LOCUS Y00318 1965 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for complement control protein factor I.
ACCESSION Y00318 M25615
VERSION Y00318.1
KEYWORDS complement control protein factor I; serine proteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1965)
AUTHORS Lyons A.
JOURNAL Submitted (27-MAY-1987) to the INSDC. Alan Lyons , Celltech Ltd,
250 Bath Road, Slough, Berks, England.
REFERENCE 2
AUTHORS Catterall C.F., Lyons A., Sim R.B., Day A.J., Harris T.J.R.
TITLE Characterization of primary amino acid sequence of human complement
control protein factor I from an analysis of cDNA clones
JOURNAL Biochem. J. 242(3), 849-856(1987).
PUBMED 2954545
COMMENT Data kindly reviewed (25-JUN-1987) by Lyons A.
FEATURES Location/Qualifiers
source 1..1965
/db_xref="H-InvDB:HIT000325280"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="PFI29, lambda FI"
/tissue_type="liver"
/db_xref="taxon:9606"
misc_feature 31..83
/note="5'leader sequence"
CDS <84..1781
/note="factor I"
/db_xref="GOA:P05156"
/db_xref="H-InvDB:HIT000325280.14"
/db_xref="HGNC:HGNC:5394"
/db_xref="InterPro:IPR001190"
/db_xref="InterPro:IPR001254"
/db_xref="InterPro:IPR001314"
/db_xref="InterPro:IPR002172"
/db_xref="InterPro:IPR002350"
/db_xref="InterPro:IPR003884"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR017448"
/db_xref="InterPro:IPR018114"
/db_xref="InterPro:IPR023415"
/db_xref="InterPro:IPR033116"
/db_xref="InterPro:IPR036055"
/db_xref="InterPro:IPR036058"
/db_xref="InterPro:IPR036772"
/db_xref="PDB:2XRC"
/db_xref="PDB:5O32"
/db_xref="UniProtKB/Swiss-Prot:P05156"
/protein_id="CAA68416.1"
/translation="KVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCVCK
LPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINS
TECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYIS
QMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA
GFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLP
WQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIE
YVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCI
VSGWGREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSG
GPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV"
CDS <84..>1046
/note="heavy chain of factor I"
/db_xref="GOA:Q6LAM1"
/db_xref="InterPro:IPR001190"
/db_xref="InterPro:IPR002172"
/db_xref="InterPro:IPR002350"
/db_xref="InterPro:IPR003884"
/db_xref="InterPro:IPR017448"
/db_xref="InterPro:IPR023415"
/db_xref="InterPro:IPR036055"
/db_xref="InterPro:IPR036058"
/db_xref="InterPro:IPR036772"
/db_xref="UniProtKB/TrEMBL:Q6LAM1"
/protein_id="CAA68417.1"
/translation="KVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCVCK
LPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINS
TECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYIS
QMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA
GFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKR"
CDS <1047..1781
/note="light chain of factor I"
/db_xref="GOA:Q6LAM0"
/db_xref="InterPro:IPR001254"
/db_xref="InterPro:IPR001314"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR018114"
/db_xref="InterPro:IPR033116"
/db_xref="UniProtKB/TrEMBL:Q6LAM0"
/protein_id="CAA68418.1"
/translation="IVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLR
ASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNK
KDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFY
GNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPG
VYTKVANYFDWISYHVGRPFISQYNV"
BASE COUNT 604 a 358 c 457 g 544 t
ORIGIN
1 gagagacaaa gaccccgaac acctccaaca tgaagcttct tcatgttttc ctgttatttc
61 tgtgcttcca cttaaggttt tgcaaggtca cttatacatc tcaagaggat ctggtggaga
121 aaaagtgctt agcaaaaaaa tatactcacc tctcctgcga taaagtcttc tgccagccat
181 ggcagagatg cattgagggc acctgtgttt gtaaactacc gtatcagtgc ccaaagaatg
241 gcactgcagt gtgtgcaact aacaggagaa gcttcccaac atactgtcaa caaaagagtt
301 tggaatgtct tcatccaggg acaaagtttt taaataacgg aacatgcaca gccgaaggaa
361 agtttagtgt ttccttgaag catggaaata cagattcaga gggaatagtt gaagtaaaac
421 ttgtggacca agataagaca atgttcatat gcaaaagcag ctggagcatg agggaagcca
481 acgtggcctg ccttgacctt gggtttcaac aaggtgctga tactcaaaga aggtttaagt
541 tgtctgatct ctctataaat tccactgaat gtctacatgt gcattgccga ggattagaga
601 ccagtttggc tgaatgtact tttactaaga gaagaactat gggttaccag gatttcgctg
661 atgtggtttg ttatacacag aaagcagatt ctccaatgga tgacttcttt cagtgtgtga
721 atgggaaata catttctcag atgaaagcct gtgatggtat caatgattgt ggagaccaaa
781 gtgatgaact gtgttgtaaa gcatgccaag gcaaaggctt ccattgcaaa tcgggtgttt
841 gcattccaag ccagtatcaa tgcaatggtg aggtggactg cattacaggg gaagatgaag
901 ttggctgtgc aggctttgca tctgtggctc aagaagaaac agaaattttg actgctgaca
961 tggatgcaga aagaagacgg ataaaatcat tattacctaa actatcttgt ggagttaaaa
1021 acagaatgca cattcgaagg aaacgaattg tgggaggaaa gcgagcacaa ctgggagacc
1081 tcccatggca ggtggcaatt aaggatgcca gtggaatcac ctgtggggga atttatattg
1141 gtggctgttg gattctgact gctgcacatt gtctcagagc cagtaaaact catcgttacc
1201 aaatatggac aacagtagta gactggatac accccgacct taaacgtata gtaattgaat
1261 acgtggatag aattattttc catgaaaact acaatgcagg cacttaccaa aatgacatcg
1321 ctttgattga aatgaaaaaa gacggaaaca aaaaagattg tgagctgcct cgttccatcc
1381 ctgcctgtgt cccctggtct ccttacctat tccaacctaa tgatacatgc atcgtttctg
1441 gctggggacg agaaaaagat aacgaaagag tcttttcact tcagtggggt gaagttaaac
1501 taataagcaa ctgctctaag ttttacggaa atcgtttcta tgaaaaagaa atggaatgtg
1561 caggtacata tgatggttcc atcgatgcct gtaaagggga ctctggaggc cccttagtct
1621 gtatggatgc caacaatgtg acttatgtct ggggtgttgt gagttggggg gaaaactgtg
1681 gaaaaccaga gttcccaggt gtttacacca aagtggccaa ttattttgac tggattagct
1741 accatgtagg aaggcctttt atttctcagt acaatgtata aaattgtgat ctctctcttc
1801 attctattct ttttctctca agagttccat ttaatggaaa taaaacggta taattaataa
1861 ttctctaggg gggaaaaatg aagcaaatct cattggatat ttttaaaggt ctccacagag
1921 tttatgccat attggaattt tgttgtataa ttctcnngcg aattc
//