LOCUS Y08302 2303 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for MAP kinase phosphatase 4.
ACCESSION Y08302
VERSION Y08302.1
KEYWORDS dual specificity phosphatase; MAP kinase phosphatase;
mitogen-activated protein kinase phosphatase; MPK4 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Muda M., Boschert U., Smith A., Antonsonn B., Gillieron C.,
Chabert C., Camps M., Martinou I., Ashworth A., Arkinstall S.
TITLE Molecular cloning and functional characterization of a novel
mitogen-activated protein kinase phosphatase, MKP-4
JOURNAL J Biol Chem 272(8), 5141-5151(1997).
PUBMED 9030581
REFERENCE 2 (bases 1 to 2303)
AUTHORS Muda M.
JOURNAL Submitted (23-SEP-1996) to the INSDC. M. Muda, Geneva Biomedical
Research Institute, 14 chemin des Aulx, CH-1228 Plan-les-Ouates,
Geneva, SWITZERLAND
FEATURES Location/Qualifiers
source 1..2303
/db_xref="H-InvDB:HIT000325434"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="MKP-4"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS 114..1268
/gene="MKP4"
/product="mitogen-activated protein kinase phosphatase 4"
/note="MAP kinase phosphatase"
/note="dual specificity phosphatase"
/db_xref="GOA:Q99956"
/db_xref="H-InvDB:HIT000325434.15"
/db_xref="HGNC:HGNC:3076"
/db_xref="InterPro:IPR000340"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR008343"
/db_xref="InterPro:IPR020422"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036873"
/db_xref="PDB:2HXP"
/db_xref="PDB:3LJ8"
/db_xref="UniProtKB/Swiss-Prot:Q99956"
/protein_id="CAA69610.1"
/translation="MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSV
ALPALLLRRLRRGSLSVRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEA
ESVLGTLLQKLREEGYLAYYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVV
GLGSLCLGSDCSDAESEADRDSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARD
SANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFI
DEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFM
GQLLDFERSLRLEERHSQEQGSGGQASAASNPPSFFTTPTSDGAFELAPT"
regulatory 2264..2269
/regulatory_class="polyA_signal_sequence"
polyA_site 2284
BASE COUNT 360 a 733 c 748 g 462 t
ORIGIN
1 cgcttcccgc cgcccgagct tcggaaactt cccggccgcg acgcagggaa ccggcgcgga
61 gaaccgagca gagcggagcg cccgtggtcc agcgtgtagg gagccgatcg cccatggagg
121 gtctgggccg ctcgtgcctg tggctgcgtc gggagctgtc gcccccgcgg ccgcggctcc
181 tgctcctgga ctgccgcagc cgcgagctgt acgagtcggc gcgcatcggt ggggcgctga
241 gcgtggccct gccggcgctc ctgctgcgcc gcctgcggag gggcagcctg tcggtgcgcg
301 cgctcctgcc tgggccgccg ctgcagccgc ccccgcctgc ccccgtgctc ctgtacgacc
361 agggcggggg ccggcgccgg cgcggggagg ccgaggccga ggccgaggag tgggaggccg
421 agtcggtgct gggcaccctg ctgcagaagc tgcgagagga aggctacctg gcctactacc
481 tccagggagg cttcagcaga ttccaggccg agtgccctca cctgtgtgag accagccttg
541 ctggccgtgc cggctccagc atggcgccgg tgcccggtcc agtgcccgtg gtggggttgg
601 gcagcctgtg cctgggctcc gactgctctg atgcggaatc cgaggctgac cgcgactcca
661 tgagctgtgg cctggattcg gagggtgcca cacccccacc agtggggctg cgggcatcct
721 tccctgtcca gatcctgccc aacctctatc tgggcagtgc ccgggattcc gccaatttgg
781 agagcctggc caaactgggc atccgctaca tcctcaatgt cacccccaac ctcccaaact
841 tcttcgagaa gaatggtgac tttcactaca agcagatccc catctccgac cactggagcc
901 agaacctgtc gcggttcttt ccggaggcca ttgagttcat tgatgaggcc ttgtcccaga
961 actgcggggt gctcgtccac tgcttggcgg gggtcagccg ttctgtcacc gtcactgtgg
1021 cctacctcat gcagaagctc cacctctctc tcaacgatgc ctatgacctg gtcaagagga
1081 agaagtctaa catctccccc aacttcaact tcatggggca gttgctggac tttgagcgca
1141 gcttgcggct ggaggagcgc cactcgcagg agcagggcag tggggggcag gcatctgcgg
1201 cctccaaccc gccctccttc ttcaccaccc ccaccagtga tggcgccttc gagctggccc
1261 ccacctaggg ccccgtggcc ggcaggccgg cccctgcccc acccccaccc acgggtgtcc
1321 ctgcccactc gtgtggcaag ggaggggagg gcaggagggc tcggcctgag cagggtgctg
1381 gggggagagc gcaatacctc acgcgggctg ccgtcctaat caacgtgcct atggcgggac
1441 cacgctcgga gcctgcctct tctgcgactg ttactttttc tttgcgggat gggggtgggg
1501 gttccctctc caggtggttg tccaagccca ggtcccggcc ctgggtgctc agccagctcg
1561 gctaggccct gcgcctccct gcgcttcccc cttcaggaag ggtgtgtgcc acctcgttgc
1621 actggatccc agtggctgct tgggggagag gcgtttgcca tcactggtgt tgtcacctcc
1681 ctgtttctcc accaagggct tgggcctctc ggggctgggg cctcccaggg gatggggacc
1741 cagaggtgca gtggccgccc acatccatgg cctaggagct actgggcagg ttcccggcca
1801 cacatctggt gggctgtttt gttttttttt ttcctcttcc cccagatgtc ttgacgggat
1861 cactggggct ctttgtgagt gagggtggcc aaactaccgc cggaggagat ggggtctcag
1921 agcgagagct gcggaggggg aggggaagaa gaaggcctca cttttgctgc tgcggggccc
1981 acacagccgc tgctactttg gggggtgggg aaggggccaa gctgcagaca cacacagtca
2041 ttcatttctg tccacacccc tgtgggtggc gggtgtgcgt gtgtgtgctt gtgtgtgcgc
2101 acgtgtcggc gctcacacac acatgctagc ccactgatgc acccagccca gggctggcag
2161 tctttgcagc gtggggccgt ctcaccctgg agcctggaga ggatctatgc ttgtttgttt
2221 ttgtaatcca tatcatagtt gctttcttta attgttcctt ctgaataaac agtttattta
2281 agataaaaaa aaaaaaaaaa aaa
//