LOCUS       Y11312                  7654 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens mRNA for phosphoinositide 3-kinase.
ACCESSION   Y11312
VERSION     Y11312.1
KEYWORDS    C2 domain; phosphoinositide 3-kinase; PI3K gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Brown R.A., Ho L.K.F., Weber-Hall S., Shipley J.M., Fry M.J.
  TITLE     Identification and cDNA cloning of a novel mammalian C2
            domain-containing phosphoinositide 3-kinase, HsC2-PI3K
  JOURNAL   Biochem. Biophys. Res. Commun. 233(2), 537-544(1997).
   PUBMED   9144573
REFERENCE   2
  AUTHORS   Brown R.A.
  JOURNAL   Submitted (17-FEB-1997) to the INSDC. R.A. Brown, Institute Of
            Cancer Research, Cell Biology And Experimental Pathology, 15
            Cotswold Road, Sutton, Surrey, SM2 5NG, UK
  REMARK    revised by [3]
REFERENCE   3  (bases 1 to 7654)
  AUTHORS   Brown R.A.
  JOURNAL   Submitted (19-JAN-1998) to the INSDC. R.A. Brown, Institute Of
            Cancer Research, Cell Biology And Experimental Pathology, 15
            Cotswold Road, Sutton, Surrey, SM2 5NG, UK
FEATURES             Location/Qualifiers
     source          1..7654
                     /db_xref="H-InvDB:HIT000325644"
                     /organism="Homo sapiens"
                     /chromosome="1"
                     /map="q32"
                     /mol_type="mRNA"
                     /cell_line="MCF-7"
                     /db_xref="taxon:9606"
     5'UTR           1..515
                     /gene="C2-PI3K"
     CDS             516..5420
                     /gene="C2-PI3K"
                     /product="phosphoinositide 3-kinase"
                     /EC_number="2.7.1.137"
                     /db_xref="GOA:O00750"
                     /db_xref="H-InvDB:HIT000325644.13"
                     /db_xref="HGNC:HGNC:8972"
                     /db_xref="InterPro:IPR000008"
                     /db_xref="InterPro:IPR000341"
                     /db_xref="InterPro:IPR000403"
                     /db_xref="InterPro:IPR001263"
                     /db_xref="InterPro:IPR001683"
                     /db_xref="InterPro:IPR002420"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR015433"
                     /db_xref="InterPro:IPR016024"
                     /db_xref="InterPro:IPR018936"
                     /db_xref="InterPro:IPR029071"
                     /db_xref="InterPro:IPR035892"
                     /db_xref="InterPro:IPR036871"
                     /db_xref="InterPro:IPR036940"
                     /db_xref="InterPro:IPR042134"
                     /db_xref="InterPro:IPR042236"
                     /db_xref="UniProtKB/Swiss-Prot:O00750"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /protein_id="CAA72168.1"
                     /translation="MSSTQDNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDK
                     EENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGP
                     PNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLP
                     PRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGG
                     QGRLLGSVDYDGINDAITRLNLKSTYDVEMLRDATRGWKEGRGPLDFSKDTSGKPVAR
                     SKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDE
                     EVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALT
                     FTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYC
                     RKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLF
                     DTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQ
                     PKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEA
                     CHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKDMCSPLQTRRAHFSKYLFH
                     LIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPL
                     FNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPP
                     GDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLV
                     LASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAE
                     LLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQ
                     YLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFF
                     ALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDL
                     RQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG
                     VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLK
                     TTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCC
                     QAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI
                     ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKI
                     FHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGR
                     SRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSD
                     GTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQK
                     TTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIR
                     LRELDLAQEKTGWFALGSRSHGTL"
     3'UTR           5421..7654
                     /gene="C2-PI3K"
BASE COUNT         1693 a         2102 c         2031 g         1828 t
ORIGIN      
        1 actcactata gggctcgagc ggccgcccgg gcaggtaaga atcagaagac atttgtgctt
       61 tggggagcag aggccctcag ggtatagaga aggaagaaga gagaggttca ctgtagtcct
      121 gaagcagaaa taagacctgt ggctgaagga agccttagca attcactcct tcctcttcct
      181 gagaactctc tgtaggaagt ctcacctagc agaggcttca cagtatttca gagaagccaa
      241 agattgtttg cctctttgga aactgttatc cttccatcat gactgtgtca ctcctgccac
      301 tgttccacca tagagatggc gtcctttgca gcaaaccgta agttataagg atgagggaag
      361 aagagtagag ggccaaaagg attccatttt gaggaaaaac tacagtttgc cttgccaggt
      421 agaagaatca ggcgcccaga caccatgtca caaccctcca gaactgacgt tggcaggaag
      481 tagagacttt gttgcctgtg tcccccatcc tcaccatgtc ttcgactcag gacaatgggg
      541 aacactggaa gtccctggag tctgtgggca tcagccgcaa agaactagcg atggccgaag
      601 ccctgcagat ggagtatgat gccctgtccc ggctccggca tgacaaggag gagaacagag
      661 ccaagcagaa cgcagacccc tctctcatca gctgggatga gcctggggta gacttttaca
      721 gcaagccagc aggaaggcgg accgacctca agctgttacg cggtctctct ggctctgatc
      781 ctacccttaa ctacaactca ctatccccac aggaagggcc gcccaaccac tctacctccc
      841 aagggccaca gcctggctca gatccctggc ccaaaggctc cctgtctgga gactatctct
      901 acatttttga tggttcagat gggggagtct cttcgtcccc aggaccaggg gacatagagg
      961 gctcttgcaa gaaactatcc ccacctcctc tgcctccccg agcttctatc tgggataccc
     1021 ctcccctgcc tcccagaaag gggtccccct catcctccaa gatctcccag cccagtgaca
     1081 tcaacacttt ctctttggtc gaacaattgc caggcaaact gctagagcat cggatcctag
     1141 aagaggaaga ggtgctggga ggtgggggtc aggggcgcct actggggtct gtggactatg
     1201 atggtatcaa tgatgcaatt actaggctca acttgaaatc gacctatgat gtggagatgt
     1261 tgcgggatgc caccaggggc tggaaggagg gccgagggcc gctggacttc agcaaagaca
     1321 cctctggaaa acccgtggcc aggagcaaga ctatgccccc tcaggtgccc ccccgcacct
     1381 atgcctcccg ctatggcaac cgaaagaatg cgacgcctgg caagaaccgc cggatttctg
     1441 cagccccggt gggctcccgg ccccacactg ttgccaatgg ccatgagttg tttgaggtct
     1501 cagaagagag agatgaggag gttgctgcat tttgccacat gctggatatc cttcgatctg
     1561 gctctgacat ccaagactac ttcctcactg gctatgtctg gagtgctgtc acccctagcc
     1621 cagagcacct cggggatgag gtcaacctga aggtgactgt gttgtgtgac aggcttcaag
     1681 aggcactcac tttcacctgc aactgttcct ccactgtaga cttgcttatc taccagaccc
     1741 tgtgctacac ccatgatgac ctgaggaatg tggacgtggg tgactttgtg ctaaagccct
     1801 gcgggctgga ggagttcctg cagaacaagc atgccttggg cagtcatgag tacatccaat
     1861 actgccgcaa gtttgacatt gacattcggc tacagctgat ggagcagaag gttgtgcgca
     1921 gtgacctggc ccggacggtg aatgatgacc agagcccctc caccttgaac tacctcgtcc
     1981 atctccaaga gaggcctgtc aagcagacca tcagcaggca ggccctgagt cttctgttcg
     2041 acacttacca caatgaggtg gatgccttcc tgctggctga tggagacttc ccactgaagg
     2101 ctgacagggt ggtccagtcc gtcaaggcca tctgcaacgc cctggccgcc gtggaaaccc
     2161 ctgagatcac cagtgctctc aaccagctgc ccccctgccc ctcccgcatg cagcctaaaa
     2221 ttcagaagga tcccagtgtc ttggctgtga gggaaaaccg agagaaggtc gtggaagccc
     2281 tgaccgctgc catcttggac ctggtggagc tgtactgcaa cacattcaac gcagacttcc
     2341 agacggcagt gcccgggagc cgcaagcatg acctggtcca ggaggcctgc catttcgcca
     2401 ggtccctggc cttcactgtc tatgccaccc accgcatccc catcatctgg gctaccagct
     2461 atgaagattt ctacctctcc tgctccctca gccatggcgg caaggacatg tgcagccccc
     2521 tgcagacccg aagagctcac ttctccaagt acctcttcca cctcatcgtc tgggaccagc
     2581 agatctgctt cccagtgcag gtgaaccggc tgcctcggga gacactgctg tgtgccactc
     2641 tctatgctct gcccatcccc ccaccgggga gctcctcaga ggccaataag cagcggcggg
     2701 tgcctgaagc cctgggctgg gtcactaccc cactcttcaa cttcaggcag gtcctgacct
     2761 gtggccggaa gcttctgggt ttgtggccag caacacagga aaatcccagc gcccgttgga
     2821 gtgcacctaa tttccaccag ccagacagtg tcatcctgca gattgacttc cccacctcgg
     2881 cctttgacat caagttcacc agcccccctg gagacaagtt cagcccccgc tatgagtttg
     2941 gcagcctccg ggaagaagac cagcgcaagc ttaaagacat catgcagaaa gagtccttgt
     3001 actggctcac tgatgctgac aagaagcgcc tgtgggagaa gcgatattac tgccactcgg
     3061 aggtgagctc gctccccctg gtgctcgcca gcgcccccag ctgggagtgg gcttgcctgc
     3121 ctgacatcta tgttctcctg aagcagtgga cccacatgaa ccaccaggat gccctggggc
     3181 tcctgcatgc caccttcccg gaccaggagg tgcgtcgtat ggctgtgcag tggattggct
     3241 cactctcaga tgctgagctg ctagactacc tgccccagct ggtacaggcc ctgaagtatg
     3301 aatgctacct ggacagcccg ttggtgcgct tcctcctgaa acgagctgtg tctgacttga
     3361 gagtgactca ctacttcttc tggttactga aggacggcct caaggactct cagttcagca
     3421 tccgctacca gtatctgctg gcagccttac tgtgctgctg tggcaagggg ctgagagaag
     3481 agtttaaccg ccagtgctgg cttgtcaatg ccctggccaa actggcccag caggtccggg
     3541 aggcagcccc atctgcaagg cagggaatcc tccgcacggg cctggaggag gtgaagcagt
     3601 tctttgccct caatggctcg tgccgcttgc cactcagccc cagtctgctg gttaagggaa
     3661 ttgtgcccag ggactgttcc tacttcaact ccaatgctgt ccccctcaaa ctctccttcc
     3721 aaaatgtgga tcccctgggt gagaacatcc gtgtcatctt caagtgtggg gacgaccttc
     3781 gccaggacat gctaacgctg cagatgattc gcatcatgag caagatctgg gtccaggagg
     3841 ggctggacat gcgcatggtc atcttccgct gcttctccac cggccggggc agagggatgg
     3901 tggagatgat ccctaatgct gagaccctgc gtaagatcca ggtggagcat ggggtgaccg
     3961 gctcgttcaa ggaccggccc ctggcagact ggctgcagaa acacaaccct ggggaggacg
     4021 agtatgagaa ggctgtggag aactttatct actcctgcgc tggctgctgc gtggccacgt
     4081 acgtcttggg catctgtgac cgacataatg acaacatcat gctgaagacc actggtcaca
     4141 tgttccacat tgattttggc cgcttcctgg gccatgccca gatgtttggc aacatcaagc
     4201 gggaccgtgc cccctttgtc ttcacctcgg acatggcgta tgtcatcaac gggggtgaca
     4261 agccttccag ccgcttccat gattttgttg acctttgctg ccaagcctac aacctcattc
     4321 gcaagcacac ccacctcttc ctcaaccttc tgggcctgat gttgtcctgt gggatccctg
     4381 aactctcaga cctggaggac ctcaagtatg tgtacgatgc cctgaggcct caggatacag
     4441 aggccaatgc cactacctac ttcactaggt tgattgagtc cagcctgggc agtgtagcca
     4501 caaagctcaa ttttttcatc cataatctgg ctcagatgaa gttcacgggc tcagatgacc
     4561 ggctgaccct ctcctttgcc tcccgaacac acactctcaa gagctctggc cgaatcagtg
     4621 atgttttcct ctgccgccat gagaagatct tccaccccaa caaaggctat atatatgtgg
     4681 taaaggtgat gcgagagaac actcacgagg ccacctacat ccagcggacc tttgaggagt
     4741 tccaggaatt acacaataag ttgcggctgc tcttcccttc ttcccacttg cccagcttcc
     4801 ctagtcgctt cgtgatcggc cgctcccggg gagaggcggt ggccgagcgg cggagggagg
     4861 agctaaacgg ttacatctgg cacttgatcc acgcaccccc tgaggtggcc gagtgtgatt
     4921 tggtgtacac cttcttccac ccactgcccc gggatgagaa ggctatgggc accagcccag
     4981 ctcctaagtc ctcagatggc acatgggccc ggcccgtcgg aaaggtggga ggggaggtga
     5041 agctgtccat ctcctacaaa aacaataaac tcttcatcat ggtgatgcat attcggggct
     5101 tgcaactgct ccaggatgga aatgaccctg acccctatgt gaaaatttac ctccttcctg
     5161 accctcagaa aaccactaag aggaaaacca aagtggcccg gaaaacctgc aatcctacct
     5221 acaatgagat gttggtatat gatgggatcc ccaagggtga cctgcagcag cgggagctcc
     5281 agctgagcgt gctgagtgag cagggattct gggagaacgt cctcctcggt gaggtgaaca
     5341 tccgcctgcg agagctggac ctggctcagg agaagaccgg ctggttcgcc ctgggatctc
     5401 gaagtcatgg caccttgtga gcccagcaga gccaccaccc agcatcccag gctggtggca
     5461 ggagctgggg gagaggactc tcccctgtga gactcctcct tgtgaagggc cagggccctg
     5521 ggcaggcctc cagctcggtc caggtgattc tggcctctgt ggtaggaggc agggagagta
     5581 agacatgctc tgctgtctct tcctctggag actgaacttg ggttggttgt gatgagcagc
     5641 cccttggagg ctgtgaggtt gcagcaaagt tttaagttta ccttgtgtca agggagcaat
     5701 gcttggtttg gggaatgtgt ggggtgggct gtatgaagta ccattttggg ggtgggtggg
     5761 tggatatctt aatttttatt tttaaaaaat gaaatagtga tgttgtccta actgggacag
     5821 gaagccttgc gagaagggac gtacctatgc cccacaaggc aagagaggaa cactatttgg
     5881 actttttgta tgattaaggt tcttattgga cttttcccta ggtttttttt ttttgttatt
     5941 gttgttgttg ttccgttttc tagctatagg aactatctgg ggaggggccc agtgggtcct
     6001 cggccagagc cctctctaag gacaggttgg ggagggttgg ggagggctgc ctgtgctgga
     6061 ctgaggcttg tgccactggg cctttctgat tttgcctcca aaggagagcg ctgtgatacc
     6121 tacatgtgta aggaagggcc ttccgtattg gggttctgcc aaggacccgt attcagggac
     6181 ccatgctctt ttggggggac ttttcctctt gtcttcccta ctttattagg acttgccctg
     6241 aataccattt tctacccctt gcccctccat tctcctggcc cttctggggg tcagctggtc
     6301 tctatgaata tgctgggggt gcttccccat aggtctctcc cttcatttgt ctctggtggg
     6361 acaaaatact gactcagtcc ttagatgtag tttcacccaa gagcatcttg gccctgggaa
     6421 gaggtcccta ggctgcagat gctactgact gcttgctagg tagcctctgg aaagcattcc
     6481 ccatccatca ctccccactt ctttctgctg tgctgcttcc ctcccaaact ccatttctgt
     6541 cacccttttt ataagacttt tcctcattct gtggggccat aaacctattt agtctggagc
     6601 caaagggatg ccctatctga aggaaagggg catggggtgg gggattccat caaaactgtt
     6661 gttttttgcc ccatgatttt tctttggtca gtaggaggct ggattggagt ggtgattatt
     6721 cccctggagc taagctcagg agcccgaagg gagagactga gactgactcc cttatctctt
     6781 catattcttt attccctacc agatggattt tttttttttt ttttggagac ggagtctcgc
     6841 cctgtcgcca ggctggagtg tagtggcatg atctcgactc actgcaaaat ctgcctcccg
     6901 ggttcaagcg attctcctac ctcagcctcc cgagtagctg ggattacagg catgtgccac
     6961 cacgccaagc taatttttgt atttttagta gagacggggt ttcaccatgt tggccaggat
     7021 ggtctcgatc tcttgacctc gtgatctgcc tgccttggcc tcccaaagtg ctgggattac
     7081 aggcgtgagc caccatgccc cgccccagat ggattttaca tttgctcttt tgtgtttcgc
     7141 tccaaagggt tgtcttcctc gccaaaagga gggagggact ttgaatttga tatgaatctt
     7201 taaaaccaga attggctgga tatttcccat gattgggaaa agagtgaaat gaggacattc
     7261 tgtaaactgt ccctccctaa ttccaaggat cagaaactcc ccgttttgct gactcattcc
     7321 ataactggag aaagaagctc cattgaccga agccacaggg cagcatggaa gtttaaattt
     7381 tctctaaaat taaaatgcca aggataaagc tggctgcttc caggaggggg aagaggagtg
     7441 gggagtgggc ggtgaaactt ttccagatga acggaccata aatgtgttac tggctttgtg
     7501 cctgtagctc attttattat gacctatatg ctcctgattt aaagagatct gtgtactgtt
     7561 tacttcccac ttcccagaat cccttgtatc tcctttctcg ggaattgtat tttctaataa
     7621 atgacatttg agaaaaaaaa aaaaaaaaaa aaaa
//