LOCUS X83368 5397 bp mRNA linear HUM 07-OCT-1996 DEFINITION H.sapiens mRNA for phosphatidylinositol 3 kinase gamma. ACCESSION X83368 VERSION X83368.1 KEYWORDS phosphatidylinositol 3-kinase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nuernberg B., Gierschik P., Seedorf K., Hsuan J.J., Waterfield M.D., Wetzker R. TITLE Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase JOURNAL Science, e1252229 269(5224), 690-693(1995). PUBMED 7624799 REFERENCE 2 AUTHORS Waterfield M.D. JOURNAL Submitted (08-DEC-1994) to the INSDC. M.D. Waterfield, Ludwig-Inst. for Cancer Research, Courtauld Building, 91 Riding House Street, London, W1P 8BT, UK REMARK Revised by [3] REFERENCE 3 (bases 1 to 5397) AUTHORS Waterfield M.D. JOURNAL Submitted (23-AUG-1996) to the INSDC. M.D. Waterfield, Ludwig-Inst. for Cancer Research, Courtauld Building, 91 Riding House Street, London, W1P 8BT, UK COMMENT X83368 is homologous to M93252. FEATURES Location/Qualifiers source 1..5397 /db_xref="H-InvDB:HIT000323949" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="U937" /db_xref="taxon:9606" CDS 324..3629 /product="idem" /note="phosphatidylinositol 3 kinase gamma, p110 gamma" /note="activated by G protein alpha and betagammma subunits" /db_xref="GOA:P48736" /db_xref="H-InvDB:HIT000323949.13" /db_xref="HGNC:HGNC:8978" /db_xref="InterPro:IPR000341" /db_xref="InterPro:IPR000403" /db_xref="InterPro:IPR001263" /db_xref="InterPro:IPR002420" /db_xref="InterPro:IPR003113" /db_xref="InterPro:IPR008290" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR015433" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR018936" /db_xref="InterPro:IPR029071" /db_xref="InterPro:IPR035892" /db_xref="InterPro:IPR036940" /db_xref="InterPro:IPR042236" /db_xref="PDB:1E8Y" /db_xref="PDB:1E8Z" /db_xref="PDB:1HE8" /db_xref="PDB:2A4Z" /db_xref="PDB:2A5U" /db_xref="PDB:2CHW" /db_xref="PDB:2CHX" /db_xref="PDB:2CHZ" /db_xref="PDB:2V4L" /db_xref="PDB:3APC" /db_xref="PDB:3APD" /db_xref="PDB:3APF" /db_xref="PDB:3CSF" /db_xref="PDB:3CST" /db_xref="PDB:3DBS" /db_xref="PDB:3DPD" /db_xref="PDB:3ENE" /db_xref="PDB:3IBE" /db_xref="PDB:3L08" /db_xref="PDB:3L13" /db_xref="PDB:3L16" /db_xref="PDB:3L17" /db_xref="PDB:3L54" /db_xref="PDB:3LJ3" /db_xref="PDB:3MJW" /db_xref="PDB:3ML8" /db_xref="PDB:3ML9" /db_xref="PDB:3NZS" /db_xref="PDB:3NZU" /db_xref="PDB:3OAW" /db_xref="PDB:3P2B" /db_xref="PDB:3PRE" /db_xref="PDB:3PRZ" /db_xref="PDB:3PS6" /db_xref="PDB:3QAQ" /db_xref="PDB:3QAR" /db_xref="PDB:3QJZ" /db_xref="PDB:3QK0" /db_xref="PDB:3R7Q" /db_xref="PDB:3R7R" /db_xref="PDB:3S2A" /db_xref="PDB:3SD5" /db_xref="PDB:3T8M" /db_xref="PDB:3TJP" /db_xref="PDB:3TL5" /db_xref="PDB:3ZVV" /db_xref="PDB:3ZW3" /db_xref="PDB:4ANU" /db_xref="PDB:4ANV" /db_xref="PDB:4ANW" /db_xref="PDB:4ANX" /db_xref="PDB:4AOF" /db_xref="PDB:4DK5" /db_xref="PDB:4EZJ" /db_xref="PDB:4EZK" /db_xref="PDB:4EZL" /db_xref="PDB:4F1S" /db_xref="PDB:4FA6" /db_xref="PDB:4FAD" /db_xref="PDB:4FHJ" /db_xref="PDB:4FHK" /db_xref="PDB:4FJY" /db_xref="PDB:4FJZ" /db_xref="PDB:4FLH" /db_xref="PDB:4FUL" /db_xref="PDB:4G11" /db_xref="PDB:4GB9" /db_xref="PDB:4HLE" /db_xref="PDB:4HVB" /db_xref="PDB:4J6I" /db_xref="PDB:4KZ0" /db_xref="PDB:4KZC" /db_xref="PDB:4PS3" /db_xref="PDB:4PS7" /db_xref="PDB:4PS8" /db_xref="PDB:4URK" /db_xref="PDB:4WWN" /db_xref="PDB:4WWO" /db_xref="PDB:4WWP" /db_xref="PDB:4XX5" /db_xref="PDB:4XZ4" /db_xref="PDB:5EDS" /db_xref="PDB:5G2N" /db_xref="PDB:5G55" /db_xref="PDB:5JHA" /db_xref="PDB:5JHB" /db_xref="PDB:5KAE" /db_xref="PDB:5OQ4" /db_xref="PDB:5T23" /db_xref="PDB:6AUD" /db_xref="PDB:6C1S" /db_xref="PDB:6FH5" /db_xref="PDB:6GQ7" /db_xref="UniProtKB/Swiss-Prot:P48736" /protein_id="CAA58284.1" /translation="MELENYKQPVVLREDNCRRRRRMKPRSAASLSSMELIPIEFVLP TSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKK GQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYD VTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNC IFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGR DEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGY HEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQV LCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPS SESKGKVRLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPD KENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPL TAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVG LTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEM LQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIE KCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWET ESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKS PTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYK SFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILF SMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLH LVLGIKQGEKHSA" BASE COUNT 1534 a 1224 c 1207 g 1432 t ORIGIN 1 gaattcggca cgagcacttc cttctcggct agattatctg aaactgttgt cggttcttga 61 gatgatacta ccaccgaatg tctgtgtttc attgtctagt ccaacctgta ttgtggatat 121 ctacaacgtt ccggcaatag ttttgcaggt gcatcacatt tttgtttttg ttttgggagg 181 aaaagggagg gcacggcagc caggcttcat attcctacaa gtgcatgctt caagattact 241 gtacttacag tgtttccaac atcttctcat aaaaggggaa agcttcatag cctcaaccat 301 gaaggaaacc agtcgcatag ggcatggagc tggagaacta taaacagccc gtggtgctga 361 gagaggacaa ctgccgaagg cgccggagga tgaagccgcg cagtgctgcc agcctgtcct 421 ccatggagct catccccatc gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc 481 ccgaaacggc gctgctgcac gtggccggcc acggcaacgt ggagcagatg aaggcccagg 541 tgtggctgcg agcgctggag accagcgtgg cggcggactt ctaccaccgg ctgggaccgc 601 atcacttcct cctgctctat cagaagaagg ggcagtggta cgagatctac gacaagtacc 661 aggtggtgca gactctggac tgcctgcgct actggaaggc cacgcaccgg agcccgggcc 721 agatccacct ggtgcagcgg cacccgccct ccgaggagtc ccaagccttc cagcggcagc 781 tcacggcgct gattggctat gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg 841 agttcacgcg ccgtggcttg gtgaccccgc gcatggcgga ggtggccagc cgcgacccca 901 agctctacgc catgcacccg tgggtgacgt ccaagcccct cccggagtac ctgtggaaga 961 agattgccaa caactgcatc ttcatcgtca ttcaccgcag caccaccagc cagaccatta 1021 aggtctcacc cgacgacacc cccggcgcca tcctgcagag cttcttcacc aagatggcca 1081 agaagaaatc tctgatggat attcccgaaa gccaaagcga acaggatttt gtgctgcgcg 1141 tctgtggccg ggatgagtac ctggtgggcg aaacgcccat caaaaacttc cagtgggtga 1201 ggcactgcct caagaacgga gaagagattc acgtggtact ggacacgcct ccagacccgg 1261 ccctagacga ggtgaggaag gaagagtggc cgctggtgga cgactgcacg ggagtcaccg 1321 gctaccatga gcagcttacc atccacggca aggaccacga gagtgtgttc accgtgtccc 1381 tgtgggactg cgaccgcaag ttcagggtca agatcagagg cattgatatc cccgtcctgc 1441 ctcggaacac cgacctcaca gtttttgtag aggcaaacat ccagcatggg caacaagtcc 1501 tttgccaaag gagaaccagc cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc 1561 ttgagttcag tatcaaaatc aaagacttgc ccaaaggggc tctactgaac ctccagatct 1621 actgcggtaa agctccagca ctgtccagca aggcctctgc agagtccccc agttctgagt 1681 ccaagggcaa agttcggctt ctctattatg tgaacctgct gctgatagac caccgtttcc 1741 tcctgcgccg tggagaatac gtcctccaca tgtggcagat atctgggaag ggagaagacc 1801 aaggaagctt caatgctgac aaactcacgt ctgcaactaa cccagacaag gagaactcaa 1861 tgtccatctc cattcttctg gacaattact gccacccgat agccctgcct aagcatcagc 1921 ccacccctga cccggaaggg gaccgggttc gagcagaaat gcccaaccag cttcgcaagc 1981 aattggaggc gatcatagcc actgatccac ttaaccctct cacagcagag gacaaagaat 2041 tgctctggca ttttagatac gaaagcctta agcacccaaa agcatatcct aagctattta 2101 gttcagtgaa atggggacag caagaaattg tggccaaaac ataccaattg ttggccagaa 2161 gggaagtctg ggatcaaagt gctttggatg ttgggttaac aatgcagctc ctggactgca 2221 acttctcaga tgaaaatgta agagccattg cagttcagaa actggagagc ttggaggacg 2281 atgatgttct gcattacctt ctacaattgg tccaggctgt gaaatttgaa ccataccatg 2341 atagcgccct tgccagattt ctgctgaagc gtggtttaag aaacaaaaga attggtcact 2401 ttttgttttg gttcttgaga agtgagatag cccagtccag acactatcag cagaggttcg 2461 ctgtgattct ggaagcctat ctgaggggct gtggcacagc catgctgcac gactttaccc 2521 aacaagtcca agtaatcgag atgttacaaa aagtcaccct tgatattaaa tcgctctctg 2581 ctgaaaagta tgacgtcagt tcccaagtta tttcacaact taaacaaaag cttgaaaacc 2641 tgcagaattc tcaactcccc gaaagcttta gagttccata tgatcctgga ctgaaagcag 2701 gagcgctggc aattgaaaaa tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg 2761 agtttaaatg tgccgatcct acagccctat caaatgaaac aattggaatt atctttaaac 2821 atggtgatga tctgcgccaa gacatgctta ttttacagat tctacgaatc atggagtcta 2881 tttgggagac tgaatctttg gatctatgcc tcctgccata tggttgcatt tcaactggtg 2941 acaaaatagg aatgatcgag attgtgaaag acgccacgac aattgccaaa attcagcaaa 3001 gcacagtggg caacacggga gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa 3061 aatcccctac tgaagaaaag tttcaggcag cagtggagag atttgtttat tcctgtgcag 3121 gctactgtgt ggcaaccttt gttcttggaa taggcgacag acacaatgac aatattatga 3181 tcaccgagac aggaaaccta tttcatattg acttcgggca cattcttggg aattacaaaa 3241 gtttcctggg cattaataaa gagagagtgc catttgtgct aacccctgac ttcctctttg 3301 tgatgggaac ttctggaaag aagacaagcc cacacttcca gaaatttcag gacatctgtg 3361 ttaaggctta tctagccctt cgtcatcaca caaacctact gatcatcctg ttctccatga 3421 tgctgatgac aggaatgccc cagttaacaa gcaaagaaga cattgaatat atccgggatg 3481 ccctcacagt ggggaaaaat gaggaggatg ctaaaaagta ttttcttgat cagatcgaag 3541 tttgcagaga caaaggatgg actgtgcagt ttaattggtt tctacatctt gttcttggca 3601 tcaaacaagg agagaaacat tcagcctaat actttaggct agaatcaaaa acaagttagt 3661 gttctatggt ttaaattagc atagcaatca tcgaacttgg atttcaaatg caatagacat 3721 tgtgaaagct ggcatttcag aagtatagct cttttcctac ctgaactctt ccctggagaa 3781 aagatgttgg cattgctgat tgtttggtta agcaatgtcc agtgctagga ttatttgcag 3841 gtttggtttt ttctcatttg tctgtggcat tggagaatat tctcggttta aacagactaa 3901 tgacttcctt attgtccctg atattttgac tatcttacta ttgagtgctt ctggaaattc 3961 tttggaataa ttgatgacat ctattttcat ctgggtttag tctcaatttt ggttatcttt 4021 gtgttcctca agctctttaa agaaaaagat gtaatcgttg taacctttgt ctcattcctt 4081 aaatgatgct tccaaacatc tccttagtgt ctgcaggtgt tagtggtgtg ctaaaagcaa 4141 ggaaagcgag ttagtctttt cagtgtcttt tgcaattcaa ttcttttgtc atgtataact 4201 gagacacaca aacacagcag gagaaatcta aaccgttgtg ccttgacctt cctctgctgg 4261 tcttgttcca gggttatgaa tatgaaaaaa tagagatgag actttttgtg tcaactctgt 4321 ccacaagagt gagttatcta gtatgattag tatagctttc tccagcatgg cagcaggaag 4381 taactacagg gcctctttta tgcctgacat ttcttccctt cctttttccc tgcctccctt 4441 tttcatcaat tgcaatgctc ccacaactct ttacagactt gtgaaatctt caagaacacc 4501 tttactctat aactcaaaaa ttagttgaaa aataattact tctcaaggat tattagaatc 4561 ttaggtactt atttgtaaag atgtttagtg actttttttt caagtatcta taaaggaggc 4621 agattctaga aaatatgaat tagtttccaa atgccttaat tttaaacttt ggcctgaaca 4681 gttttttctt tttcttaatg gaagaagata tttaatatct taaaaatatt ccaagttagg 4741 aagaacacta cttgccttat ccatttccca tttaaaggac ttttaaactt tgacacagtc 4801 cttcagattt cctgaaaatc cttgaaatat cttactttaa aaatattttc atctctgaaa 4861 tatctcgtta tttattggag gtattgttta accttagata gaccattaaa ttatttataa 4921 aatattttgt aattactgta gctaatacat tacatagaaa aaactatgtt aacagtgtct 4981 ctgtttaagt ataatcagat ataaatatat aacttaattt tttaatttta aaaaatagat 5041 acctgtttga ctttgaggta gtccaggcct ttttcttttt tttttttttt aatgtgtgca 5101 aaagcccaaa ggttcctaag cctggctgca aagaagaatc aacagggaca ctttttaaaa 5161 acactcttat cagcctgggg caacacagtg agactccatc tcttaaaaaa aaaattagct 5221 gggtatagtg gtatgtgcct gtagtcccag gtactcagga ggctgaggca ggaggattgc 5281 ctgagcccag gaggtggaaa ctgcagagag tcatgatcat gtccttacac tccagcctgg 5341 ataacagagc gagaccctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa actcgag //