LOCUS X95653 2576 bp mRNA linear HUM 21-OCT-2008
DEFINITION H.sapiens mRNA for enhancer of zeste.
ACCESSION X95653
VERSION X95653.1
KEYWORDS zeste enhancer gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 2 (bases 1 to 2576)
AUTHORS Antonarakis S.E.
JOURNAL Submitted (13-FEB-1996) to the INSDC. S.E. Antonarakis, Division of
Medical Genetics, University of Geneva School of Medicine, Rue
Michel-Servet 1, CH-1211 Geneva, SWITZERLAND
REFERENCE 3 (bases 1 to 2576)
AUTHORS Chen H.M., Rossier C., Antonarakis S.E.
TITLE Cloning of a human homolog of the Drosophila enhancer of zeste gene
(EZH2) that maps to chromosome 21q22.2
JOURNAL Genomics 38(1), 30-37(1996).
PUBMED 8954776
COMMENT Related protein P42124
FEATURES Location/Qualifiers
source 1..2576
/db_xref="H-InvDB:HIT000324919"
/organism="Homo sapiens"
/chromosome="21"
/map="q22.2"
/mol_type="mRNA"
/dev_stage="fetal"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 58..2298
/gene="EZH2"
/product="enhancer of zeste"
/db_xref="GOA:Q15910"
/db_xref="H-InvDB:HIT000324919.14"
/db_xref="HGNC:HGNC:3527"
/db_xref="InterPro:IPR001005"
/db_xref="InterPro:IPR001214"
/db_xref="InterPro:IPR021654"
/db_xref="InterPro:IPR026489"
/db_xref="InterPro:IPR033467"
/db_xref="InterPro:IPR041343"
/db_xref="InterPro:IPR041355"
/db_xref="PDB:2C6V"
/db_xref="PDB:4MI0"
/db_xref="PDB:4MI5"
/db_xref="PDB:5GSA"
/db_xref="PDB:5H14"
/db_xref="PDB:5H15"
/db_xref="PDB:5H17"
/db_xref="PDB:5H19"
/db_xref="PDB:5H24"
/db_xref="PDB:5H25"
/db_xref="PDB:5HYN"
/db_xref="PDB:5IJ7"
/db_xref="PDB:5IJ8"
/db_xref="PDB:5LS6"
/db_xref="PDB:5U5T"
/db_xref="PDB:5U62"
/db_xref="PDB:5WG6"
/db_xref="PDB:5WUK"
/db_xref="PDB:6C23"
/db_xref="PDB:6C24"
/db_xref="UniProtKB/Swiss-Prot:Q15910"
/protein_id="CAA64955.1"
/translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSS
NRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLN
AVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGD
RECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKF
PSDKILEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQ
SLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEF
AAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGEN
NDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDN
FCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQL
KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQC
NTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGW
GIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGN
KIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFVDYRYSQADALKYVGIE
REMEIP"
polyA_site 2558
BASE COUNT 826 a 513 c 612 g 625 t
ORIGIN
1 gaattccggg cgacgcgcgg gaacaacgcg agtcggcgcg cgggacgaag aataatcatg
61 ggccagactg ggaagaaatc tgagaaggga ccagtttgtt ggcggaagcg tgtaaaatca
121 gagtacatgc gactgagaca gctcaagagg ttcagacgag ctgatgaagt aaagagtatg
181 tttagttcca atcgtcagaa aattttggaa agaacggaaa tcttaaacca agaatggaaa
241 cagcgaagga tacagcctgt gcacatcctg acttctgtga gctcattgcg cgggactagg
301 gagtgttcgg tgaccagtga cttggatttt ccaacacaag tcatcccatt aaagactctg
361 aatgcagttg cttcagtacc cataatgtat tcttggtctc ccctacagca gaattttatg
421 gtggaagatg aaactgtttt acataacatt ccttatatgg gagatgaagt tttagatcag
481 gatggtactt tcattgaaga actaataaaa aattatgatg ggaaagtaca cggggataga
541 gaatgtgggt ttataaatga tgaaattttt gtggagttgg tgaatgccct tggtcaatat
601 aatgatgatg acgatgatga tgatggagac gatcctgaag aaagagaaga aaagcagaaa
661 gatctggagg atcaccgaga tgataaagaa agccgcccac ctcggaaatt tccttctgat
721 aaaattttgg aggccatttc ctcaatgttt ccagataagg gcacagcaga agaactaaag
781 gaaaaatata aagaactcac cgaacagcag ctcccaggcg cacttcctcc tgaatgtacc
841 cccaacatag atggaccaaa tgctaaatct gttcagagag agcaaagctt acactccttt
901 catacgcttt tctgtaggcg atgttttaaa tatgactgct tcctacatcc ttttcatgca
961 acacccaaca cttataagcg gaagaacaca gaaacagctc tagacaacaa accttgtgga
1021 ccacagtgtt accagcattt ggagggagca aaggagtttg ctgctgctct caccgctgag
1081 cggataaaga ccccaccaaa acgtccagga ggccgcagaa gaggacggct tcccaataac
1141 agtagcaggc ccagcacccc caccattaat gtgctggaat caaaggatac agacagtgat
1201 agggaagcag ggactgaaac ggggggagag aacaatgata aagaagaaga agagaagaaa
1261 gatgaaactt cgagctcctc tgaagcaaat tctcggtgtc aaacaccaat aaagatgaag
1321 ccaaatattg aacctcctga gaatgtggag tggagtggtg ctgaagcctc aatgtttaga
1381 gtcctcattg gcacttacta tgacaatttc tgtgccattg ctaggttaat tgggaccaaa
1441 acatgtagac aggtgtatga gtttagagtc aaagaatcta gcatcatagc tccagctccc
1501 gctgaggatg tggatactcc tccaaggaaa aagaagagga aacaccggtt gtgggctgca
1561 cactgcagaa agatacagct gaaaaaggac ggctcctcta accatgttta caactatcaa
1621 ccctgtgatc atccacggca gccttgtgac agttcgtgcc cttgtgtgat agcacaaaat
1681 ttttgtgaaa agttttgtca atgtagttca gagtgtcaaa accgctttcc gggatgccgc
1741 tgcaaagcac agtgcaacac caagcagtgc ccgtgctacc tggctgtccg agagtgtgac
1801 cctgacctct gtcttacttg tggagccgct gaccattggg acagtaaaaa tgtgtcctgc
1861 aagaactgca gtattcagcg gggctccaaa aagcatctat tgctggcacc atctgacgtg
1921 gcaggctggg ggatttttat caaagatcct gtgcagaaaa atgaattcat ctcagaatac
1981 tgtggagaga ttatttctca agatgaagct gacagaagag ggaaagtgta tgataaatac
2041 atgtgcagct ttctgttcaa cttgaacaat gattttgtgg tggatgcaac ccgcaagggt
2101 aacaaaattc gttttgcaaa tcattcggta aatccaaact gctatgcaaa agttatgatg
2161 gttaacggtg atcacaggat aggtattttt gccaagagag ccatccagac tggcgaagag
2221 ctgtttgttg attacagata cagccaggct gatgccctga agtatgtcgg catcgaaaga
2281 gaaatggaaa tcccttgaca tctgctacct cctccccctc ctctgaaaca gctgccttag
2341 cttcaggaac ctcgagtact gtgggcaatt tagaaaaaga acatgcagtt tgaaattctg
2401 aatttgcaaa gtactgtaag aataatttat agtaatgagt ttaaaaatca actttttatt
2461 gccttctcac cagctgcaaa gtgttttgta ccagtgaatt tttgcaataa tgcagtatgg
2521 tacatttttc aactttgaat aaagaatact tgaacttgaa aaaaaaaaaa aaaaaa
//