LOCUS X96757 1587 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for MAP kinase kinase.
ACCESSION X96757
VERSION X96757.1
KEYWORDS MAP kinase kinase; SAPKK3 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1587)
AUTHORS Cuenda A., Alonso G., Morrice N., Jones M., Meier R., Cohen P.,
Nebreda A.R.
TITLE Purification and cDNA cloning of SAPKK3, the major activator of
RK/p38 in stress- and cytokine-stimulated monocytes and epithelial
cells
JOURNAL EMBO J. 15(16), 4156-4164(1996).
PUBMED 8861944
REFERENCE 2 (bases 1 to 1587)
AUTHORS Nebreda A.
JOURNAL Submitted (21-MAR-1996) to the INSDC. A. Nebreda, European
Molecular Biology Laboratory, Meyerhofstrasse 1, D- 69117
Heidelberg, FRG
COMMENT Related sequences: U39064, U39065, U39066, U39656 & U39657
FEATURES Location/Qualifiers
source 1..1587
/db_xref="H-InvDB:HIT000324962"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="BJAB"
/cell_type="B cell"
/db_xref="taxon:9606"
CDS 273..1277
/gene="SAPKK3"
/product="MAP kinase kinase"
/db_xref="GOA:P52564"
/db_xref="H-InvDB:HIT000324962.14"
/db_xref="HGNC:HGNC:6846"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR008271"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR017441"
/db_xref="PDB:2Y8O"
/db_xref="PDB:3ENM"
/db_xref="PDB:3FME"
/db_xref="PDB:3VN9"
/db_xref="PDB:5ETF"
/db_xref="UniProtKB/Swiss-Prot:P52564"
/protein_id="CAA65532.1"
/translation="MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ
NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI
SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV
SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP
YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP
QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
"
BASE COUNT 493 a 334 c 359 g 401 t
ORIGIN
1 cttttagctg ccagccctgg cccatcatgt agctgcagca cagccttccc taacgttgca
61 actgggggaa aaatcacttt ccagtctgtt ttgcaaggtg tgcatttcca tcttgattcc
121 ctgaaagtcc atctgctgca tcggtcaaga gaaactccac ttgcatgaag attgcacgcc
181 tgcagcttgc atctttgttg caaaactagc tacagaagag aagcaaggca aagtcttttg
241 tgctcccctc ccccatcaaa ggaaagggga aaatgtctca gtcgaaaggc aagaagcgaa
301 accctggcct taaaattcca aaagaagcat ttgaacaacc tcagaccagt tccacaccac
361 ctagagattt agactccaag gcttgcattt ctattggaaa tcagaacttt gaggtgaagg
421 cagatgacct ggagcctata atggaactgg gacgaggtgc gtacggggtg gtggagaaga
481 tgcggcacgt gcccagcggg cagatcatgg cagtgaagcg gatccgagcc acagtaaata
541 gccaggaaca gaaacggcta ctgatggatt tggatatttc catgaggacg gtggactgtc
601 cattcactgt caccttttat ggcgcactgt ttcgggaggg tgatgtgtgg atctgcatgg
661 agctcatgga tacatcacta gataaattct acaaacaagt tattgataaa ggccagacaa
721 ttccagagga catcttaggg aaaatagcag tttctattgt aaaagcatta gaacatttac
781 atagtaagct gtctgtcatt cacagagacg tcaagccttc taatgtactc atcaatgctc
841 tcggtcaagt gaagatgtgc gattttggaa tcagtggcta cttggtggac tctgttgcta
901 aaacaattga tgcaggttgc aaaccataca tggcccctga aagaataaac ccagagctca
961 accagaaggg atacagtgtg aagtctgaca tttggagtct gggcatcacg atgattgagt
1021 tggccatcct tcgatttccc tatgattcat ggggaactcc atttcagcag ctcaaacagg
1081 tggtagagga gccatcgcca caactcccag cagacaagtt ctctgcagag tttgttgact
1141 ttacctcaca gtgcttaaag aagaattcca aagaacggcc tacataccca gagctaatgc
1201 aacatccatt tttcacccta catgaatcca aaggaacaga tgtggcatct tttgtaaaac
1261 tgattcttgg agactaaaaa gcagtggact taatcggttg accctactgt ggattggtgg
1321 gtttcggggt gaagcaagtt cactacagca tcaatagaaa gtcatctttg agataattta
1381 accctgcctc tcagagggtt ttctctccca attttctttt tactccccct cttaaggggg
1441 ccttggaatc tatagtatag aatgaactgt ctagatggat gaattatgat aaaggcttag
1501 gacttcaaaa ggtgattaaa tatttaatga tgtgtcatat gaaaaaaaaa aaaaaaaaaa
1561 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//