LOCUS X91171 6064 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for laminin alpha 4 protein.
ACCESSION X91171
VERSION X91171.1
KEYWORDS LAMA4 gene; laminin alpha 4 protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Richards A., Al-Imara L., Pope F.M.
TITLE The complete cDNA sequence of laminin alpha 4 and its relationship
to the other human laminin alpha chains
JOURNAL Eur. J. Biochem. 238(3), 813-821(1996).
PUBMED 8706685
REFERENCE 2 (bases 1 to 6064)
AUTHORS Richards A.J.
JOURNAL Submitted (31-AUG-1995) to the INSDC. A.J. Richards, University of
Cambridge, MRC Connective Tissue Genetics Group, Strangeways
Research Lab., Worts Causeway, Cambridge CB2 4RN, UK
REFERENCE 3 (bases 1 to 6064)
AUTHORS Durkin M.E., Loechel F., Mattei M., Gilpin B.J., Albrechtsen R.,
Wewer U.M.
TITLE Tissue-specific expression of the human laminin alpha5-chain, and
mapping of the gene to human chromosome 20q13.2-13.3 and to distal
mouse chromosome 2 near the locus for the ragged (Ra) mutation
JOURNAL FEBS Lett. 411(2-3), 296-300(1997).
PUBMED 9271224
COMMENT Overlaps with X76939 and X70904
FEATURES Location/Qualifiers
source 1..6064
/db_xref="H-InvDB:HIT000324447"
/organism="Homo sapiens"
/chromosome="6"
/map="q21"
/mol_type="mRNA"
/clone_lib="lambda ZAP II"
/tissue_type="heart"
/db_xref="taxon:9606"
CDS 284..5734
/gene="LAMA4"
/product="laminin alpha 4"
/db_xref="GOA:Q16363"
/db_xref="H-InvDB:HIT000324447.14"
/db_xref="HGNC:HGNC:6484"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR001791"
/db_xref="InterPro:IPR002049"
/db_xref="InterPro:IPR009254"
/db_xref="InterPro:IPR010307"
/db_xref="InterPro:IPR013320"
/db_xref="UniProtKB/Swiss-Prot:Q16363"
/protein_id="CAA62596.1"
/translation="MALSSAWRSVLPLWLLWSAACSRAASGDDNAFPFDIEGSSAVGR
QDPPETSEPRVALGRLPPAAEKCNAGFFHTLSGECVPCDCNGNSNECLDGSGYCVHCQ
RNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCICNEN
YAGPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQCRNCLRNTTG
FKCERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPPTGCDKCVWDLTDD
LRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALRKIQINN
AENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKIQEIN
NKMLYYGEEHELSPKEISEKLVLAQKMLEEIRSRQPFFTQRELVDEEADEAYELLSQA
ESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNHVRDAEDMNRATAARQRD
HEKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQ
VKLSNLSNLSHDLVQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYENIV
NYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHKDESENLLNQARELQAKAESSSDE
AVADTSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRTTME
VQQATAPMANNLTNWSQNLQHFDSSAYNTAVNSARDAVRNLTEVVPQLLDQLRTVEQK
RPASNVSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDLKAFTSLSL
YMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLDS
KPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPED
TVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSVPCAR
DKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGS
MFFRLEMRNGYLHVFYDFGFSSGRVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVV
DRRHVKSMDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKD
FNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPN
GLLFYYASGSDVFSISLDNGTVIMDVKGIKVQSVDKQYNDGLSHFVISSVSPTRYELI
VDKSRVGSKNPTKGKIEQTQASEKKFYFGGSPISAQYANFTGCISNAYFTRVDRDVEV
EDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVA
LKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRT
RSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDVIFI
RERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGC
LSNLQLNGASITSASQTFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFE
VRPRSSSGTLVHGHSVNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHR
ITVIRDSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTG
CIRHFVIDGHPVSFSKAALVSGAVSINSCPAA"
regulatory 6016..6021
/regulatory_class="polyA_signal_sequence"
regulatory 6037..6042
/regulatory_class="polyA_signal_sequence"
polyA_site 6043
BASE COUNT 1786 a 1370 c 1496 g 1412 t
ORIGIN
1 agaaggtaaa aagggagtgg tgagaatgaa tgtgagaagg aagccaggac agcgcagtcc
61 ccagtcccga acggccaggg agaggaggtg gcctagcgct ggcggggctc accccaatcc
121 gtctgccttt tgatgccgta ctctgctggt tgcgcagcca cctcgggata ctgcacacgg
181 agaggaggga aaataagcga ggcaccgccg caccacgcgg gagacctacg gagacccaca
241 gcgcccgagc cctggaagag cactactgga tgtcagcgga gaaatggctt tgagctcagc
301 ctggcgctcg gttctgcctc tgtggctcct ctggagcgct gcctgctccc gcgccgcgtc
361 cggggacgac aacgcttttc cttttgacat tgaagggagc tcagcggttg gcaggcaaga
421 cccgcctgag acgagcgaac cccgcgtggc tctgggacgc ctgccgcctg cggccgagaa
481 atgcaatgct ggattctttc acaccctgtc gggagaatgt gtgccctgcg actgtaatgg
541 caattccaac gagtgtttgg acggctcagg atactgtgtg cactgccagc ggaacacaac
601 aggagagcac tgtgaaaagt gtctggatgg ttatatcgga gattccatca ggggagcacc
661 ccaattctgc cagccgtgcc cctgtcccct gccccacttg gccaattttg cagaatcctg
721 ctataggaaa aatggagctg ttcggtgcat ttgtaacgaa aattatgctg gacctaactg
781 tgaaagatgt gctcccggtt actatggaaa ccccttactc attggaagca cctgtaagaa
841 atgtgactgc agtggaaatt cagatcccaa cctgatcttt gaagattgtg atgaagtcac
901 tggccagtgt aggaattgct tacgcaacac caccggattc aagtgtgaac gttgcgctcc
961 tggctactat ggggacgcca ggatagccaa gaactgtgca gtgtgcaact gcgggggagg
1021 cccatgtgac agtgtaaccg gagaatgctt ggaagaaggt tttgaacccc ctacaggctg
1081 tgataagtgc gtctgggacc tgactgatga cctgcggtta gcagcgctct ccatcgagga
1141 aggcaaatcc ggggtgctga gcgtatcctc tggggccgcc gctcataggc acgtgaatga
1201 aatcaacgcc accatctacc tcctcaaaac aaaattgtca gaaagagaaa accaatacgc
1261 cctaagaaag atacaaatca acaatgctga gaacacgatg aaaagccttc tgtctgacgt
1321 agaggaatta gttgaaaagg aaaatcaagc ctccagaaaa ggacaacttg ttcagaagga
1381 aagcatggac accattaacc acgcaagtca gctggtagag caagcccatg atatgaggga
1441 taaaatccaa gagatcaaca acaagatgct ctattatggg gaagagcatg aacttagccc
1501 caaggaaatc tctgagaagc tggtgttggc ccagaagatg cttgaagaga ttagaagccg
1561 tcaaccattt ttcacccaac gggagctcgt ggatgaggag gcagatgagg cttacgaact
1621 actgagccag gctgagagct ggcagcggct gcacaatgag acccgcactc tgtttcctgt
1681 cgtcctggag cagctggatg actacaatgc taagttgtca gatctccagg aagcacttga
1741 ccaggccctt aaccatgtca gggatgccga agacatgaac agggccacag cagccaggca
1801 gcgggaccat gagaaacaac aggaaagagt gagggaacaa atggaagtgg tgaacatgtc
1861 tctgagcaca tctgcggact ctctgacaac acctcgtcta actctttcag aacttgatga
1921 tataataaag aatgcgtcag ggatttatgc agaaatagat ggagccaaaa gtgaactaca
1981 agtaaaacta tctaacctaa gtaacctcag ccatgattta gtccaagaag ctattgacca
2041 tgcacaggac cttcaacaag aagctaatga attgagcagg aagttgcaca gttcagatat
2101 gaacgggctg gtacagaagg ctttggatgc atcaaatgtc tatgaaaata ttgttaatta
2161 tgttagtgaa gccaatgaaa cagcagaatt tgctttgaac accactgacc gaatttatga
2221 tgcggtgagt gggattgata ctcaaatcat ttaccataaa gatgaaagtg agaacctcct
2281 caatcaagcc agagaactgc aagcaaaggc agagtctagc agtgatgaag cagtggctga
2341 cactagcagg cgtgtgggtg gagccctagc aaggaaaagt gcccttaaaa ccagactcag
2401 tgatgccgtt aagcaactac aagcagcaga gagaggggat gcccagcagc gcctggggca
2461 gtctagactg atcaccgagg aagccaacag gacgacgatg gaggtgcagc aggccactgc
2521 ccccatggcc aacaatctaa ccaactggtc acagaatctt caacattttg actcttctgc
2581 ttacaacact gcagtgaact ctgctaggga tgcagtaaga aatctgaccg aggttgtccc
2641 tcagctcctg gatcagcttc gtacggttga gcagaagcga cctgcaagca acgtttctgc
2701 cagcatccag aggatccgag agctcattgc tcagaccaga agtgttgcca gcaagatcca
2761 agtctccatg atgtttgatg gccagtcagc tgtggaagtg cactcgagaa ccagtatgga
2821 tgacttaaag gccttcacgt ctctgagcct gtacatgaaa ccccctgtga agcggccgga
2881 actgaccgag actgcagatc agtttatcct gtacctcgga agcaaaaacg ccaaaaaaga
2941 gtatatgggt cttgcaatca aaaatgataa tctggtatac gtctataatt tgggaactaa
3001 agatgtggag attcccctgg actccaagcc cgtcagttcc tggcctgctt acttcagcat
3061 tgtcaagatt gaaagggtgg gaaaacatgg aaaggtgttt ttaacagtcc cgagtctaag
3121 tagcacagca gaggaaaagt tcattaaaaa gggggaattt tcgggagatg actctctgct
3181 ggacctggac cctgaggaca cagtgtttta tgttggtgga gtgccttcca acttcaagct
3241 ccctaccagc ttaaacctgc ctggctttgt tggctgcctg gaactggcca ctttgaataa
3301 tgatgtgatc agcttgtaca actttaagca catctataat atggacccct ccacatcagt
3361 gccatgtgcc cgagataagc tggccttcac tcagagtcgg gctgccagtt acttcttcga
3421 tggctccggt tatgccgtgg tgagagacat cacaaggaga gggaaatttg gtcaggtgac
3481 tcgctttgac atagaagttc gaacaccagc tgacaacggc cttattctcc tgatggtcaa
3541 tggaagtatg tttttcagac tggaaatgcg caatggttac ctacatgtgt tctatgattt
3601 tggattcagc agtggccgtg tgcatcttga agatacgtta aagaaagctc aaattaatga
3661 tgcaaaatac catgagatct caatcattta ccacaatgat aagaaaatga tcttggtagt
3721 tgacagaagg catgtcaaga gcatggataa tgaaaagatg aaaatacctt ttacagatat
3781 atacattgga ggagctcctc cagaaatctt acaatccagg gccctcagag cacaccttcc
3841 cctagatatc aacttcagag gatgcatgaa gggcttccag ttccaaaaga aggacttcaa
3901 tttactggag cagacagaaa ccctgggagt tggttatgga tgcccagaag actcacttat
3961 atctcgcaga gcatatttca atggacagag cttcattgct tcaattcaga aaatatcttt
4021 ctttgatggc tttgaaggag gttttaattt ccgaacatta caaccaaatg ggttactatt
4081 ctattatgct tcagggtcag acgtgttctc catctcactg gataatggta ctgtcatcat
4141 ggatgtaaag ggaatcaaag ttcagtcagt agataagcag tacaatgatg ggctgtccca
4201 cttcgtcatt agctctgtct cacccacaag atatgaactg atagtagata aaagcagagt
4261 tgggagtaag aatcctacca aagggaaaat agaacagaca caagcaagtg aaaagaagtt
4321 ttacttcggt ggctcaccaa tcagtgctca gtatgctaat ttcactggct gcataagtaa
4381 tgcctacttt accagggtgg atagagatgt ggaggttgaa gatttccaac ggtatactga
4441 aaaggtccac acttctcttt atgagtgtcc cattgagtct tcaccattgt ttctcctcca
4501 taaaaaagga aaaaatttat ccaagcctaa agcaagtcag aataaaaagg gagggaaaag
4561 taaagatgca ccttcatggg atcctgttgc tctgaaactc ccagagcgga atactccaag
4621 aaactctcat tgccaccttt ccaacagccc tagagcaata gagcacgcct atcaatatgg
4681 aggaacagcc aacagccgcc aagagtttga acacttaaaa ggagattttg gtgccaaatc
4741 tcagttttcc attcgtctga gaactcgttc ctcccatggc atgatcttct atgtctcaga
4801 tcaagaagag aatgacttca tgactctatt tttggcccat ggccgcttgg tttacatgtt
4861 taatgttggt cacaaaaaac tgaagattag aagccaggag aaatacaatg atggcctgtg
4921 gcatgatgtg atatttattc gagaaaggag cagtggccga ctggtaattg atggtctccg
4981 agtcctagaa gaaagtcttc ctcctactga agctacctgg aaaatcaagg gtcccattta
5041 tttgggaggt gtggctcctg gaaaggctgt gaaaaatgtt cagattaact ccatctacag
5101 ttttagtggc tgtctcagca atctccagct caatggggcc tccatcacct ctgcttctca
5161 gacattcagt gtgacccctt gctttgaagg ccccatggaa acaggaactt acttttcaac
5221 agaaggagga tacgtggttc tagatgaatc tttcaatatt ggattgaagt ttgaaattgc
5281 atttgaagtc cgtcccagaa gcagttccgg aaccctggtc cacggccaca gtgtcaatgg
5341 ggagtaccta aatgttcaca tgaaaaatgg acaggtcata gtgaaagtca ataatggcat
5401 cagagatttt tccacctcag taacacccaa gcagagtctc tgtgatggca gatggcacag
5461 aattacagtt attagagatt ctaatgtggt tcagttggat gtggactctg aagtgaacca
5521 tgtggttgga cccctgaatc caaaaccaat tgatcacagg gagcctgtgt ttgttggagg
5581 tgttccagaa tctctactga caccacgctt ggcccccagc aaacccttca caggctgcat
5641 acgccacttt gtgattgatg gacacccagt gagcttcagt aaagcagccc tggtcagcgg
5701 cgccgtaagc atcaactcct gtccagcagc ctgacatgac agagcacagc tgcccaaata
5761 caaagttctt tagagcactg aaagaaacac aaagccagcc aggaggaaca gtaactcttc
5821 cttcgggtgg aagctttcat cgagttgaac aggacttaaa cgaatcatca gggaccggat
5881 atttcttatt tctcatttgg attcttaacc ttgaatccaa agtgtctgca atggacaaca
5941 attgaaggag aggcaaactt acttgtattg agagcacacg caattcctac tggtgaaatt
6001 actgtttctg tttctaataa aatagaaggg attccaaata aaaaaaaaaa aaaaaaaaaa
6061 aaaa
//