LOCUS X83929 3299 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens mRNA for type 3 desmocollin.
ACCESSION X83929
VERSION X83929.1
KEYWORDS desmocollin; desmocollin type 3; DSC3 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS King I.A., Sullivan K.H., Bennett R., Buxton R.S.
TITLE The desmocollins of human foreskin epidermis: identification and
chromosomal assignment of a third gene and expression patterns of
the three isoforms
JOURNAL J. Invest. Dermatol. 105(3), 314-321(1995).
PUBMED 7665906
REFERENCE 2 (bases 1 to 3299)
AUTHORS Buxton R.S.
JOURNAL Submitted (16-JAN-1995) to the INSDC. R.S. Buxton, National Inst.
of Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
FEATURES Location/Qualifiers
source 1..3299
/db_xref="H-InvDB:HIT000324013"
/organism="Homo sapiens"
/chromosome="18"
/map="18q12.1"
/mol_type="mRNA"
/clone_lib="lambda gt11"
/cell_type="keratinocyte"
/db_xref="taxon:9606"
CDS 22..2712
/gene="DSC3"
/product="desmocollin type 3"
/db_xref="GOA:Q14574"
/db_xref="H-InvDB:HIT000324013.13"
/db_xref="HGNC:HGNC:3037"
/db_xref="InterPro:IPR000233"
/db_xref="InterPro:IPR002126"
/db_xref="InterPro:IPR009122"
/db_xref="InterPro:IPR014868"
/db_xref="InterPro:IPR015919"
/db_xref="InterPro:IPR020894"
/db_xref="InterPro:IPR027397"
/db_xref="UniProtKB/Swiss-Prot:Q14574"
/protein_id="CAA58781.1"
/translation="MAAAGPRRSVRGAVCLHLLLTLVIFSRDGEACKKVILNVPSKLE
ADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKR
KQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVE
SDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTA
DGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTM
HTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFG
LIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVN
FTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRV
TALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRY
KKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVN
IEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWS
LTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSR
STGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAP
GDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHH
HTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEG
RGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR"
misc_feature 427..2091
/note="extracellular domain"
mat_peptide 427..2709
/gene="DSC3"
/product="desmocollin type 3"
misc_feature 517..525
/note="pot. N-linked glycosylation site"
misc_feature 1195..1203
/note="pot. N-linked glycosylation site"
misc_feature 1657..1665
/note="pot. N-linked glycosylation site"
misc_feature 1906..1914
/note="pot. N-linked glycosylation site"
misc_feature 2092..2163
/note="transmembrane domain"
misc_feature 2164..2709
/note="cytoplasmic domain Dsc3a"
misc_feature 2590..2598
/note="pot. O-phosphorylation site"
BASE COUNT 1067 a 619 c 714 g 899 t
ORIGIN
1 gaattccggc ccggcatccc gatggccgcc gctgggcccc ggcgctccgt gcgcggagcc
61 gtctgcctgc atctgctgct gaccctcgtg atcttcagtc gtgatggtga agcctgcaaa
121 aaggtgatac ttaatgtacc ttctaaacta gaggcagaca aaataattgg cagagttaat
181 ttggaagagt gcttcaggtc tgcagacctc atccggtcaa gtgatcctga tttcagagtt
241 ctaaatgatg ggtcagtgta cacagccagg gctgttgcgc tgtctgataa gaaaagatca
301 tttaccatat ggctttctga caaaaggaaa cagacacaga aagaggttac tgtgctgcta
361 gaacatcaga agaaggtatc gaagacaaga cacactagag aaactgttct caggcgtgcc
421 aagaggagat gggcacctat tccttgctct atgcaagaga attccttggg ccctttccca
481 ttgtttcttc aacaagttga atctgatgca gcacagaact atactgtctt ctactcaata
541 agtggacgtg gagttgataa agaaccttta aatttgtttt atatagaaag agacactgga
601 aatctatttt gcactcggcc tgtggatcgt gaagaatatg atgtttttga tttgattgct
661 tatgcgtcaa ctgcagatgg atattcagca gatctgcccc tcccactacc catcagggta
721 gaggatgaaa atgacaacca ccctgttttc acagaagcaa tttataattt tgaagttttg
781 gaaagtagta gacctggtac tacagtgggg gtggtttgtg ccacagacag agatgaaccg
841 gacacaatgc atacgcgcct gaaatacagc attttgcagc agacaccaag gtcacctggg
901 ctcttttctg tgcatcccag cacaggcgta atcaccacag tctctcatta tttggacaga
961 gaggttgtag acaagtactc attgataatg aaagtacaag acatggatgg ccagtttttt
1021 ggattgatag gcacatcaac ttgtatcata acagtaacag attcaaatga taatgcaccc
1081 actttcagac aaaatgctta tgaagcattt gtagaggaaa atgcattcaa tgtggaaatc
1141 ttacgaatac ctatagaaga taaggattta attaacactg ccaattggag agtcaatttt
1201 accattttaa agggaaatga aaatggacat ttcaaaatca gcacagacaa agaaactaat
1261 gaaggtgttc tttctgttgt aaagccactg aattatgaag aaaaccgtca agtgaacctg
1321 gaaattggag taaacaatga agcgccattt gctagagata ttcccagagt gacagccttg
1381 aacagagcct tggttacagt tcatgtgagg gatctggatg aggggcctga atgcactcct
1441 gcagcccaat atgtgcggat taaagaaaac ttagcagtgg ggtcaaagat caacggctat
1501 aaggcatatg accccgaaaa tagaaatggc aatggtttaa ggtacaaaaa attgcatgat
1561 cctaaaggtt ggatcaccat tgatgaaatt tcagggtcaa tcataacttc caaaatcctg
1621 gatagggagg ttgaaactcc caaaaatgag ttgtataata ttacagtcct ggcaatagac
1681 aaagatgata gatcatgtac tggaacactt gctgtgaaca ttgaagatgt aaatgataat
1741 ccaccagaaa tacttcaaga atatgtagtc atttgcaaac caaaaatggg gtataccgac
1801 attttagctg ttgatcctga tgaacctgtc catggagctc cattttattt cagtttgccc
1861 aatacttctc cagaaatcag tagactgtgg agcctcacca aagttaatga tacagctgcc
1921 cgtctttcat atcagaaaaa tgctggattt caagaatata ccattcctat tactgtaaaa
1981 gacagggccg gccaagctgc aacaaaatta ttgagagtta atctgtgtga atgtactcat
2041 ccaactcagt gtcgtgcgac ttcaaggagt acaggagtaa tacttggaaa atgggcaatc
2101 cttgcaatat tactgggtat agcactgctc ttttctgtat tgctaacttt agtatgtgga
2161 gtttttggtg caactaaagg gaaacgtttt cctgaagatt tagcacagca aaacttaatt
2221 atatcaaaca cagaagcacc tggagacgat agagtgtgct ctgccaatgg atttatgacc
2281 caaactacca acaactctag ccaaggtttt tgtggtacta tgggatcagg aatgaaaaat
2341 ggagggcagg aaaccattga aatgatgaaa ggaggaaacc agaccttgga atcctgccgg
2401 ggggctgggc atcatcatac cctggactcc tgcaggggag gacacacgga ggtggacaac
2461 tgcagataca cttactcgga gtggcacagt tttactcagc cccgtctcgg tgaaaaattg
2521 catcgatgta atcagaatga agaccgcatg ccatcccaag attatgtcct cacttataac
2581 tatgagggaa gaggatctcc agctggttct gtgggctgct gcagtgaaaa gcaggaagaa
2641 gatggccttg actttttaaa taatttggaa cccaaattta ttacattagc agaagcatgc
2701 acaaagagat aatgtcacag tgctacaatt aggtctttgt cagacattct ggaggtttcc
2761 aaaaataata ttgtaaagtt caatttcaac atgtatgtat atgatgattt ttttctcaat
2821 tttgaattat gctactcacc aattatattt ttaaagcaag ttgttgctta tcttttccaa
2881 aaagtgaaaa atgttaaaac agacaactgg taaatctcaa actccagcac tggaattaag
2941 gtctctaaag catctgctct tttttttttt acggatattt tagtaataaa tatgctggat
3001 aaatattagt ccaacaatag ctaagttatg ctaatatcac attattatgt attcacttta
3061 agtgatagtt taaaaaataa acaagaaata ttgagtatca ctatgtgaag aaagttttgg
3121 aaaagaaaca atgaagactg aattaaatta aaaatgttgc agctcataaa gaattgggac
3181 tcacccctac tgcactacca aattcatttg actttggagg caaaatgtgt tgaagtgccc
3241 tatgaagtag caattttcta taggaatata gttggaagta aacggaatcc gcggaattc
//