LOCUS       Y00109                  1980 bp    mRNA    linear   HUM 23-MAR-1995
DEFINITION  Human mRNA for mitochondrial aldehyde dehydrogenase (ALDH I).
ACCESSION   Y00109
VERSION     Y00109.1
KEYWORDS    aldehyde dehydrogenase; dehydrogenase; signal peptide.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Braun T.
  JOURNAL   Submitted (30-MAR-1987) to the INSDC. Thomas Braun, Institute of
            Human Genetics, University of Hamburg, Institut fuer Humangenetik,
            2000 Hamburg 54, Butenfeld 32, Fed. Rep. , Germ.
REFERENCE   2
  AUTHORS   Braun T., Bober E., Singh S., Agarwal D.P., Goedde H.W.
  TITLE     Isolation and sequence analysis of a full length cDNA clone coding
            for human mitochondrial aldehyde dehydrogenase
  JOURNAL   Nucleic Acids Res. 15(7), 3179-3179(1987).
   PUBMED   3562250
COMMENT     see x05409 for further ALDHI cDNA sequence
FEATURES             Location/Qualifiers
     source          1..1980
                     /db_xref="H-InvDB:HIT000325271"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="fetal (22th week)"
                     /clone_lib="human fetal muscle cDNA"
                     /tissue_type="muscle"
                     /db_xref="taxon:9606"
     CDS             31..1578
                     /note="precursor polypeptide (AA -36 to 479)"
                     /db_xref="GOA:P05091"
                     /db_xref="H-InvDB:HIT000325271.13"
                     /db_xref="HGNC:HGNC:404"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="InterPro:IPR029510"
                     /db_xref="PDB:1CW3"
                     /db_xref="PDB:1NZW"
                     /db_xref="PDB:1NZX"
                     /db_xref="PDB:1NZZ"
                     /db_xref="PDB:1O00"
                     /db_xref="PDB:1O01"
                     /db_xref="PDB:1O02"
                     /db_xref="PDB:1O04"
                     /db_xref="PDB:1O05"
                     /db_xref="PDB:1ZUM"
                     /db_xref="PDB:2ONM"
                     /db_xref="PDB:2ONN"
                     /db_xref="PDB:2ONO"
                     /db_xref="PDB:2ONP"
                     /db_xref="PDB:2VLE"
                     /db_xref="PDB:3INJ"
                     /db_xref="PDB:3INL"
                     /db_xref="PDB:3N80"
                     /db_xref="PDB:3N81"
                     /db_xref="PDB:3N82"
                     /db_xref="PDB:3N83"
                     /db_xref="PDB:3SZ9"
                     /db_xref="PDB:4FQF"
                     /db_xref="PDB:4FR8"
                     /db_xref="PDB:4KWF"
                     /db_xref="PDB:4KWG"
                     /db_xref="PDB:5L13"
                     /db_xref="UniProtKB/Swiss-Prot:P05091"
                     /protein_id="CAA68290.1"
                     /translation="MLRAAAAWPAWAPPLVSRRHPGRAAPNQQPEVFCNQIFINNEWH
                     DAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAREGRPGAFQLGSPWRRMDASHRGRL
                     LNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIP
                     IDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALY
                     VANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSN
                     LKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFV
                     VRSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR
                     GYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKD
                     LDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTV
                     KVPQKNS"
     sig_peptide     31..138
                     /note="put. signal peptide (AA -36 to -1)"
     mat_peptide     139..1575
                     /note="mature ALDHI (AA 1-479)"
     variation       1534..1534
                     /note="postulated site for point mutation (g --> a
                     substitution)"
     misc_feature    1962..1967
                     /note="polyA signal"
     polyA_site      1980..1980
                     /note="polyA site"
BASE COUNT          466 a          515 c          563 g          436 t
ORIGIN      
        1 ggtcccctcc ctgtccgcta gcccgctgcg atgttgcgcg ctgccgccgc ttggcccgcc
       61 tgggcgccgc ctcttgtcag ccgccgccac ccaggccgtg ctgcccccaa ccagcagccc
      121 gaggtcttct gcaaccagat tttcataaac aatgaatggc acgatgccgt cagcaggaaa
      181 acattcccca ccgtcaatcc gtccactgga gaggtcatct gtcaggtagc tgaaggggac
      241 aaggaagatg tggacaaggc acgtgaaggc cgcccgggcg ccttccagct gggctcacct
      301 tggcgccgca tggacgcatc acacaggggc cggctgctga accgcctggc cgatctgatc
      361 gagcgggacc ggacctacct ggcggccttg gagaccctgg acaatggcaa gccctatgtc
      421 atctcctacc tggtggattt ggacatggtc ctcaaatgtc tccggtatta tgccggctgg
      481 gctgataagt accacgggaa aaccatcccc attgacggag acttcttcag ctacacacgc
      541 catgaacctg tgggggtgtg cgggcagatc attccgtgga atttcccgct cctgatgcaa
      601 gcatggaagc tgggcccagc cttggcaact ggaaacgtgg ttgtgatgaa ggtagctgag
      661 cagacacccc tcaccgccct ctatgtggcc aacctgatca aggaggctgg ctttccccct
      721 ggtgtggtca acattgtgcc tggatttggc cccacggctg gggccgccat tgcctcccat
      781 gaggatgtgg acaaagtggc attcacaggc tccactgaga ttggccgcgt aatccaggtt
      841 gctgctggga gcagcaacct caagagagtg accttggagc tgggggggaa gagccccaac
      901 atcatcatgt cagatgccga tatggattgg gccgtggaac aggcccactt cgccctgttc
      961 ttcaaccagg gccagtgctg ctgtgccggc tcccggacct tcgtgcagga ggacatctat
     1021 gatgagtttg tggtgcggag cgttgcccgg gccaagtctc gggtggtcgg gaaccccttt
     1081 gatagcaaga ccgagcaggg gccgcaggtg gatgaaactc agtttaagaa gatcctcggc
     1141 tacatcaaca cggggaagca agagggggcg aagctgctgt gtggtggggg cattgctgct
     1201 gaccgtggtt acttcatcca gcccactgtg tttggagatg tgcaggatgg catgaccatc
     1261 gccaaggagg agatcttcgg gccagtgatg cagatcctga agttcaagac catagaggag
     1321 gttgttggga gagccaacaa ttccacgtac gggctggccg cagctgtctt cacaaaggat
     1381 ttggacaagg ccaattacct gtcccaggcc ctccaggcgg gcactgtgtg ggtcaactgc
     1441 tatgatgtgt ttggagccca gtcacccttt ggtggctaca agatgtcggg gagtggccgg
     1501 gagttgggcg agtacgggct gcaggcatac actgaagtga aaactgtcac agtcaaagtg
     1561 cctcagaaga actcataaga atcatgcaag cttcctccct cagccattga tggaaagttc
     1621 agcaagatca gcaacaaaac caagaaaaat gatccttgcg tgctgaatat ctgaaaagag
     1681 aaatttttcc tacaaaatct cttgggtcaa gaaagttcta gaatttgaat tgataaacat
     1741 ggtgggttgg ctgagggtaa gagtatatga ggaacctttt aaacgacaac aatactgcta
     1801 gctttcagga tgatttttaa aaaatagatt caaatgtgtt atcctctctc tgaaacgctt
     1861 cctataactc gagtttatag gggaagaaaa agctattgtt tacaattata tcaccattaa
     1921 ggcaactgct acaccctgct ttgtattctg ggctaagatt cattaaaaac tagctgctct
//