagaagac cagcgcaagc ttaaagacat catgcagaaa gagtccttgt 3001 actggctcac tgatgctgac aagaagcgcc tgtgggagaa gcgatattac tgccactcgg 3061 aggtgagctc gctccccctg gtgctcgcca gcgcccccag ctgggagtgg gcttgcctgc 3121 ctgacatcta tgttctcctg aagcagtgga cccacatgaa ccaccaggat gccctggggc 3181 tcctgcatgc caccttcccg gaccaggagg tgcgtcgtat ggctgtgcag tggattggct 3241 cactctcaga tgctgagctg ctagactacc tgccccagct ggtacaggcc ctgaagtatg 3301 aatgctacct ggacagcccg ttggtgcgct tcctcctgaa acgagctgtg tctgacttga 3361 gagtgactca ctacttcttc tggttactga aggacggcct caaggactct cagttcagca 3421 tccgctacca gtatctgctg gcagccttac tgtgctgctg tggcaagggg ctgagagaag 3481 agtttaaccg ccagtgctgg cttgtcaatg ccctggccaa actggcccag caggtccggg 3541 aggcagcccc atctgcaagg cagggaatcc tccgcacggg cctggaggag gtgaagcagt 3601 tctttgccct caatggctcg tgccgcttgc cactcagccc cagtctgctg gttaagggaa 3661 ttgtgcccag ggactgttcc tacttcaact ccaatgctgt ccccctcaaa ctctccttcc 3721 aaaatgtgga tcccctgggt gagaacatcc gtgtcatctt caagtgtggg gacgaccttc 3781 gccaggacat gctaacgctg cagatgattc gcatcatgag caagatctgg gtccaggagg 3841 ggctggacat gcgcatggtc atcttccgct gcttctccac cggccggggc agagggatgg 3901 tggagatgat ccctaatgct gagaccctgc gtaagatcca ggtggagcat ggggtgaccg 3961 gctcgttcaa ggaccggccc ctggcagact ggctgcagaa acacaaccct ggggaggacg 4021 agtatgagaa ggctgtggag aactttatct actcctgcgc tggctgctgc gtggccacgt 4081 acgtcttggg catctgtgac cgacataatg acaacatcat gctgaagacc actggtcaca 4141 tgttccacat tgattttggc cgcttcctgg gccatgccca gatgtttggc aacatcaagc 4201 gggaccgtgc cccctttgtc ttcacctcgg acatggcgta tgtcatcaac gggggtgaca 4261 agccttccag ccgcttccat gattttgttg acctttgctg ccaagcctac aacctcattc 4321 gcaagcacac ccacctcttc ctcaaccttc tgggcctgat gttgtcctgt gggatccctg 4381 aactctcaga cctggaggac ctcaagtatg tgtacgatgc cctgaggcct caggatacag 4441 aggccaatgc cactacctac ttcactaggt tgattgagtc cagcctgggc agtgtagcca 4501 caaagctcaa ttttttcatc cataatctgg ctcagatgaa gttcacgggc tcagatgacc 4561 ggctgaccct ctcctttgcc tcccgaacac acactctcaa gagctctggc cgaatcagtg 4621 atgttttcct ctgccgccat gagaagatct tccaccccaa caaaggctat atatatgtgg 4681 taaaggtgat gcgagagaac actcacgagg ccacctacat ccagcggacc tttgaggagt 4741 tccaggaatt acacaataag ttgcggctgc tcttcccttc ttcccacttg cccagcttcc 4801 ctagtcgctt cgtgatcggc cgctcccggg gagaggcggt ggccgagcgg cggagggagg 4861 agctaaacgg ttacatctgg cacttgatcc acgcaccccc tgaggtggcc gagtgtgatt 4921 tggtgtacac cttcttccac ccactgcccc gggatgagaa ggctatgggc accagcccag 4981 ctcctaagtc ctcagatggc acatgggccc ggcccgtcgg aaaggtggga ggggaggtga 5041 agctgtccat ctcctacaaa aacaataaac tcttcatcat ggtgatgcat attcggggct 5101 tgcaactgct ccaggatgga aatgaccctg acccctatgt gaaaatttac ctccttcctg 5161 accctcagaa aaccactaag aggaaaacca aagtggcccg gaaaacctgc aatcctacct 5221 acaatgagat gttggtatat gatgggatcc ccaagggtga cctgcagcag cgggagctcc 5281 agctgagcgt gctgagtgag cagggattct gggagaacgt cctcctcggt gaggtgaaca 5341 tccgcctgcg agagctggac ctggctcagg agaagaccgg ctggttcgcc ctgggatctc 5401 gaagtcatgg caccttgtga gcccagcaga gccaccaccc agcatcccag gctggtggca 5461 ggagctgggg gagaggactc tcccctgtga gactcctcct tgtgaagggc cagggccctg 5521 ggcaggcctc cagctcggtc caggtgattc tggcctctgt ggtaggaggc agggagagta 5581 agacatgctc tgctgtctct tcctctggag actgaacttg ggttggttgt gatgagcagc 5641 cccttggagg ctgtgaggtt gcagcaaagt tttaagttta ccttgtgtca agggagcaat 5701 gcttggtttg gggaatgtgt ggggtgggct gtatgaagta ccattttggg ggtgggtggg 5761 tggatatctt aatttttatt tttaaaaaat gaaatagtga tgttgtccta actgggacag 5821 gaagccttgc gagaagggac gtacctatgc cccacaaggc aagagaggaa cactatttgg 5881 actttttgta tgattaaggt tcttattgga cttttcccta ggtttttttt ttttgttatt 5941 gttgttgttg ttccgttttc tagctatagg aactatctgg ggaggggccc agtgggtcct 6001 cggccagagc cctctctaag gacaggttgg ggagggttgg ggagggctgc ctgtgctgga 6061 ctgaggcttg tgccactggg cctttctgat tttgcctcca aaggagagcg ctgtgatacc 6121 tacatgtgta aggaagggcc ttccgtattg gggttctgcc aaggacccgt attcagggac 6181 ccatgctctt ttggggggac ttttcctctt gtcttcccta ctttattagg acttgccctg 6241 aataccattt tctacccctt gcccctccat tctcctggcc cttctggggg tcagctggtc 6301 tctatgaata tgctgggggt gcttccccat aggtctctcc cttcatttgt ctctggtggg 6361 acaaaatact gactcagtcc ttagatgtag tttcacccaa gagcatcttg gccctgggaa 6421 gaggtcccta ggctgcagat gctactgact gcttgctagg tagcctctgg aaagcattcc 6481 ccatccatca ctccccactt ctttctgctg tgctgcttcc ctcccaaact ccatttctgt 6541 cacccttttt ataagacttt tcctcattct gtggggccat aaacctattt agtctggagc 6601 caaagggatg ccctatctga aggaaagggg catggggtgg gggattccat caaaactgtt 6661 gttttttgcc ccatgatttt tctttggtca gtaggaggct ggattggagt ggtgattatt 6721 cccctggagc taagctcagg agcccgaagg gagagactga gactgactcc cttatctctt 6781 catattcttt attccctacc agatggattt tttttttttt ttttggagac ggagtctcgc 6841 cctgtcgcca ggctggagtg tagtggcatg atctcgactc actgcaaaat ctgcctcccg 6901 ggttcaagcg attctcctac ctcagcctcc cgagtagctg ggattacagg catgtgccac 6961 cacgccaagc taatttttgt atttttagta gagacggggt ttcaccatgt tggccaggat 7021 ggtctcgatc tcttgacctc gtgatctgcc tgccttggcc tcccaaagtg ctgggattac 7081 aggcgtgagc caccatgccc cgccccagat ggattttaca tttgctcttt tgtgtttcgc 7141 tccaaagggt tgtcttcctc gccaaaagga gggagggact ttgaatttga tatgaatctt 7201 taaaaccaga attggctgga tatttcccat gattgggaaa agagtgaaat gaggacattc 7261 tgtaaactgt ccctccctaa ttccaaggat cagaaactcc ccgttttgct gactcattcc 7321 ataactggag aaagaagctc cattgaccga agccacaggg cagcatggaa gtttaaattt 7381 tctctaaaat taaaatgcca aggataaagc tggctgcttc caggaggggg aagaggagtg 7441 gggagtgggc ggtgaaactt ttccagatga acggaccata aatgtgttac tggctttgtg 7501 cctgtagctc attttattat gacctatatg ctcctgattt aaagagatct gtgtactgtt 7561 tacttcccac ttcccagaat cccttgtatc tcctttctcg ggaattgtat tttctaataa 7621 atgacatttg agaaaaaaaa aaaaaaaaaa aaaa //