LOCUS X93996 3171 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for AFX protein.
ACCESSION X93996
VERSION X93996.1
KEYWORDS AFX gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Borkhardt A., Repp R., Haas O.A., Leis T., Harbott J., Kreuder J.,
Hammermann J., Henn T., Lampert F.
TITLE Cloning and characterization of AFX, the gene that fuses to MLL in
acute leukemias with a t(X;11)(q13;q23)
JOURNAL Oncogene 14(2), 195-202(1997).
PUBMED 9010221
REFERENCE 2 (bases 1 to 3171)
AUTHORS Borkhardt A.
JOURNAL Submitted (04-DEC-1995) to the INSDC. A. Borkhardt,
Universitaets-Kinderlinik, Feulgenstr. 12, Giessen, D-35392, FRG
FEATURES Location/Qualifiers
source 1..3171
/db_xref="H-InvDB:HIT000324763"
/organism="Homo sapiens"
/chromosome="X"
/mol_type="mRNA"
/germline
/db_xref="taxon:9606"
mRNA 1..3171
CDS 183..1688
/gene="AFX"
/db_xref="GOA:P98177"
/db_xref="H-InvDB:HIT000324763.13"
/db_xref="HGNC:HGNC:7139"
/db_xref="InterPro:IPR001766"
/db_xref="InterPro:IPR030456"
/db_xref="InterPro:IPR032067"
/db_xref="InterPro:IPR036388"
/db_xref="InterPro:IPR036390"
/db_xref="PDB:1E17"
/db_xref="PDB:3L2C"
/db_xref="UniProtKB/Swiss-Prot:P98177"
/protein_id="CAA63819.1"
/translation="MRIQPQKAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPP
EVEPDLGEKVHTEGRSEPILLPSRLSEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSY
AEFISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKF
IKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAP
PEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEV
LAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPL
HTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTL
LLLGGLPSSSKLATGVGLCPKPLEARGPSSLVPTLSMIAPPPVMASAPIPKALGTPVL
TPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP"
BASE COUNT 742 a 855 c 909 g 665 t
ORIGIN
1 gggacagctt agggactatc gtcctgggac tagggggaag ttcgcgactt tctgaagact
61 ggcaggaatg tgcctcctgg ccctcgatgc ttcccccctg aggggaggca tcgtgaggga
121 ctgtggcagg cttcactgaa cgctgagccg gggaggtcca actccacgta tggatccggg
181 gaatgagaat tcagccacag aaggccgccg cgatcataga cctagatccc gacttcgaac
241 cccagagccg tccccgctcc tgcacctggc cccttccccg accagagatc gctaaccagc
301 cgtccgagcc gcccgaggtg gagccagatc tgggggaaaa ggtacacacg gaggggcgct
361 cagagccgat cctgttgccc tctcggctct cagagccggc cgggggcccc cagcccggaa
421 tcctgggggc tgtaacaggt cctcggaagg gaggctcccg ccggaatgcc tggggaaatc
481 agtcatatgc agaattcatc agccaggcca ttgaaagcgc cccggagaag cgactgacac
541 ttgcccagat ttacgagtgg atggtccgta ctgtacccta cttcaaggac aagggtgaca
601 gcaacagctc agcaggatgg aagaactcga tccgccacaa cctgtccctg cacagcaagt
661 tcatcaaggt tcacaacgag gccaccggca aaagctcttg gtggatgctg aaccctgagg
721 gaggcaagag cggcaaagcc ccccgccgcc gggccgcctc catggatagc agcagcaagc
781 tgctccgggg ccgcagtaaa gcccccaaga agaaaccatc tgtgctgcca gctccacccg
841 aaggtgccac tccaacgagc cctgtcggcc actttgccaa gtggtcaggc agcccttgct
901 ctcgaaaccg tgaagaagcc gatatgtgga ccaccttccg tccacgaagc agttcaaatg
961 ccagcagtgt cagcacccgg ctgtccccct tgaggccaga gtctgaggtg ctggcggagg
1021 aaataccagc ttcagtcagc agttatgcag ggggtgtccc tcccaccctc aatgaaggtc
1081 tagagctgtt agatgggctc aatctcacct cttcccattc cctgctatct cggagtggtc
1141 tctctggctt ctctttgcag catcctgggg ttaccggccc cttacacacc tacagcagct
1201 cccttttcag cccagcagag gggcccctgt cagcaggaga agggtgcttc tccagctccc
1261 aggctctgga ggccctgctc acctctgata cgccaccacc ccctgctgac gtcctcatga
1321 cccaggtaga tcccattctg tcccaggctc cgactcttct gttgctgggg gggcttcctt
1381 cctccagtaa gctggccacg ggcgtcggcc tgtgtcccaa gcccctagag gctcgaggcc
1441 ccagcagtct ggttcccacc ctttctatga tagcaccacc tccagtcatg gcaagtgccc
1501 ccatccccaa ggctctgggg actcctgtgc tcacaccccc tactgaagct gcaagccaag
1561 acagaatgcc tcaggatcta gatcttgata tgtatatgga gaacctggag tgtgacatgg
1621 ataacatcat cagtgacctc atggatgagg gcgagggact ggacttcaac tttgagccag
1681 atccctgagt catgcctgga agctttgtcc cctgcttcag atgtggagcc aggcgtgttc
1741 atatctactc tttacccttg agccctcccc aggaatttgg gaccctgctt tagagctagg
1801 gtggggtctg gtcacacaca ggtgttgaag aaattataaa gataaagctg ccccatctgg
1861 ggacgatatg gggagggaga tgggagggga aaggggagag ggtttttctc actgtgccaa
1921 ttagggggta aggccccctc tcaggagcca tcatcggctt tccccattcc tacccactta
1981 ggctttgtag caagatgagc aatgctgttg gaaatgtgaa gtcaccagtg gccttacccc
2041 tgcctttggg agcaggattt ttttgtagag agtcttatct gagctgagcc aggctagctg
2101 gagcctggga tttctatgca gtggcccctt aggccagtga tgtgcggtgg gtgggctgtt
2161 taggggatct ggaagggcca aggtctgagc actggagtgg ctcgccaggc caaatcaccc
2221 ttagaaggct gcagataaca gaaaggcttt ttataaactt ttaaagaaat ataaacacaa
2281 atatagagat tttttaacca tggcagggtg ctagtggtgg gcagaatgct tttttttctt
2341 tctgaaggct ttgtgatagt gacatgatac aaacactaca gacaataaat attaggagac
2401 acagggaagt ggggagaggt ggggagtaat agtaaacaca gggaagagct cccctacgga
2461 ccaggtatag agaaaggtct atgcagaaat aggttagagt ttccctaaca aaaaagctaa
2521 cccaggtccc ctcattcctt caacttgtgc ctgggagtgt gtggtgttag ggtgcagcca
2581 cactcttcta tgacccagca tgggttagtg ctatggtggg agagtacatt gaaggcctgg
2641 aattagcttg gggccaggga agggactggg aggggagaga agagaaggag ggaaggattt
2701 aggatggtaa agttaggtac agagacctcc ctgttcaagg cccctgacag ctgtccctgc
2761 ccttcttccc cttccctgac tgcaggggtt atgtggaagt gtgtgtggca gcaggcagcg
2821 gggaggggag gaacagggaa gggggagctg gggagcttgg ctgagggtct gggaaatgag
2881 cagggatggg gggggatgtg gatcaggttt actagcacct gccagggagg ccatctgggg
2941 ctccttctcc accccagccc ccaaagcagc ccttccccca gtgccctttg catcgtcccc
3001 tcccccaccc ctgctgtggg ttcccatcat ttcctgtgtc agcgcctggc ctacccagat
3061 tgtatcatgt gctagattgg agtggggaag tgtgtcaaat caataaatga ataaattcaa
3121 taaatgccta taaccagcag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
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