LOCUS       Y08416                  1588 bp    mRNA    linear   HUM 21-OCT-2008
DEFINITION  H.sapiens mRNA for nicotinic acetylcholine receptor beta4 subunit
            precursor.
ACCESSION   Y08416
VERSION     Y08416.1
KEYWORDS    nAChR gene; nicotinic acetylcholine receptor beta-4 subunit.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Groot Kormelink P.J., Luyten W.H.M.L.
  TITLE     Cloning and sequence of full-length cDNAs encoding the human
            neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3
            and beta4 and expression of seven nAChR subunits in the human
            neuroblastoma cell line SH-SY5Y and/or IMR-32
  JOURNAL   FEBS Lett. 400(3), 309-314(1997).
   PUBMED   9009220
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Groot Kormelink P.J.
  JOURNAL   Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen
            Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30,
            B-2340 Beerse, BELGIUM
REFERENCE   3
  AUTHORS   Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G.
  TITLE     Stoichiometry of human recombinant neuronal nicotinic receptors
            containing the beta3 subunit expressed in Xenopus oocytes
  JOURNAL   J. Physiol. (Lond.) 529, 565-577(2000).
REFERENCE   4
  AUTHORS   Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G.
  TITLE     Formation of functional alpha3beta4alpha5 human neuronal nicotinic
            receptors in Xenopus oocytes: a reporter mutation approach
  JOURNAL   Br. J. Pharmacol. 134(4), 789-796(2001).
   PUBMED   11606319
REFERENCE   5
  AUTHORS   Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D.,
            Sivilotti L.G.
  TITLE     The effects of beta3 subunit incorporation on the pharmacology and
            single channel properties of oocyte-expressed human alpha3beta4
            neuronal nicotinic receptors
  JOURNAL   J Biol Chem 278(45), 44033-44040(2003).
   PUBMED   12912995
FEATURES             Location/Qualifiers
     source          1..1588
                     /db_xref="H-InvDB:HIT000325447"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="SH-SY5Y"
                     /cell_line="IMR-32"
                     /cell_type="neuroblastoma"
                     /db_xref="taxon:9606"
     5'UTR           1..91
     sig_peptide     92..160
     CDS             92..1588
                     /gene="nAChRB4"
                     /product="nicotinic acetylcholine receptor beta4 subunit
                     precursor"
                     /db_xref="GOA:P30926"
                     /db_xref="H-InvDB:HIT000325447.12"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="InterPro:IPR002394"
                     /db_xref="InterPro:IPR006029"
                     /db_xref="InterPro:IPR006201"
                     /db_xref="InterPro:IPR006202"
                     /db_xref="InterPro:IPR018000"
                     /db_xref="InterPro:IPR036719"
                     /db_xref="InterPro:IPR036734"
                     /db_xref="PDB:2ASG"
                     /db_xref="UniProtKB/Swiss-Prot:P30926"
                     /protein_id="CAA69693.1"
                     /translation="MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLI
                     RPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNI
                     LRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYF
                     PFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPS
                     YVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTF
                     FLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVK
                     RCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNP
                     ASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVED
                     WKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD"
     mat_peptide     161..1585
BASE COUNT          312 a          544 c          401 g          331 t
ORIGIN      
        1 ctggaccggc gctcactcga ccgcgcggct cacgggtgcc ctgtgacccc acagcggagc
       61 tcgcggcggc tgccacccgg ccccgccggc catgaggcgc gcgccttccc tggtcctttt
      121 cttcctggtc gccctttgcg ggcgcgggaa ctgccgcgtg gccaatgcgg aggaaaagct
      181 gatggacgac cttctgaaca aaacccgtta caataacctg atccgcccag ccaccagctc
      241 ctcacagctc atctccatca agctgcagct ctccctggcc cagcttatca gcgtgaatga
      301 gcgagagcag atcatgacca ccaatgtctg gctgaaacag gaatggactg attaccgcct
      361 gacctggaac agctcccgct acgagggtgt gaacatcctg aggatccctg caaagcgcat
      421 ctggttgcct gacatcgtgc tttacaacaa cgccgacggg acctatgagg tgtctgtcta
      481 caccaacttg atagtccggt ccaacggcag cgtcctgtgg ctgccccctg ccatctacaa
      541 gagcgcctgc aagattgagg tgaagtactt tcccttcgac cagcagaact gcaccctcaa
      601 gttccgctcc tggacctatg accacacgga gatagacatg gtcctcatga cgcccacagc
      661 cagcatggat gactttactc ccagtggtga gtgggacata gtggccctcc cagggagaag
      721 gacagtgaac ccacaagacc ccagctacgt ggacgtgact tacgacttca tcatcaagcg
      781 caagcctctg ttctacacca tcaacctcat catcccctgc gtgctcacca ccttgctggc
      841 catcctcgtc ttctacctgc catccgactg cggcgagaag atgacactgt gcatctcagt
      901 gctgctggca ctgacattct tcctgctgct catctccaag atcgtgccac ccacctccct
      961 cgatgtgcct ctcatcggca agtacctcat gttcaccatg gtgctggtca ccttctccat
     1021 cgtcaccagc gtctgtgtgc tcaatgtgca ccaccgctcg cccagcaccc acaccatggc
     1081 accctgggtc aagcgctgct tcctgcacaa gctgcctacc ttcctcttca tgaagcgccc
     1141 tggccccgac agcagcccgg ccagagcctt cccgcccagc aagtcatgcg tgaccaagcc
     1201 cgaggccacc gccacctcca ccagcccctc caacttctat gggaactcca tgtactttgt
     1261 gaaccccgcc tctgcagctt ccaagtctcc agccggctct accccggtgg ctatccccag
     1321 ggatttctgg ctgcggtcct ctgggaggtt ccgacaggat gtgcaggagg cattagaagg
     1381 tgtcagcttc atcgcccagc acatgaagaa tgacgatgaa gaccagagtg tcgttgagga
     1441 ctggaagtac gtggctatgg tggtggaccg gctgttcctg tgggtgttca tgtttgtgtg
     1501 cgtcctgggc actgtggggc tcttcctacc gcccctcttc cagacccatg cagcttctga
     1561 ggggccctac gctgcccagc gtgactga
//