LOCUS Y10055 3868 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for phosphoinositide 3-kinase.
ACCESSION Y10055
VERSION Y10055.2
KEYWORDS p110delta; phosphoinositide 3-kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Vanhaesebroeck B.A.M., Welham M.J., Kotani K., Stein R.,
Warne P.H., Zvelebil M.J., Higashi K., Volinia S., Downward J.,
Waterfield M.D.
TITLE P110delta, a novel phosphoinositide 3-kinase in leukocytes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94(9), 4330-4335(1997).
PUBMED 9113989
REFERENCE 2 (bases 1 to 3868)
AUTHORS Vanhaesebroeck B.A.M.
JOURNAL Submitted (13-DEC-1996) to the INSDC. B.A.M. Vanhaesebroeck, Ludwig
Institute For Cancer Research, UCL/Middlesex Hospital Branch, 91
Riding House Street, London N3 2EJ, UK
FEATURES Location/Qualifiers
source 1..3868
/db_xref="H-InvDB:HIT000325552"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="U937"
/db_xref="taxon:9606"
CDS 197..3331
/gene="P110delta"
/product="phosphoinositide 3-kinase"
/db_xref="GOA:O00329"
/db_xref="H-InvDB:HIT000325552.14"
/db_xref="HGNC:HGNC:8977"
/db_xref="InterPro:IPR000341"
/db_xref="InterPro:IPR000403"
/db_xref="InterPro:IPR001263"
/db_xref="InterPro:IPR002420"
/db_xref="InterPro:IPR003113"
/db_xref="InterPro:IPR008290"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR015433"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR018936"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR035892"
/db_xref="InterPro:IPR036940"
/db_xref="InterPro:IPR037703"
/db_xref="InterPro:IPR042236"
/db_xref="PDB:5DXU"
/db_xref="PDB:5M6U"
/db_xref="PDB:5T8F"
/db_xref="PDB:5UBT"
/db_xref="PDB:5VLR"
/db_xref="PDB:6G6W"
/db_xref="UniProtKB/Swiss-Prot:O00329"
/protein_id="CAA71149.2"
/translation="MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLST
IKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLV
AREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWE
AWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMA
CALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTM
VHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVN
ADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCF
ALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKG
ELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQ
LQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLY
LLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESY
LDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVL
MKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTL
LAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMD
VLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALL
NWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH
FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGL
LFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTK
VNWLAHNVSKDNRQ"
BASE COUNT 800 a 1191 c 1140 g 737 t
ORIGIN
1 gaattcggca cgagcggccg cgagcagagc cgcccagccc tgccagctgc gccgggacga
61 taaggagtca ggccagggcg ggatgacact cattgattct aaagcatctt taatctgcca
121 ggcggagggg gctttgctgg tctttcttgg actattccag agaggacaac tgtcatctgg
181 gaagtaacaa cgcaggatgc cccctggggt ggactgcccc atggaattct ggaccaagga
241 ggagaatcag agcgttgtgg ttgacttcct gctgcccaca ggggtctacc tgaacttccc
301 tgtgtcccgc aatgccaacc tcagcaccat caagcagctg ctgtggcacc gcgcccagta
361 tgagccgctc ttccacatgc tcagtggccc cgaggcctat gtgttcacct gcatcaacca
421 gacagcggag cagcaagagc tggaggacga gcaacggcgt ctgtgtgacg tgcagccctt
481 cctgcccgtc ctgcgcctgg tggcccgtga gggcgaccgc gtgaagaagc tcatcaactc
541 acagatcagc ctcctcatcg gcaaaggcct ccacgagttt gactccttgt gcgacccaga
601 agtgaacgac tttcgcgcca agatgtgcca attctgcgag gaggcggccg cccgccggca
661 gcagctgggc tgggaggcct ggctgcagta cagtttcccc ctgcagctgg agccctcggc
721 tcaaacctgg gggcctggta ccctgcggct cccgaaccgg gcccttctgg tcaacgttaa
781 gtttgagggc agcgaggaga gcttcacctt ccaggtgtcc accaaggacg tgccgctggc
841 gctgatggcc tgtgccctgc ggaagaaggc cacagtgttc cggcagccgc tggtggagca
901 gccggaagac tacacgctgc aggtgaacgg caggcatgag tacctgtatg gcagctaccc
961 gctctgccag ttccagtaca tctgcagctg cctgcacagt gggttgaccc ctcacctgac
1021 catggtccat tcctcctcca tcctcgccat gcgggatgag cagagcaacc ctgcccccca
1081 ggtccagaaa ccgcgtgcca aaccacctcc cattcctgcg aagaagcctt cctctgtgtc
1141 cctgtggtcc ctggagcagc cgttccgcat cgagctcatc cagggcagca aagtgaacgc
1201 cgacgagcgg atgaagctgg tggtgcaggc cgggcttttc cacggcaacg agatgctgtg
1261 caagacggtg tccagctcgg aggtgagcgt gtgctcggag cccgtgtgga agcagcggct
1321 ggagttcgac atcaacatct gcgacctgcc ccgcatggcc cgtctctgct ttgcgctgta
1381 cgccgtgatc gagaaagcca agaaggctcg ctccaccaag aagaagtcca agaaggcgga
1441 ctgccccatt gcctgggcca acctcatgct gtttgactac aaggaccagc ttaagaccgg
1501 ggaacgctgc ctctacatgt ggccctccgt cccagatgag aagggcgagc tgctgaaccc
1561 cacgggcact gtgcgcagta accccaacac ggatagcgcc gctgccctgc tcatctgcct
1621 gcccgaggtg gccccgcacc ccgtgtacta ccccgccctg gagaagatct tggagctggg
1681 gcgacacagc gagtgtgtgc atgtcaccga ggaggagcag ctgcagctgc gggaaatcct
1741 ggagcggcgg gggtctgggg agctgtatga gcacgagaag gacctggtgt ggaagctgcg
1801 gcatgaagtc caggagcact tcccggaggc gctagcccgg ctgctgctgg tcaccaagtg
1861 gaacaagcat gaggatgtgg cccagatgct ctacctgctg tgctcctggc cggagctgcc
1921 cgtcctgagc gccctggagc tgctagactt cagcttcccc gattgccacg taggctcctt
1981 cgccatcaag tcgctgcgga aactgacgga cgatgagctg ttccagtacc tgctgcagct
2041 ggtgcaggtg ctcaagtacg agtcctacct ggactgcgag ctgaccaaat tcctgctgga
2101 ccgggccctg gccaaccgca agatcggcca cttccttttc tggcacctcc gctccgagat
2161 gcacgtgccg tcggtggccc tgcgcttcgg cctcatcctg gaggcctact gcaggggcag
2221 cacccaccac atgaaggtgc tgatgaagca gggggaagca ctgagcaaac tgaaggccct
2281 gaatgacttc gtcaagctga gctctcagaa gacccccaag ccccagacca aggagctgat
2341 gcacttgtgc atgcggcagg aggcctacct agaggccctc tcccacctgc agtccccact
2401 cgaccccagc accctgctgg ctgaagtctg cgtggagcag tgcaccttca tggactccaa
2461 gatgaagccc ctgtggatca tgtacagcaa cgaggaggca ggcagcggcg gcagcgtggg
2521 catcatcttt aagaacgggg atgacctccg gcaggacatg ctgaccctgc agatgatcca
2581 gctcatggac gtcctgtgga agcaggaggg gctggacctg aggatgaccc cctatggctg
2641 cctccccacc ggggaccgca caggcctcat tgaggtggta ctccgttcag acaccatcgc
2701 caacatccaa ctcaacaaga gcaacatggc agccacagcc gccttcaaca aggatgccct
2761 gctcaactgg ctgaagtcca agaacccggg ggaggccctg gatcgagcca ttgaggagtt
2821 caccctctcc tgtgctggct attgtgtggc cacatatgtg ctgggcattg gcgatcggca
2881 cagcgacaac atcatgatcc gagagagtgg gcagctgttc cacattgatt ttggccactt
2941 tctggggaat ttcaagacca agtttggaat caaccgcgag cgtgtcccat tcatcctcac
3001 ctacgacttt gtccatgtga ttcagcaggg gaagactaat aatagtgaga aatttgaacg
3061 gttccggggc tactgtgaaa gggcctacac catcctgcgg cgccacgggc ttctcttcct
3121 ccacctcttt gccctgatgc gggcggcagg cctgcctgag ctcagctgct ccaaagacat
3181 ccagtatctc aaggactccc tggcactggg gaaaacagag gaggaggcac tgaagcactt
3241 ccgagtgaag tttaacgaag ccctccgtga gagctggaaa accaaagtga actggctggc
3301 ccacaacgtg tccaaagaca acaggcagta gtggctcctc ccagccctgg gcccaagagg
3361 aggcggctgc gggtcgtggg gaccaagcac attggtccta aaggggctga agagcctgaa
3421 ctgcacctaa cgggaaagaa ccgacatggc tgccttttgt ttacactggt tatttattta
3481 tgacttgaaa tagtttaagg agctaaacag ccataaacgg aaacgcctcc ttcatgcagc
3541 ggcggtgctg ggccccccga ggctgcacct ggctctcggc tgaggattgt caccccaagt
3601 cttccagctg gtggatctgg gcccagcaaa gactgttctc ctcccgaggg aaccttcttc
3661 ccaggcctcc cgccagactg cctgggtcct ggcgcctggc ggtcacctgg tgcctactgt
3721 ccgacaggat gccttgatcc tcgtgcgacc caccctgtgt atcctcccta gactgagttc
3781 tggcagctcc ccgaggcagc cggggtaccc tctagattca gggatgcttg ctctccactt
3841 ttcaagtggg tcttgggtac gagaattc
//