LOCUS X98033 2619 bp mRNA linear HUM 29-APR-1997
DEFINITION H.sapiens mRNA for E6-AP isoform-III.
ACCESSION X98033
VERSION X98033.1
KEYWORDS E6-AP gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Yamamoto Y., Huibregtse J.M., Howley P.M.
TITLE The human E6-AP gene (UBE3A) encodes three potential protein
isoforms generated by differential splicing
JOURNAL Genomics 41(2), 263-266(1997).
PUBMED 9143503
REFERENCE 2 (bases 1 to 2619)
AUTHORS Yamamoto Y.
JOURNAL Submitted (13-MAY-1996) to the INSDC. Y. Yamamoto, Harvard Medical
School, Pathology, 200 Longwood Ave. Boston, MA. 02115, USA
FEATURES Location/Qualifiers
source 1..2619
/db_xref="H-InvDB:HIT000325031"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="primary keratinocyte"
/db_xref="taxon:9606"
CDS 61..2619
/gene="E6-AP"
/note="isoform III"
/db_xref="GOA:Q05086"
/db_xref="H-InvDB:HIT000325031.12"
/db_xref="HGNC:HGNC:12496"
/db_xref="InterPro:IPR000569"
/db_xref="InterPro:IPR017134"
/db_xref="InterPro:IPR032353"
/db_xref="InterPro:IPR035983"
/db_xref="InterPro:IPR042556"
/db_xref="PDB:1C4Z"
/db_xref="PDB:1D5F"
/db_xref="PDB:1EQX"
/db_xref="PDB:2KR1"
/db_xref="PDB:4GIZ"
/db_xref="PDB:4XR8"
/db_xref="UniProtKB/Swiss-Prot:Q05086"
/protein_id="CAA66656.1"
/translation="MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNA
AAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDV
TYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA
KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRR
VYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIGMENRNLHSP
EYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFN
SRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE
ERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN
KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDH
IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGM
FTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGT
FRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPI
TNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR
NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLG
KLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML"
BASE COUNT 873 a 457 c 571 g 718 t
ORIGIN
1 atggccacag cttgtaaaag atcaggagaa cctcagtctg acgacattga agctagccga
61 atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc
121 tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg
181 gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt
241 gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc
301 cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa
361 gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga
421 gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg
481 gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca
541 aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg
601 gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat
661 ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac
721 accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg
781 tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat
841 ctgaatttgt tcattatcgg aatggagaat agaaatctcc acagtcctga atatctggaa
901 atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa
961 ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt
1021 cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat
1081 gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta
1141 gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag
1201 tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct
1261 cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt
1321 atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat
1381 tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata
1441 ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt
1501 gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg
1561 agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc
1621 gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa
1681 ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc
1741 aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca
1801 tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt
1861 tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg
1921 aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa
1981 gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca
2041 cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt
2101 ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat
2161 aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa
2221 tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg
2281 aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac
2341 tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga
2401 ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta
2461 aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc
2521 tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg
2581 aaggccatca cgtatgccaa aggatttggc atgctgtaa
//