LOCUS Y00716 3926 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for complement factor H. ACCESSION Y00716 M32093 X07525 VERSION Y00716.1 KEYWORDS complement factor H; glycoprotein; regulatory protein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3926) AUTHORS Day A.J. JOURNAL Submitted (25-FEB-1988) to the INSDC. Day A.J., MRC Immunochemistry Unit, Dept. of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU. REFERENCE 2 (bases 1 to 3926) AUTHORS Ripoche J., Day A.J., Harris T.J.R., Sim R.B. TITLE The complete amino acid sequence of human complement factor H JOURNAL Biochem. J. 249(2), 593-602(1988). PUBMED 2963625 COMMENT see Immunogenetics 27:211-214(1988) concerning TYR <-> HIS at AA 384 see X07523 for truncated (1.8 kb) mRNA sequence FEATURES Location/Qualifiers source 1..3926 /db_xref="H-InvDB:HIT000325312" /organism="Homo sapiens" /mol_type="mRNA" /clone_lib="human liver cDNA in pat153/PvuII/8" /clone="B-38-1, R2a and PE3" /tissue_type="liver" /db_xref="taxon:9606" sig_peptide 74..127 CDS 74..3769 /product="factor H" /db_xref="GOA:P08603" /db_xref="H-InvDB:HIT000325312.14" /db_xref="HGNC:HGNC:4883" /db_xref="InterPro:IPR000436" /db_xref="InterPro:IPR035976" /db_xref="PDB:1FHC" /db_xref="PDB:1HAQ" /db_xref="PDB:1HCC" /db_xref="PDB:1HFH" /db_xref="PDB:1HFI" /db_xref="PDB:1KOV" /db_xref="PDB:2BZM" /db_xref="PDB:2G7I" /db_xref="PDB:2IC4" /db_xref="PDB:2JGW" /db_xref="PDB:2JGX" /db_xref="PDB:2KMS" /db_xref="PDB:2QFG" /db_xref="PDB:2QFH" /db_xref="PDB:2RLP" /db_xref="PDB:2RLQ" /db_xref="PDB:2UWN" /db_xref="PDB:2V8E" /db_xref="PDB:2W80" /db_xref="PDB:2W81" /db_xref="PDB:2WII" /db_xref="PDB:2XQW" /db_xref="PDB:3GAU" /db_xref="PDB:3GAV" /db_xref="PDB:3GAW" /db_xref="PDB:3KXV" /db_xref="PDB:3KZJ" /db_xref="PDB:3OXU" /db_xref="PDB:3R62" /db_xref="PDB:3RJ3" /db_xref="PDB:3SW0" /db_xref="PDB:4AYD" /db_xref="PDB:4AYE" /db_xref="PDB:4AYI" /db_xref="PDB:4AYM" /db_xref="PDB:4B2R" /db_xref="PDB:4B2S" /db_xref="PDB:4J38" /db_xref="PDB:4K12" /db_xref="PDB:4ONT" /db_xref="PDB:4ZH1" /db_xref="PDB:5NBQ" /db_xref="PDB:5O32" /db_xref="PDB:5O35" /db_xref="PDB:5WTB" /db_xref="PDB:6ATG" /db_xref="UniProtKB/Swiss-Prot:P08603" /protein_id="CAA68704.1" /translation="MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPE GTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGN VFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSS AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVING SPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGD YSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGG LYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFP YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSK SSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSIRCGKDGWSAQPTCIKS CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE RECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICK EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQ LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD PEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG RWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETT CYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK CLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV TCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG NKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRG YRLSSRSHTLRTTCWDGKLEYPTCAKR" mat_peptide 128..3766 /product="factor H" variation 994 /replace="c" /note="polymorphism" variation 1277 /replace="t" /note="polymorphism" misc_feature 1409..1409 /note="divergenec point of full length (4.3 kb) and truncated (1.8 kb) mRNA species" variation 2881 /replace="g" /note="polymorphism" BASE COUNT 1306 a 689 c 855 g 1076 t ORIGIN 1 aattcttgga agaggagaac tggacgttgt gaacagagtt agctggtaaa tgtcctctta 61 aaagatccaa aaaatgagac ttctagcaaa gattatttgc cttatgttat gggctatttg 121 tgtagcagaa gattgcaatg aacttcctcc aagaagaaat acagaaattc tgacaggttc 181 ctggtctgac caaacatatc cagaaggcac ccaggctatc tataaatgcc gccctggata 241 tagatctctt ggaaatgtaa taatggtatg caggaaggga gaatgggttg ctcttaatcc 301 attaaggaaa tgtcagaaaa ggccctgtgg acatcctgga gatactcctt ttggtacttt 361 tacccttaca ggaggaaatg tgtttgaata tggtgtaaaa gctgtgtata catgtaatga 421 ggggtatcaa ttgctaggtg agattaatta ccgtgaatgt gacacagatg gatggaccaa 481 tgatattcct atatgtgaag ttgtgaagtg tttaccagtg acagcaccag agaatggaaa 541 aattgtcagt agtgcaatgg aaccagatcg ggaataccat tttggacaag cagtacggtt 601 tgtatgtaac tcaggctaca agattgaagg agatgaagaa atgcattgtt cagacgatgg 661 tttttggagt aaagagaaac caaagtgtgt ggaaatttca tgcaaatccc cagatgttat 721 aaatggatct cctatatctc agaagattat ttataaggag aatgaacgat ttcaatataa 781 atgtaacatg ggttatgaat acagtgaaag aggagatgct gtatgcactg aatctggatg 841 gcgtccgttg ccttcatgtg aagaaaaatc atgtgataat ccttatattc caaatggtga 901 ctactcacct ttaaggatta aacacagaac tggagatgaa atcacgtacc agtgtagaaa 961 tggtttttat cctgcaaccc ggggaaatac agccaaatgc acaagtactg gctggatacc 1021 tgctccgaga tgtaccttga aaccttgtga ttatccagac attaaacatg gaggtctata 1081 tcatgagaat atgcgtagac catactttcc agtagctgta ggaaaatatt actcctatta 1141 ctgtgatgaa cattttgaga ctccgtcagg aagttactgg gatcacattc attgcacaca 1201 agatggatgg tcgccagcag taccatgcct cagaaaatgt tattttcctt atttggaaaa 1261 tggatataat caaaatcatg gaagaaagtt tgtacagggt aaatctatag acgttgcctg 1321 ccatcctggc tacgctcttc caaaagcgca gaccacagtt acatgtatgg agaatggctg 1381 gtctcctact cccagatgca tccgtgtcaa aacatgttcc aaatcaagta tagatattga 1441 gaatgggttt atttctgaat ctcagtatac atatgcctta aaagaaaaag cgaaatatca 1501 atgcaaacta ggatatgtaa cagcagatgg tgaaacatca ggatcaatta gatgtgggaa 1561 agatggatgg tcagctcaac ccacgtgcat taaatcttgt gatatcccag tatttatgaa 1621 tgccagaact aaaaatgact tcacatggtt taagctgaat gacacattgg actatgaatg 1681 ccatgatggt tatgaaagca atactggaag caccactggt tccatagtgt gtggttacaa 1741 tggttggtct gatttaccca tatgttatga aagagaatgc gaacttccta aaatagatgt 1801 acacttagtt cctgatcgca agaaagacca gtataaagtt ggagaggtgt tgaaattctc 1861 ctgcaaacca ggatttacaa tagttggacc taattccgtt cagtgctacc actttggatt 1921 gtctcctgac ctcccaatat gtaaagagca agtacaatca tgtggtccac ctcctgaact 1981 cctcaatggg aatgttaagg aaaaaacgaa agaagaatat ggacacagtg aagtggtgga 2041 atattattgc aatcctagat ttctaatgaa gggacctaat aaaattcaat gtgttgatgg 2101 agagtggaca actttaccag tgtgtattgt ggaggagagt acctgtggag atatacctga 2161 acttgaacat ggctgggccc agctttcttc ccctccttat tactatggag attcagtgga 2221 attcaattgc tcagaatcat ttacaatgat tggacacaga tcaattacgt gtattcatgg 2281 agtatggacc caacttcccc agtgtgtggc aatagataaa cttaagaagt gcaaatcatc 2341 aaatttaatt atacttgagg aacatttaaa aaacaagaag gaattcgatc ataattctaa 2401 cataaggtac agatgtagag gaaaagaagg atggatacac acagtctgca taaatggaag 2461 atgggatcca gaagtgaact gctcaatggc acaaatacaa ttatgcccac ctccacctca 2521 gattcccaat tctcacaata tgacaaccac actgaattat cgggatggag aaaaagtatc 2581 tgttctttgc caagaaaatt atctaattca ggaaggagaa gaaattacat gcaaagatgg 2641 aagatggcag tcaataccac tctgtgttga aaaaattcca tgttcacaac cacctcagat 2701 agaacacgga accattaatt catccaggtc ttcacaagaa agttatgcac atgggactaa 2761 attgagttat acttgtgagg gtggtttcag gatatctgaa gaaaatgaaa caacatgcta 2821 catgggaaaa tggagttctc cacctcagtg tgaaggcctt ccttgtaaat ctccacctga 2881 gatttctcat ggtgttgtag ctcacatgtc agacagttat cagtatggag aagaagttac 2941 gtacaaatgt tttgaaggtt ttggaattga tgggcctgca attgcaaaat gcttaggaga 3001 aaaatggtct caccctccat catgcataaa aacagattgt ctcagtttac ctagctttga 3061 aaatgccata cccatgggag agaagaagga tgtgtataag gcgggtgagc aagtgactta 3121 cacttgtgca acatattaca aaatggatgg agccagtaat gtaacatgca ttaatagcag 3181 atggacagga aggccaacat gcagagacac ctcctgtgtg aatccgccca cagtacaaaa 3241 tgcttatata gtgtcgagac agatgagtaa atatccatct ggtgagagag tacgttatca 3301 atgtaggagc ccttatgaaa tgtttgggga tgaagaagtg atgtgtttaa atggaaactg 3361 gacggaacca cctcaatgca aagattctac aggaaaatgt gggccccctc cacctattga 3421 caatggggac attacttcat tcccgttgtc agtatatgct ccagcttcat cagttgagta 3481 ccaatgccag aacttgtatc aacttgaggg taacaagcga ataacatgta gaaatggaca 3541 atggtcagaa ccaccaaaat gcttacatcc gtgtgtaata tcccgagaaa ttatggaaaa 3601 ttataacata gcattaaggt ggacagccaa acagaagctt tattcgagaa caggtgaatc 3661 agttgaattt gtgtgtaaac ggggatatcg tctttcatca cgttctcaca cattgcgaac 3721 aacatgttgg gatgggaaac tggagtatcc aacttgtgca aaaagataga atcaatcata 3781 aagtgcacac ctttattcag aactttagta ttaaatcagt tctcaatttc attttttatg 3841 tattgtttta ctccttttta ttcatacgta aaattttgga ttaatttgtg aaaatgtaat 3901 tataagctga gaccggtggc tctctt //