LOCUS Y00630 1900 bp mRNA linear HUM 07-OCT-2008 DEFINITION Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2, PAI-2). ACCESSION Y00630 VERSION Y00630.1 KEYWORDS anti-urokinase; plasminogen activator-inhibitor type 2. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1900) AUTHORS Webb A.C. JOURNAL Submitted (12-JUN-1987) to the INSDC. Andrew C. Webb, Department of Biological Sciences, Wellesley College, Wellesley, MA 02181, USA. REFERENCE 2 AUTHORS Webb A.C., Collins K.L., Snyder S.F., Alexander S.J., Rosenwasser L.J., Eddy R.L., Shows T.B., Auron P.E. TITLE Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor JOURNAL J. Exp. Med. 166(1), 77-94(1987). PUBMED 3496414 COMMENT *source=LPS-stimulated monocytes; clone=pcD-1214 PAI-2 is a member CC of the serine protease inhibitor (serpin) superfamily. It inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. FEATURES Location/Qualifiers source 1..1900 /db_xref="H-InvDB:HIT000325296" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 73..1320 /note="PAI-2 precursor (AA -22 to 393)" /db_xref="GOA:P05120" /db_xref="H-InvDB:HIT000325296.14" /db_xref="HGNC:HGNC:8584" /db_xref="InterPro:IPR000215" /db_xref="InterPro:IPR015556" /db_xref="InterPro:IPR023795" /db_xref="InterPro:IPR023796" /db_xref="InterPro:IPR036186" /db_xref="InterPro:IPR042178" /db_xref="InterPro:IPR042185" /db_xref="PDB:1BY7" /db_xref="PDB:1JRR" /db_xref="PDB:2ARQ" /db_xref="PDB:2ARR" /db_xref="UniProtKB/Swiss-Prot:P05120" /protein_id="CAA68666.1" /translation="MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYM GSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADK IHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLE CAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNG LYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVS TGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFN KGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADH PFLFLIMHKITNCILFFGRFSSP" sig_peptide 73..138 /note="signal peptide (AA -22 to -1)" mat_peptide 139..1317 /note="PAI-2 (AA 1 - 393)" misc_feature 295..297 /note="N-glycosylation site" misc_feature 415..417 /note="N-glycosylation site" misc_feature 1087..1089 /note="N-glycosylation site" misc_feature 1210..1212 /note="active site of PAI-2" misc_feature 1568..1577 /note="AT-rich sequence (pot. RNase target)" misc_feature 1597..1609 /note="AT-rich sequence (pot. RNase target)" misc_feature 1647..1703 /note="AT-rich sequence (pot. RNase target)" BASE COUNT 592 a 393 c 380 g 535 t ORIGIN 1 acaactctca gaggagcatt gcccgtcaga cagcaactca gagaataacc agagaacaac 61 cagattgaaa caatggagga tctttgtgtg gcaaacacac tctttgccct caatttattc 121 aagcatctgg caaaagcaag ccccacccag aacctcttcc tctccccatg gagcatctcg 181 tccaccatgg ccatggtcta catgggctcc aggggcagca ccgaagacca gatggccaag 241 gtgcttcagt ttaatgaagt gggagccaat gcagttaccc ccatgactcc agagaacttt 301 accagctgtg ggttcatgca gcagatccag aagggtagtt atcctgatgc gattttgcag 361 gcacaagctg cagataaaat ccattcatcc ttccgctctc tcagctctgc aatcaatgca 421 tccacaggga attatttact ggaaagtgtc aataagctgt ttggtgagaa gtctgcgagc 481 ttccgggaag aatatattcg actctgtcag aaatattact cctcagaacc ccaggcagta 541 gacttcctag aatgtgcaga agaagctaga aaaaagatta attcctgggt caagactcaa 601 accaaaggca aaatcccaaa cttgttacct gaaggttctg tagatgggga taccaggatg 661 gtcctggtga atgctgtcta cttcaaagga aagtggaaaa ctccatttga gaagaaacta 721 aatgggcttt atcctttccg tgtaaactcg gctcagcgca cacctgtaca gatgatgtac 781 ttgcgtgaaa agctaaacat tggatacata gaagacctaa aggctcagat tctagaactc 841 ccatatgctg gagatgttag catgttcttg ttgcttccag atgaaattgc cgatgtgtcc 901 actggcttgg agctgctgga aagtgaaata acctatgaca aactcaacaa gtggaccagc 961 aaagacaaaa tggctgaaga tgaagttgag gtatacatac cccagttcaa attagaagag 1021 cattatgaac tcagatccat tctgagaagc atgggcatgg aggacgcctt caacaaggga 1081 cgggccaatt tctcagggat gtcggagagg aatgacctgt ttctttctga agtgttccac 1141 caagccatgg tggatgtgaa tgaggagggc actgaagcag ccgctggcac aggaggtgtt 1201 atgacaggga gaactggaca tggaggccca cagtttgtgg cagatcatcc ttttcttttt 1261 cttattatgc ataagataac caactgcatt ttatttttcg gcagattttc ctcaccctaa 1321 aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc tcagaattgc 1381 tatttcaaat tgccaaaaat ttagagatgt tttctacata tttctgctct tctgaacaac 1441 ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat tataacatga 1501 caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga ttttccttac 1561 tatcagttta tttttataac attaactttt actttgttat ttattatttt atataatggt 1621 gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta tagaagcaga 1681 tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg aagaataagt 1741 aggtaccctc catgcccttc tgtaataaat atctggaaaa aacattaaac aataggcaaa 1801 tatatgttat gtgcatttct agaaatacat aacacatata tatgtctgta tcttatattc 1861 aattgcaagt atataataaa taaacctgct tccaaacaac //