LOCUS       X96395                  4864 bp    mRNA    linear   HUM 21-OCT-2008
DEFINITION  H.sapiens mRNA for canalicular multidrug resistance protein.
ACCESSION   X96395
VERSION     X96395.2
KEYWORDS    ABC transporter protein; canalicular multidrug resistance protein;
            cmrp gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   2
  AUTHORS   Keppler D.
  JOURNAL   Submitted (27-FEB-1996) to the INSDC. D. Keppler, DKFZ, Abteilung
            Tumorbiochemie, Im Neuenheimer Feld 280, D-69120 Heidelberg, FRG
  REMARK    revised by [4]
REFERENCE   3
  AUTHORS   Buchler M., Konig J., Brom M., Kartenbeck J., Spring H., Horie T.,
            Keppler D.
  TITLE     cDNA cloning of the hepatocyte canalicular isoform of the multidrug
            resistance protein, cMrp, reveals a novel conjugate export pump
            deficient in hyperbilirubinemic mutant rats
  JOURNAL   J Biol Chem 271(25), 15091-15098(1996).
   PUBMED   8662992
REFERENCE   4
  AUTHORS   Keppler D.
  JOURNAL   Submitted (21-AUG-1996) to the INSDC. D. Keppler, DKFZ, Abteilung
            Tumorbiochemie, Im Neuenheimer Feld 280, D-69120 Heidelberg, FRG
  REMARK    revised by [5]
REFERENCE   5  (bases 1 to 4864)
  AUTHORS   Keppler D.
  JOURNAL   Submitted (24-MAY-2001) to the INSDC. D. Keppler, DKFZ, Abteilung
            Tumorbiochemie, Im Neuenheimer Feld 280, D-69120 Heidelberg, FRG
FEATURES             Location/Qualifiers
     source          1..4864
                     /db_xref="H-InvDB:HIT000324940"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             38..4675
                     /gene="cmrp"
                     /product="canalicular multidrug resistance protein"
                     /db_xref="GOA:Q92887"
                     /db_xref="H-InvDB:HIT000324940.14"
                     /db_xref="HGNC:HGNC:53"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR005292"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR030247"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="UniProtKB/Swiss-Prot:Q92887"
                     /protein_id="CAA65259.2"
                     /translation="MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLA
                     PWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYT
                     NPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNS
                     NLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYK
                     RPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGL
                     NKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDI
                     FTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKV
                     RTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVL
                     SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSG
                     IKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYV
                     LVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDT
                     SAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLIS
                     AMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALL
                     PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKH
                     IFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA
                     KNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLS
                     RSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQ
                     AIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGAL
                     GLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDI
                     STVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSR
                     QLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSN
                     RWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEI
                     ETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
                     TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLT
                     IIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGN
                     LSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHR
                     LHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF"
BASE COUNT         1334 a         1141 c         1130 g         1259 t
ORIGIN      
        1 atagaagagt cttcgttcca gacgcagtcc aggaatcatg ctggagaagt tctgcaactc
       61 tactttttgg aattcctcat tcctggacag tccggaggca gacctgccac tttgttttga
      121 gcaaactgtt ctggtgtgga ttcccttggg cttcctatgg ctcctggccc cctggcagct
      181 tctccacgtg tataaatcca ggaccaagag atcctctacc accaaactct atcttgctaa
      241 gcaggtattc gttggttttc ttcttattct agcagccata gagctggccc ttgtactcac
      301 agaagactct ggacaagcca cagtccctgc tgttcgatat accaatccaa gcctctacct
      361 aggcacatgg ctcctggttt tgctgatcca atacagcaga caatggtgtg tacagaaaaa
      421 ctcctggttc ctgtccctat tctggattct ctcgatactc tgtggcactt tccaatttca
      481 gactctgatc cggacactct tacagggtga caattctaat ctagcctact cctgcctgtt
      541 cttcatctcc tacggattcc agatcctgat cctgatcttt tcagcatttt cagaaaataa
      601 tgagtcatca aataatccat catccatagc ttcattcctg agtagcatta cctacagctg
      661 gtatgacagc atcattctga aaggctacaa gcgtcctctg acactcgagg atgtctggga
      721 agttgatgaa gagatgaaaa ccaagacatt agtgagcaag tttgaaacgc acatgaagag
      781 agagctgcag aaagccaggc gggcactcca gagacggcag gagaagagct cccagcagaa
      841 ctctggagcc aggctgcctg gcttgaacaa gaatcagagt caaagccaag atgcccttgt
      901 cctggaagat gttgaaaaga aaaaaaagaa gtctgggacc aaaaaagatg ttccaaaatc
      961 ctggttgatg aaggctctgt tcaaaacttt ctacatggtg ctcctgaaat cattcctact
     1021 gaagctagtg aatgacatct tcacgtttgt gagtcctcag ctgctgaaat tgctgatctc
     1081 ctttgcaagt gaccgtgaca catatttgtg gattggatat ctctgtgcaa tcctcttatt
     1141 cactgcggct ctcattcagt ctttctgcct tcagtgttat ttccaactgt gcttcaagct
     1201 gggtgtaaaa gtacggacag ctatcatggc ttctgtatat aagaaggcat tgaccctatc
     1261 caacttggcc aggaaggagt acaccgttgg agaaacagtg aacctgatgt ctgtggatgc
     1321 ccagaagctc atggatgtga ccaacttcat gcacatgctg tggtcaagtg ttctacagat
     1381 tgtcttatct atcttcttcc tatggagaga gttgggaccc tcagtcttag caggtgttgg
     1441 ggtgatggtg cttgtaatcc caattaatgc gatactgtcc accaagagta agaccattca
     1501 ggtcaaaaat atgaagaata aagacaaacg tttaaagatc atgaatgaga ttcttagtgg
     1561 aatcaagatc ctgaaatatt ttgcctggga accttcattc agagaccaag tacaaaacct
     1621 ccggaagaaa gagctcaaga acctgctggc ctttagtcaa ctacagtgtg tagtaatatt
     1681 cgtcttccag ttaactccag tcctggtatc tgtggtcaca ttttctgttt atgtcctggt
     1741 ggatagcaac aatattttgg atgcacaaaa ggccttcacc tccattaccc tcttcaatat
     1801 cctgcgcttt cccctgagca tgcttcccat gatgatctcc tccatgctcc aggccagtgt
     1861 ttccacagag cggctagaga agtacttggg aggggatgac ttggacacat ctgccattcg
     1921 acatgactgc aattttgaca aagccatgca gttttctgag gcctccttta cctgggaaca
     1981 tgattcggaa gccacagtcc gagatgtgaa cctggacatt atggcaggcc aacttgtggc
     2041 tgtgataggc cctgtcggct ctgggaaatc ctccttgata tcagccatgc tgggagaaat
     2101 ggaaaatgtc cacgggcaca tcaccatcaa gggcaccact gcctatgtcc cacagcagtc
     2161 ctggattcag aatggcacca taaaggacaa catccttttt ggaacagagt ttaatgaaaa
     2221 gaggtaccag caagtactgg aggcctgtgc tctcctccca gacttggaaa tgctgcctgg
     2281 aggagatttg gctgagattg gagagaaggg tataaatctt agtgggggtc agaagcagcg
     2341 gatcagcctg gccagagcta cctaccaaaa tttagacatc tatcttctag atgaccccct
     2401 gtctgcagtg gatgctcatg taggaaaaca tatttttaat aaggtcttgg gccccaatgg
     2461 cctgttgaaa ggcaagactc gactcttggt tacacatagc atgcactttc ttcctcaagt
     2521 ggatgagatt gtagttctgg ggaatggaac aattgtagag aaaggatcct acagtgctct
     2581 cctggccaaa aaaggagagt ttgctaagaa tctgaagaca tttctaagac atacaggccc
     2641 tgaagaggaa gccacagtcc atgatggcag tgaagaagaa gacgatgact atgggctgat
     2701 atccagtgtg gaagagatcc ccgaagatgc agcctccata accatgagaa gagagaacag
     2761 ctttcgtcga acacttagcc gcagttctag gtccaatggc aggcatctga agtccctgag
     2821 aaactccttg aaaactcgga atgtgaatag cctgaaggaa gacgaagaac tagtgaaagg
     2881 acaaaaacta attaagaagg aattcataga aactggaaag gtgaagttct ccatctacct
     2941 ggagtaccta caagcaatag gattgttttc gatattcttc atcatccttg cgtttgtgat
     3001 gaattctgtg gcttttattg gatccaacct ctggctcagt gcttggacca gtgactctaa
     3061 aatcttcaat agcaccgact atccagcatc tcagagggac atgagagttg gagtctacgg
     3121 agctctggga ttagcccaag gtatatttgt gttcatagca catttctgga gtgcctttgg
     3181 tttcgtccat gcatcaaata tcttgcacaa gcaactgctg aacaatatcc ttcgagcacc
     3241 tatgagattt tttgacacaa cacccacagg ccggattgtg aacaggtttg ccggcgatat
     3301 ttccacagtg gatgacaccc tgcctcagtc cttgcgcagc tggattacat gcttcctggg
     3361 gataatcagc acccttgtca tgatctgcat ggccactcct gtcttcacca tcatcgtcat
     3421 tcctcttggc attatttatg tatctgttca gatgttttat gtgtctacct cccgccagct
     3481 gaggcgtctg gactctgtca ccaggtcccc aatctactct cacttcagcg agaccgtatc
     3541 aggtttgcca gttatccgtg cctttgagca ccagcagcga tttctgaaac acaatgaggt
     3601 gaggattgac accaaccaga aatgtgtctt ttcctggatc acctccaaca ggtggcttgc
     3661 aattcgcctg gagctggttg ggaacctgac tgtcttcttt tcagccttga tgatggttat
     3721 ttatagagat accctaagtg gggacactgt tggctttgtt ctgtccaatg cactcaatat
     3781 cacacaaacc ctgaactggc tggtgaggat gacatcagaa atagagacca acattgtggc
     3841 tgttgagcga ataactgagt acacaaaagt ggaaaatgag gcaccctggg tgactgataa
     3901 gaggcctccg ccagattggc ccagcaaagg caagatccag tttaacaact accaagtgcg
     3961 gtaccgacct gagctggatc tggtcctcag agggatcact tgtgacatcg gtagcatgga
     4021 gaagattggt gtggtgggca ggacaggagc tggaaagtca tccctcacaa actgcctctt
     4081 cagaatctta gaggctgccg gtggtcagat tatcattgat ggagtagata ttgcttccat
     4141 tgggctccac gacctccgag agaagctgac catcatcccc caggacccca tcctgttctc
     4201 tggaagcctg aggatgaatc tcgacccttt caacaactac tcagatgagg agatttggaa
     4261 ggccttggag ctggctcacc tcaagtcttt tgtggccagc ctgcaacttg ggttatccca
     4321 cgaagtgaca gaggctggtg gcaacctgag cataggccag aggcagctgc tgtgcctggg
     4381 cagggctctg cttcggaaat ccaagatcct ggtcctggat gaggccactg ctgcggtgga
     4441 tctagagaca gacaacctca ttcagacgac catccaaaac gagttcgccc actgcacagt
     4501 gatcaccatc gcccacaggc tgcacaccat catggacagt gacaaggtaa tggtcctaga
     4561 caacgggaag attatagagt gcggcagccc tgaagaactg ctacaaatcc ctggaccctt
     4621 ttactttatg gctaaggaag ctggcattga gaatgtgaac agcacaaaat tctagcagaa
     4681 ggccccatgg gttagaaaag gactataaga ataatttctt atttaatttt attttttata
     4741 aaatacagaa tacatacaaa agtgtgtata aaatgtacgt tttaaaaaag gataagtgaa
     4801 cacccatgaa cctactaccc aggttaagaa aataaatgtc accaggtact tgaaaaaaaa
     4861 aaaa
//