LOCUS Y00638 4315 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for leukocyte common antigen (T200).
ACCESSION Y00638
VERSION Y00638.1
KEYWORDS leukocyte common antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4315)
AUTHORS Saito H.
JOURNAL Submitted (07-OCT-1987) to the INSDC. Saito H., Dana-Farber Cancer
Institute, 44 Binney Street, Boston MA 02115.
REFERENCE 2 (bases 1 to 4315)
AUTHORS Streuli M., Hall L.R., Saga Y., Schlossman S.F., Saito H.
TITLE Differential usage of three exons generates at least five different
mRNAs encoding human leukocyte common antigens
JOURNAL J. Exp. Med. 166(5), 1548-1566(1987).
PUBMED 2824653
COMMENT The protein has various names: T200, B220 and CD45.
Differential usage of three exons of the human LCA gene
yields at least five different mRNAs thereby generating the
diversity of LCA proteins.
FEATURES Location/Qualifiers
source 1..4315
/db_xref="H-InvDB:HIT000325298"
/organism="Homo sapiens"
/chromosome="chromosome 1"
/mol_type="mRNA"
/clone="LCA6/2"
/tissue_type="tonsil lymphocytes"
/db_xref="taxon:9606"
CDS 87..4001
/note="LCA (AA -23 to 1281)"
/db_xref="GOA:P08575"
/db_xref="H-InvDB:HIT000325298.13"
/db_xref="HGNC:HGNC:9666"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR016335"
/db_xref="InterPro:IPR024739"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036116"
/db_xref="PDB:1YGR"
/db_xref="PDB:1YGU"
/db_xref="PDB:5FMV"
/db_xref="PDB:5FN6"
/db_xref="PDB:5FN7"
/db_xref="UniProtKB/Swiss-Prot:P08575"
/protein_id="CAA68669.1"
/translation="MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLS
SDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSV
QTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDP
VSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIA
TTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKN
ASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQ
NITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGE
PQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPY
TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRD
RNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFIL
HHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQ
LMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV
DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE
QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV
NKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG
RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFG
ETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRN
SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVM
IAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDL
KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKL
PQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRK
ARLGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP
LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS"
sig_peptide 87..155
/note="signal peptide (AA -23 to -1)"
mat_peptide 156..3998
/note="mature LCA (AA 1 - 1281)"
misc_feature 156..1811
/note="extracellular domain"
misc_feature 1812..1877
/note="transmembrane domain"
misc_feature 1878..3998
/note="cytoplasmic domain"
BASE COUNT 1422 a 878 c 892 g 1123 t
ORIGIN
1 ggaaattgtt cctcgtctga taagacaaca gtggagaaag gacgcatgct gtttcttagg
61 gacacggctg gcttccagat atgaccatgt atttgtggct taaactcttg gcatttggct
121 ttgcctttct ggacacagaa gtatttgtga cagggcaaag cccaacacct tcccccactg
181 gattgactac agcaaagatg cccagtgttc cactttcaag tgacccctta cctactcaca
241 ccactgcatt ctcacccgca agcacctttg aaagagaaaa tgacttctca gagaccacaa
301 cttctcttag tccagacaat acttccaccc aagtatcccc ggactctttg gataatgcta
361 gtgcttttaa taccacaggt gtttcatcag tacagacgcc tcaccttccc acgcacgcag
421 actcgcagac gccctctgct ggaactgaca cgcagacatt cagcggctcc gccgccaatg
481 caaaactcaa ccctacccca ggcagcaatg ctatctcaga tgtcccagga gagaggagta
541 cagccagcac ctttcctaca gacccagttt ccccattgac aaccaccctc agccttgcac
601 accacagctc tgctgcctta cctgcacgca cctccaacac caccatcaca gcgaacacct
661 cagatgccta ccttaatgcc tctgaaacaa ccactctgag cccttctgga agcgctgtca
721 tttcaaccac aacaatagct actactccat ctaagccaac atgtgatgaa aaatatgcaa
781 acatcactgt ggattactta tataacaagg aaactaaatt atttacagca aagctaaatg
841 ttaatgagaa tgtggaatgt ggaaacaata cttgcacaaa caatgaggtg cataacctta
901 cagaatgtaa aaatgcgtct gtttccatat ctcataattc atgtactgct cctgataaga
961 cattaatatt agatgtgcca ccaggggttg aaaagtttca gttacatgat tgtacacaag
1021 ttgaaaaagc agatactact atttgtttaa aatggaaaaa tattgaaacc tttacttgtg
1081 atacacagaa tattacctac agatttcagt gtggtaatat gatatttgat aataaagaaa
1141 ttaaattaga aaaccttgaa cccgaacatg agtataagtg tgactcagaa atactctata
1201 ataaccacaa gtttactaac gcaagtaaaa ttattaaaac agattttggg agtccaggag
1261 agcctcagat tattttttgt agaagtgaag ctgcacatca aggagtaatt acctggaatc
1321 cccctcaaag atcatttcat aattttaccc tctgttatat aaaagagaca gaaaaagatt
1381 gcctcaatct ggataaaaac ctgatcaaat atgatttgca aaatttaaaa ccttatacga
1441 aatatgtttt atcattacat gcctacatca ttgcaaaagt gcaacgtaat ggaagtgctg
1501 caatgtgtca tttcacaact aaaagtgctc ctccaagcca ggtctggaac atgactgtct
1561 ccatgacatc agataatagt atgcatgtca agtgtaggcc tcccagggac cgtaatggcc
1621 cccatgaacg ttaccatttg gaagttgaag ctggaaatac tctggttaga aatgagtcgc
1681 ataagaattg cgatttccgt gtaaaagatc ttcaatattc aacagactac acttttaagg
1741 cctattttca caatggagac tatcctggag aaccctttat tttacatcat tcaacatctt
1801 ataattctaa ggcactgata gcatttctgg catttctgat tattgtgaca tcaatagccc
1861 tgcttgttgt tctctacaaa atctatgatc tacataagaa aagatcctgc aatttagatg
1921 aacagcagga gcttgttgaa agggatgatg aaaaacaact gatgaatgtg gagccaatcc
1981 atgcagatat tttgttggaa acttataaga ggaagattgc tgatgaagga agaccttttc
2041 tggctgaatt tcagagcatc ccgcgggtgt tcagcaagtt tcctataaag gaagctcgaa
2101 agccctttaa ccagaataaa aaccgttatg ttgacattct tccttatgat tataaccgtg
2161 ttgaactctc tgagataaac ggagatgcag ggtcaaacta cataaatgcc agctatattg
2221 atggtttcaa agaacccagg aaatacattg ctgcacaagg tcccagggat gaaactgttg
2281 atgatttctg gaggatgatt tgggaacaga aagccacagt tattgtcatg gtcactcgat
2341 gtgaagaagg aaacaggaac aagtgtgcag aatactggcc gtcaatggaa gagggcactc
2401 gggcttttgg agatgttgtt gtaaagatca accagcacaa aagatgtcca gattacatca
2461 ttcagaaatt gaacattgta aataaaaaag aaaaagcaac tggaagagag gtgactcaca
2521 ttcagttcac cagctggcca gaccacgggg tgcctgagga tcctcacttg ctcctcaaac
2581 tgagaaggag agtgaatgcc ttcagcaatt tcttcagtgg tcccattgtg gtgcactgca
2641 gtgctggtgt tgggcgcaca ggaacctata tcggaattga tgccatgcta gaaggcttgg
2701 aagccgagaa caaagtggat gtttatggtt atgttgtcaa gctaaggcga cagagatgcc
2761 tgatggttca agtagaggcc cagtacatct tgatccatca ggctttggtg gaatacaatc
2821 agtttggaga aacagaagtg aatttgtctg aattacatcc atatctacat aacatgaaga
2881 aaagggatcc acccagtgag ccgtctccac tagaggctga attccagaga cttccttcat
2941 ataggagctg gaggacacag cacattggaa atcaagaaga aaataaaagt aaaaacagga
3001 attctaatgt catcccatat gactataaca gagtgccact taaacatgag ctggaaatga
3061 gtaaagagag tgagcatgat tcagatgaat cctctgatga tgacagtgat tcagaggaac
3121 caagcaaata catcaatgca tcttttataa tgagctactg gaaacctgaa gtgatgattg
3181 ctgctcaggg accactgaag gagaccattg gtgacttttg gcagatgatc ttccaaagaa
3241 aagtcaaagt tattgttatg ctgacagaac tgaaacatgg agaccaggaa atctgtgctc
3301 agtactgggg agaaggaaag caaacatatg gagatattga agttgacctg aaagacacag
3361 acaaatcttc aacttatacc cttcgtgtct ttgaactgag acattccaag aggaaagact
3421 ctcgaactgt gtaccagtac caatatacaa actggagtgt ggagcagctt cctgcagaac
3481 ccaaggaatt aatctctatg attcaggtcg tcaaacaaaa acttccccag aagaattcct
3541 ctgaagggaa caagcatcac aagagtacac ctctactcat tcactgcagg gatggatctc
3601 agcaaacggg aatattttgt gctttgttaa atctcttaga aagtgcggaa acagaagagg
3661 tagtggatat ttttcaagtg gtaaaagctc tacgcaaagc taggctaggc atggtttcca
3721 cattcgagca atatcaattc ctatatgacg tcattgccag cacctaccct gctcagaatg
3781 gacaagtaaa gaaaaacaac catcaagaag ataaaattga atttgataat gaagtggaca
3841 aagtaaagca ggatgctaat tgtgttaatc cacttggtgc cccagaaaag ctccctgaag
3901 caaaggaaca ggctgaaggt tctgaaccca cgagtggcac tgaggggcca gaacattctg
3961 tcaatggtcc tgcaagtcca gctttaaatc aaggttcata ggaaaagaca taaatgagga
4021 aactccaaac ctcctgttag ctgttatttc tatttttgta gaagtaggaa gtgaaaatag
4081 gtatacagtg gattaattaa atgcagcgaa ccaatatttg tagaagggtt atattttact
4141 actgtggaaa aatatttaag atagttttgc cagaacagtt tgtacagacg tatgcttatt
4201 ttaaaatttt atctcttatt cagtaaaaaa caacttcttt gtaatcgtta tgagtgtata
4261 tgtatgtgtg tatgggtgtg tgtttgtgtg agagacagag aaagagagag aattc
//