LOCUS X87159 2564 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for beta subunit of epithelial amiloride-sensitive
sodium channel.
ACCESSION X87159
VERSION X87159.1
KEYWORDS beta subunit; epithelial amiloride-sensitive sodium channel;
epithelial sodium channel; SCNN1 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Voilley N., Bassilana F., Migon C., Merscher S., Mattei M.G.,
Carle G.F., Lazdunski M., Barbry P.
TITLE Cloning, chromosomal localization, and physical linkage of the beta
and gamma subunits (SCNN1B and SCNN1G) of the human epithelial
amiloride-sensitive sodium channel
JOURNAL Genomics 28(3), 560-565(1995).
PUBMED 7490094
REFERENCE 2 (bases 1 to 2564)
AUTHORS Voilley N.
JOURNAL Submitted (11-MAY-1995) to the INSDC. N. Voilley, CNRS-UPR411,
Inst.de Pharmacologie molecularie et cellulaire, 660 route des
Lucioles Sophia Antipolis, F- 06560 Valbonne, FRANCE
COMMENT Related sequence: U16023
FEATURES Location/Qualifiers
source 1..2564
/db_xref="H-InvDB:HIT000324262"
/organism="Homo sapiens"
/chromosome="16"
/map="16p12-13"
/mol_type="mRNA"
/dev_stage="adult"
/tissue_type="lung"
/db_xref="taxon:9606"
CDS 128..2050
/gene="SCNN1B"
/product="epithelial amiloride-sensitive sodium channel,
beta-subunit"
/db_xref="GOA:P51168"
/db_xref="H-InvDB:HIT000324262.14"
/db_xref="HGNC:HGNC:10600"
/db_xref="InterPro:IPR001873"
/db_xref="InterPro:IPR004724"
/db_xref="InterPro:IPR020903"
/db_xref="PDB:6BQN"
/db_xref="UniProtKB/Swiss-Prot:P51168"
/protein_id="CAA60632.1"
/translation="MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICE
GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASP
FKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHH
PMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEW
YILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFN
WGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTGGVRLMLHEQRSYPFIRDEGI
YAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQ
DHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCND
TQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIE
ESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRR
AQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLR
LQPLDVIESDSEGDAI"
misc_difference 1921..2384
/note="Region absent in other clone from same library; no
loss of function."
BASE COUNT 582 a 808 c 663 g 511 t
ORIGIN
1 tcgccgggtg tcccagtgtc accaacactc ggccgccgcc gccagcttgg cgcgcaccgc
61 cgcctccgcc accgccgaca gcgcgcatcc tccgtgtccc cgctccgccg cccgagcagg
121 tgccactatg cacgtgaaga agtacctgct gaagggcctg catcggctgc agaagggccc
181 cggctacacg tacaaggagc tgctggtgtg gtactgcgac aacaccaaca cccacggccc
241 caagcgcatc atctgtgagg ggcccaagaa gaaagccatg tggttcctgc tcaccctgct
301 cttcgccgcc ctcgtctgct ggcagtgggg catcttcatc aggacctact tgagctggga
361 ggtcagcgtc tccctctccg taggcttcaa gaccatggac ttccccgccg tcaccatctg
421 caatgctagc cccttcaagt attccaaaat caagcatttg ctgaaggacc tggatgagct
481 gatggaagct gtcctggaga gaatcctggc tcctgagcta agccatgcca atgccaccag
541 gaacctgaac ttctccatct ggaaccacac acccctggtc cttattgatg aacggaaccc
601 ccaccacccc atggtccttg atctctttgg agacaaccac aatggcttaa caagcagctc
661 agcatcagaa aagatctgta atgcccacgg gtgcaaaatg gccatgagac tatgtagcct
721 caacaggacc cagtgtacct tccggaactt caccagtgct acccaggcat tgacagagtg
781 gtacatcctg caggccacca acatctttgc acaggtgcca cagcaggagc tagtagagat
841 gagctacccc ggcgagcaga tgatcctggc ctgcctattc ggagctgagc cctgcaacta
901 ccggaacttc acgtccatct tctaccctca ctatggcaac tgttacatct tcaactgggg
961 catgacagag aaggcacttc cttcggccaa ccctggaact gaattcggcc tgaagttgat
1021 cctggacata ggccaggaag actacgtccc cttccttgcg tccacgggcg gggtcaggct
1081 gatgcttcac gagcagaggt catacccctt catcagagat gagggcatct acgccatgtc
1141 ggggacagag acgtccatcg gggtactcgt ggataagctt cagcgcatgg gggagcccta
1201 cagcccgtgc accgtgaatg gttctgaggt ccccgtccaa aacttctaca gtgactacaa
1261 cacgacctac tccatccagg cctgtcttcg ctcctgcttc caagaccaca tgatccgtaa
1321 ctgcaactgt ggccactacc tgtacccact gccccgtggg gagaaatact gcaacaaccg
1381 ggacttccca gactgggccc attgctactc agatctacag atgagcgtgg cgcagagaga
1441 gacctgcatt ggcatgtgca aggagtcctg caatgacacc cagtacaaga tgaccatctc
1501 catggctgac tggccttctg aggcctccga ggactggatt ttccacgtct tgtctcagga
1561 gcgggaccaa agcaccaata tcaccctgag caggaaggga attgtcaagc tcaacatcta
1621 cttccaagaa tttaactatc gcaccattga agaatcagca gccaataaca tcgtctggct
1681 gctctcgaat ctgggtggcc agtttggctt ctggatgggg ggctctgtgc tgtgcctcat
1741 cgagtttggg gagatcatca tcgactttgt gtggatcacc atcatcaagc tggtggcctt
1801 ggccaagagc ctacggcagc ggcgagccca agccagctac gctggcccac cgcccaccgt
1861 ggccgagctg gtggaggccc acaccaactt tggcttccag cctgacacgg ccccccgcag
1921 ccccaacact gggccctacc ccagtgagca ggccctgccc atcccaggca ccccgccccc
1981 caactatgac tccctgcgtc tgcagccgct ggacgtcatc gagtctgaca gtgagggtga
2041 tgccatctaa ccctgcccct gtccaccccg ggtgggtgaa actcactgag cagccaagac
2101 tgttgcccga ggactcactg tatggtgccc tctccaaagg gtcgggaggg tagctctcca
2161 ggccagagct tgtgtccttc aacagagagg ccagcggcaa ctggtccgtt actggccaag
2221 ggctctgaag aatcaacggt gctggtacag gatacaggaa taaattgtat cttcacctgg
2281 ttcctaccct cgtccctacc tgtcctgatc ctggtcctga agacccctcg gaacaccctc
2341 tcctggtggc aggccacttc cctcccagtg ccagtctcca tccaccccag agaggaacag
2401 gcgggtgggc catgtggttt tctccttcct ggccttggct ggcctctggg gcaggggtgg
2461 tggagagatg gaagggcatc aggtgtaggg accctgccaa gtggcacctg atttactcta
2521 gaaaataaaa gtagaaaata ctgagaaaaa aaaaaaaaaa aaaa
//