LOCUS X99894 1525 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA coding for insulin promoter factor 1.
ACCESSION X99894
VERSION X99894.1
KEYWORDS GSG gene; insululin promoter factor 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Marshak S., Totary H., Cerasi E., Melloul D.
TITLE Purification of the beta-cell glucose-sensitive factor that
transactivates the insulin gene differentially in normal and
transformed islet cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93(26), 15057-15062(1996).
PUBMED 8986763
REFERENCE 2 (bases 1 to 1525)
AUTHORS Melloul D.
JOURNAL Submitted (07-AUG-1996) to the INSDC. D. Melloul, Hadassah
University Hospital, Endocrinology, POBox 12 000, 91 120 Jerusalem,
ISRAEL
FEATURES Location/Qualifiers
source 1..1525
/db_xref="H-InvDB:HIT000325251"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult"
/tissue_type="pancreatic islets of Langerhans"
/note="isolated by RT-PCR of human islet mRNA"
/db_xref="taxon:9606"
CDS 100..951
/gene="GSF"
/product="insulin promoter factor 1 (IPF-1)"
/note="Glucose sensitive factor is similar to homeodomain
protein IPF-1"
/db_xref="GOA:P52945"
/db_xref="H-InvDB:HIT000325251.14"
/db_xref="HGNC:HGNC:6107"
/db_xref="InterPro:IPR001356"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR017970"
/db_xref="InterPro:IPR017995"
/db_xref="InterPro:IPR020479"
/db_xref="PDB:6F8F"
/db_xref="UniProtKB/Swiss-Prot:P52945"
/protein_id="CAA68169.1"
/translation="MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPP
PPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPE
GAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLE
LEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGG
GVAEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAP
RRPQEPR"
BASE COUNT 288 a 518 c 474 g 245 t
ORIGIN
1 cgggagtggg aacgccacac agtgccaaat ccccggctcc agctcccgac tcccggctcc
61 cggctcccgg ctcccggtgc ccaatcccgg gccgcagcca tgaacggcga ggagcagtac
121 tacgcggcca cgcagcttta caaggaccca tgcgcgttcc agcgaggccc ggcgccggag
181 ttcagcgcca gcccccctgc gtgcctgtac atgggccgcc agcccccgcc gccgccgccg
241 cacccgttcc ctggcgccct gggcgcgctg gagcagggca gccccccgga catctccccg
301 tacgaggtgc cccccctcgc cgacgacccc gcggtggcgc accttcacca ccacctcccg
361 gctcagctcg cgctccccca cccgcccgcc gggcccttcc cggagggagc cgagccgggc
421 gtcctggagg agcccaaccg cgtccagctg cctttcccat ggatgaagtc taccaaagct
481 cacgcgtgga aaggccagtg ggcaggcggc gcctacgctg cggagccgga ggagaacaag
541 cggacgcgca cggcctacac gcgcgcacag ctgctagagc tggagaagga gttcctattc
601 aacaagtaca tctcacggcc gcgccgggtg gagctggctg tcatgttgaa cttgaccgag
661 agacacatca agatctggtt ccaaaaccgc cgcatgaagt ggaaaaagga ggaggacaag
721 aagcgcggcg gcgggacagc tgtcgggggt ggcggggtcg cggagcctga gcaggactgc
781 gccgtgacct ccggcgagga gcttctggcg ctgccgccgc cgccgccccc cggaggtgct
841 gtgccgcccg ctgcccccgt tgccgcccga gagggccgcc tgccgcctgg ccttagcgcg
901 tcgccacagc cctccagcgt cgcgcctcgg cggccgcagg aaccacgatg agaggcagga
961 gctgctcctg gctgaggggc ttcaaccact cgccgaggag gagcagaggg cctaggagga
1021 ccccgggcgt ggaccacccg ccctggcagt tgaatggggc ggcaattgcg gggcccacct
1081 tagaccgaag gggaaaaccc gctctctcag gcgcatgtgc cagttggggc cccgcgggta
1141 gatgccggca ggccttccgg aagaaaaaga gccattggtt tttgtagtat tggggccctc
1201 ttttagtgat actggattgg cgttgtttgt ggctgttgcg cacatccctg ccctcctaca
1261 gcactccacc ttgggacctg tttagagaag ccggctcttc aaagacaatg gaaactgtac
1321 catacacatt ggaaggctcc ctaacacaca cagcggggaa gctgggccga gtaccttaat
1381 ctgccataaa gccattctta ctcgggcgac ccctttaagt ttagaaataa ttgaaaggaa
1441 atgtttgagt tttcaaagat cccgtgaaat tgatgccagt ggaatacagt gagtcctcct
1501 cttcctctgg catcaatttc acccg
//