LOCUS       Y00630                  1900 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for Arg-Serpin (plasminogen activator-inhibitor 2,
            PAI-2).
ACCESSION   Y00630
VERSION     Y00630.1
KEYWORDS    anti-urokinase; plasminogen activator-inhibitor type 2.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Webb A.C.
  JOURNAL   Submitted (12-JUN-1987) to the INSDC. Andrew C. Webb, Department of
            Biological Sciences, Wellesley College, Wellesley, MA 02181, USA.
REFERENCE   2
  AUTHORS   Webb A.C., Collins K.L., Snyder S.F., Alexander S.J.,
            Rosenwasser L.J., Eddy R.L., Shows T.B., Auron P.E.
  TITLE     Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment,
            and homology to plasminogen activator-inhibitor
  JOURNAL   J. Exp. Med. 166(1), 77-94(1987).
   PUBMED   3496414
COMMENT     *source=LPS-stimulated monocytes; clone=pcD-1214
            PAI-2 is a member CC   of the serine protease inhibitor (serpin)
            superfamily. It inhibits urokinase-type plasminogen activator.
            The monocyte derived PAI-2 is distinct from the endothelial
            cell-derived PAI-1.
FEATURES             Location/Qualifiers
     source          1..1900
                     /db_xref="H-InvDB:HIT000325296"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             73..1320
                     /note="PAI-2 precursor (AA -22 to 393)"
                     /db_xref="GOA:P05120"
                     /db_xref="H-InvDB:HIT000325296.14"
                     /db_xref="HGNC:HGNC:8584"
                     /db_xref="InterPro:IPR000215"
                     /db_xref="InterPro:IPR015556"
                     /db_xref="InterPro:IPR023795"
                     /db_xref="InterPro:IPR023796"
                     /db_xref="InterPro:IPR036186"
                     /db_xref="InterPro:IPR042178"
                     /db_xref="InterPro:IPR042185"
                     /db_xref="PDB:1BY7"
                     /db_xref="PDB:1JRR"
                     /db_xref="PDB:2ARQ"
                     /db_xref="PDB:2ARR"
                     /db_xref="UniProtKB/Swiss-Prot:P05120"
                     /protein_id="CAA68666.1"
                     /translation="MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYM
                     GSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADK
                     IHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLE
                     CAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNG
                     LYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVS
                     TGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFN
                     KGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADH
                     PFLFLIMHKITNCILFFGRFSSP"
     sig_peptide     73..138
                     /note="signal peptide (AA -22 to -1)"
     mat_peptide     139..1317
                     /note="PAI-2 (AA 1 - 393)"
     misc_feature    295..297
                     /note="N-glycosylation site"
     misc_feature    415..417
                     /note="N-glycosylation site"
     misc_feature    1087..1089
                     /note="N-glycosylation site"
     misc_feature    1210..1212
                     /note="active site of PAI-2"
     misc_feature    1568..1577
                     /note="AT-rich sequence (pot. RNase target)"
     misc_feature    1597..1609
                     /note="AT-rich sequence (pot. RNase target)"
     misc_feature    1647..1703
                     /note="AT-rich sequence (pot. RNase target)"
BASE COUNT          592 a          393 c          380 g          535 t
ORIGIN      
        1 acaactctca gaggagcatt gcccgtcaga cagcaactca gagaataacc agagaacaac
       61 cagattgaaa caatggagga tctttgtgtg gcaaacacac tctttgccct caatttattc
      121 aagcatctgg caaaagcaag ccccacccag aacctcttcc tctccccatg gagcatctcg
      181 tccaccatgg ccatggtcta catgggctcc aggggcagca ccgaagacca gatggccaag
      241 gtgcttcagt ttaatgaagt gggagccaat gcagttaccc ccatgactcc agagaacttt
      301 accagctgtg ggttcatgca gcagatccag aagggtagtt atcctgatgc gattttgcag
      361 gcacaagctg cagataaaat ccattcatcc ttccgctctc tcagctctgc aatcaatgca
      421 tccacaggga attatttact ggaaagtgtc aataagctgt ttggtgagaa gtctgcgagc
      481 ttccgggaag aatatattcg actctgtcag aaatattact cctcagaacc ccaggcagta
      541 gacttcctag aatgtgcaga agaagctaga aaaaagatta attcctgggt caagactcaa
      601 accaaaggca aaatcccaaa cttgttacct gaaggttctg tagatgggga taccaggatg
      661 gtcctggtga atgctgtcta cttcaaagga aagtggaaaa ctccatttga gaagaaacta
      721 aatgggcttt atcctttccg tgtaaactcg gctcagcgca cacctgtaca gatgatgtac
      781 ttgcgtgaaa agctaaacat tggatacata gaagacctaa aggctcagat tctagaactc
      841 ccatatgctg gagatgttag catgttcttg ttgcttccag atgaaattgc cgatgtgtcc
      901 actggcttgg agctgctgga aagtgaaata acctatgaca aactcaacaa gtggaccagc
      961 aaagacaaaa tggctgaaga tgaagttgag gtatacatac cccagttcaa attagaagag
     1021 cattatgaac tcagatccat tctgagaagc atgggcatgg aggacgcctt caacaaggga
     1081 cgggccaatt tctcagggat gtcggagagg aatgacctgt ttctttctga agtgttccac
     1141 caagccatgg tggatgtgaa tgaggagggc actgaagcag ccgctggcac aggaggtgtt
     1201 atgacaggga gaactggaca tggaggccca cagtttgtgg cagatcatcc ttttcttttt
     1261 cttattatgc ataagataac caactgcatt ttatttttcg gcagattttc ctcaccctaa
     1321 aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc tcagaattgc
     1381 tatttcaaat tgccaaaaat ttagagatgt tttctacata tttctgctct tctgaacaac
     1441 ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat tataacatga
     1501 caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga ttttccttac
     1561 tatcagttta tttttataac attaactttt actttgttat ttattatttt atataatggt
     1621 gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta tagaagcaga
     1681 tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg aagaataagt
     1741 aggtaccctc catgcccttc tgtaataaat atctggaaaa aacattaaac aataggcaaa
     1801 tatatgttat gtgcatttct agaaatacat aacacatata tatgtctgta tcttatattc
     1861 aattgcaagt atataataaa taaacctgct tccaaacaac
//