LOCUS Y00749 1167 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for endothelin.
ACCESSION Y00749
VERSION Y00749.1
KEYWORDS endothelin; vasoconstrictor peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1167)
AUTHORS Itoh Y.
JOURNAL Submitted (05-APR-1988) to the INSDC. Itoh Y., Wadai 7, Tsukuba,
Ibaraki 300-42, Japan.
REFERENCE 2 (bases 1 to 1167)
AUTHORS Itoh Y., Yanagisawa M., Ohkubo S., Kimura C., Kosaka T., Inoue A.,
Ishida N., Mitsui Y., Onda H., Fujino M., Masaki T.
TITLE Cloning and sequence analysis of cDNA encoding the precursor of a
human endothelium-derived vasoconstrictor peptide, endothelin:
identity of human and porcine endothelin
JOURNAL FEBS Lett. 231(2), 440-444(1988).
PUBMED 3282927
COMMENT Data kindly reviewed (01-JUN-1988) by Itoh Y.
FEATURES Location/Qualifiers
source 1..1167
/db_xref="H-InvDB:HIT000325315"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="pHET4-3"
/tissue_type="placenta"
/db_xref="taxon:9606"
CDS 253..891
/note="preproendothelin (AA -17 to 195)"
/db_xref="GOA:P05305"
/db_xref="H-InvDB:HIT000325315.13"
/db_xref="HGNC:HGNC:3176"
/db_xref="InterPro:IPR001928"
/db_xref="InterPro:IPR019764"
/db_xref="InterPro:IPR020475"
/db_xref="PDB:1EDN"
/db_xref="PDB:1EDP"
/db_xref="PDB:1T7H"
/db_xref="PDB:1V6R"
/db_xref="PDB:5GLH"
/db_xref="PDB:6DK5"
/db_xref="UniProtKB/Swiss-Prot:P05305"
/protein_id="CAA68718.1"
/translation="MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPP
WRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKA
TDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQL
VRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW"
sig_peptide 253..303
/note="put. signal peptide (AA -17 to -1)"
mat_peptide 409..471
/note="mature endothelin (AA 36 - 56)"
BASE COUNT 288 a 309 c 299 g 271 t
ORIGIN
1 ctgcgccagg cgaacgggtc ctgcgcctcc tgcagtccca gctctccacc gccgcgtgcg
61 cctgcagacg ctccgctcgc tgccttctct cctggcaggc gctgcctttt ctccccgtta
121 aagggcactt gggctgaagg atcgctttga gatctgagga acccgcagcg ctttgaggga
181 cctgaagctg tttttcttcg ttttcctttg ggttcagttt gaacgggagg tttttgatcc
241 ctttttttca gaatggatta tttgctcatg attttctctc tgctgtttgt ggcttgccaa
301 ggagctccag aaacagcagt cttaggcgct gagctcagcg cggtgggtga gaacggcggg
361 gagaaaccca ctcccagtcc accctggcgg ctccgccggt ccaagcgctg ctcctgctcg
421 tccctgatgg ataaagagtg tgtctacttc tgccacctgg acatcatttg ggtcaacact
481 cccgagcacg ttgttccgta tggacttgga agccctaggt ccaagagagc cttggagaat
541 ttacttccca caaaggcaac agaccgtgag aatagatgcc aatgtgctag ccaaaaagac
601 aagaagtgct ggaatttttg ccaagcagga aaagaactca gggctgaaga cattatggag
661 aaagactgga ataatcataa gaaaggaaaa gactgttcca agcttgggaa aaagtgtatt
721 tatcagcagt tagtgagagg aagaaaaatc agaagaagtt cagaggaaca cctaagacaa
781 accaggtcgg agaccatgag aaacagcgtc aaatcatctt ttcatgatcc caagctgaaa
841 ggcaagccct ccagagagcg ttatgtgacc cacaaccgag cacattggtg acagacttcg
901 gggcctgtct gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac
961 cctggctggg atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagcg
1021 tcctcgttca aaacattcca agaaaggtta aggagttccc ccaaccatct tcactggctt
1081 ccatcagtgg taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag
1141 cagaaacaca cagtcacatt cgaattc
//