LOCUS Y08416 1588 bp mRNA linear HUM 21-OCT-2008 DEFINITION H.sapiens mRNA for nicotinic acetylcholine receptor beta4 subunit precursor. ACCESSION Y08416 VERSION Y08416.1 KEYWORDS nAChR gene; nicotinic acetylcholine receptor beta-4 subunit. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Groot Kormelink P.J., Luyten W.H.M.L. TITLE Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 JOURNAL FEBS Lett. 400(3), 309-314(1997). PUBMED 9009220 REFERENCE 2 (bases 1 to 1588) AUTHORS Groot Kormelink P.J. JOURNAL Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30, B-2340 Beerse, BELGIUM REFERENCE 3 AUTHORS Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G. TITLE Stoichiometry of human recombinant neuronal nicotinic receptors containing the beta3 subunit expressed in Xenopus oocytes JOURNAL J. Physiol. (Lond.) 529, 565-577(2000). REFERENCE 4 AUTHORS Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G. TITLE Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach JOURNAL Br. J. Pharmacol. 134(4), 789-796(2001). PUBMED 11606319 REFERENCE 5 AUTHORS Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D., Sivilotti L.G. TITLE The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors JOURNAL J Biol Chem 278(45), 44033-44040(2003). PUBMED 12912995 FEATURES Location/Qualifiers source 1..1588 /db_xref="H-InvDB:HIT000325447" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="SH-SY5Y" /cell_line="IMR-32" /cell_type="neuroblastoma" /db_xref="taxon:9606" 5'UTR 1..91 sig_peptide 92..160 CDS 92..1588 /gene="nAChRB4" /product="nicotinic acetylcholine receptor beta4 subunit precursor" /db_xref="GOA:P30926" /db_xref="H-InvDB:HIT000325447.12" /db_xref="HGNC:HGNC:1964" /db_xref="InterPro:IPR002394" /db_xref="InterPro:IPR006029" /db_xref="InterPro:IPR006201" /db_xref="InterPro:IPR006202" /db_xref="InterPro:IPR018000" /db_xref="InterPro:IPR036719" /db_xref="InterPro:IPR036734" /db_xref="PDB:2ASG" /db_xref="UniProtKB/Swiss-Prot:P30926" /protein_id="CAA69693.1" /translation="MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLI RPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNI LRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYF PFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPS YVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTF FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVK RCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNP ASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVED WKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD" mat_peptide 161..1585 BASE COUNT 312 a 544 c 401 g 331 t ORIGIN 1 ctggaccggc gctcactcga ccgcgcggct cacgggtgcc ctgtgacccc acagcggagc 61 tcgcggcggc tgccacccgg ccccgccggc catgaggcgc gcgccttccc tggtcctttt 121 cttcctggtc gccctttgcg ggcgcgggaa ctgccgcgtg gccaatgcgg aggaaaagct 181 gatggacgac cttctgaaca aaacccgtta caataacctg atccgcccag ccaccagctc 241 ctcacagctc atctccatca agctgcagct ctccctggcc cagcttatca gcgtgaatga 301 gcgagagcag atcatgacca ccaatgtctg gctgaaacag gaatggactg attaccgcct 361 gacctggaac agctcccgct acgagggtgt gaacatcctg aggatccctg caaagcgcat 421 ctggttgcct gacatcgtgc tttacaacaa cgccgacggg acctatgagg tgtctgtcta 481 caccaacttg atagtccggt ccaacggcag cgtcctgtgg ctgccccctg ccatctacaa 541 gagcgcctgc aagattgagg tgaagtactt tcccttcgac cagcagaact gcaccctcaa 601 gttccgctcc tggacctatg accacacgga gatagacatg gtcctcatga cgcccacagc 661 cagcatggat gactttactc ccagtggtga gtgggacata gtggccctcc cagggagaag 721 gacagtgaac ccacaagacc ccagctacgt ggacgtgact tacgacttca tcatcaagcg 781 caagcctctg ttctacacca tcaacctcat catcccctgc gtgctcacca ccttgctggc 841 catcctcgtc ttctacctgc catccgactg cggcgagaag atgacactgt gcatctcagt 901 gctgctggca ctgacattct tcctgctgct catctccaag atcgtgccac ccacctccct 961 cgatgtgcct ctcatcggca agtacctcat gttcaccatg gtgctggtca ccttctccat 1021 cgtcaccagc gtctgtgtgc tcaatgtgca ccaccgctcg cccagcaccc acaccatggc 1081 accctgggtc aagcgctgct tcctgcacaa gctgcctacc ttcctcttca tgaagcgccc 1141 tggccccgac agcagcccgg ccagagcctt cccgcccagc aagtcatgcg tgaccaagcc 1201 cgaggccacc gccacctcca ccagcccctc caacttctat gggaactcca tgtactttgt 1261 gaaccccgcc tctgcagctt ccaagtctcc agccggctct accccggtgg ctatccccag 1321 ggatttctgg ctgcggtcct ctgggaggtt ccgacaggat gtgcaggagg cattagaagg 1381 tgtcagcttc atcgcccagc acatgaagaa tgacgatgaa gaccagagtg tcgttgagga 1441 ctggaagtac gtggctatgg tggtggaccg gctgttcctg tgggtgttca tgtttgtgtg 1501 cgtcctgggc actgtggggc tcttcctacc gcccctcttc cagacccatg cagcttctga 1561 ggggccctac gctgcccagc gtgactga //