LOCUS X98330 15731 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for ryanodine receptor 2.
ACCESSION X98330
VERSION X98330.1
KEYWORDS ryanodine receptor 2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Tunwell R.E.A., Wickenden C., Bertrand B.M.A., Shevchenko V.I.,
Walsh M.B., Allen P.D., Lai F.A.
TITLE The human cardiac muscles ryanodine receptor-calcium release
channel; Identification, primary structure and topological analysis
JOURNAL Biochem. J. 318, 477-487(1996).
PUBMED 8809036
REFERENCE 2 (bases 1 to 15731)
AUTHORS Lai F.A.
JOURNAL Submitted (06-JUN-1996) to the INSDC. T. Lai, National Institute
for Medical Research, Neurophysiology, The Ridgeway, Mill Hill,
London NW7 1AA, UK
FEATURES Location/Qualifiers
source 1..15731
/db_xref="H-InvDB:HIT000325073"
/organism="Homo sapiens"
/mol_type="mRNA"
/sex="male"
/dev_stage="22 years old"
/tissue_type="heart"
/db_xref="taxon:9606"
CDS 122..15025
/product="ryanodine receptor 2"
/db_xref="GOA:Q92736"
/db_xref="H-InvDB:HIT000325073.14"
/db_xref="HGNC:HGNC:10484"
/db_xref="InterPro:IPR000699"
/db_xref="InterPro:IPR001870"
/db_xref="InterPro:IPR002048"
/db_xref="InterPro:IPR003032"
/db_xref="InterPro:IPR003877"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR009460"
/db_xref="InterPro:IPR011992"
/db_xref="InterPro:IPR013320"
/db_xref="InterPro:IPR013333"
/db_xref="InterPro:IPR013662"
/db_xref="InterPro:IPR014821"
/db_xref="InterPro:IPR016093"
/db_xref="InterPro:IPR035761"
/db_xref="InterPro:IPR035762"
/db_xref="InterPro:IPR035764"
/db_xref="InterPro:IPR035910"
/db_xref="InterPro:IPR036300"
/db_xref="PDB:4JKQ"
/db_xref="UniProtKB/Swiss-Prot:Q92736"
/protein_id="CAA66975.1"
/translation="MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGN
RLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMM
KTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW
TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPIS
SGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWR
LETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSS
KEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAI
MHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIE
SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVY
SSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLE
ASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVA
VRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHT
EPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIART
VSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGI
KVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVS
LTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQ
HPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQL
TSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNP
RLVPYTPLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIF
RAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWH
QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPV
CSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVP
SNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG
GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQ
EKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQ
EPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESM
SPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNV
FQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSR
ISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALG
NHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYI
VPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPL
DILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHI
LQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPE
PVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALT
ARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGS
LDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESV
IEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSV
RMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFP
KMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVM
DNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAV
FCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSP
NSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSI
LRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEV
QDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGT
EHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDV
PLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ
KKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNIT
IPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEI
YRWPIKESLKTMLARTMRTERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDM
SNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDR
EKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFD
GGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKE
MVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF
LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFG
EDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLD
KHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHV
MEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDE
GAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSE
AELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSK
SHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLI
VAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAI
RWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRS
KKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKL
IEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKS
CHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVA
ATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKA
EGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIII
STVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTG
NQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG
NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKR
DFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTN
LSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEK
PQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEE
SEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKD
MVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPD
PTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLI
PHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEK
AKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVA
FAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYM
EPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDI
KGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDARE
KKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAH
LLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD
TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVIL
LAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA
NYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN"
BASE COUNT 4498 a 3407 c 3874 g 3952 t
ORIGIN
1 cgcgcggccc cctccagccc ccggctcccg gcagcagaag cagaaggcag cgccaggggc
61 cgccgccgcc gccgagctcc gcggggctcg ggagccggcc ccggcgagga ggcgcggaac
121 catggccgat gggggcgagg gcgaagacga gatccagttc ctgcgaactg atgatgaagt
181 ggttctgcag tgcaccgcaa ccatccacaa agaacaacag aagctatgct tggcagcaga
241 aggatttggc aacagacttt gtttcttgga gtccacttcc aattccaaga atgtgccccc
301 agacctctcc atctgcacct ttgtgctgga gcagtccctc tctgtccggg cgctgcagga
361 gatgctggct aacaccgtgg agaaatcaga agggcaagtt gatgtggaaa aatggaaatt
421 catgatgaag actgctcaag gtggtggtca tcgaacactc ctctacggac atgccatatt
481 gctgcgccat tcctatagtg gcatgtatct gtgctgcctg tccacctccc ggtcttcaac
541 tgataagctg gcttttgatg ttggcttgca agaggacacc acaggggagg cttgttggtg
601 gaccatacac cctgcctcta agcagcgatc agaaggagaa aaagtacgag ttggagatga
661 cctcatctta gttagcgtgt cctctgaaag gtacttgcac ttgtcttatg gcaacggcag
721 cttacacgtg gatgccgctt tccagcagac tctctggagc gtggccccaa tcagctcagg
781 aagtgaggca gcccaagggt atctcattgg tggtgatgtc ctcaggttgc tgcatggaca
841 catggacgag tgtctcactg tcccttcagg agaacatggt gaagagcagc ggagaactgt
901 tcattatgaa ggtggcgctg tgtctgttca tgcacgttcc ctttggagac tagagacgct
961 aagagttgcg tggagtggaa gccacataag atggggacag ccattccgac tacgccatgt
1021 cacaacagga aaatacttga gtctcatgga agacaaaaac cttctactca tggacaaaga
1081 gaaagctgat gtaaaatcaa cagcatttac cttccggtct tccaaggaaa aattggatgt
1141 aggggtgaga aaagaagtag atggcatggg aacatctgaa ataaaatacg gtgactcagt
1201 atgctatata caacatgtag acacaggcct atggcttact taccagtctg tggacgtgaa
1261 atccgtgaga atgggatcta tacaacgtaa ggctattatg catcatgaag gccacatgga
1321 tgatggcata agtttgtcga gatcccagca tgaagaatca cgcacagccc gagttatccg
1381 gagcacagtc ttccttttca atagatttat aaggggcctt gatgctctca gcaagaaagc
1441 gaaggcttcc acagtcgatt tgcctataga gtccgtaagc ctaagtctgc aggatctcat
1501 tggctacttc caccccccag atgagcattt agagcatgaa gacaaacaga acagactacg
1561 agccctgaag aatcggcaaa atctcttcca ggaagaggga atgatcaacc tcgtgcttga
1621 gtgcatagac cgtttgcacg tctacagcag tgcagcacac tttgctgatg ttgctgggcg
1681 agaagcagga gagtcttgga aatccattct gaattctctg tatgagttgc tggcggctct
1741 aattagagga aatcgtaaaa actgtgctca attttctggc tccctcgact ggttgatcag
1801 cagattggaa agactggaag cttcttcagg cattctggaa gttttacact gtgttttagt
1861 agaaagtcca gaagctctaa atattattaa agaaggacat attaaatcta ttatctcact
1921 tttagacaaa catggaagaa atcacaaggt tctggatgtc ttgtgctcac tctgtgtttg
1981 ccacggggtt gcagtccgtt ctaaccagca tctcatctgt gacaatctcc taccaggaag
2041 agacttgtta ttgcagacac gtcttgtgaa ccatgtcagc agcatgagac ccaatatttt
2101 tctgggcgtc agtgaaggtt ctgctcagta taagaaatgg tactatgaat tgatggtgga
2161 ccacacagag ccctttgtga cagctgaagc aactcacctg cgagtgggct gggcttccac
2221 tgaaggatat tctccctacc ctggaggggg cgaagagtgg ggtggaaatg gtgttggaga
2281 tgatctcttc tcctatggat ttgatggcct tcatctctgg tcaggttgta ttgctcgtac
2341 tgtaagctca ccaaaccaac atctgttaag aactgatgat gtcatcagtt gctgtttaga
2401 tctgagtgcc ccaagcatct cgttccgaat taatggacaa cctgttcaag gaatgtttga
2461 gaatttcaac atcgatggcc tcttctttcc agtcgttagt ttctctgcag gaataaaagt
2521 acgctttctg cttggagggc gacatggaga attcaaattt cttcctccac ctgggtatgc
2581 tccttgttat gaagctgttc tgccaaaaga aaagttgaaa gtggaacaca gccgagagta
2641 caagcaagaa agaacttaca cacgcgacct gctgggcccc acagtttccc tgacgcaagc
2701 tgccttcaca cccatccctg tggataccag ccagatcgtg ttgcctcctc atctagaaag
2761 aataagagaa aaactggcag agaatatcca tgaactctgg gttatgaata aaattgagct
2821 tggctggcag tatggtccgg ttagagatga caacaagaga caacacccat gcctggtgga
2881 gttctccaag ctgcctgaac aggagcgcaa ttacaactta caaatgtcgc ttgagaccct
2941 gaagactttg ttggcattag gatgtcatgt gggtatatca gatgaacatg ctgaagacaa
3001 ggtgaaaaaa atgaagctac ccaagaatta ccagctgaca agtggataca agcctgcccc
3061 tatggacctg agctttatca aactcacccc atcgcaagaa gcaatggtgg acaagttggc
3121 agaaaatgca cataatgtgt gggcgcggga tcgaatccgg cagggctgga cttatggcat
3181 ccaacaggac gtaaagaaca gaagaaatcc tcgccttgtt ccctacactc ctctggatga
3241 ccgaaccaag aaatccaaca aggacagcct ccgcgaggct gtgcgcacgc tgctggggta
3301 cggctacaac ttggaagcac cagatcaaga tcatgcagcc agagccgaag tgtgcagcgg
3361 caccggggaa aggttccgaa tcttccgtgc cgagaagacc tatgcagtga aggccggacg
3421 gtggtatttt gaatttgaga cggtcactgc tggagacatg agggttggtt ggagtcgtcc
3481 tggttgtcaa ccggatcagg agcttggctc agatgaacgt gcctttgcct ttgatggctt
3541 caaggcccag cggtggcatc agggcaatga acactatggg cgctcttggc aagcaggcga
3601 tgtcgtgggg tgtatggttg acatgaacga acacaccatg atgttcacac tgaatggtga
3661 aatccttctt gatgattcag gctcagaact ggctttcaag gactttgatg ttggcgatgg
3721 attcatacct gtgtgtagcc ttggagtggc tcaagtgggt aggatgaact ttggaaagga
3781 tgtcagcacc ttgaaatatt tcaccatctg tggcttacaa gagggctatg aaccatttgc
3841 cgttaataca aacagggata ttaccatgtg gctgagcaag aggcttcctc agtttcttca
3901 agttccatca aaccatgaac atatagaggt gaccagaata gacggcacca tagacagttc
3961 cccatgttta aaggtcactc agaagtcttt tggttctcag aacagcaaca ctgatatcat
4021 gttttatcgc ctgagcatgc cgatcgagtg cgcggaggtc ttctccaaga cggtggctgg
4081 agggctccct ggggctggcc tttttgggcc caagaatgac ttggaagatt atgatgctga
4141 ttctgacttt gaggttctga tgaagacagc tcatggccat ctagtgcccg atcgtgttga
4201 caaagacaaa gaagctacta aaccagagtt taacaaccac aaagattatg cccaggaaaa
4261 gccctctcgt ctgaaacaaa gatttttgct tagaagaaca aagccagatt acagcacaag
4321 ccattctgca agactcaccg aagatgtcct tgctgatgat cgggatgact atgatttctt
4381 gatgcaaacg tccacgtact attactcagt gagaatcttt cctggacaag aacctgctaa
4441 tgtctgggtg ggctggatta catcagattt ccatcagtat gacacaggct ttgacttgga
4501 cagagttcgc acagtaacag ttactctagg agatgaaaaa ggaaaagtgc atgaaagcat
4561 caaacgcagc aactgctata tggtatgtgc gggtgagagc atgagccccg ggcaaggacg
4621 caacaataat ggactggaga ttggctgtgt ggtggatgct gccagcgggc tgctcacatt
4681 cattgccaat ggcaaggaac tgagcacata ctatcaggtg gaaccgagta caaaattatt
4741 tcctgcggtt tttgcacaag ctacaagtcc caatgttttc cagtttgagt tgggaagaat
4801 aaagaatgtg atgcctctct cggcgggatt attcaagagt gagcacaaga accccgtgcc
4861 gcagtgcccc ccgcgcctcc acgtgcagtt cctgtcacac gtcctgtgga gcagaatgcc
4921 caaccagttt ttgaaggtag atgtgtctcg aataagtgaa cgccaaggct ggttggtgca
4981 gtgtttggat cctctgcagt tcatgtctct tcatatccct gaggaaaaca gatctgttga
5041 catcttagag ttgacagagc aggaggaatt gctgaaattt cactatcaca ctctccggct
5101 ctactcagcc gtctgtgctc ttgggaacca ccgggtggcc catgccctgt gcagccatgt
5161 ggatgaacct cagctcctct atgccattga gaacaagtac atgcctggtt tgctgcgtgc
5221 tggctactat gacctgctga ttgacatcca cctgagctcc tatgccactg ccaggctcat
5281 gatgaacaac gagtacattg tccccatgac ggaggagacg aagagcatca ccctgttccc
5341 tgatgagaac aaaaaacacg gccttccagg gatcggcctc agcacctccc tcaggccacg
5401 gatgcagttt tcctccccca gttttgtaag cattagtaat gaatgttacc agtacagtcc
5461 agagttccca ctggacatcc tcaagtccaa aaccatacag atgctgacag aagctgttaa
5521 agagggcagt cttcatgccc gggacccagt tggagggact actgaattcc tctttgtacc
5581 tctcatcaag cttttctata ccctgctgat catgggcatc tttcacaacg aggacttgaa
5641 gcacatcttg cagttgattg agcccagtgt gtttaaagaa gctgccactc cggaggagga
5701 gagtgacacg ctggagaaag agctcagtgt ggacgatgca aagctgcaag gagctggtga
5761 ggaagaagcc aaggggggca agcggcccaa ggaaggcctg ctccaaatga aactgccaga
5821 gccagttaaa ttgcagatgt gcctactgct tcagtacctc tgtgactgcc aggtccggca
5881 ccggatagaa gccattgtag ccttttcaga tgattttgtg gctaagctcc aagacaatca
5941 acgtttccga tacaacgaag tcatgcaagc cttaaacatg tcagctgcac tcacagccag
6001 gaagacaaag gaatttagat caccacctca agaacagatc aatatgcttc tcaattttaa
6061 ggatgacaaa agtgaatgtc catgtccaga agaaattcgt gaccaactat tggatttcca
6121 tgaagatttg atgacacatt gtggaattga gctggatgaa gatgggtctc tggatggaaa
6181 cagtgattta acaattagag ggcgtctgct atccctggta gaaaaggtga catatctgaa
6241 gaagaagcaa gcagaaaaac cagttgagag tgactccaaa aagtcctcca ctctgcagca
6301 gctgatttct gagaccatgg tccgatgggc tcaggagtct gtcattgaag accccgagct
6361 ggtgagggcc atgtttgtgt tgctccatcg gcagtatgac ggcattgggg gtcttgttcg
6421 ggccctgcca aagacctaca cgataaatgg tgtgtccgtg gaggacacca tcaacctgct
6481 ggcatccctt ggtcagattc ggtccctgct gagtgtgaga atgggcaaag aagaagagaa
6541 gctcatgatt cgtggattag gggatattat gaataacaaa gtgttttacc agcaccctaa
6601 tctcatgagg gcactgggga tgcacgagac tgtgatggag gtcatggtga acgtccttgg
6661 aggtggagag tccaaggaaa tcacctttcc caagatggtg gccaactgtt gccgttttct
6721 ctgttacttc tgtcgtataa gtaggcagaa tcaaaaagct atgtttgatc atctcagtta
6781 tttactggaa aacagcagtg ttggtcttgc ctccccagct atgagaggtt caacaccact
6841 ggatgtggct gcagcttcgg tgatggataa taatgaacta gcattagctc tgcgtgagcc
6901 ggatctagaa aaggtagttc gttatttggc tggttgtgga ctgcaaagtt gccagatgct
6961 ggtgtctaag ggctatccag acattgggtg gaacccagtt gaaggagaga gatatcttga
7021 ctttctcaga tttgctgtct tctgtaatgg ggagagtgtg gaggaaaatg caaatgtcgt
7081 ggtgagattg ctcattcgga ggcctgagtg ttttggtcct gctttgagag gagaaggtgg
7141 gaatgggctt cttgcagcaa tggaagaagc catcaaaatc gccgaggatc cttcccgaga
7201 tggtccctca ccaaatagcg gatccagtaa aacacttgac acagaggagg aggaagatga
7261 cactatccac atggggaacg cgatcatgac cttctattca gctttgattg acctcttggg
7321 acgctgtgct cctgagatgc atttgattca tgccgggaag ggagaagcca tcagaattag
7381 gtccattttg agatccctca ttcccctggg agatttggtg ggcgttatca gcatcgcttt
7441 tcagatgcca acaatagcca aagatgggaa tgtggtggaa cctgacatgt ctgcggggtt
7501 ttgcccagat cacaaggcag ccatggtttt attccttgac agggtctatg ggattgaggt
7561 tcaagacttc ctcctccatc ttcttgaggt tggctttctg ccagatctcc gggcggctgc
7621 ttctttagat acggcagctt tgagtgctac agacatggcc ttggccctca atcggtacct
7681 ttgcacagcc gtcttgccat tgttaacaag atgtgctcct ctctttgctg gcacagagca
7741 ccacgcttct ctcattgact cattacttca tactgtgtat agactttcta agggctgttc
7801 acttaccaaa gctcagcggg attccataga agtttgttta ctctctattt gtggacaact
7861 gagaccttct atgatgcagc acttactcag aagattagta tttgatgtcc cattattaaa
7921 tgaacacgca aagatgcctc ttaaactgct gacaaatcat tatgaaagat gctggaaata
7981 ttactgcctg cctggagggt ggggaaactt tggtgctgcc tcagaagaag aacttcattt
8041 atcaagaaag ttgttctggg gcatttttga tgccctgtct caaaagaaat atgaacaaga
8101 acttttcaaa ctggcactgc cttgcctgag tgcagttgcg ggagctttgc ctccagacta
8161 catggagtca aattatgtca gtatgatgga aaaacagtca tcaatggatt ctgaagggaa
8221 ctttaaccca caacctgttg atacctcaaa tattacaatt cctgagaaat tggaatactt
8281 cattaacaaa tatgcagaac actcccatga caaatggtca atggacaagt tggcaaatgg
8341 atggatttat ggagaaatat attcagactc ttctaaggtt cagccattaa tgaagccata
8401 taagctattg tctgaaaagg aaaaagaaat ttatcgctgg ccaatcaaag aatctttaaa
8461 aactatgctg gctaggacta tgagaactga aagaactcgg gagggagaca gcatggccct
8521 ttacaaccgg actcgtcgta tttctcagac aagccaggtt tctgtggacg ctgcccatgg
8581 ttacagtccc cgggccattg acatgagcaa tgttacacta tctagagacc tgcatgctat
8641 ggcagaaatg atggctgaaa actaccataa tatatgggca aagaaaaaga aaatggagtt
8701 ggagtccaaa ggaggaggaa accatcctct gctggtgccc tatgatacac tgacagccaa
8761 agagaaagcc aaggatagag aaaaagcaca ggacatcctc aagttcttgc agatcaatgg
8821 atatgctgta tccagaggat ttaaggacct ggaactggac acgccttcta ttgagaaacg
8881 atttgcctat agtttcctcc aacaactcat tcgctatgtg gatgaagccc atcagtatat
8941 cctggagttt gatggtggca gcagaggcaa aggagaacat ttcccttatg aacaagaaat
9001 caagttcttt gcaaaagtcg ttcttccttt aattgatcag tatttcaaaa accatcgttt
9061 atacttctta tctgcagcaa gcagacctct ctgctctgga ggacatgctt ccaacaaaga
9121 gaaagaaatg gtgactagcc tattctgcaa acttggagtt cttgtcaggc ataggatttc
9181 actatttggc aatgatgcaa catcaattgt caactgtctt catattttgg gtcagacttt
9241 ggatgcaagg acagtgatga agactggcct ggagagtgtt aaaagtgcac tcagagcttt
9301 tctggacaac gctgcagagg atctggagaa gaccatggaa aacctcaagc agggccagtt
9361 cactcacacc cgaaaccagc ccaaaggggt tactcagatt atcaattaca ccacagtggc
9421 cctgctgcca atgctgtcgt cattatttga acatattggc cagcatcagt tcggagaaga
9481 cctaatattg gaagatgtcc aggtgtcttg ttatagaatt ctgactagct tatatgcttt
9541 gggaaccagc aagagtattt acgtggagag gcaacgttct gcattaggag aatgtctagc
9601 tgcctttgct ggtgcttttc ctgtagcatt tttggaaact catctggaca aacataatat
9661 ttactccatc tacaatacca agtcttcacg agaaagagca gctctcagtt tgccaactaa
9721 tgtggaagat gtttgtccaa acattccgtc tttggagaaa ctcatggaag aaatcgtgga
9781 attagccgag tccggcattc gctacactca aatgccacat gtcatggaag tcatactgcc
9841 catgctttgc agctacatgt ctcgttggtg ggagcatgga cctgagaaca atccagaacg
9901 ggccgagatg tgctgcacag ccctgaactc agagcacatg aacacacttc tagggaacat
9961 attgaaaatc atatataata acttggggat tgatgaggga gcctggatga agaggctagc
10021 agtgttttcc cagcctataa taaataaagt gaaacctcag ctcttgaaaa ctcatttctt
10081 gccgttaatg gagaaactca agaaaaaggc agctacggtg gtgtctgagg aagaccacct
10141 gaaagctgag gccagggggg acatgtcgga ggcagaactc ctcatcctag atgagttcac
10201 cacactggcc agagatctct atgccttcta ccctctcttg attagatttg tggactataa
10261 cagggcaaag tggctaaagg agcctaaccc agaagcagag gagctcttcc gcatggtggc
10321 tgaagtgttt atctactggt cgaagtccca taatttcaaa agagaagagc agaacttcgt
10381 tgtacagaat gaaatcaaca atatgtcttt ccttattact gataccaagt caaagatgtc
10441 aaaggcagct gtttctgatc aggaaaggaa gaaaatgaag cgcaaaggag atcggtattc
10501 catgcagacc tctctgattg tagcagctct gaagcggtta ctgcccattg ggttgaacat
10561 ctgtgcccct ggggaccagg agctcattgc tctggccaaa aatcgattta gcctgaaaga
10621 tactgaggat gaagtacgag atataatccg cagcaatatt catttacaag gcaagttgga
10681 ggatcctgct attagatggc aaatggctct ttacaaagac ttaccaaaca ggactgatga
10741 tacctcagat ccagagaaga cggtagaaag agtattggat atagcaaatg tgctttttca
10801 tcttgaacag aagtctaaac gtgtgggtcg aagacattac tgtctggtgg aacatcctca
10861 gagatctaaa aaggctgtat ggcataaact actgtctaag cagaggaaaa gggctgttgt
10921 agcctgcttc cggatggccc ccttatataa tctgccaagg catcgggctg tcaatctctt
10981 tcttcaggga tatgaaaagt cttggattga aacagaagaa cattactttg aagataaact
11041 gatagaagat ttagcaaaac ctggggctga acctccagaa gaagatgaag gcactaagag
11101 agttgatcct ctacatcagc tgatccttct gtttagtcgg acagctttaa cagagaaatg
11161 caaactggag gaagattttt tatatatggc ctatgcagat attatggcaa agagttgtca
11221 tgatgaggaa gatgacgatg gtgaagagga agtgaagagt tttgaagaaa aagaaatgga
11281 aaagcaaaag cttctatacc agcaagcccg actccacgat cgtggcgcgg ctgagatggt
11341 gctacagaca atcagtgcca gcaaaggtga aactggacca atggtagcag ctactctgaa
11401 acttggaatt gctattttaa atggtgggaa ctccacagta cagcagaaaa tgcttgacta
11461 cctcaaggag aaaaaggatg tgggcttctt tcagagcctg gccggcctga tgcagtcatg
11521 tagtgtcctt gacctaaatg catttgagcg acaaaacaaa gctgaaggtc ttgggatggt
11581 gacagaggaa ggatcaggag aaaaggttct gcaggacgat gagttcacct gtgacctctt
11641 ccgattcctg caactactct gtgagggaca caactcagat tttcagaatt atctgagaac
11701 tcagactggc aataatacaa ctgtcaacat aattatctcc actgtagact acctactgag
11761 agttcaggaa tcaattagtg acttttattg gtattactct gggaaagatg ttattgatga
11821 acaaggacaa cggaatttct ccaaagctat ccaagtggca aaacaagtct ttaacactct
11881 tacagagtat attcagggtc cttgcactgg gaatcaacag agtttggcac acagcaggct
11941 gtgggatgct gtggtcggct ttcttcatgt gtttgcccat atgcagatga agctgtcgca
12001 ggattccagt caaattgagc tattaaaaga attaatggat ctgcagaagg atatggtggt
12061 catgttgctg tccatgttag aaggtaatgt tgttaatgga acgattggca aacagatggt
12121 ggatatgctt gtggaatctt ccaacaacgt ggagatgatt ctcaaatttt ttgacatgtt
12181 cttaaaacta aaggatttga cgtcgtctga tacttttaaa gaatatgacc ccgatggcaa
12241 gggagtcatt tccaagaggg acttccacaa agcgatggag agccataagc actacacgca
12301 gtcagaaacg gaatttcttt tgtcttgtgc ggagacggat gagaatgaaa ccctcgacta
12361 cgaagagttc gtcaaacgct tccacgaacc tgcgaaggac atcggcttca acgtcgccgt
12421 ccttctgaca aacctctctg agcacatgcc caacgatacc cgacttcaga cttttctgga
12481 attagcagag agcgtcctga attatttcca gccctttctg ggccgcatcg aaatcatggg
12541 aagcgccaaa cgcatcgaga gggtctattt tgaaatcagt gagtccagcc gaacccagtg
12601 ggagaagccc caggtcaagg agtccaaaag acagttcata tttgacgtgg tcaacgaagg
12661 cggagagaaa gagaagatgg aactctttgt gaacttctgc gaggacacca tctttgaaat
12721 gcagctggcg gctcagatct cggagtcgga cttgaacgag aggtcagcga ataaggaaga
12781 aagcgagaag gagaggccgg aagagcaggg gccgaggatg gctttcttct ccattctgac
12841 ggtcaggtcg gccctgtttg cgctcaggta caatatcttg acccttatgc gaatgctcag
12901 tctgaagagc ctgaagaagc agatgaaaaa agtaaaaaag atgaccgtga aggacatggt
12961 cacggccttc ttttcatcct actggagtat tttcatgacc ctcttgcact tcgtggccag
13021 cgttttcaga ggctttttcc gcatcatttg cagcctgctg cttgggggaa gcctcgtcga
13081 aggtgctaaa aagatcaaag ttgcagaact gttagccaac atgccagacc ccactcagga
13141 tgaggttaga ggagatgggg aggagggaga gaggaaaccc ctggaagccg ccctgccctc
13201 cgaggatctg accgacttaa aggagctgac agaggaaagt gaccttcttt cggacatctt
13261 tggcctggat ctgaagagag aaggaggaca gtacaaactg attcctcata atccaaatgc
13321 tgggctcagt gacctcatga gcaacccagt ccccatgcct gaggtgcagg aaaaatttca
13381 ggaacagaag gcaaaagaag aagaaaagga agaaaaagaa gaaaccaaat ctgaacctga
13441 aaaagccgag ggagaagatg gagaaaaaga agagaaagcc aaggaagaca agggcaaaca
13501 aaagttgagg cagcttcaca cacacagata cggagaacca gaagtgccag agtcagcatt
13561 ctggaagaaa atcatagcat atcaacagaa acttctaaac tattttgctc gcaactttta
13621 caacatgaga atgttagcct tatttgtcgc atttgctatc aatttcatct tgctctttta
13681 taaggtctcc acttcttctg tggttgaagg aaaggagctc cccacgagaa gttcaagtga
13741 aaatgccaaa gtgacaagcc tggacagcag ctcccataga atcatcgcag ttcactatgt
13801 actagaggag agcagcggct acatggagcc cacgttgcgt atcttagcta ttctgcacac
13861 ggtcatttct ttcttctgca tcattggata ctactgcttg aaagtcccat tggttatttt
13921 taagcgagaa aaggaagtgg cacggaaatt ggaatttgat gggctttata ttacagaaca
13981 gccttcagaa gatgatatta aaggccagtg ggatagactc gtaatcaaca cacagtcatt
14041 tcccaacaac tactgggaca aatttgttaa aagaaaggtt atggataaat atggagagtt
14101 ctacggccga gacagaatca gtgaattact tggcatggac aaggcagctc tggacttcag
14161 tgatgccaga gaaaagaaga agccaaagaa agacagctcc ttatcagctg tactgaactc
14221 cattgatgtg aagtatcaga tgtggaaact aggagtcgtt ttcactgaca actccttcct
14281 ctacctagcc tggtatatga ctatgtctgt tcttggacac tataacaact ttttttttgc
14341 cgctcacctt ctcgacattg ctatgggatt caagacatta agaaccatct tgtcctcagt
14401 aactcacaat ggcaaacagc tcgtattaac cgttggctta ttagctgttg ttgtatacct
14461 atacactgtg gtggcattca attttttccg aaaattctac aataaaagtg aagatggtga
14521 tacaccagat atgaaatgtg acgatatgct aacatgctat atgttccaca tgtatgttgg
14581 agttcgtgct ggaggaggga tcggggatga aatcgaagac ccagcaggag atgaatatga
14641 gatctatcga atcatctttg acatcacttt cttcttcttt gttattgtca ttctcttggc
14701 cataatacaa ggtctaatta ttgatgcttt tggagaacta agagaccaac aggaacaagt
14761 caaagaagac atggagacca aatgcttcat ctgtgggata ggcaatgatt acttcgacac
14821 agtgccacat ggctttgaaa cccacacttt acaggagcac aacttggcta attacttgtt
14881 ttttctgatg tatcttataa acaaagatga aacagaacac acaggacagg aatcttatgt
14941 ctggaagatg tatcaagaaa ggtgttggga atttttccca gcaggggatt gcttccggaa
15001 acagtatgaa gaccagctaa attaaactca gacccaatca cctctaaaaa ccaaaaccct
15061 acccctctct ctccctctct caatttctct gctctcttgg aaacattttg ctgattttgt
15121 gaattgccag cgatgtgtgt tttctgggag catcgaagct ctgtttcgga agagctgttt
15181 cctcccccca ccttttgtat ttactttgag actaaagact gaagaataat ctaaattcat
15241 actcagacaa aaaaaggaat tctggaaaga aaaccattct ggacactgtc ataacacaca
15301 tagatagatt ttcttctgag actcccggag tcttctcgag ctacgagacc ttcacagaga
15361 cacgtggcag ccacactcac ccagcctctt tatttcacca tcctggaagg aaactgtctg
15421 tctaatggtc acagagcact gtagcactta acagattgcc atggacacca gttgcgaagg
15481 gaaatagtgc cttactatat gtgggttgag ctatgcagaa gatacgtgca tgaaaaaaca
15541 tctttatttt ctttatgtcg acctttcttt tcttagattg attttgtgag gttttttttt
15601 tttcctttag tcttttcttt agtgggggag ggtaagaaaa gcagtttgca cttaaaaaga
15661 aaaaaaaaaa acgggtggtg tgtctcagga caaaaggagg ctcttctcat tcagctaaat
15721 tcacatttgc c
//