LOCUS X85030 2466 bp mRNA linear HUM 14-NOV-2006
DEFINITION H.sapiens mRNA for skeletal muscle-specific calpain.
ACCESSION X85030
VERSION X85030.1
KEYWORDS calcium-dependent protease; calpain; nCL1 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2466)
AUTHORS Richard I.
JOURNAL Submitted (28-FEB-1995) to the INSDC. I. Richard, Genethon B.P. 60,
F- 91002 Evry Cedex, FRANCE
REFERENCE 2
AUTHORS Richard I., Broux O., Allamand V., Fougerousse F.,
Chiannilkulchai N., Bourg N., Brenguier L., Devaud C.,
Pasturaud P., Roudaut C., Hillaire D., Passos-Bueno M.R., Zatz M.,
Tishfield J., Fardeau M., Jackson C.E., Cohen D., Beckmann J.S.
TITLE Mutations in the proteolytic enzyme calpain 3 cause limb-girdle
muscular dystrophy type 2A
JOURNAL Cell 81(1), 27-40(1995).
PUBMED 7720071
FEATURES Location/Qualifiers
source 1..2466
/db_xref="H-InvDB:HIT000324096"
/organism="Homo sapiens"
/chromosome="15"
/map="15q15.1-q15.2"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..2466
/gene="nCL1"
/standard_name="calcium activated neutral protease"
/product="calpain"
/EC_number="3.4.22.17"
/db_xref="GOA:P20807"
/db_xref="H-InvDB:HIT000324096.12"
/db_xref="HGNC:HGNC:1480"
/db_xref="InterPro:IPR000169"
/db_xref="InterPro:IPR001300"
/db_xref="InterPro:IPR002048"
/db_xref="InterPro:IPR011992"
/db_xref="InterPro:IPR018247"
/db_xref="InterPro:IPR022682"
/db_xref="InterPro:IPR022683"
/db_xref="InterPro:IPR022684"
/db_xref="InterPro:IPR029531"
/db_xref="InterPro:IPR033883"
/db_xref="InterPro:IPR036213"
/db_xref="InterPro:IPR038765"
/db_xref="PDB:1Y9V"
/db_xref="PDB:4OKH"
/db_xref="PDB:6BDT"
/db_xref="PDB:6BGP"
/db_xref="PDB:6BJD"
/db_xref="PDB:6BKJ"
/db_xref="UniProtKB/Swiss-Prot:P20807"
/protein_id="CAA59403.1"
/translation="MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYS
AIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRP
PEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYA
GIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEA
LKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGT
SPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGH
AYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVT
EDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNF
PDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYE
VPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQE
GEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEG
KGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVN
KHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSG
TINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHA
FDKDGDGIIKLNVLEWLQLTMYA"
exon 1..309
/number=1
exon 310..379
/number=2
exon 380..498
/number=3
exon 499..632
/number=4
exon 633..801
/number=5
exon 802..945
/number=6
exon 946..1029
/number=7
exon 1030..1115
/number=8
exon 1116..1193
/number=9
exon 1194..1354
/number=10
exon 1355..1524
/number=11
exon 1525..1536
/number=12
exon 1537..1745
/number=13
exon 1746..1782
/number=14
exon 1783..1800
/number=15
exon 1801..1914
/number=16
exon 1915..1992
/number=17
exon 1993..2050
/number=18
exon 2051..2115
/number=19
exon 2116..2184
/number=20
exon 2185..2263
/number=21
exon 2264..2380
/number=22
exon 2381..2439
/number=23
exon 2440..2466
/number=24
BASE COUNT 657 a 636 c 662 g 511 t
ORIGIN
1 atgccgaccg tcattagcgc atctgtggct ccaaggacag cggctgagcc ccggtcccca
61 gggccagttc ctcacccggc ccagagcaag gccactgagg ctgggggtgg aaacccaagt
121 ggcatctatt cagccatcat cagccgcaat tttcctatta tcggagtgaa agagaagaca
181 ttcgagcaac ttcacaagaa atgtctagaa aagaaagttc tttatgtgga ccctgagttc
241 ccaccggatg agacctctct cttttatagc cagaagttcc ccatccagtt cgtctggaag
301 agacctccgg aaatttgcga gaatccccga tttatcattg atggagccaa cagaactgac
361 atctgtcaag gagagctagg ggactgctgg tttctcgcag ccattgcctg cctgaccctg
421 aaccagcacc ttcttttccg agtcataccc catgatcaaa gtttcatcga aaactacgca
481 gggatcttcc acttccagtt ctggcgctat ggagagtggg tggacgtggt tatagatgac
541 tgcctgccaa cgtacaacaa tcaactggtt ttcaccaagt ccaaccaccg caatgagttc
601 tggagtgctc tgctggagaa ggcttatgct aagctccatg gttcctacga agctctgaaa
661 ggtgggaaca ccacagaggc catggaggac ttcacaggag gggtggcaga gttttttgag
721 atcagggatg ctcctagtga catgtacaag atcatgaaga aagccatcga gagaggctcc
781 ctcatgggct gctccattga tgatggcacg aacatgacct atggaacctc tccttctggt
841 ctgaacatgg gggagttgat tgcacggatg gtaaggaata tggataactc actgctccag
901 gactcagacc tcgaccccag aggctcagat gaaagaccga cccggacaat cattccggtt
961 cagtatgaga caagaatggc ctgcgggctg gtcagaggtc acgcctactc tgtcacgggg
1021 ctggatgagg tcccgttcaa aggtgagaaa gtgaagctgg tgcggctgcg gaatccgtgg
1081 ggccaggtgg agtggaacgg ttcttggagt gatagatgga aggactggag ctttgtggac
1141 aaagatgaga aggcccgtct gcagcaccag gtcactgagg atggagagtt ctggatgtcc
1201 tatgaggatt tcatctacca tttcacaaag ttggagatct gcaacctcac ggccgatgct
1261 ctgcagtctg acaagcttca gacctggaca gtgtctgtga acgagggccg ctgggtacgg
1321 ggttgctctg ccggaggctg ccgcaacttc ccagatactt tctggaccaa ccctcagtac
1381 cgtctgaagc tcctggagga ggacgatgac cctgatgact cggaggtgat ttgcagcttc
1441 ctggtggccc tgatgcagaa gaaccggcgg aaggaccgga agctaggggc cagtctcttc
1501 accattggct tcgccatcta cgaggttccc aaagagatgc acgggaacaa gcagcacctg
1561 cagaaggact tcttcctgta caacgcctcc aaggccagga gcaaaaccta catcaacatg
1621 cgggaggtgt cccagcgctt ccgcctgcct cccagcgagt acgtcatcgt gccctccacc
1681 tacgagcccc accaggaggg ggaattcatc ctccgggtct tctctgaaaa gaggaacctc
1741 tctgaggaag ttgaaaatac catctccgtg gatcggccag tgaaaaagaa aaaaaccaag
1801 cccatcatct tcgtttcgga cagagcaaac agcaacaagg agctgggtgt ggaccaggag
1861 tcagaggagg gcaaaggcaa aacaagccct gataagcaaa agcagtcccc acagccacag
1921 cctggcagct ctgatcagga aagtgaggaa cagcaacaat tccggaacat tttcaagcag
1981 atagcaggag atgacatgga gatctgtgca gatgagctca agaaggtcct taacacagtc
2041 gtgaacaaac acaaggacct gaagacacac gggttcacac tggagtcctg ccgtagcatg
2101 attgcgctca tggatacaga tggctctgga aagctcaacc tgcaggagtt ccaccacctc
2161 tggaacaaga ttaaggcctg gcagaaaatt ttcaaacact atgacacaga ccagtccggc
2221 accatcaaca gctacgagat gcgaaatgca gtcaacgacg caggattcca cctcaacaac
2281 cagctctatg acatcattac catgcggtac gcagacaaac acatgaacat cgactttgac
2341 agtttcatct gctgcttcgt taggctggag ggcatgttca gagcttttca tgcatttgac
2401 aaggatggag atggtatcat caagctcaac gttctggagt ggctgcagct caccatgtat
2461 gcctga
//