LOCUS Y00819 1888 bp mRNA linear HUM 14-NOV-2006
DEFINITION Human mRNA for tyrosinase (EC 1.14.18.1).
ACCESSION Y00819
VERSION Y00819.1
KEYWORDS monophenol monooxygenase; tyrosinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1888)
AUTHORS Bouchard B.
JOURNAL Submitted (12-APR-1989) to the INSDC. Bouchard B., Memorial Sloan
Kettering Cancer Center, 1250 First Avenue, New York, N.Y. 10028,
USA.
REFERENCE 2 (bases 1 to 1888)
AUTHORS Bouchard B., Fuller B.B., Vijayasaradhi S., Houghton A.N.
TITLE Induction of pigmentation in mouse fibroblasts by expression of
human tyrosinase cDNA
JOURNAL J. Exp. Med. 169(6), 2029-2042(1989).
PUBMED 2499655
COMMENT The sequence overlaps with that reported by Kwon et. al. in
Proc. Natl. Acad. Sci. USA 84:7473-7477(1987) <J03581>.
FEATURES Location/Qualifiers
source 1..1888
/db_xref="H-InvDB:HIT000325329"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10"
/clone="BBTY.1."
/tissue_type="human melanoma"
/db_xref="taxon:9606"
mRNA <1..1888
/note="tyrosinase mRNA"
CDS <1..1596
/codon_start=1
/product="put. tyrosinase preprotein"
/db_xref="GOA:P14679"
/db_xref="H-InvDB:HIT000325329.13"
/db_xref="HGNC:HGNC:12442"
/db_xref="InterPro:IPR002227"
/db_xref="InterPro:IPR008922"
/db_xref="UniProtKB/Swiss-Prot:P14679"
/protein_id="CAA68756.1"
/translation="GRMLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGD
RSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNC
GNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQ
MKNGSTPMFNDINIYDLFVWIHYYVSMDALLGGYEIWRDIDFAHEAPAFLPWHRLFLL
RWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQI
VCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSM
DKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHH
AFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYD
YSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQ
LPEEKQPLLMEKEDYHSLYQSHL"
sig_peptide <1..57
/codon_start=1
/note="put. signal peptide (AA -19 to -1)"
mat_peptide 58..1593
/product="tyrosinase (AA 1-512)"
BASE COUNT 498 a 447 c 425 g 518 t
ORIGIN
1 ggaagaatgc tcctggctgt tttgtactgc ctgctgtgga gtttccagac ctccgctggc
61 catttcccta gagcctgtgt ctcctctaag aacctgatgg agaaggaatg ctgtccaccg
121 tggagcgggg acaggagtcc ctgtggccag ctttcaggca gaggttcctg tcagaatatc
181 cttctgtcca atgcaccact tgggcctcaa tttcccttca caggggtgga tgaccgggag
241 tcgtggcctt ccgtctttta taataggacc tgccagtgct ctggcaactt catgggattc
301 aactgtggaa actgcaagtt tggcttttgg ggaccaaact gcacagagag acgactcttg
361 gtgagaagaa acatcttcga tttgagtgcc ccagagaagg acaaattttt tgcctacctc
421 actttagcaa agcataccat cagctcagac tatgtcatcc ccatagggac ctatggccaa
481 atgaaaaatg gatcaacacc catgtttaac gacatcaata tttatgacct ctttgtctgg
541 atccattatt atgtgtcaat ggatgcactg cttgggggat atgaaatctg gagagacatt
601 gattttgccc atgaagcacc agcttttctg ccttggcata gactcttctt gttgcggtgg
661 gaacaagaaa tccagaagct gacaggagat gaaaacttca ctattccata ttgggactgg
721 cgggatgcag aaaagtgtga catttgcaca gatgagtaca tgggaggtca gcaccccaca
781 aatcctaact tactcagccc agcatcattc ttctcctctt ggcagattgt ctgtagccga
841 ttggaggagt acaacagcca tcagtcttta tgcaatggaa cgcccgaggg acctttacgg
901 cgtaatcctg gaaaccatga caaatccaga accccaaggc tcccctcttc agctgatgta
961 gaattttgcc tgagtttgac ccaatatgaa tctggttcca tggataaagc tgccaatttc
1021 agctttagaa atacactgga aggatttgct agtccactta ctgggatagc ggatgcctct
1081 caaagcagca tgcacaatgc cttgcacatc tatatgaatg gaacaatgtc ccaggtacag
1141 ggatctgcca acgatcctat cttccttctt caccatgcat ttgttgacag tatttttgag
1201 cagtggctcc gaaggcaccg tcctcttcaa gaagtttatc cagaagccaa tgcacccatt
1261 ggacataacc gggaatccta catggttcct tttataccac tgtacagaaa tggtgatttc
1321 tttatttcat ccaaagatct gggctatgac tatagctatc tacaagattc agacccagac
1381 tcttttcaag actacattaa gtcctatttg gaacaagcga gtcggatctg gtcatggctc
1441 cttggggcgg cgatggtagg ggccgtcctc actgccctgc tggcagggct tgtgagcttg
1501 ctgtgtcgtc acaagagaaa gcagcttcct gaagaaaagc agccactcct catggagaaa
1561 gaggattacc acagcttgta tcagagccat ttataaaagg cttaggcaat agagtagggc
1621 caaaaagcct gacctcactc taactcaaag taatgtccag gttcccagag aatatctgct
1681 ggtatttttc tgtaaagacc atttgcaaaa ttgtaaccta atacaaagtg tagccttctt
1741 ccaactcagg tagaacacac ctgtctttgt cttgctgttt tcactcagcc cttttaacat
1801 tttcccctaa gcccatatgt ctaaggaaag gatgctattt ggtaatgagg aactgttatt
1861 tgtatgtgaa ttaaagtgct cttatttt
//