LOCUS X98400 2450 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for mannan-binding lectin-associated serine
protease-2.
ACCESSION X98400
VERSION X98400.1
KEYWORDS lectin-associated protein; mannan-binding protein; MASP; serine
protease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Thiel S., Vorup-Jensen T., Stover C.M., Schwaeble W., Laursen S.B.,
Poulsen K., Willis A.C., Eggleton P., Hansen S., Holmskov U.,
Reid K.B.M., Jensenius J.C.
TITLE Identification and characterization of a novel protein of the human
complement system, mannan-binding lectin-associated serine
protease-2 (MASP-2)
JOURNAL Unpublished.
REFERENCE 2 (bases 1 to 2450)
AUTHORS Thiel S.
JOURNAL Submitted (08-JUN-1996) to the INSDC. S. Thiel, University of
Aarhus, Dept. of Medical Microbiol. & Immunol., Bartholin Building,
Wilhelm Meyers Alle, 8000 Aarhus C, Denmark
FEATURES Location/Qualifiers
source 1..2450
/db_xref="H-InvDB:HIT000325078"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="4"
/db_xref="taxon:9606"
CDS 37..2097
/product="MASP-2"
/product="mannan-binding lectin-associated serine
protease-2"
/db_xref="GOA:O00187"
/db_xref="H-InvDB:HIT000325078.13"
/db_xref="HGNC:HGNC:6902"
/db_xref="InterPro:IPR000152"
/db_xref="InterPro:IPR000436"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR000859"
/db_xref="InterPro:IPR001254"
/db_xref="InterPro:IPR001314"
/db_xref="InterPro:IPR001881"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR013032"
/db_xref="InterPro:IPR018097"
/db_xref="InterPro:IPR033116"
/db_xref="InterPro:IPR035914"
/db_xref="InterPro:IPR035976"
/db_xref="InterPro:IPR037571"
/db_xref="PDB:1Q3X"
/db_xref="PDB:1SZB"
/db_xref="PDB:1ZJK"
/db_xref="PDB:3TVJ"
/db_xref="PDB:4FXG"
/db_xref="PDB:5JPM"
/db_xref="UniProtKB/Swiss-Prot:O00187"
/protein_id="CAA67050.1"
/translation="MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQE
RRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPG
KDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHL
GGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLE
EGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTI
TFVTDESGDHTGWKIHYTSTAHACPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYEL
LQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVI
QYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQK
AKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPH
YTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDD
IGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESG
GKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI
ISDF"
BASE COUNT 609 a 644 c 617 g 580 t
ORIGIN
1 ctcgtgcaat tcggcacgag gctggacggg cacaccatga ggctgctgac cctcctgggc
61 cttctgtgtg gctcggtggc caccccctta ggcccgaagt ggcctgaacc tgtgttcggg
121 cgcctggcat cccccggctt tccaggggag tatgccaatg accaggagcg gcgctggacc
181 ctgactgcac cccccggcta ccgcctgcgc ctctacttca cccacttcga cctggagctc
241 tcccacctct gcgagtacga cttcgtcaag ctgagctcgg gggccaaggt gctggccacg
301 ctgtgcgggc aggagagcac agacacggag cgggcccctg gcaaggacac tttctactcg
361 ctgggctcca gcctggacat taccttccgc tccgactact ccaacgagaa gccgttcacg
421 gggttcgagg ccttctatgc agccgaggac attgacgagt gccaggtggc cccgggagag
481 gcgcccacct gcgaccacca ctgccacaac cacctgggcg gtttctactg ctcctgccgc
541 gcaggctacg tcctgcaccg taacaagcgc acctgctcag ccctgtgctc cggccaggtc
601 ttcacccaga ggtctgggga gctcagcagc cctgaatacc cacggccgta tcccaaactc
661 tccagttgca cttacagcat cagcctggag gaggggttca gtgtcattct ggactttgtg
721 gagtccttcg atgtggagac acaccctgaa accctgtgtc cctacgactt tctcaagatt
781 caaacagaca gagaagaaca tggcccattc tgtgggaaga cattgcccca caggattgaa
841 acaaaaagca acacggtgac catcaccttt gtcacagatg aatcaggaga ccacacaggc
901 tggaagatcc actacacgag cacagcgcac gcttgccctt atccgatggc gccacctaat
961 ggccacgttt cacctgtgca agccaaatac atcctgaaag acagcttctc catcttttgc
1021 gagactggct atgagcttct gcaaggtcac ttgcccctga aatcctttac tgcagtttgt
1081 cagaaagatg gatcttggga ccggccaatg cccgcgtgca gcattgttga ctgtggccct
1141 cctgatgatc tacccagtgg ccgagtggag tacatcacag gtcctggagt gaccacctac
1201 aaagctgtga ttcagtacag ctgtgaagag accttctaca caatgaaagt gaatgatggt
1261 aaatatgtgt gtgaggctga tggattctgg acgagctcca aaggagaaaa atcactccca
1321 gtctgtgagc ctgtttgtgg actatcagcc cgcacaacag gagggcgtat atatggaggg
1381 caaaaggcaa aacctggtga ttttccttgg caagtcctga tattaggtgg aaccacagca
1441 gcaggtgcac ttttatatga caactgggtc ctaacagctg ctcatgccgt ctatgagcaa
1501 aaacatgatg catccgccct ggacattcga atgggcaccc tgaaaagact atcacctcat
1561 tatacacaag cctggtctga agctgttttt atacatgaag gttatactca tgatgctggc
1621 tttgacaatg acatagcact gattaaattg aataacaaag ttgtaatcaa tagcaacatc
1681 acgcctattt gtctgccaag aaaagaagct gaatccttta tgaggacaga tgacattgga
1741 actgcatctg gatggggatt aacccaaagg ggttttcttg ctagaaatct aatgtatgtc
1801 gacataccga ttgttgacca tcaaaaatgt actgctgcat atgaaaagcc accctatcca
1861 aggggaagtg taactgctaa catgctttgt gctggcttag aaagtggggg caaggacagc
1921 tgcagaggtg acagcggagg ggcactggtg tttctagata gtgaaacaga gaggtggttt
1981 gtgggaggaa tagtgtcctg gggttccatg aattgtgggg aagcaggtca gtatggagtc
2041 tacacaaaag ttattaacta tattccctgg atcgagaaca taattagtga tttttaactt
2101 gcgtgtctgc agtcaaggat tcttcatttt tagaaatgcc tgtgaagacc ttggcagcga
2161 cgtggctcga gaagcattca tcattactgt ggacatggca gttgttgctc cacccaaaaa
2221 aacagactcc aggtgaggct gctgtcattt ctccacttgc cagtttaatt ccagccttac
2281 ccattgactc aaggggacat aaaccacgag agtgacagtc atctttgccc acccagtgta
2341 atgtcactgc tcaaattaca tttcattacc ttaaaaagcc agtctctttt catactggct
2401 gttggcattt ctgtaaactg cctgtccatg ctctttgttt ttaaacttgt
//