LOCUS Y08419 1407 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens mRNA for nicotinic acetylcholine receptor alpha5 subunit
precursor.
ACCESSION Y08419
VERSION Y08419.1
KEYWORDS nAChR gene; nicotinic acetylcholine receptor alpha 5 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Groot Kormelink P.J., Luyten W.H.M.L.
TITLE Cloning and sequence of full-length cDNAs encoding the human
neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3
and beta4 and expression of seven nAChR subunits in the human
neuroblastoma cell line SH-SY5Y and/or IMR-32
JOURNAL FEBS Lett. 400(3), 309-314(1997).
PUBMED 9009220
REFERENCE 2 (bases 1 to 1407)
AUTHORS Groot Kormelink P.J.
JOURNAL Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen
Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30,
B-2340 Beerse, BELGIUM
REFERENCE 3
AUTHORS Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G.
TITLE Formation of functional alpha3beta4alpha5 human neuronal nicotinic
receptors in Xenopus oocytes: a reporter mutation approach
JOURNAL Br. J. Pharmacol. 134(4), 789-796(2001).
PUBMED 11606319
FEATURES Location/Qualifiers
source 1..1407
/db_xref="H-InvDB:HIT000325450"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="IMR-32"
/cell_line="SH-SY5Y"
/cell_type="neuroblastoma"
/db_xref="taxon:9606"
sig_peptide 1..129
CDS 1..1407
/gene="nAChRA5"
/product="nicotinic acetylcholine receptor alpha5 subunit
precursor"
/db_xref="GOA:P30532"
/db_xref="H-InvDB:HIT000325450.12"
/db_xref="HGNC:HGNC:1959"
/db_xref="InterPro:IPR002394"
/db_xref="InterPro:IPR006029"
/db_xref="InterPro:IPR006201"
/db_xref="InterPro:IPR006202"
/db_xref="InterPro:IPR018000"
/db_xref="InterPro:IPR036719"
/db_xref="InterPro:IPR036734"
/db_xref="UniProtKB/Swiss-Prot:P30532"
/protein_id="CAA69696.1"
/translation="MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIA
KHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQE
WIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTW
TPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEW
EIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPS
NEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFA
INIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNT
LEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPV
IYKWANILIPVHIGNANK"
mat_peptide 130..1404
BASE COUNT 386 a 276 c 316 g 429 t
ORIGIN
1 atggcggcgc gggggtcagg gccccgcgcg ctccgcctgc tgctcttggt ccagctggtc
61 gcggggcgct gcggtctagc gggcgcggcg ggcggcgcgc agagaggatt atctgaacct
121 tcttctattg caaaacatga agatagtttg cttaaggatt tatttcaaga ctacgaaaga
181 tgggttcgtc ctgtggaaca cctgaatgac aaaataaaaa taaaatttgg acttgcaata
241 tctcaattgg tggatgtgga tgagaaaaat cagttaatga caacaaacgt ctggttgaaa
301 caggaatgga tagatgtaaa attaagatgg aaccctgatg actatggtgg aataaaagtt
361 atacgtgttc cttcagactc tgtctggaca ccagacatcg ttttgtttga taatgcagat
421 ggacgttttg aagggaccag tacgaaaaca gtcatcaggt acaatggcac tgtcacctgg
481 actccaccgg caaactacaa aagttcctgt accatagatg tcacgttttt cccatttgac
541 cttcagaact gttccatgaa atttggttct tggacttatg atggatcaca ggttgatata
601 attctagagg accaagatgt agacaagaga gatttttttg ataatggaga atgggagatt
661 gtgagtgcaa cagggagcaa aggaaacaga accgacagct gttgctggta tccgtatgtc
721 acttactcat ttgtaatcaa gcgcctgcct ctcttttata ccttgttcct tataataccc
781 tgtattgggc tctcattttt aactgtactt gtcttctatc ttccttcaaa tgaaggtgaa
841 aagatttgtc tctgcacttc agtacttgtg tctttgactg tcttccttct ggttattgaa
901 gagatcatac catcatcttc aaaagtcata cctctaattg gagagtatct ggtatttacc
961 atgatttttg tgacactgtc aattatggta accgtcttcg ctatcaacat tcatcatcgt
1021 tcttcctcaa cacataatgc catggcgcct ttggtccgca agatatttct tcacacgctt
1081 cccaaactgc tttgcatgag aagtcatgta gacaggtact tcactcagaa agaggaaact
1141 gagagtggta gtggaccaaa atcttctaga aacacattgg aagctgcgct cgattctatt
1201 cgctacatta caagacacat catgaaggaa aatgatgtcc gtgaggttgt tgaagattgg
1261 aaattcatag cccaggttct tgatcggatg tttctgtgga cttttctttt cgtttcaatt
1321 gttggatctc ttgggctttt tgttcctgtt atttataaat gggcaaatat attaatacca
1381 gttcatattg gaaatgcaaa taagtga
//