LOCUS X84075 4575 bp mRNA linear HUM 07-JUL-1995
DEFINITION H.sapiens mRNA for cardiac myosin binding protein-C.
ACCESSION X84075
VERSION X84075.1
KEYWORDS cardiac myosin-binding protein; Mybp-C gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Gautel M., Zuffardi O., Freiburg A., Labeit S.
TITLE Phosphorylation switches specific for the cardiac isoform of myosin
binding protein-C: a modulator of cardiac contraction?
JOURNAL EMBO J. 14(9), 1952-1960(1995).
PUBMED 7744002
REFERENCE 2 (bases 1 to 4575)
AUTHORS Labeit S.
JOURNAL Submitted (25-JAN-1995) to the INSDC. S. Labeit, EMBL Heidelberg,
Meyerhofstr. 1, 69117 Heidelberg, FRG
REMARK Sequence revised by author, 19-MAY-95
FEATURES Location/Qualifiers
source 1..4575
/db_xref="H-InvDB:HIT000324022"
/organism="Homo sapiens"
/chromosome="11"
/map="p11.2"
/variety="caucasian"
/isolate="CCPR"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="Stratagene #936208"
/tissue_type="heart"
/db_xref="taxon:9606"
CDS 33..3857
/gene="Mybp-C"
/product="cardiac myosin-binding protein C"
/db_xref="GOA:Q14896"
/db_xref="H-InvDB:HIT000324022.14"
/db_xref="HGNC:HGNC:7551"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR036179"
/db_xref="InterPro:IPR040849"
/db_xref="PDB:1GXE"
/db_xref="PDB:1PD6"
/db_xref="PDB:2AVG"
/db_xref="PDB:2K1M"
/db_xref="PDB:2MQ0"
/db_xref="PDB:2MQ3"
/db_xref="PDB:2V6H"
/db_xref="PDB:3CX2"
/db_xref="PDB:5K6P"
/db_xref="PDB:6CXI"
/db_xref="PDB:6CXJ"
/db_xref="PDB:6G2T"
/db_xref="UniProtKB/Swiss-Prot:Q14896"
/protein_id="CAA58882.1"
/translation="MPEPGKKPVSAFSKKPRSVEVAAGSPAVFEAETERAGVKVRWQR
GGSDISASNKYGLATEGTRHTLTVREVGPADQGSYAVIAGSSKVKFDLKVIEAEKAEP
MLAPAPAPAEATGAPGEAPAPAAELGESAPSPKGSSSAALNGPTPGAPDDPIGLFVMR
PQDGEVTVGGSITFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASK
VYLFELHITDAQPAFTGSYRCEVSTKDKFECSNFNLTVHEAMGTGDLDLLSAFRRTSL
AGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQAPPSEYE
RIAFQYGVTDLRGMLKRLKGMRRDEKKSTAFQKKLEPAYQVSKGHKIRLTVELADHDA
EVKWLKNGQEIQMSGSKYIFESIGAKRTLTISQCSLADDAAYQCVVGGEKCSTELFVK
EPPVLITRPLEDQLVMVGQRVEFECEVSEEGAQVKWLKDGVELTREETFKYRFKKDGQ
RHHLIINEAMLEDAGHYALCTSGGQALRELIVQEKKLEVYQSIADLMVGAKDQAVFKC
EVSDENVRGVWLKNGKELVPDSRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFACN
LSAKLHFMEVKIDFVPRQEPPKIHLDCPGRIPDTIVVVAGNKLRLDVPISGDPAPTVI
WQKAITQGNKAPARPAPDAPEDTGDSDEWVFDKKLLCETEGRVRVETTKDRSIFTVEG
AEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYD
GGQPILGYILERKKKKSYRWMQLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSR
PSPASQPFMPIGPPSEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCPEGCS
EWVAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTEPVTVQEILQRPR
LQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVSIRNSPTDTIL
FIRAARRVHSGTYQVTVRIENMEDKATLVLQVVDKPSPPQDLRVTDAWGLNVALEWKP
PQDVGNTELWGYTVQKADKKTMEWFTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVG
FSDRAATTKEPVFIPRPGITYEPPNYKALDFSEAPSFTQPLVNRSVIAGYTAMLCCAV
RGSPKPKISWFKNGLDLGEDARFRMFSKQGVLTLEIRKPCPFDGGIYVCRATNLQGEA
RCECRLEVRVPQ"
misc_feature 33..335
/note="N-terminal module possibly specific to cardiac
isomorfs"
misc_feature 336..488
/note="prolin-rich N-terminal domain"
misc_feature 489..799
/note="module I (IgG)"
misc_feature 801..1115
/note="phosphorylation domain (cardiac-specific Mubp-C
motif)"
/experiment="experimental evidence, no additional details
recorded"
misc_feature 1116..1388
/note="module II (IgG)"
misc_feature 1389..1661
/note="module III (IgG)"
misc_feature 1662..1931
/note="module IV (IgG)"
misc_feature 1932..1964
/note="unique insertion"
misc_feature 1965..2345
/note="module V (Ig G)"
misc_feature 2346..2639
/note="module VI (fn-3)"
misc_feature 2640..2942
/note="module VII (fn-3)"
misc_feature 2943..3227
/note="module VIII (IgG)"
misc_feature 3228..3572
/note="module IX (fn-3)"
misc_feature 3573..3854
/note="module X (Ig G)"
BASE COUNT 1033 a 1310 c 1393 g 839 t
ORIGIN
1 catggtgagt gcctggtgtg acgtctctca ggatgcctga gccggggaag aagccagtct
61 cagcctttag caagaagcca cggtcagtgg aagtggccgc aggcagccct gccgtgttcg
121 aggccgagac agagcgggca ggagtgaagg tgcgctggca gcgcggaggc agtgacatca
181 gcgccagcaa caagtacggc ctggccacag agggcacacg gcatacgctg acagtgcggg
241 aagtgggccc tgccgaccag ggatcttacg cagtcattgc tggctcctcc aaggtcaagt
301 tcgacctcaa ggtcatagag gcagagaagg cagagcccat gctggcccct gcccctgccc
361 ctgctgaggc cactggagcc cctggagaag ccccggcccc agccgctgag ctgggagaaa
421 gtgccccaag tcccaaaggg tcaagctcag cagctctcaa tggtcctacc cctggagccc
481 ccgatgaccc cattggcctc ttcgtgatgc ggccacagga tggcgaggtg accgtgggtg
541 gcagcatcac cttctcagcc cgcgtggccg gcgccagcct cctgaagccg cctgtggtca
601 agtggttcaa gggcaaatgg gtggacctga gcagcaaggt gggccagcac ctgcagctgc
661 acgacagcta cgaccgcgcc agcaaggtct atctgttcga gctgcacatc accgatgccc
721 agcctgcctt cactggcagc taccgctgtg aggtgtccac caaggacaaa tttgaatgct
781 ccaacttcaa tctcactgtc cacgaggcca tgggcaccgg agacctggac ctcctatcag
841 ccttccgccg cacgagcctg gctggaggtg gtcggcggat cagtgatagc catgaggaca
901 ctgggattct ggacttcagc tcactgctga aaaagagaga cagtttccgg accccgaggg
961 actcgaagct ggaggcacca gcagaggagg acgtgtggga gatcctacgg caggcacccc
1021 catctgagta cgagcgcatc gccttccagt acggcgtcac tgacctgcgc ggcatgctaa
1081 agaggctcaa gggcatgagg cgcgatgaga agaagagcac agcctttcag aagaagctgg
1141 agccggccta ccaggtgagc aaaggccaca agatccggct gaccgtggaa ctggctgacc
1201 atgacgctga ggtcaaatgg ctcaagaatg gccaggagat ccagatgagc ggcagcaagt
1261 acatctttga gtccatcggt gccaagcgta ccctgaccat cagccagtgc tcattggcgg
1321 acgacgcagc ctaccagtgc gtggtgggtg gcgagaagtg tagcacggag ctctttgtga
1381 aagagccccc tgtgctcatc acgcgcccct tggaggacca gctggtgatg gtggggcagc
1441 gggtggagtt tgagtgtgaa gtatcggagg agggggcgca agtcaaatgg ctgaaggacg
1501 gggtggagct gacccgggag gagaccttca aataccggtt caagaaggac gggcagagac
1561 accacctgat catcaacgag gccatgctgg aggacgcggg gcactatgca ctgtgcacta
1621 gcgggggcca ggcgctgcgt gagctcattg tgcaggaaaa gaagctggag gtgtaccaga
1681 gcatcgcaga cctgatggtg ggcgcaaagg accaggcggt gttcaaatgt gaggtctcag
1741 atgagaatgt tcggggtgtg tggctgaaga atgggaagga gctggtgccc gacagccgca
1801 taaaggtgtc ccacatcggg cgggtccaca aactgaccat tgacgacgtc acacctgccg
1861 acgaggctga ctacagcttt gtgcccgagg gcttcgcctg caacctgtca gccaagctcc
1921 acttcatgga ggtcaagatt gacttcgtac ccaggcagga acctcccaag atccacctgg
1981 actgcccagg ccgcatacca gacaccattg tggttgtagc tggaaataag ctacgtctgg
2041 acgtccctat ctctggggac cctgctccca ctgtgatctg gcagaaggct atcacgcagg
2101 ggaataaggc cccagccagg ccagccccag atgccccaga ggacacaggt gacagcgatg
2161 agtgggtgtt tgacaagaag ctgctgtgtg agaccgaggg ccgggtccgc gtggagacca
2221 ccaaggaccg cagcatcttc acggtcgagg gggcagagaa ggaagatgag ggcgtctaca
2281 cggtcacagt gaagaaccct gtgggcgagg accaggtcaa cctcacagtc aaggtcatcg
2341 acgtgccaga cgcacctgcg gcccccaaga tcagcaacgt gggagaggac tcctgcacag
2401 tacagtggga gccgcctgcc tacgatggcg ggcagcccat cctgggctac atcctggagc
2461 gcaagaagaa gaagagctac cggtggatgc agctgaactt cgacctgatt caggagctga
2521 gtcatgaagc gcggcgcatg atcgagggcg tggtgtacga gatgcgcgtc tacgcggtca
2581 acgccatcgg catgtccagg cccagccctg cctcccagcc cttcatgcct atcggtcccc
2641 ccagcgaacc cacccacctg gcagtagagg acgtctctga caccacggtc tccctcaagt
2701 ggcggccccc agagcgcgtg ggagcaggag gcctggatgg ctacagcgtg gagtactgcc
2761 cagagggctg ctcagagtgg gtggctgccc tgcaggggct gacagagcac acatcgatac
2821 tggtgaagga cctgcccacg ggggcccggc tgcttttccg agtgcgggca cacaatatgg
2881 cagggcctgg agcccctgtt accaccacgg agccggtgac agtgcaggag atcctgcaac
2941 ggccacggct tcagctgccc aggcacctgc gccagaccat tcagaagaag gtcggggagc
3001 ctgtgaacct tctcatccct ttccagggca agccccggcc tcaggtgacc tggaccaaag
3061 aggggcagcc cctggcaggc gaggaggtga gcatccgcaa cagccccaca gacaccatcc
3121 tgttcatccg ggccgctcgc cgcgtgcatt caggcactta ccaggtgacg gtgcgcattg
3181 agaacatgga ggacaaggcc acgctggtgc tgcaggttgt tgacaagcca agtcctcccc
3241 aggatctccg ggtgactgac gcctggggtc ttaatgtggc tctggagtgg aagccacccc
3301 aggatgtcgg caacacggaa ctctgggggt acacagtgca gaaagccgac aagaagacca
3361 tggagtggtt caccgtcttg gagcattacc gccgcaccca ctgcgtggtg ccagagctca
3421 tcattggcaa tggctactac ttccgcgtct tcagccagaa tatggttggc tttagtgaca
3481 gagcggccac caccaaggag cccgtcttta tccccagacc aggcatcacc tatgagccac
3541 ccaactataa ggccctggac ttctccgagg ccccaagctt cacccagccc ctggtgaacc
3601 gctcggtcat cgcgggctac actgctatgc tctgctgtgc tgtccggggt agccccaagc
3661 ccaagatttc ctggttcaag aatggcctgg acctgggaga agacgcccgc ttccgcatgt
3721 tcagcaagca gggagtgttg actctggaga ttagaaagcc ctgccccttt gacgggggca
3781 tctatgtctg cagggccacc aacttacagg gcgaggcacg gtgtgagtgc cgcctggagg
3841 tgcgagtgcc tcagtgacca ggctggctcc tggggatggc caggtacaac cggatgccag
3901 ccccgtgcca ggagcctgga gggaagttgg ggaaacccct ccctactgtt ggatgtatgt
3961 gtgacaagtg tgtctcctgt gctgcgatgg gggatcagca gggcagttgt cgggcagtcc
4021 tgagtgggtg ttgcacagac tggtccacag ggctcctgaa ggaagcccct ggatctttgg
4081 ggtaaaagga gggtggcctc aagaaacaat gtctggggac aggcctttct ggcctgctat
4141 gtcttcccaa tgtttattgg gcaataaaag ataagtgcag tcacagagaa ctcactcttc
4201 atcacctgag ctcaccatag tctaatagaa aacaaccgaa accaaataat tcaagcactg
4261 cttattacaa ttttactggg tctctatttt accctcctac aagcctcaga gtacttcgag
4321 tctcccttca ccatttccga cggcatctac ggctcaacat tttttgtagc cacaggcttc
4381 cacggacttc acgtcattat tggctcaact ttcctcacta tctgcttcat ccgccaacta
4441 atatttcact ttacatccaa acatcacttt ggcttcgaag ccgccgcctg atactggcat
4501 tttgtagatg tggtttgact atttctgtat gtctccatct attgatgagg gtcttaaaaa
4561 aaaaaaaaaa aaaaa
//