LOCUS X83618 2058 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for 3-hydroxy-3-methylglutaryl coenzyme A synthase.
ACCESSION X83618
VERSION X83618.1
KEYWORDS hydroxymethyl-CoA synthetase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Mascaro C., Buesa C., Ortiz J.A., Haro D., Hegardt F.G.
TITLE Molecular cloning and tissue expression of human mitochondrial
3-hydroxy-3-methylglutaryl-CoA synthase
JOURNAL Arch. Biochem. Biophys. 317(2), 385-390(1995).
PUBMED 7893153
REFERENCE 2 (bases 1 to 2058)
AUTHORS Hegardt F.G.
JOURNAL Submitted (23-DEC-1994) to the INSDC. F.G. Hegardt, Unit of
Biochemistry,, University of Barcelona, School of Pharmacy, Avda.
Diagonal 643, 08028 Barcelona, SPAIN
COMMENT Related sequences: M33648, M60657, U12788, X52625, X66435, X73679,
X77516
and J. Biol. Chem. 261, 3710-3716 (1986).
FEATURES Location/Qualifiers
source 1..2058
/db_xref="H-InvDB:HIT000323976"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 52..1578
/product="hydroxymethylglutaryl-CoA synthase"
/EC_number="4.1.3.5"
/db_xref="GOA:P54868"
/db_xref="H-InvDB:HIT000323976.14"
/db_xref="HGNC:HGNC:5008"
/db_xref="InterPro:IPR000590"
/db_xref="InterPro:IPR010122"
/db_xref="InterPro:IPR013528"
/db_xref="InterPro:IPR013746"
/db_xref="InterPro:IPR016039"
/db_xref="PDB:2WYA"
/db_xref="UniProtKB/Swiss-Prot:P54868"
/protein_id="CAA58593.1"
/translation="MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPL
AKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDI
NSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGI
DTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLI
GPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKK
IQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKG
LEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLAS
LLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLA
SRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV
"
BASE COUNT 518 a 533 c 500 g 507 t
ORIGIN
1 cggtttctgc tgggtttctg aactgctggg tttctgcttg ctcctctgga gatgcagcgt
61 ctgttgactc cagtgaagcg cattctgcaa ctgacaagag cggtgcagga aacctccctc
121 acacctgctc gcctgctccc agtagcccac caaaggtttt ctacagcctc tgctgtcccc
181 ctggccaaaa cagatacttg gccaaaggac gtgggcatcc tggccctgga ggtctacttc
241 ccagcccaat atgtggacca aactgacctg gagaagtata acaatgtgga agcaggaaag
301 tatacagtgg gcttgggcca gacccgtatg ggcttctgct cagtccaaga ggacatcaac
361 tccctgtgcc tgacggtggt gcaacggctg atggagcgca tacagctccc atgggactct
421 gtgggcaggc tggaagtagg cactgagacc atcattgaca agtccaaagc tgtcaaaaca
481 gtgctcatgg aactcttcca ggattcaggc aatactgata ttgagggcat agataccacc
541 aatgcctgct acggtggtac tgcctccctc ttcaatgctg ccaactggat ggagtccagt
601 tcctgggatg gtcgttatgc catggtggtc tgtggagaca ttgccgtcta tcccagtggt
661 aatgctcgtc ccacaggtgg ggccggagct gtggctatgc tgattggccc aaaggcccct
721 ctggccctgg agcgagggct gaggggaacc catatggaga atgtgtatga cttctacaaa
781 ccaaatttgg cctcggagta cccaatagtg gatgggaagc tttccatcca gtgctacttg
841 cgggccttgg atcgatgtta cacatcatac cgtaaaaaaa tccagaatca gtggaagcaa
901 gctggcagcg atcgaccctt cacccttgac gatttacagt atatgatctt tcatacaccc
961 ttttgcaaga tggtccagaa gtctctggct cgcctgatgt tcaatgactt cctgtcagcc
1021 agcagtgaca cacaaaccag cttatataag gggctggagg ctttcggggg gctaaagctg
1081 gaagacacct acaccaacaa ggacctggat aaagcacttc taaaggcctc tcaggacatg
1141 ttcgacaaga aaaccaaggc ttccctttac ctctccactc acaatgggaa catgtacacc
1201 tcatccctgt acgggtgcct ggcctcgctt ctgtcccacc actctgccca agaactggct
1261 ggctccagga ttggtgcctt ctcttatggc tctggtttag cagcaagttt cttttcattt
1321 cgagtatccc aggatgctgc tccaggctct cccctggaca agttggtgtc cagcacatca
1381 gacctgccaa aacgcctagc ctcccgaaag tgtgtgtctc ctgaggagtt cacagaaata
1441 atgaaccaaa gagagcaatt ctaccataag gtgaatttct ccccacctgg tgacacaaac
1501 agccttttcc caggtacttg gtacctggag cgagtggacg agcagcatcg ccgaaagtat
1561 gcccggcgtc ccgtctaaag gtgttctgca gatccatgga aagcttcctg ggaaacgtat
1621 gctagcagag cttctccccg tgaatcatat ttttaagatc ccactcttag ctggtaaatg
1681 aatttgaatc gacatagtag ccccataagc atcagccctg tagagtgagg agccatctct
1741 agcgggccct tcattcctct ccatgctgca atcactgtcc tgggcttatg gtgcctatgg
1801 actaggggtc ctttgtgaaa gagcaagatg gagcaatgga gagaagacct cttcctgaat
1861 cactggactc cagaaatgtg catgcagatc agctgttgcc ttcaagatcc agataaactt
1921 tcctgtcatg tgttagaact ttattattat taatattgtt aaacttctgt gctgttcctg
1981 tgaatctcca aattttgtac cttgttctaa gctaatatat agcaattaaa aagagagaaa
2041 gagaaaaaaa aaaaaaaa
//