LOCUS Y00064 2454 bp mRNA linear HUM 07-OCT-2008
DEFINITION Human mRNA for secretogranin I (chromogranin B).
ACCESSION Y00064
VERSION Y00064.1
KEYWORDS chromogranin B; phosphoprotein; secretogranin I; secretory protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2454)
AUTHORS Huttner W.B.
JOURNAL Submitted (10-APR-1987) to the INSDC. Huttner W.B., EMBL,
Meyerhofstr.1, 6900 Heidelberg.
REFERENCE 2 (bases 1 to 2454)
AUTHORS Benedum U.M., Lamouroux A., Konecki D.S., Hille A., Baeuerle P.A.,
Frank R., Lottspeich F., Mallet J., Huttner W.B.
TITLE The primary structure of human secretogranin I (chromogranin B):
comparison with chromogranin A reveals homologous terminal domains
and a large intervening variable region
JOURNAL EMBO J. 6(5), 1203-1211(1987).
PUBMED 3608978
COMMENT A disulfid-bond is reported between Cys-16 (bp 218-220)
and Cys-37 (bp 281-283) is reported.
Data kindly reviewed (04-JUN-1987) by W.B. Huttner
FEATURES Location/Qualifiers
source 1..2454
/db_xref="H-InvDB:HIT000325267"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="lambda gt10 cDNA"
/tissue_type="primary tumor (pheochromocytoma)"
/db_xref="taxon:9606"
CDS 113..2146
/note="precursor polypeptide (AA -20 to 657)"
/db_xref="GOA:P05060"
/db_xref="H-InvDB:HIT000325267.13"
/db_xref="HGNC:HGNC:1930"
/db_xref="InterPro:IPR001819"
/db_xref="InterPro:IPR001990"
/db_xref="InterPro:IPR018054"
/db_xref="UniProtKB/Swiss-Prot:P05060"
/protein_id="CAA68271.1"
/translation="MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNA
LSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRG
EAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKS
QREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSE
THAAGHSQEKTHSREKSSQESGEEAGSQENHPQESKGQPRSQEESEEGEEDATSEVDK
RRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRA
SEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSL
ELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQE
NQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSS
HHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEY
NYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFY
DSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG"
sig_peptide 113..172
/note="signal peptide (AA -20 to -1)"
mat_peptide 173..2143
/note="mature secretogranin I (chromogranin B) (AA 1-657)"
misc_feature 629..631
/note="tyrosine sulfation site"
misc_feature 943..945
/note="pot. N-glycosylation site"
misc_feature 1253..1255
/note="major tyrosine sulfation site"
misc_feature 2433..2438
/note="pot. polyA signal"
polyA_site 2454..2454
/note="polyA site"
BASE COUNT 779 a 545 c 715 g 415 t
ORIGIN
1 ccaggaggca cgctggtttt ccggggccgc tccatcgcgc cttcctcctg cgcctcgctt
61 ctccggtcca gccgccatct tcctttccgc acaggggccg ccgagcgggg ccatgcagcc
121 aacgctgctt ctcagcctcc tgggagccgt ggggctggcg gctgtcaatt ccatgccagt
181 ggataacagg aaccacaatg aaggaatggt gactcgctgc atcattgagg tcctctcaaa
241 tgccttgtcg aagtccagcg ctccacccat cacccctgag tgccgccaag tcctgaagac
301 gagtagaaaa gacgtcaaag acaaagagac aactgaaaat gaaaacacaa agtttgaagt
361 aagattgtta agagacccag ctgatgcctc ggaagcccac gagtcctcca gcaggggaga
421 ggcaggagcc ccaggggagg aggacatcca aggcccaaca aaggcagaca cagagaaatg
481 ggcagaggga ggcgggcaca gccgagagcg agcggatgag ccccagtgga gcctctatcc
541 ctccgacagc caagtctctg aagaagtgaa gacacgccat tctgagaaga gccagagaga
601 ggatgaggag gaggaggagg gagagaacta tcaaaaaggg gagcgagggg aagatagcag
661 tgaagagaaa caccttgaag agccaggaga gacacaaaac gcttttctca atgaaagaaa
721 gcaggcttca gctataaaaa aagaggagtt agtggccaga tcggaaacac atgctgccgg
781 gcattctcag gagaagacac atagccgaga gaagagtagc caggagagtg gagaggaggc
841 agggagccag gagaatcacc cccaggagtc taaaggccaa ccccgaagcc aggaagaatc
901 tgaggaaggt gaggaagatg ccacctctga ggtggacaaa cgacgcacga ggcccagaca
961 ccaccacggg aggagcaggc ccgacaggtc ctctcaagga gggagtcttc cctctgagga
1021 aaagggacac ccccaggagg aatctgagga gtcaaacgtc agcatggcca gtttagggga
1081 aaagagggac caccattcaa cccactacag ggcttcagag gaagaacctg aatatggaga
1141 agaaataaag ggttatccag gcgtccaggc ccctgaggac ctggagtggg agcgctatag
1201 gggcagagga agtgaagaat acagggctcc aagacctcag agtgaggaga gttgggatga
1261 ggaggacaag agaaactacc ccagcttaga gcttgataag atggcacatg gatatggtga
1321 agaaagtgag gaagagaggg gccttgagcc gggaaaggga cgccatcaca gaggcagggg
1381 aggggagcca cgtgcctatt tcatgtctga caccagagaa gagaaaaggt tcttgggtga
1441 aggacaccac cgtgtccaag aaaaccagat ggacaaggca aggaggcatc cacaaggtgc
1501 gtggaaagag ctggacagaa attatctcaa ctacggtgag gaaggagccc cagggaagtg
1561 gcagcagcag ggagacctgc aggacactaa agaaaacagg gaggaagcta ggtttcaaga
1621 taaacaatat agctcccatc acacagctga aaagaggaag agattagggg aactgttcaa
1681 cccatactac gaccctctcc agtggaagag cagccatttt gaaagaagag acaacatgaa
1741 tgacaatttt ctcgagggtg aggaggaaaa tgagctgacc ttgaacgaga agaatttctt
1801 cccagaatac aactatgact ggtgggagaa aaagcccttc tctgaggatg tgaactgggg
1861 gtatgagaag agaaacctcg ccagggtccc caagctggac ctgaaaaggc aatatgacag
1921 ggtggcccaa ctggaccagc tccttcacta caggaagaag tcagctgagt ttccagactt
1981 ctatgattct gaggagccgg tgagcaccca ccaggaggca gaaaatgaaa aggacagggc
2041 tgaccagaca gtcctgacag aggacgagaa aaaagaactc gaaaacttgg ctgcaatgga
2101 tttggaacta cagaagatag ctgagaaatt cagccaaagg ggctgactgt cattggagcg
2161 gtgggcactg ttaagaagca gccatcacat gatctgtttt tcaccacttc actgaaagac
2221 accatttata tacccaaggg cagaaagtag aacttactat tcattaaatg tttgacacaa
2281 ttggaattgt ctttaatttc tgtcagaatg ctattgaaaa tgtgaattgc atgacttgta
2341 gcatattctt ttctgcaaaa tagacatatt aacatgctta tgacaatgac tgtgctactg
2401 tctttggaaa aatgtttgtc tcagttggaa ataataaaag attcacctga gacc
//