LOCUS X98031 2628 bp mRNA linear HUM 29-APR-1997
DEFINITION H.sapiens mRNA for E6-AP isoform-II.
ACCESSION X98031
VERSION X98031.1
KEYWORDS E6-AP gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Yamamoto Y., Huibregtse J.M., Howley P.M.
TITLE The human E6-AP gene (UBE3A) encodes three potential protein
isoforms generated by differential splicing
JOURNAL Genomics 41(2), 263-266(1997).
PUBMED 9143503
REFERENCE 2 (bases 1 to 2628)
AUTHORS Yamamoto Y.
JOURNAL Submitted (13-MAY-1996) to the INSDC. Y. Yamamoto, Harvard Medical
School, Pathology, 200 Longwood Ave. Boston, MA. 02115, USA
FEATURES Location/Qualifiers
source 1..2628
/db_xref="H-InvDB:HIT000325029"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="primary keratinocyte"
/db_xref="taxon:9606"
CDS 70..2628
/gene="E6-AP"
/note="isoform II"
/db_xref="GOA:Q05086"
/db_xref="H-InvDB:HIT000325029.12"
/db_xref="HGNC:HGNC:12496"
/db_xref="InterPro:IPR000569"
/db_xref="InterPro:IPR017134"
/db_xref="InterPro:IPR032353"
/db_xref="InterPro:IPR035983"
/db_xref="InterPro:IPR042556"
/db_xref="PDB:1C4Z"
/db_xref="PDB:1D5F"
/db_xref="PDB:1EQX"
/db_xref="PDB:2KR1"
/db_xref="PDB:4GIZ"
/db_xref="PDB:4XR8"
/db_xref="UniProtKB/Swiss-Prot:Q05086"
/protein_id="CAA66654.1"
/translation="MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNA
AAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDV
TYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA
KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRR
VYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIGMENRNLHSP
EYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFN
SRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGE
ERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETEN
KFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDH
IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGM
FTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGT
FRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPI
TNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSR
NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLG
KLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML"
BASE COUNT 875 a 457 c 575 g 721 t
ORIGIN
1 atggagaagc tgcaccagtg ttattggaaa tcaggagaac ctcagtctga cgacattgaa
61 gctagccgaa tgaagcgagc agctgcaaag catctaatag aacgctacta ccaccagtta
121 actgagggct gtggaaatga agcctgcacg aatgagtttt gtgcttcctg tccaactttt
181 cttcgtatgg ataataatgc agcagctatt aaagccctcg agctttataa gattaatgca
241 aaactctgtg atcctcatcc ctccaagaaa ggagcaagct cagcttacct tgagaactcg
301 aaaggtgccc ccaacaactc ctgctctgag ataaaaatga acaagaaagg cgctagaatt
361 gattttaaag atgtgactta cttaacagaa gagaaggtat atgaaattct tgaattatgt
421 agagaaagag aggattattc ccctttaatc cgtgttattg gaagagtttt ttctagtgct
481 gaggcattgg tacagagctt ccggaaagtt aaacaacaca ccaaggaaga actgaaatct
541 cttcaagcaa aagatgaaga caaagatgaa gatgaaaagg aaaaagctgc atgttctgct
601 gctgctatgg aagaagactc agaagcatct tcctcaagga taggtgatag ctcacaggga
661 gacaacaatt tgcaaaaatt aggccctgat gatgtgtctg tggatattga tgccattaga
721 agggtctaca ccagattgct ctctaatgaa aaaattgaaa ctgcctttct caatgcactt
781 gtatatttgt cacctaacgt ggaatgtgac ttgacgtatc acaatgtata ctctcgagat
841 cctaattatc tgaatttgtt cattatcgga atggagaata gaaatctcca cagtcctgaa
901 tatctggaaa tggctttgcc attattttgc aaagcgatga gcaagctacc ccttgcagcc
961 caaggaaaac tgatcagact gtggtctaaa tacaatgcag accagattcg gagaatgatg
1021 gagacatttc agcaacttat tacttataaa gtcataagca atgaatttaa cagtcgaaat
1081 ctagtgaatg atgatgatgc cattgttgct gcttcgaagt gcttgaaaat ggtttactat
1141 gcaaatgtag tgggagggga agtggacaca aatcacaatg aagaagatga tgaagagccc
1201 atccctgagt ccagcgagct gacacttcag gaacttttgg gagaagaaag aagaaacaag
1261 aaaggtcctc gagtggaccc cctggaaact gaacttggtg ttaaaaccct ggattgtcga
1321 aaaccactta tcccttttga agagtttatt aatgaaccac tgaatgaggt tctagaaatg
1381 gataaagatt atactttttt caaagtagaa acagagaaca aattctcttt tatgacatgt
1441 ccctttatat tgaatgctgt cacaaagaat ttgggattat attatgacaa tagaattcgc
1501 atgtacagtg aacgaagaat cactgttctc tacagcttag ttcaaggaca gcagttgaat
1561 ccatatttga gactcaaagt tagacgtgac catatcatag atgatgcact tgtccggcta
1621 gagatgatcg ctatggaaaa tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa
1681 ggagaacaag gagttgatga gggaggtgtt tccaaagaat tttttcagct ggttgtggag
1741 gaaatcttca atccagatat tggtatgttc acatacgatg aatctacaaa attgttttgg
1801 tttaatccat cttcttttga aactgagggt cagtttactc tgattggcat agtactgggt
1861 ctggctattt acaataactg tatactggat gtacattttc ccatggttgt ctacaggaag
1921 ctaatgggga aaaaaggaac ttttcgtgac ttgggagact ctcacccagt tctatatcag
1981 agtttaaaag atttattgga gtatgaaggg aatgtggaag atgacatgat gatcactttc
2041 cagatatcac agacagatct ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt
2101 gataaaattc caattacaaa tgaaaacagg aaggaatttg tcaatcttta ttctgactac
2161 attctcaata aatcagtaga aaaacagttc aaggcttttc ggagaggttt tcatatggtg
2221 accaatgaat ctcccttaaa gtacttattc agaccagaag aaattgaatt gcttatatgt
2281 ggaagccgga atctagattt ccaagcacta gaagaaacta cagaatatga cggtggctat
2341 accagggact ctgttctgat tagggagttc tgggaaatcg ttcattcatt tacagatgaa
2401 cagaaaagac tcttcttgca gtttacaacg ggcacagaca gagcacctgt gggaggacta
2461 ggaaaattaa agatgattat agccaaaaat ggcccagaca cagaaaggtt acctacatct
2521 catacttgct ttaatgtgct tttacttccg gaatactcaa gcaaagaaaa acttaaagag
2581 agattgttga aggccatcac gtatgccaaa ggatttggca tgctgtaa
//