LOCUS X96401 4811 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for ROX protein.
ACCESSION X96401
VERSION X96401.1
KEYWORDS CA repeat; polymorphic dinucleotide repeat; rox gene; ROX protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A.,
Tonlorenzi R., Lo Nigro C., Messali S., Zollo M., Ledbetter D.H.,
Brent R., Ballabio A., Carrozzo R.
TITLE Rox, a novel bHLHZip protein expressed in quiescent cells that
heterodimerizes with Max, binds a non-canonical E box and acts as a
transcriptional repressor
JOURNAL EMBO J. 16(10), 2892-2906(1997).
PUBMED 9184233
REFERENCE 2 (bases 1 to 4811)
AUTHORS Carrozzo R.
JOURNAL Submitted (01-MAR-1996) to the INSDC. R. Carrozzo, Hospital San
Raffaele, Via Olgettina 60, I 20132 Milano, ITALY
REFERENCE 3
AUTHORS Lo Nigro C., Venesio T., Reymond A., Meroni G., Alberici P.,
Cainarca S., Enrico F., Stack M., Ledbetter D.H., Liscia D.S.,
Ballabio A., Carrozzo R.
TITLE The human ROX gene: genomic structure and mutation analysis in
human breast tumors
JOURNAL Genomics 49(2), 275-282(1998).
PUBMED 9598315
COMMENT Related sequence X69879
FEATURES Location/Qualifiers
source 1..4811
/db_xref="H-InvDB:HIT000324941"
/organism="Homo sapiens"
/chromosome="17"
/map="p13.3"
/mol_type="mRNA"
/dev_stage="foetus"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 213..1961
/gene="rox"
/product="ROX protein"
/db_xref="GOA:Q99583"
/db_xref="H-InvDB:HIT000324941.14"
/db_xref="HGNC:HGNC:7188"
/db_xref="InterPro:IPR011598"
/db_xref="InterPro:IPR036638"
/db_xref="UniProtKB/Swiss-Prot:Q99583"
/protein_id="CAA65265.1"
/translation="MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKAN
SLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLP
PPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPN
GSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGG
IGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEK
EYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASE
GEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALP
PAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHAS
VIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQL
PLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPV
TMVTMPSFPVSTLKLA"
repeat_region 4217..4254
/rpt_unit_seq="ca"
/note="polymorphic dinucleotide repeat"
regulatory 4753..4758
/regulatory_class="polyA_signal_sequence"
BASE COUNT 974 a 1630 c 1304 g 903 t
ORIGIN
1 aaatttgcaa ttttatattt tgcaaatatt ttgagagaca ttgatttttc tccccgtgct
61 cccccgttct tccctgcgga gtgcgctgcg ccgcccagcc ctgtcgcccc ccggaggtga
121 tccctccctc ctgcctgccc gccagcctga cctgtgcccg gctcgcgggc cgcagcctcg
181 gccccggcgc gcccccggca gctctcggcg cgatgagcat agagacgcta ctggaggcgg
241 cccgcttcct ggaatggcaa gcgcagcaac aacagagagc acgtgaggag caggagcggc
301 ttcgcttgga gcaggagcga gagcaggaac agaagaaggc caatagcctg gccaggctgg
361 cacataccct tcctgtggag gaaccccgca tggaggcgcc acccctgcct ctgtctccac
421 cggctccccc gccggcaccc ccaccaccac ttgccacccc tgccccactg actgtcatcc
481 ctatccctgt ggtgaccaac tcccctcagc ctctaccccc acccccaccc ttgcccgcgg
541 cagcccagcc tctgcccctg gcgcctcgtc agccggccct ggttggcgcc cccggactca
601 gcattaagga gcctgccccc ctgcccagca ggccgcaggt gcccacccct gctcccctac
661 tgccggactc gaaggccacc attccaccca atggcagccc caagcctttg cagcccctcc
721 ccacgcctgt cctgaccata gcgccacacc ctggagtcca gcctcagctg gccccccagc
781 agccgccccc acccacgctg gggaccctga agttggcacc agctgaagaa gtcaaatcca
841 gtgaacagaa gaagaggccc ggggggatcg gaaccagaga agtccacaac aaattggaga
901 agaacaggag ggcccatctg aaagagtgct ttgagaccct gaagcggaac atccccaacg
961 tggatgacaa gaagacgtcc aatctgagcg tgctgcggac ggcgctgcgg tacatccagt
1021 ccctgaagag gaaggagaag gaatatgagc atgaaatgga gcggctggca cgtgagaaga
1081 ttgccacgca gcagcggctg gcagagctca agcacgagct gagccagtgg atggacgtac
1141 tggagattga ccgcgtgctg cggcagacgg gccagcccga ggatgaccag gcctccacct
1201 ccaccgcctc tgagggtgag gacaacatag acgaggatat ggaggaggac cgggcgggcc
1261 tgggcccacc taagctgagc catcgtcccc agccggagct gctgaagtcc accctgccac
1321 cccccagcac cacccctgcg cctctgcctc cacacccaca ccctcacccc cactccgtgg
1381 ccctacctcc tgcccacctc cccgtgcagc agcagcagcc acagcagaag acccctctgc
1441 cagcccctcc tcccccaccg gctgcccctg cccagacact ggtgccagct ccagcccatc
1501 tggtggcgac ggctgggggt ggctccacgg tcatcgccca cacagctacc actcacgctt
1561 cagtcatcca gactgtgaac cacgttctgc aggggccagg cggcaagcac atcgcccaca
1621 tcgccccctc ggcccccagc cctgcggtgc aactggcgcc tgccacaccc cccattgggc
1681 acatcactgt gcaccctgcc accctcaacc atgtggccca cctgggctcc cagctgccct
1741 tgtacccgca gcccgtggca gtgagccaca tcgcccacac cctctcgcac cagcaagtca
1801 acggcacggc cggcctgggg cccccggcta ctgtcatggc aaagccggcc gtgggggctc
1861 aggtggtgca ccacccccag ctggtgggcc agaccgtgct caaccctgtg accatggtca
1921 ccatgccctc cttcccagtc agcacactca agctggcttg aggacgaggc cactcagagg
1981 cccccagtgg ggacagggag ggggacctgt cccccactct ctcacccacc agctccacac
2041 attccagcca ggcccaggcc agccccccca cccaccccca ggcctcctag gggaaggggg
2101 tgcaaagact ctgagccaag ggagggaagg gccaccctgc tgcactagga cttggtaaga
2161 tgactctgag aaaatgcgag actctgatgg aatgtgccac ctgtccggcc cagtgccagc
2221 tccagtgccg ctcctgcttc ccctccctac cctcggaaat cagtgcgatg tggacgtcac
2281 gctccctgac ttcttccccc ggccctgccc cggccttcgt gtgctgctgc tgctattgct
2341 gtctggtgaa ggtggcccag gcccccggct ttcctccgga gcctcatgtt ctcttcccag
2401 gcctttggag gggaaatggg gaaagcagaa ctgaagccac ttggcccaga aagctgcgga
2461 ttggggtgat aaggggcctt gctctgagca caggtgacag atcataggaa gtggctggtc
2521 tggagtccca cccggacagg tggggcctca gcctggggct ctctgacccg gttgcagtca
2581 ctgtgattcg ttaccgtaga tactacttaa aatgattctc taccaacaat aaaccaaacc
2641 cagccactgc caagcttcct gtgccctcac cccaatccct gccactgggc tctggacctc
2701 aggagggcag gctgaggtgg ggaaggaggg acttggctgt ccttcccctt ccccgtcccc
2761 tgcagcctgg gtctggatgg gaggagagcc actgggcccc tgtccccagt ccccagccct
2821 gggcttggct cttggcttcc agaaggcagc aaagaggggc gctgtcctgc gttcagcccc
2881 tgatctctga cctctgctga gtgctgggca ctgctccaag ggacaggtgg gcctggcggc
2941 ctgtgggttt gggtgcctcc tgcagtttgg gagacatgga ccagcatctg gtcttgtttc
3001 caggagcata gaagccacat cgttgagaca tcaggaaggt aaaaacccag cggcttagcc
3061 aagccctaag cctgtcccca gaccaaccct gggacctata cagaacagag ggccagagct
3121 agggctgctg cttctgctcc agcccctttg cctctgtcct cccatcccct caacaccctg
3181 cttctcccgg ggacgctttt gagtgggccc tgcccgggga gctgcagagc agcagcacct
3241 ttctctgaga agaggtcctt ggttgggtca aggacagggc tgagcgtgga agggggagga
3301 gtcaggggct ctgtgttagg atgcggcttt ctctgcctct gggcagcctg ctttggcctt
3361 tccttgtatg tgggtgttta ttacaagtgg gccccccccc cctccccacc tggacacaca
3421 cacaccagtg gccttcagtg tagcgggagg aagccggtgt ccctggatgt gaagctcaca
3481 ctgatgggct ggggcagggg ctgggcggcg agggggcccg gggaggggac agagctgagg
3541 atttcctgga gtgccctgca ggccaagagg aggtcagcaa aggtcttgaa tagattttct
3601 ctggaaataa agaatcctta gatcctaaaa atcccttcct gttccctcct ggtcctggac
3661 acctcccagg ggactgttcc ttatttctct ctcctggtgt gggtaaaggg acagttacaa
3721 accaggtcac catcctcaga ggctgagcct gtacccaccc cagcacagcc acctgccaga
3781 cccgtggctc tgggagagag cccttttgct attccattgt gacagcgatg caggcctgac
3841 cggacggggc agttagagca gcctcgtgga gctcgcccct cccctcagcc tgcccgcctc
3901 tccctgcatc ctgagccagt gcccccgggc ctgcacagat acctcatcat ccacccgctg
3961 cccctccccg tccctgtccc cagcatcggg ggcctgcaaa tctagtgccg aaatctagtg
4021 ccgaatgact atgtccagat tggtgacgat gggtgttgct gtttttcttg tgtttgtgaa
4081 cgcatgtgat gctgtggaag tgggcagtca ccacccagcc cttccttggg cgtctccccc
4141 agagtgctgt cgggaccaca tctgtcctca cctgtgggag cgcctggccc tccctcccta
4201 gcccttccag cctgggacac acacacacac acacacacac acacacacac acacgcacgc
4261 acacgcacac atcttacctc tcatgcgtgt tttacctttt gatgttcaga gtggctcact
4321 ggctgggagt ccttacctcg gggaggaggg ggaggttggt tccttggggg gccaaagaag
4381 gcagggaatg cctggagggt aactggggcc accatgaacc ccttttctcc agaaaagctg
4441 cttctccccc catcccgggt cccaccccca aacccccaga ggtggccctt gtttacagtg
4501 aggactcggc cactgtgtct ctgtttcctg aaatataaac tgtagcgacc ccagactgta
4561 gagattttta tgtgtttgga acatctgctg tgtggaaaaa aaaaaaaact acaaaaaccc
4621 taattttgta catactgtat ttttactatt gaactgtatt ctagtggctg ttcatgctcc
4681 aagactttag ttaccgagac atgaatacta tccatgtaat aagcacttgc ctggaataaa
4741 atataaaact gaaataaacc tgcactgaaa cctgagatgg agctgccaaa aaaaaaaaaa
4801 aaaaaaaaaa a
//