LOCUS Y00815 7702 bp mRNA linear HUM 19-SEP-1995
DEFINITION Human mRNA for LCA-homolog. LAR protein (leukocyte antigen
related).
ACCESSION Y00815
VERSION Y00815.1
KEYWORDS antigen; cell surface glycoprotein; glycoprotein; immunoglobulin
superfamily; LAR gene; leukocyte common antigen; neural cell
adhesion molecule; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7702)
AUTHORS Saito H.
JOURNAL Submitted (15-SEP-1988) to the INSDC. Saito H., Dana-Farber Cancer
Institute, 44 Binney Street, Boston , MA 02115.
REFERENCE 2
AUTHORS Streuli M., Krueger N.X., Hall L.R., Schlossman S.F., Saito H.
TITLE A new member of the immunoglobulin superfamily that has a
cytoplasmic region homologous to the leukocyte common antigen
JOURNAL J. Exp. Med. 168(5), 1523-1530(1988).
PUBMED 2972792
REFERENCE 3
AUTHORS Schaapveld R.Q.L., Van den Maagdenberg A.M.J.M., Schepens J.T.G.,
Weghuis D.O., Van Kessel A.G., Wieringa B., Hendriks W.J.A.J.
TITLE The mouse gene Ptprf encoding the leukocyte common antigen-related
molecule LAR: cloning, characterization, and chromosomal
localization
JOURNAL Genomics 27(1), 124-130(1995).
PUBMED 7665159
FEATURES Location/Qualifiers
source 1..7702
/db_xref="H-InvDB:HIT000325327"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/cell_type="lymphocyte"
/tissue_type="tonsil"
/db_xref="taxon:9606"
CDS 371..6064
/product="put. LAR preprotein (AA -16 to 1881)"
/db_xref="GOA:P10586"
/db_xref="H-InvDB:HIT000325327.14"
/db_xref="HGNC:HGNC:9670"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:1LAR"
/db_xref="PDB:2DJU"
/db_xref="PDB:2DN7"
/db_xref="PDB:2EDX"
/db_xref="PDB:2EDY"
/db_xref="PDB:2YD5"
/db_xref="PDB:2YD8"
/db_xref="PDB:4N5U"
/db_xref="UniProtKB/Swiss-Prot:P10586"
/protein_id="CAA68754.1"
/translation="MVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVC
QATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNS
LGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVR
RVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLE
LSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNS
EPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSE
AVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPN
AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF
QAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDT
LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADS
RNGVITQYSVAHEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGP
GPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVR
LENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGAR
SKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPN
TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHV
TGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDT
TYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKS
AVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPD
LLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEE
LELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPL
SPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVI
LIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHP
PIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYD
HSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV
VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKR
ELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID
AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL
YAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYEL
TRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIV
MLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRT
IRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITL
SIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT"
sig_peptide 371..418
/note="put. signal peptide (AA -16 to -1)"
mat_peptide 419..6061
/note="put. LAR protein (AA 1 - 1881)"
misc_feature 419..4120
/note="put. extracellular domain"
misc_feature 4121..4192
/note="put. transmembrane domain"
misc_feature 4193..6061
/note="put. cytoplasmic domain"
BASE COUNT 1636 a 2286 c 2292 g 1488 t
ORIGIN
1 cgggagcggc gggagcggtg gcggcggcag aggcggcggc tccagcttcg gctccggctc
61 gggctcgggc tccggctccg gctccggctc cggctccagc tcgggtggcg gtggcgggag
121 cgggaccagg tggaggcggc ggcggcagag gagtgggagc agcggcccta gcggcttgcg
181 gggggacatg cggaccgacg gcccctggat aggcggaagg agtggaggcc ctggtgcccg
241 gcccttggtg ctgagtatcc agcaagagtg accggggtga agaagcaaag actcggttga
301 ttgtcctggg ctgtggctgg ctgtggagct agagccctgg atggcccctg agccagcccc
361 agggaggacg atggtgcccc ttgtgcctgc actggtgatg cttggtttgg tggcaggcgc
421 ccatggtgac agcaaacctg tcttcattaa agtccctgag gaccagactg ggctgtcagg
481 aggggtagcc tccttcgtgt gccaagctac aggagaaccc aagccgcgca tcacatggat
541 gaagaagggg aagaaagtca gctcccagcg cttcgaggtc attgagtttg atgatggggc
601 agggtcagtg cttcggatcc agccattgcg ggtgcagcga gatgaagcca tctatgagtg
661 tacagctact aacagcctgg gtgagatcaa cactagtgcc aagctctcag tgctcgaaga
721 ggaacagctg ccccctgggt tcccttccat cgacatgggg cctcagctga aggtggtgga
781 gaaggcacgc acagccacca tgctatgtgc cgcaggcgga aatccagacc ctgagatttc
841 ttggttcaag gacttccttc ctgtagaccc tgccacgagc aacggccgca tcaagcagct
901 gcgttcaggt gccttgcaga tagagagcag tgaggaatcc gaccaaggca agtacgagtg
961 tgtggcgacc aactcggcag gcacacgtta ctcagcccct gcgaacctgt atgtgcgagt
1021 gcgccgcgtg gctcctcgtt tctccatccc tcccagcagc caggaggtga tgccaggcgg
1081 cagcgtgaac ctgacatgcg tggcagtggg tgcacccatg ccctacgtga agtggatgat
1141 gggggccgag gagctcacca aggaggatga gatgccagtt ggccgcaacg tcctggagct
1201 cagcaatgtc gtacgctctg ccaactacac ctgtgtggcc atctcctcgc tgggcatgat
1261 cgaggccaca gcccaggtca cagtgaaagc tcttccaaag cctccgattg atcttgtggt
1321 gacagagaca actgccacca gtgtcaccct cacctgggac tctgggaact cggagcctgt
1381 aacctactat ggcatccagt accgcgcagc gggcacggag ggcccctttc aggaggtgga
1441 tggtgtggcc accacccgct acagcattgg cggcctcagc cctttctcgg aatatgcctt
1501 ccgcgtgctg gcggtgaaca gcatcgggcg agggccgccc agcgaggcag tgcgggcacg
1561 cacgggagaa caggcgccct ccagcccacc gcgccgcgtg caggcacgca tgctgagcgc
1621 cagcaccatg ctggtgcagt gggagcctcc cgaggagccc aacggcctgg tgcggggata
1681 ccgcgtctac tatactccgg actcccgccg ccccccgaac gcctggcaca agcacaacac
1741 cgacgcgggg ctcctcacga ccgtgggcag cctgctgcct ggcatcacct acagcctgcg
1801 cgtgcttgcc ttcaccgccg tgggcgatgg ccctcccagc cccaccatcc aggtcaagac
1861 gcagcaggga gtgcctgccc agcccgcgga cttccaggcc gaggtggagt cggacaccag
1921 gatccagctc tcgtggctgc tgccccctca ggagcggatc atcatgtatg aactggtgta
1981 ctgggcggca gaggacgaag accaacagca caaggtcacc ttcgacccaa cctcctccta
2041 cacactagag gacctgaagc ctgacacact ctaccgcttc cagctggctg cacgctcgga
2101 tatgggggtg ggcgtcttca cccccaccat tgaggcccgc acagcccagt ccaccccctc
2161 cgcccctccc cagaaggtga tgtgtgtgag catgggctcc accacggtcc gggtaagttg
2221 ggtcccgccg cctgccgaca gccgcaacgg cgttatcacc cagtactccg tggcccacga
2281 ggcggtggac ggcgaggacc gcgggcggca tgtggtggat ggcatcagcc gtgagcactc
2341 cagctgggac ctggtgggcc tggagaagtg gacggagtac cgggtgtggg tgcgggcaca
2401 cacagacgtg ggccccggcc ccgagagcag cccggtgctg gtgcgcaccg atgaggacgt
2461 gcccagcggg cctccgcgga aggtggaggt ggagccactg aactccactg ctgtgcatgt
2521 ctactggaag ctgcctgtcc ccagcaagca gcatggccag atccgcggct accaggtcac
2581 ctacgtgcgg ctggagaatg gcgagccccg tggactcccc atcatccaag acgtcatgct
2641 agccgaggcc cagtggcggc cagaggagtc cgaggactat gaaaccacta tcagcggcct
2701 gaccccggag accacctact ccgttactgt tgctgcctat accaccaagg gggatggtgc
2761 ccgcagcaag cccaaaattg tcactacaac aggtgcagtc ccaggccggc ccaccatgat
2821 gatcagcacc acggccatga acactgcgct gctccagtgg cacccaccca aggaactgcc
2881 tggcgagctg ctgggctacc ggctgcagta ctgccgggcc gacgaggcgc ggcccaacac
2941 catagatttc ggcaaggatg accagcactt cacagtcacc ggcctgcaca aggggaccac
3001 ctacatcttc cggcttgctg ccaagaaccg ggctggcttg ggtgaggagt tcgagaagga
3061 gatcaggacc cccgaggacc tgcccagcgg cttcccccaa aacctgcatg tgacaggact
3121 gaccacgtct accacagaac tggcctggga cccgccagtg ctggcggaga ggaacgggcg
3181 catcatcagc tacaccgtgg tgttccgaga catcaacagc caacaggagc tgcagaacat
3241 cacgacagac acccgcttta cccttactgg cctcaagcca gacaccactt acgacatcaa
3301 ggtccgcgca tggaccagca aaggctctgg cccactcagc cccagcatcc agtcccggac
3361 catgccggtg gagcaagtgt ttgccaagaa cttccgggtg gcggctgcaa tgaagacgtc
3421 tgtgctgctc agctgggagg ttcccgactc ctataagtca gctgtgccct ttaagattct
3481 gtacaatggg cagagtgtgg aggtggacgg gcactcgatg cggaagctga tcgcagacct
3541 gcagcccaac acagagtact cgtttgtgct gatgaaccgt ggcagcagcg cagggggcct
3601 gcagcacctg gtgtccatcc gcacagcccc cgacctcctg cctcacaagc cgctgcctgc
3661 ctctgcctac atagaggacg gccgcttcga tctctccatg ccccatgtgc aagacccctc
3721 gcttgtcagg tggttctaca ttgttgtggt acccattgac cgtgtgggcg ggagcatgct
3781 gacgccaagg tggagcacac ccgaggaact ggagctggac gagcttctag aagccatcga
3841 gcaaggcgga gaggagcagc ggcggcggcg gcggcaggca gaacgtctga agccatatgt
3901 ggctgctcaa ctggatgtgc tcccggagac ctttaccttg ggggacaaga agaactaccg
3961 gggcttctac aaccggcccc tgtctccgga cttgagctac cagtgctttg tgcttgcctc
4021 cttgaaggaa cccatggacc agaagcgcta tgcctccagc ccctactcgg atgagatcgt
4081 ggtccaggtg acaccagccc agcagcagga ggagccggag atgctgtggg tgacgggtcc
4141 cgtgctggca gtcatcctca tcatcctcat tgtcatcgcc atcctcttgt tcaaaaggaa
4201 aaggacccac tctccgtcct ctaaggatga gcagtcgatc ggactgaagg actccttgct
4261 ggcccactcc tctgaccctg tggagatgcg gaggctcaac taccagaccc caggtatgcg
4321 agaccaccca cccatcccca tcaccgacct ggcggacaac atcgagcgcc tcaaagccaa
4381 cgatggcctc aagttctccc aggagtatga gtccatcgac cctggacagc agttcacgtg
4441 ggagaattca aacctggagg tgaacaagcc caagaaccgc tatgcgaatg tcatcgccta
4501 cgaccactct cgagtcatcc ttacctctat cgatggcgtc cccgggagtg actacatcaa
4561 tgccaactac atcgatggct accgcaagca gaatgcctac atcgccacgc agggccccct
4621 gcccgagacc atgggcgatt tctggagaat ggtgtgggaa cagcgcacgg ccactgtggt
4681 catgatgaca cggctggagg agaagtcccg ggtaaaatgt gatcagtact ggccagcccg
4741 tggcaccgag acctgtggcc ttattcaggt gaccctgttg gacacagtgg agctggccac
4801 atacactgtg cgcaccttcg cactccacaa gagtggctcc agtgagaagc gtgagctgcg
4861 tcagtttcag ttcatggcct ggccagacca tggagttcct gagtacccaa ctcccatcct
4921 ggccttccta cgacgggtca aggcctgcaa ccccctagac gcagggccca tggtggtgca
4981 ctgcagcgcg ggcgtgggcc gcaccggctg cttcatcgtg attgatgcca tgttggagcg
5041 gatgaagcac gagaagacgg tggacatcta tggccacgtg acctgcatgc gatcacagag
5101 gaactacatg gtgcagacgg aggaccagta cgtgttcatc catgaggcgc tgctggaggc
5161 tgccacgtgc ggccacacag aggtgcctgc ccgcaacctg tatgcccaca tccagaagct
5221 gggccaagtg cctccagggg agagtgtgac cgccatggag ctcgagttca agttgctggc
5281 cagctccaag gcccacacgt cccgcttcat cagcgccaac ctgccctgca acaagttcaa
5341 gaaccggctg gtgaacatca tgccctacga attgacccgt gtgtgtctgc agcccatccg
5401 tggtgtggag ggctctgact acatcaatgc cagcttcctg gatggttata gacagcagaa
5461 ggcctacata gctacacagg ggcctctggc agagagcacc gaggacttct ggcgcatgct
5521 atgggagcac aattccacca tcatcgtcat gctgaccaag cttcgggaga tgggcaggga
5581 gaaatgccac cagtactggc cagcagagcg ctctgctcgc taccagtact ttgttgttga
5641 cccgatggct gagtacaaca tgccccagta tatcctgcgt gagttcaagg tcacggatgc
5701 ccgggatggg cagtcaagga caatccggca gttccagttc acagactggc cagagcaggg
5761 cgtgcccaag acaggcgagg gattcattga cttcatcggg caggtgcata agaccaagga
5821 gcagtttgga caggatgggc ctatcacggt gcactgcagt gctggcgtgg gccgcaccgg
5881 ggtgttcatc actctgagca tcgtcctgga gcgcatgcgc tatgagggcg tggtcgacat
5941 gtttcagacc gtgaagaccc tgcgtacaca gcgtcctgcc atggtgcaga cagaggacca
6001 gtatcagctg tgctaccgtg cggccctgga gtacctcggc agctttgacc actatgcaac
6061 gtaactaccg ctcccctctc ctccgccacc cccgccgtgg ggctccggag gggacccagc
6121 tcctctgagc cataccgacc atcgtccagc cctcctacgc agatgctgtc actggcagag
6181 cacagcccac ggggatcaca gcgtttcagg aacgttgcca caccaatcag agagcctaga
6241 acatccctgg gcaagtggat ggcccagcag gcaggcactg tggcccttct gtccaccaga
6301 cccacctgga gcccgcttca agctctctgt tgcgctcccg catttctcat gcttcttctc
6361 atggggtggg gttggggcaa agcctccttt ttaatacatt aagtggggta gactgaggga
6421 ttttagcctc ttccctctga tttttccttt cgcgaatccg tatctgcaga atgggccact
6481 gtaggggttg gggtttattt tgttttgttt tttttttttt tttgtatgac ttctgctgaa
6541 ggacagaaca ttgccttcct cgtgcagagc tggggctgcc agcctgagcg gaggctcggc
6601 cgtgggccgg gaggcagtgc tgatccggct gctcctccag cccttcagac gagatcctgt
6661 ttcagctaaa tgcagggaaa ctcaatgttt ttttaagttt tgttttccct ttaaagcctt
6721 tttttaggcc acattgacag tggtgggcgg ggagaagata gggaacactc atccctggtc
6781 gtctatccca gtgtgtgttt aacattcaca gcccagaacc acagatgtgt ctgggagagc
6841 ctggcaaggc attcctcatc accatcgtgt ttgcaaaggt taaaacaaaa acaaaaaacc
6901 acaaaaataa aaaacaaaaa aaacaaaaaa cccaaaaaaa aaaaaaaaaa gagtcagccc
6961 ttggcttctg cttcaaaccc tcaagagggg aagcaactcc gtgtgcctgg ggttcccgag
7021 ggagctgctg gctgacctgg gcccacagag cctggctttg gtccccagca ttgcagtatg
7081 gtgtggtgtt tgtaggctgt ggggtctggc tgtgtggcca aggtgaatag cacaggttag
7141 ggtgtgtgcc acaccccatg cacctcaggg ccaagcgggg gcgtggctgg cctttcaggt
7201 ccaggccagt gggcctggta gcacatgtct gtcctcagag caggggccag atgattttcc
7261 tccctggttt gcagctgttt tcaaagcccc cgataatcgc tcttttccac tccaagatgc
7321 cctcataaac caatgtggca agactactgg acttctatca atggtactct aatcagtcct
7381 tattatccca gcttgctgag gggcagggag agcgcctctt cctctgggca gcgctatcta
7441 gataggtaag tgggggcggg gaagggtgca tagctgtttt agctgaggga cgtggtgccg
7501 acgtccccaa acctagctag gctaagtcaa gatcaacatt ccagggttgg taatgttgga
7561 tgatgaaaca ttcattttta ccttgtggat gctagtgctg tagagttcac tgttgtacac
7621 agtctgtttt ctatttgtta agaaaaacta cagcatcatt gcataattct tgatggtaat
7681 aaatttgaat aatcagattt ct
//