LOCUS       Y00716                  3926 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for complement factor H.
ACCESSION   Y00716 M32093 X07525
VERSION     Y00716.1
KEYWORDS    complement factor H; glycoprotein; regulatory protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Day A.J.
  JOURNAL   Submitted (25-FEB-1988) to the INSDC. Day A.J., MRC Immunochemistry
            Unit, Dept. of Biochemistry, University of Oxford, South Parks
            Road, Oxford, OX1 3QU.
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Ripoche J., Day A.J., Harris T.J.R., Sim R.B.
  TITLE     The complete amino acid sequence of human complement factor H
  JOURNAL   Biochem. J. 249(2), 593-602(1988).
   PUBMED   2963625
COMMENT     see Immunogenetics 27:211-214(1988) concerning TYR <-> HIS
            at AA 384
            see X07523 for truncated (1.8 kb) mRNA sequence
FEATURES             Location/Qualifiers
     source          1..3926
                     /db_xref="H-InvDB:HIT000325312"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="human liver cDNA in pat153/PvuII/8"
                     /clone="B-38-1, R2a and PE3"
                     /tissue_type="liver"
                     /db_xref="taxon:9606"
     sig_peptide     74..127
     CDS             74..3769
                     /product="factor H"
                     /db_xref="GOA:P08603"
                     /db_xref="H-InvDB:HIT000325312.14"
                     /db_xref="HGNC:HGNC:4883"
                     /db_xref="InterPro:IPR000436"
                     /db_xref="InterPro:IPR035976"
                     /db_xref="PDB:1FHC"
                     /db_xref="PDB:1HAQ"
                     /db_xref="PDB:1HCC"
                     /db_xref="PDB:1HFH"
                     /db_xref="PDB:1HFI"
                     /db_xref="PDB:1KOV"
                     /db_xref="PDB:2BZM"
                     /db_xref="PDB:2G7I"
                     /db_xref="PDB:2IC4"
                     /db_xref="PDB:2JGW"
                     /db_xref="PDB:2JGX"
                     /db_xref="PDB:2KMS"
                     /db_xref="PDB:2QFG"
                     /db_xref="PDB:2QFH"
                     /db_xref="PDB:2RLP"
                     /db_xref="PDB:2RLQ"
                     /db_xref="PDB:2UWN"
                     /db_xref="PDB:2V8E"
                     /db_xref="PDB:2W80"
                     /db_xref="PDB:2W81"
                     /db_xref="PDB:2WII"
                     /db_xref="PDB:2XQW"
                     /db_xref="PDB:3GAU"
                     /db_xref="PDB:3GAV"
                     /db_xref="PDB:3GAW"
                     /db_xref="PDB:3KXV"
                     /db_xref="PDB:3KZJ"
                     /db_xref="PDB:3OXU"
                     /db_xref="PDB:3R62"
                     /db_xref="PDB:3RJ3"
                     /db_xref="PDB:3SW0"
                     /db_xref="PDB:4AYD"
                     /db_xref="PDB:4AYE"
                     /db_xref="PDB:4AYI"
                     /db_xref="PDB:4AYM"
                     /db_xref="PDB:4B2R"
                     /db_xref="PDB:4B2S"
                     /db_xref="PDB:4J38"
                     /db_xref="PDB:4K12"
                     /db_xref="PDB:4ONT"
                     /db_xref="PDB:4ZH1"
                     /db_xref="PDB:5NBQ"
                     /db_xref="PDB:5O32"
                     /db_xref="PDB:5O35"
                     /db_xref="PDB:5WTB"
                     /db_xref="PDB:6ATG"
                     /db_xref="UniProtKB/Swiss-Prot:P08603"
                     /protein_id="CAA68704.1"
                     /translation="MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPE
                     GTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGN
                     VFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSS
                     AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVING
                     SPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGD
                     YSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGG
                     LYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFP
                     YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSK
                     SSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSIRCGKDGWSAQPTCIKS
                     CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE
                     RECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICK
                     EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP
                     VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQ
                     LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD
                     PEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG
                     RWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETT
                     CYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK
                     CLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV
                     TCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE
                     VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG
                     NKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRG
                     YRLSSRSHTLRTTCWDGKLEYPTCAKR"
     mat_peptide     128..3766
                     /product="factor H"
     variation       994
                     /replace="c"
                     /note="polymorphism"
     variation       1277
                     /replace="t"
                     /note="polymorphism"
     misc_feature    1409..1409
                     /note="divergenec point of full length (4.3 kb) and
                     truncated (1.8 kb) mRNA species"
     variation       2881
                     /replace="g"
                     /note="polymorphism"
BASE COUNT         1306 a          689 c          855 g         1076 t
ORIGIN      
        1 aattcttgga agaggagaac tggacgttgt gaacagagtt agctggtaaa tgtcctctta
       61 aaagatccaa aaaatgagac ttctagcaaa gattatttgc cttatgttat gggctatttg
      121 tgtagcagaa gattgcaatg aacttcctcc aagaagaaat acagaaattc tgacaggttc
      181 ctggtctgac caaacatatc cagaaggcac ccaggctatc tataaatgcc gccctggata
      241 tagatctctt ggaaatgtaa taatggtatg caggaaggga gaatgggttg ctcttaatcc
      301 attaaggaaa tgtcagaaaa ggccctgtgg acatcctgga gatactcctt ttggtacttt
      361 tacccttaca ggaggaaatg tgtttgaata tggtgtaaaa gctgtgtata catgtaatga
      421 ggggtatcaa ttgctaggtg agattaatta ccgtgaatgt gacacagatg gatggaccaa
      481 tgatattcct atatgtgaag ttgtgaagtg tttaccagtg acagcaccag agaatggaaa
      541 aattgtcagt agtgcaatgg aaccagatcg ggaataccat tttggacaag cagtacggtt
      601 tgtatgtaac tcaggctaca agattgaagg agatgaagaa atgcattgtt cagacgatgg
      661 tttttggagt aaagagaaac caaagtgtgt ggaaatttca tgcaaatccc cagatgttat
      721 aaatggatct cctatatctc agaagattat ttataaggag aatgaacgat ttcaatataa
      781 atgtaacatg ggttatgaat acagtgaaag aggagatgct gtatgcactg aatctggatg
      841 gcgtccgttg ccttcatgtg aagaaaaatc atgtgataat ccttatattc caaatggtga
      901 ctactcacct ttaaggatta aacacagaac tggagatgaa atcacgtacc agtgtagaaa
      961 tggtttttat cctgcaaccc ggggaaatac agccaaatgc acaagtactg gctggatacc
     1021 tgctccgaga tgtaccttga aaccttgtga ttatccagac attaaacatg gaggtctata
     1081 tcatgagaat atgcgtagac catactttcc agtagctgta ggaaaatatt actcctatta
     1141 ctgtgatgaa cattttgaga ctccgtcagg aagttactgg gatcacattc attgcacaca
     1201 agatggatgg tcgccagcag taccatgcct cagaaaatgt tattttcctt atttggaaaa
     1261 tggatataat caaaatcatg gaagaaagtt tgtacagggt aaatctatag acgttgcctg
     1321 ccatcctggc tacgctcttc caaaagcgca gaccacagtt acatgtatgg agaatggctg
     1381 gtctcctact cccagatgca tccgtgtcaa aacatgttcc aaatcaagta tagatattga
     1441 gaatgggttt atttctgaat ctcagtatac atatgcctta aaagaaaaag cgaaatatca
     1501 atgcaaacta ggatatgtaa cagcagatgg tgaaacatca ggatcaatta gatgtgggaa
     1561 agatggatgg tcagctcaac ccacgtgcat taaatcttgt gatatcccag tatttatgaa
     1621 tgccagaact aaaaatgact tcacatggtt taagctgaat gacacattgg actatgaatg
     1681 ccatgatggt tatgaaagca atactggaag caccactggt tccatagtgt gtggttacaa
     1741 tggttggtct gatttaccca tatgttatga aagagaatgc gaacttccta aaatagatgt
     1801 acacttagtt cctgatcgca agaaagacca gtataaagtt ggagaggtgt tgaaattctc
     1861 ctgcaaacca ggatttacaa tagttggacc taattccgtt cagtgctacc actttggatt
     1921 gtctcctgac ctcccaatat gtaaagagca agtacaatca tgtggtccac ctcctgaact
     1981 cctcaatggg aatgttaagg aaaaaacgaa agaagaatat ggacacagtg aagtggtgga
     2041 atattattgc aatcctagat ttctaatgaa gggacctaat aaaattcaat gtgttgatgg
     2101 agagtggaca actttaccag tgtgtattgt ggaggagagt acctgtggag atatacctga
     2161 acttgaacat ggctgggccc agctttcttc ccctccttat tactatggag attcagtgga
     2221 attcaattgc tcagaatcat ttacaatgat tggacacaga tcaattacgt gtattcatgg
     2281 agtatggacc caacttcccc agtgtgtggc aatagataaa cttaagaagt gcaaatcatc
     2341 aaatttaatt atacttgagg aacatttaaa aaacaagaag gaattcgatc ataattctaa
     2401 cataaggtac agatgtagag gaaaagaagg atggatacac acagtctgca taaatggaag
     2461 atgggatcca gaagtgaact gctcaatggc acaaatacaa ttatgcccac ctccacctca
     2521 gattcccaat tctcacaata tgacaaccac actgaattat cgggatggag aaaaagtatc
     2581 tgttctttgc caagaaaatt atctaattca ggaaggagaa gaaattacat gcaaagatgg
     2641 aagatggcag tcaataccac tctgtgttga aaaaattcca tgttcacaac cacctcagat
     2701 agaacacgga accattaatt catccaggtc ttcacaagaa agttatgcac atgggactaa
     2761 attgagttat acttgtgagg gtggtttcag gatatctgaa gaaaatgaaa caacatgcta
     2821 catgggaaaa tggagttctc cacctcagtg tgaaggcctt ccttgtaaat ctccacctga
     2881 gatttctcat ggtgttgtag ctcacatgtc agacagttat cagtatggag aagaagttac
     2941 gtacaaatgt tttgaaggtt ttggaattga tgggcctgca attgcaaaat gcttaggaga
     3001 aaaatggtct caccctccat catgcataaa aacagattgt ctcagtttac ctagctttga
     3061 aaatgccata cccatgggag agaagaagga tgtgtataag gcgggtgagc aagtgactta
     3121 cacttgtgca acatattaca aaatggatgg agccagtaat gtaacatgca ttaatagcag
     3181 atggacagga aggccaacat gcagagacac ctcctgtgtg aatccgccca cagtacaaaa
     3241 tgcttatata gtgtcgagac agatgagtaa atatccatct ggtgagagag tacgttatca
     3301 atgtaggagc ccttatgaaa tgtttgggga tgaagaagtg atgtgtttaa atggaaactg
     3361 gacggaacca cctcaatgca aagattctac aggaaaatgt gggccccctc cacctattga
     3421 caatggggac attacttcat tcccgttgtc agtatatgct ccagcttcat cagttgagta
     3481 ccaatgccag aacttgtatc aacttgaggg taacaagcga ataacatgta gaaatggaca
     3541 atggtcagaa ccaccaaaat gcttacatcc gtgtgtaata tcccgagaaa ttatggaaaa
     3601 ttataacata gcattaaggt ggacagccaa acagaagctt tattcgagaa caggtgaatc
     3661 agttgaattt gtgtgtaaac ggggatatcg tctttcatca cgttctcaca cattgcgaac
     3721 aacatgttgg gatgggaaac tggagtatcc aacttgtgca aaaagataga atcaatcata
     3781 aagtgcacac ctttattcag aactttagta ttaaatcagt tctcaatttc attttttatg
     3841 tattgtttta ctccttttta ttcatacgta aaattttgga ttaatttgtg aaaatgtaat
     3901 tataagctga gaccggtggc tctctt
//