LOCUS Y09048 11069 bp DNA linear HUM 14-NOV-2006
DEFINITION H.sapiens PxF gene.
ACCESSION Y09048
VERSION Y09048.1
KEYWORDS Alu repetitive element; PxF protein; Sp1 binding site.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 2 (bases 1 to 11069)
AUTHORS Kammerer S.
JOURNAL Submitted (22-OCT-1996) to the INSDC. S. Kammerer,
Kinderkrankenhaus, Labor f. Molekulare Biologie, Lindwurmstr. 4, D-
80337 Muenchen, FRG
REFERENCE 3 (bases 1 to 11069)
AUTHORS Kammerer S., Arnold N., Gutensohn W., Mewes H.W., Kunau W.H.,
Hofler G., Roscher A.A., Braun A.
TITLE Genomic organization and molecular characterization of a gene
encoding HsPXF, a human peroxisomal farnesylated protein
JOURNAL Genomics 45(1), 200-210(1997).
PUBMED 9339377
FEATURES Location/Qualifiers
source 1..11069
/organism="Homo sapiens"
/chromosome="1"
/map="q22"
/mol_type="genomic DNA"
/clone_lib="EMBL3"
/clone="lambdaL15"
/cell_type="leucocyte"
/db_xref="taxon:9606"
repeat_region 342..621
/rpt_family="Alu"
/note="Alu repetitive element"
repeat_region 1832..2118
/rpt_family="Alu"
/note="Alu repetitive element"
misc_binding 2477..2482
/bound_moiety="Sp1"
/note="putative Sp1 binding site"
misc_binding 2491..2496
/bound_moiety="Sp1"
/note="putative Sp1 binding site"
exon 2543..2622
/number=1
CDS join(2553..2622,4032..4141,4561..4726,5168..5253,
5470..5631,7421..7597,7822..7866,8033..8116)
/gene="PxF"
/product="PxF protein"
/db_xref="GOA:P40855"
/db_xref="HGNC:HGNC:9713"
/db_xref="InterPro:IPR006708"
/db_xref="InterPro:IPR038322"
/db_xref="PDB:2W85"
/db_xref="PDB:2WL8"
/db_xref="PDB:3AJB"
/db_xref="PDB:3MK4"
/db_xref="PDB:5LNF"
/db_xref="UniProtKB/Swiss-Prot:P40855"
/protein_id="CAA70257.1"
/translation="MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTA
PDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLV
EQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGL
GMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKY
QEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGL
NFDLDALNLSGPPGASGEQCLIM"
exon 4032..4141
/number=2
exon 4561..4726
/number=3
exon 5168..5253
/number=4
exon 5470..5631
/number=5
repeat_region 5965..6245
/rpt_family="Alu"
/note="Alu repetitive element"
repeat_region 6370..6646
/rpt_family="Alu"
/note="Alu repetitive element"
repeat_region 6849..7133
/rpt_family="Alu"
/note="Alu repetitive element"
exon 7421..7597
/number=6
exon 7822..7866
/number=7
exon 8033..>11069
/number=8
misc_feature 8084
/note="cryptic 3' splice site (exon 8)"
regulatory 9177..9182
/regulatory_class="polyA_signal_sequence"
regulatory 9438..9443
/regulatory_class="polyA_signal_sequence"
regulatory 10774..10779
/regulatory_class="polyA_signal_sequence"
regulatory 10820..10825
/regulatory_class="polyA_signal_sequence"
regulatory 10832..10837
/regulatory_class="polyA_signal_sequence"
BASE COUNT 2987 a 2377 c 2656 g 3049 t
ORIGIN
1 tacaagatgt gaaataattg tgactcccag gcaagaatta gaatttgttc gataaactgt
61 ggagaaccat taaatcctta aggaacagag tgatatgaaa gcgttataaa atactgttat
121 tcaacagtat tcgctataca ttagaagggc agaaggagca gtcagtaggt cagtaaatac
181 tgagatgaga tgttaggaat attaggagta aaaatagaaa agcagaaaga agtttaagaa
241 ataatgcaaa gaaagaatca tgcttgtttt tgactccatt ttaattatca tctattatct
301 tttaattaac atgcttatat tacattagtt taaagccaat tgaccaagtg tagtggctca
361 catctataat cccagtactt tgggaggcca aggtgggcat atcacttgag gtcaggagtt
421 aaagaccagc ctggccaata tggtgaaaca ctgtctctac taaaaataca aaaattagtt
481 gggcatggtg gcgcgagcct gcagacccag ctactcaggt ggctgagaca ggagaatcac
541 ttgaacccgg gaggtggagg ctgcagtgag ccaaaattgc accactgcac tccagcctgg
601 gcaacagtga aactctgtct caaaaaataa aaccaataga gatgcctgtt gatagacaag
661 ttttcttttt ttgacgtgct tgttacaact atagccatat tggagataca cgtgtaagca
721 gtttgaatga gaaagtctgg aataaattat gttgcaggtg ttggaaaaca ggtttatcag
781 gaaaggattt gattacagaa gtttagaatt gtaaaggact tcaaaagtga ttagtggcag
841 aattggggct ggaatttagg ctttctaact cacagttcat aatattttga tccaaaacac
901 actacttgtg gttggaagaa aacaggtttt gcagatatga ttttacagtc tgtgccctat
961 ctgtgaagga catagtaagt gcttgatctg gtgcttgatg cagtactcaa atgtgtgttt
1021 aggaagctaa gaatgaaagt gatgaggtga cttaacacag gacttttttt catttaaaat
1081 tcttaccttg tatcatactg tgtgtatatc tcatcatacc tccggctcac ccccacttag
1141 ctaccttaca gcagggggtg gtcctgattt atctctctgt cctcactgtg cccagaacaa
1201 gaccttaata ataggtgctc tctaagtgcg aaaacagatt tgtatgtgaa acagttgcta
1261 cattctacat ctgaatagaa caattccaaa ggaggaaagg gacgtctaga gttacctcta
1321 tctgagcatt ccccgtgttc actcagttgg aggttgggtt ctgtgtggag aaaaggagat
1381 tgttcaggga aagtaagtct attactactg cattcgaatt gccctgctca gtccaaggta
1441 ccagaggctc tcttaataac attgagttct aagttcctgg ccggccctgt gtcctttaat
1501 caaacagttc taatagataa taggaaatga gagatgccac tagattgggc agacagatgt
1561 gcctgattag ggactgcgag agcaaagagt ggccaatgaa tgcctactaa gttttaaacc
1621 ctagcctggg agttgggctt tacagcagtg aagacaacag acgaaaatct ttgcgttcat
1681 ggtgtttaaa ttctgcaggg tggggagcgg agaataaaaa agtacggtag atagtatgtc
1741 agatactgtt cagtgttagg aagaaaagga acgggaatgg ccaaggaaag cgtttcagaa
1801 aagataatat ttgagggaaa caatgaagtg aagccgggcg cagtggctca cgcctgtaat
1861 cccagcactt cgggaggccg aggtgggcgg atcagctgag gtccggagtt cgagaccagc
1921 ctggccaacc agcctggcca acatgttaaa accccgtctc tacaaaaatt agtcggacgt
1981 ggtgtcgcgc gcctgtcatc ccagctacac gggaggctga ggcaggaaga atcgcttgaa
2041 cccgggaggc caaggctgca gtgagccgag atggcgccac tgcattccag cgtaggcgac
2101 agagcaagat tccttctcaa aaaaaaataa aaaaaaaaaa atgaagtgag agaaagtagt
2161 atgttatgtg ccataattgt catatcaatt atatatgttt agattctggt tatttgtagg
2221 cagtttgtct caatctggcc tactcacagc tcaggaaaaa ataatgaaag agcttcgcca
2281 ggtaatttgg gaagttgaaa gaaaggagtc cgggcctcta aaaccagaca gaaaataacc
2341 ctatcttatc cctaattctg tttcacagga gaaaagggaa aaatacccaa aacacaaaca
2401 ctcaaagctt cctggccctt taaaaatggc ggttccgcac tggtcaacaa taccattggt
2461 tacccgaggc agaagagggc gggagcgaag gggtggaggg cgtgtcggca ccgaggaggt
2521 cccgcctcct acggcaagtc ggaggtagca agatggccgc cgctgaggaa ggctgtagtg
2581 tcggggccga agcggacagg gaattggagg agcttctgga aagtaagagc ccatagtggg
2641 aaaggcccga agaggcacgt gtgaggaccc attctggggg ttaagtgaac ctgagatatt
2701 agggacgggc aggagaggct ctccaaaggt taaatggggg cggagagtct gacccccgag
2761 ccccccaaaa atctctgggt catcctgccc caccccggcg actggagctg gggagctcac
2821 ctggggtccc tcagtggtcc ggatggtgga tgtttccgca gacggcgttt catgatacct
2881 cttcaaactc ctctttaggt tactgagttc ttaaagttcg actccagcag cagtagcagc
2941 agcagcagca tttggttctt gctgggtagc gaactacgca ctcactgatg cttacattaa
3001 ctcctagcaa gctcgtggcc ggtccttgtg tgcctcgtcc tgtcttcctt aacacgaaga
3061 cacttttctc ctcctagtcc ttttctcttt ctctcgttag gcccctcaac agttctttca
3121 tcttgtcagt agctcaagcg gactcctttc ccttattttg agaaactgag gatgtggcga
3181 tttcagggga aagcagttca ccctcctgaa agacggggga tgttttctag cattactctc
3241 cactcccctg ttgacttcct gcccagagta gggccagtgc tctctcccta ggcctggcga
3301 acagaatggt ggtgaggaca caggcttttc agggcagagg tgaatttgta atcgcttgct
3361 caatcacgga gatgcgggca ggcagaaaaa tgaacagaaa ccctgaggag tgccaagtga
3421 ctgtgtaaat tagtgtacgg ttatctgcag agatcaggcc aagggagctc tagaaggttg
3481 ttggggagca ctaaactgga gaataagaga agatagttta atgccgtacc atggagtctg
3541 gtatgtagtc cctcagtctg tgctggtacc agtaccaaca ggaagctggg tgggatgtcc
3601 tgtgctttct caccaagtta ttccttttag agctccagag tgagttcaga gggatgagga
3661 catctgtgtt ctctactact gttgggtatt tgtatgggat ttctagggaa tcgttagggt
3721 gtggcaaggg agacactata gatggagatg tctctgcaga actttttaat cctctcctcc
3781 cagctctgag atggacattt gttccacctt aagggatttc tttgcctttg ctcacaataa
3841 attaggtaat ccagaaggaa gtaggaggct cattgagggt ggtctgggga ggtgggggac
3901 tcaaggagga aaattgagga aagttggcaa tttgaaaaat catattccta atgctttgcc
3961 cagaaaccac ccagccttgc ttgcattctc atctgtcgcc aacacacaca ccatgtctct
4021 tgtctctgaa ggtgctcttg atgatttcga taaagccaaa ccctccccag cacccccttc
4081 taccaccacg gcccctgatg cttcggggcc ccagaagaga tcgccaggag acactgccaa
4141 agtataaatt ccaccccctt aagggatggg gaggggatgg gcatgcagcc ctgagcagag
4201 gttgggcagg cccctatggg cagaggggaa tgtgggaggg taccttggcc tcacattggt
4261 gagtgctctt gccagcctca gtccttgtga aataaggact tgaggttgag tgggggaatc
4321 tcagagttcc ttgaaaaaat agtaggttta aatggttgga ttggtatgcc atcccatacc
4381 ctccttcaat gactagatac cttttttgct atcctcatta ggagcagtag ttagaatgtc
4441 cagtggaatt gggtaggagg gaggtgcatt tcccatagcc actgcctgtg gcttctatca
4501 gaggccaggt gcagtgtagt cctaagtaag agacgcattt cagccatcct tcccccgcag
4561 gatgccctct tcgcttccca agagaagttt ttccaggaac tattcgacag tgaactggct
4621 tcccaagcca ctgcggagtt cgagaaggca atgaaggagt tggctgagga agaaccccac
4681 ctggtggagc agttccaaaa gctctcagag gctgcaggga gagtgggtga ggagacccca
4741 gatacatgga aatatctgaa cagactctta agtctttgtt gcctgaaaac accagaattc
4801 ttagtgaagt tgatagcaat catgatgtca cagccaagga acgggtaaag gcaatgagag
4861 aaaggatggg aatccctgtt aatgaaaagg ggtgagatag gttggaaagt aatagaaaac
4921 attattcaaa actgaccatt tgaaaggtca cagtgttatt gtgggtatca tcatggagaa
4981 taaactgatg cagggtccgt gtactaaatt agatttatga aaagactatg aagataacca
5041 tagggttttc caagattggg agtgataatg attcactagt aaatgcttat atccaagctg
5101 ttaaccagtt cagtctaggc aaggaaacaa actcctaaat gacgctggct tttttaatct
5161 ctcctaggca gtgatatgac ctcccaacaa gaattcactt cttgcctaaa ggaaacacta
5221 agtggattag ccaaaaatgc cactgacctt caggtgagga gaaagtagta ggggcccaca
5281 aggggtccac tcccagacat ttctccagca gagtctcaaa agacagatgc tttgagtatc
5341 atcccaagtc tgttgctgtc ttattgtttg ttacaggcaa gtttagatag tttatctttg
5401 tcacctgaga gagtggtgag catcccaaga aggtagtata cctgctcacc tcttacttgt
5461 cctatctaga actccagcat gtcggaagaa gagctgacca aggccatgga ggggctaggc
5521 atggacgaag gggatgggga agggaacatc ctccccatca tgcagagtat tatgcagaac
5581 ctactctcca aggatgtgct gtacccatca ctgaaggaga tcacagaaaa ggtttgtgaa
5641 cttccatttc tgctttttct cttcattctc catcacatca actgatgtgg gctattttgt
5701 ctactcagag cctgcagaaa gagtaactcg agtgtgcttt ttttccttct ttatttattt
5761 gaggcaggga gagttggggg ttggggagag ttgtgtctct gagagaataa agctgtcaca
5821 cggtatgttg gggtataaga ggtataacgt ttggggtcta aggggaaatc cttcagttct
5881 agttttctat aaactggttc aagactctgg gattgttgtc tgatcaatct tgcatttctg
5941 acttcatttc tccagcaaga atttggctgg gcatggtggc tcatgctgta atccagcacc
6001 ttgggaggcc gaggcgggtg gatcacctga cctgaggtca ggagtccgag accagcctgg
6061 ccaacatgtg aaaccccgtc tgtagtaaaa atacaaaaat tatcctggcg tagtggctca
6121 cgcctgtgat cgcaactact caggaggcag caggagaatc acttgaacct gggaggcaga
6181 ggttgcagcg agctgagatt gtgccactgt actccggcct gggtgacaga gcaagactcc
6241 atctgaaaaa gaaaaagaat taactgagga tttacttact ggctttgtga tgtgaacagt
6301 gtaagcgtag tttaaatgat ggtccctgcc ataaaagagc ttatatgtgt ggttgtatca
6361 ttttgttttg agacagggtc tagctccagt tggagcacag tggcacgatc ttggctcacc
6421 acagcctccc catcccaggc tcaagtgttt ctcccatctc agcctcctga gtggctggga
6481 ctacaggtgt gtgccaccat gcttggccaa tgttttcaaa attttttgta gagttgagct
6541 ctcactatat tgctcaggct ggtctcaaac tcctgagctc aagtgatcct cccacctcag
6601 cctcccaaaa tgctgggatt acaagtgtga gccaccacac ctggctaaag agtgtagttt
6661 tactggagag ataaaataca ggaatagaag ctttcagtga catgggaaat gtgggtaagt
6721 gtgtaatgaa tagtacagac cacgagtcag caggccaaga cctgggtgga caaatccaac
6781 tctctagcaa ataatggttt ttacattttt aaggtcattt gaaaaaaact gcaaagaaaa
6841 tgtgcaatag ccgagcgtag tggctcactc ctatagtccc agcgctttgg gaggccacgg
6901 tggacagatt gcttgagccc aggagtttaa gaccagcttg agcaacatga tgaaaccctg
6961 tctctacaaa atacaaaaaa ttagccagtc acagtggtgc acacttgtag acccagctac
7021 ttggggaggc tcaggtggga ggattggctt gagcctgggg agatcgaggc tgcagtgagt
7081 ggtgatcaca ccatcacacg tccagcctgg gtgacagagt aaaactctgt ctcgaaaaaa
7141 agaaaaaaaa aacacaatag agaccatatg tggcccttga agcctaaaat attcactgtc
7201 tggcccttta cagaagctta ccaatctctg gtgaccataa atgctaacat ggccaggtga
7261 tctggttgga gtcagtgccg cttttcatga tgaacttact tatttagctt ttcgtttttc
7321 tacgtccctt tccctttcac attttaatca cattgttctg tttacccatc catatccatt
7381 gttcacttaa ttcttttcca cccattctct cttttcttag tatccagaat ggttgcagag
7441 tcatcgggaa tctctacctc cagagcagtt tgaaaaatat caggagcagc acagcgtcat
7501 gtgcaaaata tgtgagcagt ttgaggcaga gacccccaca gacagtgaaa ccactcaaaa
7561 ggctcgtttt gagatggtgc tggatcttat gcagcaggta aggcctcttg ccttctgccc
7621 actggtgctg tccacttagg tgttcagtga aggaagtatc tgggaaggat gcaatactgc
7681 tagacctagg tggaggaggg atcctctctt gtgatctctc tcagaagaaa tagagagatc
7741 attcattaga ttcctcttct ggatcctctg ttgttttctg ggcttttctc tatttcatgt
7801 tccattttcc ttattttcta gctacaagat ttaggccatc ctccaaaaga gctggctgga
7861 gagatggtga gtatgtctta tttttccaga ttttaatttg agtccccaat ttccagaatt
7921 ctttaacctc tcaggattcc acctaaggtg aaaattgtgg ctactgggga tggatcttca
7981 cgtctgtcct aaaaaatgag caactatctg agtcccttca tctcttcccc agcctcctgg
8041 cctcaacttt gacctggatg ccctcaatct ttcgggccca ccaggtgcca gtggtgaaca
8101 gtgtctgatc atgtgaaaca caacacgttt tcctctctga gtcccagcta tggggaacat
8161 ctggagtcag cagaaccatt gggacctgag gcaggagtgt cacctgcggg agaagtctgc
8221 ccgctgccct ctgtcatccc attcaagatt gtgccatacc agctgaggtt tttcctctgt
8281 ctctctagga atagggtctg tttcacaggc catttctgtg aaccctactc cattgtggtt
8341 tctgccacta tcaaagttcc agctacctgc aaggtgaagg aaggcatccc ttttggggca
8401 tgcactttct ttcctttctc aaaataatgt tatatgtggc cacactgatg ttcaccttta
8461 cgtccagggt ctttgtgcct tgtctctact ccctctcttg gatctgggga ggaggggcag
8521 agacctggga ctctgtattt ctatagttct cctggcagag cctttgagaa tggggagaaa
8581 cagcctgggc tggggctaca ggtctgtcac tatgctctct tgccttcaga cagaccattc
8641 tgaattctct aaagggaaag ggcttttgca tctaatcaca atagagttga aagagaggcc
8701 ttaggattct cctctctcta ggtgctgagc cctcacctcc ctgttccagg ctgagaactc
8761 aaatggttac cctgcttctt cctacaatgc tgtgtgatat gggtgaaccc agcccctgac
8821 cttcctctat cccctgccca tcctcccttt tacctcctct cttttttaaa cacctgttta
8881 tcccaacctt tttgagctca agctgtgata aagaagggcc catcctattt cccctcatct
8941 agtccattta cgattctcac tgactccccg tcttcctggc agacacaaat aaacccagtg
9001 tcaggtctag gaaattaatg gctattcttc cccagataca ttctggctta tttgagatac
9061 atgattctct tagaatcctg tcccttggtt caggaaagta gcttggaaaa ggagtagggg
9121 tatagcttgg gtcccttttc ctgcaaggcc ccatggggca gaatataata aatattctga
9181 gtgaggagtg tggtcttttt ctgatcttcc tcagcttccg taagttgcag agtgaggtat
9241 attaggagac tagttctaca caatattgta atgctgggtt ccatcaacac ccaccttcca
9301 caactcagtc tgcacctcag ttggcaaagg agactggatg gccatctttc ctcatgttcc
9361 cttgagtatt tcaatgtaga aagcccttca agtggtatta tattttaacc ttttacatta
9421 ttgttattaa tgttagtaat atattgttat gttttctaaa ttatttttct ttaagctgac
9481 gtggcttttt ttctgtggct cccagtgggt ctacggacct tggctgacat atgttggtag
9541 gtactctggt cagctcagct ggctgtcctg gttcactcag aagataagtc tctccaaagc
9601 aaattcacat gcattatgag tcgctttgag cttctgacat gtcacttgcc ccgaggttaa
9661 aacttttcac cccttgaaga ccttacatgt tttatggtat tggtgaggaa ggaaatgttc
9721 tcaaggtctc aggctatttg ggaaattcca actcctatac cttaccagag catggaagag
9781 cccagatctg aatgtaaaac gtctctgttc tgccagagat ggaaaaaata caggtatact
9841 tgtgatatag tcatggggct tcagtgtcac tattttctcc ttaaagctcc agccaaaaac
9901 tggacaagga tagagaggag gagggaagaa caaaagagcc cttctctatg aaccttgtgc
9961 cttctgtcct accagttttc ttttacagat tctcacttct gctagcctag ccagggctta
10021 ctccaggaat ctaaatagat gccctagtcc actttatctt tgttcccaag gcactcattt
10081 ttattttgat tttgattgaa tgtgagcagg ttgacctcag gtcacacttt gttccaaaaa
10141 cttttggaat tattccagga cttgtggtgg agttatggta ctctagggca gtctttctca
10201 aactatgtat ggtaaaggac caggtttttt gttttccagt ccttcactta tcaatatgca
10261 ttcctattgc cgatgacagg tatggagttc acactgtgtg ctgccgaccc ggcaagtttg
10321 acagcaccca aactggccag actgttctgt aggttaagtc cattgatcat gtacttggat
10381 atcacagcaa cattgaaatg ctaaaaagtt tttaaacact ctcaatttct aattcaccat
10441 gtcacagact ggtgaaaaaa aaaaaaaggt gttcactgac cagcacaagt ctgcagatca
10501 tctttgagta gcactgtttt ggggccctcg gtctctctga agaccctagc agaactgata
10561 cctacctgta tctcttgttc tctcctattt gagtttcact tccagagaac ttgttcttca
10621 gcaagaatgt gtcactagta aggacatctc tagcatttct ctagccttcc ttttctgctg
10681 ctcaaaaata atcgttacaa agcttaggtt taagctgtat atgaaatatt tatgcgactc
10741 tcaaacttta aaggagttgc tcctttgttc caaaattaaa tgtgttagat aaatttgtga
10801 ttgtatgggt ggcttcatga attaagaatt gaattaatac agactttttg ataattggga
10861 cattttcctg tgactctgga aggtcttgtc aaagccccat gaggcagtta taatatgatg
10921 ttaagatggc tttggggagc taggagaaaa cattggccca tattgaatga catggagacg
10981 gcagaccata caaaaaagga ccaaaagact tagaggaaat gggtatgcaa gaatgaatgt
11041 tatataacac tggtaaaccc accagctga
//