LOCUS       X85153                   238 bp    mRNA    linear   HUM 07-FEB-1996
DEFINITION  H.sapiens mRNA for immunoglobulin kappa variable region (clone
            8F1A-01).
ACCESSION   X85153
VERSION     X85153.1
KEYWORDS    immunoglobulin; joining region; kappa light chain; variable region.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Gause A.
  JOURNAL   Submitted (07-MAR-1995) to the INSDC. A. Gause, Medical School
            Saarland, Medizinische Klinik 1, Universitaetskliniken des
            Saarlands, 66421 Homburg/Saar, FRG
REFERENCE   2  (bases 1 to 238)
  AUTHORS   Gause A., Gundlach K., Zdichavsky M., Jacobs G., Koch B., Hopf T.,
            Pfreundschuh M.
  TITLE     The B lymphocyte in rheumatoid arthritis: analysis of rearranged V
            kappa genes from B cells infiltrating the synovial membrane
  JOURNAL   Eur. J. Immunol. 25(10), 2775-2782(1995).
   PUBMED   7589071
COMMENT     Sequence overlapping with those submitted by Schaeble, K.F.
            (Biol.Chem. Hoppe-Seyler, vol.374: 1001-22, 1993), and Cox, J.P.L.
            (Eur.J.Immunol. vol.24: 827-836, 1994)
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /chromosome="2"
                     /map="B2-Jk2"
                     /isolate="patient 8 with rheumatoid arthritis"
                     /mol_type="mRNA"
                     /clone_lib="8F1A"
                     /clone="01"
                     /clone="02"
                     /cell_type="infiltrating B-lymphocytes"
                     /tissue_type="synovial membrane"
                     /rearranged
                     /db_xref="taxon:9606"
     V_region        <1..231
                     /product="variable region of Ig kappa light chain"
                     /note="FR1"
                     /note="somatic mutations"
     J_segment       233..>238
                     /product="joining region of Ig kappa light chain"
BASE COUNT           68 a           55 c           45 g           70 t
ORIGIN      
        1 gtcaacatct cctgcaaagc cagccaggac attcatgatg atgtgaactg ctatagacag
       61 aaacctgaag aggctgctat tttcattatt caagagggta atactctcat tcctggattc
      121 ccacctcgat tcagtggcag cgggtgtgga acagatttta ccctcacaat taataacata
      181 gaatctgagg atgctgcata ttacttctgt cttcaacatg gtaatttccc tctaatct
//