LOCUS X85153 238 bp mRNA linear HUM 07-FEB-1996 DEFINITION H.sapiens mRNA for immunoglobulin kappa variable region (clone 8F1A-01). ACCESSION X85153 VERSION X85153.1 KEYWORDS immunoglobulin; joining region; kappa light chain; variable region. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Gause A. JOURNAL Submitted (07-MAR-1995) to the INSDC. A. Gause, Medical School Saarland, Medizinische Klinik 1, Universitaetskliniken des Saarlands, 66421 Homburg/Saar, FRG REFERENCE 2 (bases 1 to 238) AUTHORS Gause A., Gundlach K., Zdichavsky M., Jacobs G., Koch B., Hopf T., Pfreundschuh M. TITLE The B lymphocyte in rheumatoid arthritis: analysis of rearranged V kappa genes from B cells infiltrating the synovial membrane JOURNAL Eur. J. Immunol. 25(10), 2775-2782(1995). PUBMED 7589071 COMMENT Sequence overlapping with those submitted by Schaeble, K.F. (Biol.Chem. Hoppe-Seyler, vol.374: 1001-22, 1993), and Cox, J.P.L. (Eur.J.Immunol. vol.24: 827-836, 1994) FEATURES Location/Qualifiers source 1..238 /organism="Homo sapiens" /chromosome="2" /map="B2-Jk2" /isolate="patient 8 with rheumatoid arthritis" /mol_type="mRNA" /clone_lib="8F1A" /clone="01" /clone="02" /cell_type="infiltrating B-lymphocytes" /tissue_type="synovial membrane" /rearranged /db_xref="taxon:9606" V_region <1..231 /product="variable region of Ig kappa light chain" /note="FR1" /note="somatic mutations" J_segment 233..>238 /product="joining region of Ig kappa light chain" BASE COUNT 68 a 55 c 45 g 70 t ORIGIN 1 gtcaacatct cctgcaaagc cagccaggac attcatgatg atgtgaactg ctatagacag 61 aaacctgaag aggctgctat tttcattatt caagagggta atactctcat tcctggattc 121 ccacctcgat tcagtggcag cgggtgtgga acagatttta ccctcacaat taataacata 181 gaatctgagg atgctgcata ttacttctgt cttcaacatg gtaatttccc tctaatct //