LOCUS Y00062 4597 bp mRNA linear HUM 21-OCT-2008
DEFINITION Human mRNA for T200 leukocyte common antigen (CD45, LC-A).
ACCESSION Y00062
VERSION Y00062.1
KEYWORDS alternative splicing; cell surface antigen; cell surface
glycoprotein; leukocyte common antigen; phosphoprotein; T200
glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4597)
AUTHORS Trowbridge I.S.
JOURNAL Submitted (10-JUN-1987) to the INSDC. Trowbridge I.S. The Salk
Institute, P.O. Box 85800 San Diego, CA 92138-926 USA.
REFERENCE 2 (bases 1 to 4597)
AUTHORS Ralph S.J., Thomas M.L., Morton C.C., Trowbridge I.S.
TITLE Structural variants of human T200 glycoprotein (leukocyte-common
antigen)
JOURNAL EMBO J. 6(5), 1251-1257(1987).
PUBMED 2956090
FEATURES Location/Qualifiers
source 1..4597
/db_xref="H-InvDB:HIT000325266"
/organism="Homo sapiens"
/map="long arm of chromosome 1"
/mol_type="mRNA"
/clone_lib="pcD and lambda gt10"
/clone="pHLC-1 and lambdaHLC-1"
/cell_line="IB4 (human B cell, human tonsil)"
/db_xref="taxon:9606"
CDS 147..3578
/note="precursor polypeptide (AA -23 to 1120)"
/db_xref="GOA:P08575"
/db_xref="H-InvDB:HIT000325266.15"
/db_xref="HGNC:HGNC:9666"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016130"
/db_xref="InterPro:IPR016335"
/db_xref="InterPro:IPR024739"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR036116"
/db_xref="PDB:1YGR"
/db_xref="PDB:1YGU"
/db_xref="PDB:5FMV"
/db_xref="PDB:5FN6"
/db_xref="PDB:5FN7"
/db_xref="UniProtKB/Swiss-Prot:P08575"
/protein_id="CAA68269.1"
/translation="MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLS
PSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTC
TNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICL
KWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNA
SKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDK
NLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS
DNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAY
FHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLD
EQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKE
ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPR
DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHK
RCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF
SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYI
LIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQH
IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYIN
ASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG
EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPK
ELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEE
VVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNE
VDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS"
sig_peptide 147..215
/note="signal peptide (AA -23 to -1)"
mat_peptide 216..3575
/note="mature T200 glycoprotein (Aa 1-1120)"
misc_feature 252..260
/note="N-glycosylation site"
misc_feature 357..365
/note="N-glycosylation site"
misc_feature 441..449
/note="N-glycosylation site"
misc_feature 471..479
/note="N-glycosylation site"
misc_feature 489..497
/note="N-glycosylation site"
misc_feature 666..674
/note="N-glycosylation site"
misc_feature 795..803
/note="N-glycosylation site"
misc_feature 918..926
/note="N-glycosylation site"
misc_feature 1065..1073
/note="N-glycosylation site"
misc_feature 1125..1133
/note="N-glycosylation site"
misc_feature 1248..1256
/note="N-glycosylation site"
misc_feature 1389..1454
/note="put. transmembrane region"
polyA_site 4574..4579
/note="region of polyA site"
BASE COUNT 1554 a 809 c 912 g 1322 t
ORIGIN
1 cgacatttta actgaactgc gggataaagt gaaatctttc cgtgcagctc tacgagagga
61 ggaaattgtt cctcgtctga taagacaaca gtggagaaag gacgcatgct gtttcttagg
121 gacacggctg acttccagat atgaccatgt atttgtggct taaactcttg gcatttggct
181 ttgcctttct ggacacagaa gtatttgtga cagggcaaag cccaacacct tcccccactg
241 atgcctacct taatgcctct gaaacaacca ctctgagccc ttctggaagc gctgtcattt
301 caaccacaac aatagctact actccatcta agccaacatg tgatgaaaaa tatgcaaaca
361 tcactgtgga ttacttatat aacaaggaaa ctaaattatt tacagcaaag ctaaatgtta
421 atgagaatgt ggaatgtgga aacaatactt gcacaaacaa tgaggtgcat aaccttacag
481 aatgtaaaaa tgcgtctgtt tccatatctc ataattcatg tactgctcct gataagacat
541 taatattaga tgtgccacca ggggttgaaa agtttcagtt acatgattgt acacaagttg
601 aaaaagcaga tactactatt tgtttaaaat ggaaaaatat tgaaaccttt acttgtgata
661 cacagaatat tacctacaga tttcagtgtg gtaatatgat atttgataat aaagaaatta
721 aattagaaaa ccttgaaccc gaacatgagt ataagtgtga ctcagaaata ctctataata
781 accacaagtt tactaacgca agtaaaatta ttaaaacaga ttttgggagt ccaggagagc
841 ctcagattat tttttgtaga agtgaagctg cacatcaagg agtaattacc tggaatcccc
901 ctcaaagatc atttcataat tttaccctct gttatataaa agagacagaa aaagattgcc
961 tcaatctgga taaaaacctg atcaaatatg atttgcaaaa tttaaaacct tatacgaaat
1021 atgttttatc attacatgcc tacatcattg caaaagtgca acgtaatgga agtgctgcaa
1081 tgtgtcattt cacaactaaa agtgctcctc caagccaggt ctggaacatg actgtctcca
1141 tgacatcaga taatagtatg catgtcaagt gtaggcctcc cagggaccgt aatggccccc
1201 atgaacgtta ccatttggaa gttgaagctg gaaatactct ggttagaaat gagtcgcata
1261 agaattgcga tttccgtgta aaagatcttc aatattcaac agactacact tttaaggcct
1321 attttcacaa tggagactat cctggagaac cctttatttt acatcattca acatcttata
1381 attctaaggc actgatagca tttctggcat ttctgattat tgtgacatca atagccctgc
1441 ttgttgttct ctacaaaatc tatgatctac ataagaaaag atcctgcaat ttagatgaac
1501 agcaggagct tgttgaaagg gatgatgaaa aacaactgat gaatgtggag ccaatccatg
1561 cagatatttt gttggaaact tataagagga agattgctga tgaaggaaga ctttttctgg
1621 ctgaatttca gagcatcccg cgggtgttca gcaagtttcc tataaaggaa gctcgaaagc
1681 cctttaacca gaataaaaac cgttatgttg acattcttcc ttatgattat aaccgtgttg
1741 aactctctga gataaacgga gatgcagggt caaactacat aaatgccagc tatattgatg
1801 gtttcaaaga acccaggaaa tacattgctg cacaaggtcc cagggatgaa actgttgatg
1861 atttctggag gatgatttgg gaacagaaag ccacagttat tgtcatggtc actcgatgtg
1921 aagaaggaaa caggaacaag tgtgcagaat actggccgtc aatggaagag ggcactcggg
1981 cttttggaga tgttgttgta aagatcaacc agcacaaaag atgtccagat tacatcattc
2041 agaaattgaa cattgtaaat aaaaaagaaa aagcaactgg aagagaggtg actcacattc
2101 agttcaccag ctggccagac cacggggtgc ctgaggatcc tcacttgctc ctcaaactga
2161 gaaggagagt gaatgccttc agcaatttct tcagtggtcc cattgtggtg cactgcagtg
2221 ctggtgttgg gcgcacagga acctatatcg gaattgatgc catgctagaa ggcctggaag
2281 ccgagaacaa agtggatgtt tatggttatg ttgtcaagct aaggcgacag agatgcctga
2341 tggttcaagt agaggcccag tacatcttga tccatcaggc tttggtggaa tacaatcagt
2401 ttggagaaac agaagtgaat ttgtctgaat tacatccata tctacataac atgaagaaaa
2461 gggatccacc cagtgagccg tctccactag aggctgaatt ccagagactt ccttcatata
2521 ggagctggag gacacagcac attggaaatc aagaagaaaa taaaagtaaa aacaggaatt
2581 ctaatgtcat cccatatgac tataacagag tgccacttaa acatgagctg gaaatgagta
2641 aagagagtga gcatgattca gatgaatcct ctgatgatga cagtgattca gaggaaccaa
2701 gcaaatacat caatgcatct tttataatga gctactggaa acctgaagtg atgattgctg
2761 ctcagggacc actgaaggag accattggtg acttttggca gatgatcttc caaagaaaag
2821 tcaaagttat tgttatgctg acagaactga aacatggaga ccaggaaatc tgtgctcagt
2881 actggggaga aggaaagcaa acatatggag atattgaagt tgacctgaaa gacacagaca
2941 aatcttcaac ttataccctt cgtgtctttg aactgagaca ttccaagagg aaagactctc
3001 gaactgtgta ccagtaccaa tatacaaact ggagtgtgga gcagcttcct gcagaaccca
3061 aggaattaat ctctatgatt caggtcgtca aacaaaaact tccccagaag aattcctctg
3121 aagggaacaa gcatcacaag agtacacctc tactcattca ctgcagggat ggatctcagc
3181 aaacgggaat attttgtgct ttgttaaatc tcttagaaag tgcggaaaca gaagaggtag
3241 tggatatttt tcaagtggta aaagctctac gcaaagctag gccaggcatg gtttccacat
3301 tcgagcaata tcaattccta tatgacgtca ttgccagcac ctaccctgct cagaatggac
3361 aagtaaagaa aaacaaccat caagaagata aaattgaatt tgataatgaa gtggacaaag
3421 taaagcagga tgctaattgt gttaatccac ttggtgcccc agaaaagctc cctgaagcaa
3481 aggaacaggc tgaaggttct gaacccacga gtggcactga ggggccagaa cattctgtca
3541 atggtcctgc aagtccagcc ttaaatcaag gttcatagga aaagacataa atgaggaaac
3601 tccaaacctc ctgttagctg ttatttctat ttttgtagaa gtaggaagtg aaaataggta
3661 tacagtggat taattaaatg cagcgaacca atatttgtag aagggttata ttttactact
3721 gtggaaaaat atttaagata gttttgccag aacagtttgt acagacgtat gcttatttta
3781 aaattttatc tcttattcag taaaaaacaa cttctttgta atcgttatgt gtgtatatgt
3841 atgtgtgtat gggtgtgtgt ttgtgtgaga gacagagaaa gagagagaat tctttcaagt
3901 gaatctaaaa gcttttgctt ttcctttgtt tttatgaaga aaaaatacat tttatattag
3961 aagtgttaac ttagcttgaa ggatctgttt ttaaaaatca taaactgtgt gcagactcaa
4021 taaaatcatg tacatttctg aaatgacctc aagatgtcct ccttgttcta ctcatatata
4081 tctatcttat atacttacta ttttacttct agagatagta cataaaggtg gtatgtgtgt
4141 gtatgctact acaaaaaagt tgttaactaa attaacattg ggaaatctta tattccatat
4201 attagcattt agtccaatgt ctttttaagc ttatttaatt aaaaaatttc cagtgagctt
4261 atcatgctgt ctttacatgg ggttttcaat tttgcatgct cgattattcc ctgtacaata
4321 tttaaaattt attgcttgat acttttgaca acaaattagg ttttgtacaa ttgaacttaa
4381 ataaatgtca ttaaaataaa taaatgcaat atgtattaat attcattgta taaaaataga
4441 agaatacaaa catatttgtt aaatatttac atatgaaatt taatatagct atttttatgg
4501 aatttttcat tgatatgaaa aatatgatat tgcatatgca tagttcccat gttaaatccc
4561 attcataact ttcattaaag catttacttt gaatttc
//