LOCUS       X83368                  5397 bp    mRNA    linear   HUM 07-OCT-1996
DEFINITION  H.sapiens mRNA for phosphatidylinositol 3 kinase gamma.
ACCESSION   X83368
VERSION     X83368.1
KEYWORDS    phosphatidylinositol 3-kinase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M.,
            Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nuernberg B.,
            Gierschik P., Seedorf K., Hsuan J.J., Waterfield M.D., Wetzker R.
  TITLE     Cloning and characterization of a G protein-activated human
            phosphoinositide-3 kinase
  JOURNAL   Science, e1252229 269(5224), 690-693(1995).
   PUBMED   7624799
REFERENCE   2
  AUTHORS   Waterfield M.D.
  JOURNAL   Submitted (08-DEC-1994) to the INSDC. M.D. Waterfield, Ludwig-Inst.
            for Cancer Research, Courtauld Building, 91 Riding House Street,
            London, W1P 8BT, UK
  REMARK    Revised by [3]
REFERENCE   3  (bases 1 to 5397)
  AUTHORS   Waterfield M.D.
  JOURNAL   Submitted (23-AUG-1996) to the INSDC. M.D. Waterfield, Ludwig-Inst.
            for Cancer Research, Courtauld Building, 91 Riding House Street,
            London, W1P 8BT, UK
COMMENT     X83368 is homologous to M93252.
FEATURES             Location/Qualifiers
     source          1..5397
                     /db_xref="H-InvDB:HIT000323949"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="U937"
                     /db_xref="taxon:9606"
     CDS             324..3629
                     /product="idem"
                     /note="phosphatidylinositol 3 kinase gamma, p110 gamma"
                     /note="activated by G protein alpha and betagammma
                     subunits"
                     /db_xref="GOA:P48736"
                     /db_xref="H-InvDB:HIT000323949.13"
                     /db_xref="HGNC:HGNC:8978"
                     /db_xref="InterPro:IPR000341"
                     /db_xref="InterPro:IPR000403"
                     /db_xref="InterPro:IPR001263"
                     /db_xref="InterPro:IPR002420"
                     /db_xref="InterPro:IPR003113"
                     /db_xref="InterPro:IPR008290"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR015433"
                     /db_xref="InterPro:IPR016024"
                     /db_xref="InterPro:IPR018936"
                     /db_xref="InterPro:IPR029071"
                     /db_xref="InterPro:IPR035892"
                     /db_xref="InterPro:IPR036940"
                     /db_xref="InterPro:IPR042236"
                     /db_xref="PDB:1E8Y"
                     /db_xref="PDB:1E8Z"
                     /db_xref="PDB:1HE8"
                     /db_xref="PDB:2A4Z"
                     /db_xref="PDB:2A5U"
                     /db_xref="PDB:2CHW"
                     /db_xref="PDB:2CHX"
                     /db_xref="PDB:2CHZ"
                     /db_xref="PDB:2V4L"
                     /db_xref="PDB:3APC"
                     /db_xref="PDB:3APD"
                     /db_xref="PDB:3APF"
                     /db_xref="PDB:3CSF"
                     /db_xref="PDB:3CST"
                     /db_xref="PDB:3DBS"
                     /db_xref="PDB:3DPD"
                     /db_xref="PDB:3ENE"
                     /db_xref="PDB:3IBE"
                     /db_xref="PDB:3L08"
                     /db_xref="PDB:3L13"
                     /db_xref="PDB:3L16"
                     /db_xref="PDB:3L17"
                     /db_xref="PDB:3L54"
                     /db_xref="PDB:3LJ3"
                     /db_xref="PDB:3MJW"
                     /db_xref="PDB:3ML8"
                     /db_xref="PDB:3ML9"
                     /db_xref="PDB:3NZS"
                     /db_xref="PDB:3NZU"
                     /db_xref="PDB:3OAW"
                     /db_xref="PDB:3P2B"
                     /db_xref="PDB:3PRE"
                     /db_xref="PDB:3PRZ"
                     /db_xref="PDB:3PS6"
                     /db_xref="PDB:3QAQ"
                     /db_xref="PDB:3QAR"
                     /db_xref="PDB:3QJZ"
                     /db_xref="PDB:3QK0"
                     /db_xref="PDB:3R7Q"
                     /db_xref="PDB:3R7R"
                     /db_xref="PDB:3S2A"
                     /db_xref="PDB:3SD5"
                     /db_xref="PDB:3T8M"
                     /db_xref="PDB:3TJP"
                     /db_xref="PDB:3TL5"
                     /db_xref="PDB:3ZVV"
                     /db_xref="PDB:3ZW3"
                     /db_xref="PDB:4ANU"
                     /db_xref="PDB:4ANV"
                     /db_xref="PDB:4ANW"
                     /db_xref="PDB:4ANX"
                     /db_xref="PDB:4AOF"
                     /db_xref="PDB:4DK5"
                     /db_xref="PDB:4EZJ"
                     /db_xref="PDB:4EZK"
                     /db_xref="PDB:4EZL"
                     /db_xref="PDB:4F1S"
                     /db_xref="PDB:4FA6"
                     /db_xref="PDB:4FAD"
                     /db_xref="PDB:4FHJ"
                     /db_xref="PDB:4FHK"
                     /db_xref="PDB:4FJY"
                     /db_xref="PDB:4FJZ"
                     /db_xref="PDB:4FLH"
                     /db_xref="PDB:4FUL"
                     /db_xref="PDB:4G11"
                     /db_xref="PDB:4GB9"
                     /db_xref="PDB:4HLE"
                     /db_xref="PDB:4HVB"
                     /db_xref="PDB:4J6I"
                     /db_xref="PDB:4KZ0"
                     /db_xref="PDB:4KZC"
                     /db_xref="PDB:4PS3"
                     /db_xref="PDB:4PS7"
                     /db_xref="PDB:4PS8"
                     /db_xref="PDB:4URK"
                     /db_xref="PDB:4WWN"
                     /db_xref="PDB:4WWO"
                     /db_xref="PDB:4WWP"
                     /db_xref="PDB:4XX5"
                     /db_xref="PDB:4XZ4"
                     /db_xref="PDB:5EDS"
                     /db_xref="PDB:5G2N"
                     /db_xref="PDB:5G55"
                     /db_xref="PDB:5JHA"
                     /db_xref="PDB:5JHB"
                     /db_xref="PDB:5KAE"
                     /db_xref="PDB:5OQ4"
                     /db_xref="PDB:5T23"
                     /db_xref="PDB:6AUD"
                     /db_xref="PDB:6C1S"
                     /db_xref="PDB:6FH5"
                     /db_xref="PDB:6GQ7"
                     /db_xref="UniProtKB/Swiss-Prot:P48736"
                     /protein_id="CAA58284.1"
                     /translation="MELENYKQPVVLREDNCRRRRRMKPRSAASLSSMELIPIEFVLP
                     TSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKK
                     GQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYD
                     VTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNC
                     IFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGR
                     DEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGY
                     HEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQV
                     LCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPS
                     SESKGKVRLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPD
                     KENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPL
                     TAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVG
                     LTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK
                     RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEM
                     LQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIE
                     KCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWET
                     ESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKS
                     PTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYK
                     SFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILF
                     SMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLH
                     LVLGIKQGEKHSA"
BASE COUNT         1534 a         1224 c         1207 g         1432 t
ORIGIN      
        1 gaattcggca cgagcacttc cttctcggct agattatctg aaactgttgt cggttcttga
       61 gatgatacta ccaccgaatg tctgtgtttc attgtctagt ccaacctgta ttgtggatat
      121 ctacaacgtt ccggcaatag ttttgcaggt gcatcacatt tttgtttttg ttttgggagg
      181 aaaagggagg gcacggcagc caggcttcat attcctacaa gtgcatgctt caagattact
      241 gtacttacag tgtttccaac atcttctcat aaaaggggaa agcttcatag cctcaaccat
      301 gaaggaaacc agtcgcatag ggcatggagc tggagaacta taaacagccc gtggtgctga
      361 gagaggacaa ctgccgaagg cgccggagga tgaagccgcg cagtgctgcc agcctgtcct
      421 ccatggagct catccccatc gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc
      481 ccgaaacggc gctgctgcac gtggccggcc acggcaacgt ggagcagatg aaggcccagg
      541 tgtggctgcg agcgctggag accagcgtgg cggcggactt ctaccaccgg ctgggaccgc
      601 atcacttcct cctgctctat cagaagaagg ggcagtggta cgagatctac gacaagtacc
      661 aggtggtgca gactctggac tgcctgcgct actggaaggc cacgcaccgg agcccgggcc
      721 agatccacct ggtgcagcgg cacccgccct ccgaggagtc ccaagccttc cagcggcagc
      781 tcacggcgct gattggctat gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg
      841 agttcacgcg ccgtggcttg gtgaccccgc gcatggcgga ggtggccagc cgcgacccca
      901 agctctacgc catgcacccg tgggtgacgt ccaagcccct cccggagtac ctgtggaaga
      961 agattgccaa caactgcatc ttcatcgtca ttcaccgcag caccaccagc cagaccatta
     1021 aggtctcacc cgacgacacc cccggcgcca tcctgcagag cttcttcacc aagatggcca
     1081 agaagaaatc tctgatggat attcccgaaa gccaaagcga acaggatttt gtgctgcgcg
     1141 tctgtggccg ggatgagtac ctggtgggcg aaacgcccat caaaaacttc cagtgggtga
     1201 ggcactgcct caagaacgga gaagagattc acgtggtact ggacacgcct ccagacccgg
     1261 ccctagacga ggtgaggaag gaagagtggc cgctggtgga cgactgcacg ggagtcaccg
     1321 gctaccatga gcagcttacc atccacggca aggaccacga gagtgtgttc accgtgtccc
     1381 tgtgggactg cgaccgcaag ttcagggtca agatcagagg cattgatatc cccgtcctgc
     1441 ctcggaacac cgacctcaca gtttttgtag aggcaaacat ccagcatggg caacaagtcc
     1501 tttgccaaag gagaaccagc cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc
     1561 ttgagttcag tatcaaaatc aaagacttgc ccaaaggggc tctactgaac ctccagatct
     1621 actgcggtaa agctccagca ctgtccagca aggcctctgc agagtccccc agttctgagt
     1681 ccaagggcaa agttcggctt ctctattatg tgaacctgct gctgatagac caccgtttcc
     1741 tcctgcgccg tggagaatac gtcctccaca tgtggcagat atctgggaag ggagaagacc
     1801 aaggaagctt caatgctgac aaactcacgt ctgcaactaa cccagacaag gagaactcaa
     1861 tgtccatctc cattcttctg gacaattact gccacccgat agccctgcct aagcatcagc
     1921 ccacccctga cccggaaggg gaccgggttc gagcagaaat gcccaaccag cttcgcaagc
     1981 aattggaggc gatcatagcc actgatccac ttaaccctct cacagcagag gacaaagaat
     2041 tgctctggca ttttagatac gaaagcctta agcacccaaa agcatatcct aagctattta
     2101 gttcagtgaa atggggacag caagaaattg tggccaaaac ataccaattg ttggccagaa
     2161 gggaagtctg ggatcaaagt gctttggatg ttgggttaac aatgcagctc ctggactgca
     2221 acttctcaga tgaaaatgta agagccattg cagttcagaa actggagagc ttggaggacg
     2281 atgatgttct gcattacctt ctacaattgg tccaggctgt gaaatttgaa ccataccatg
     2341 atagcgccct tgccagattt ctgctgaagc gtggtttaag aaacaaaaga attggtcact
     2401 ttttgttttg gttcttgaga agtgagatag cccagtccag acactatcag cagaggttcg
     2461 ctgtgattct ggaagcctat ctgaggggct gtggcacagc catgctgcac gactttaccc
     2521 aacaagtcca agtaatcgag atgttacaaa aagtcaccct tgatattaaa tcgctctctg
     2581 ctgaaaagta tgacgtcagt tcccaagtta tttcacaact taaacaaaag cttgaaaacc
     2641 tgcagaattc tcaactcccc gaaagcttta gagttccata tgatcctgga ctgaaagcag
     2701 gagcgctggc aattgaaaaa tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg
     2761 agtttaaatg tgccgatcct acagccctat caaatgaaac aattggaatt atctttaaac
     2821 atggtgatga tctgcgccaa gacatgctta ttttacagat tctacgaatc atggagtcta
     2881 tttgggagac tgaatctttg gatctatgcc tcctgccata tggttgcatt tcaactggtg
     2941 acaaaatagg aatgatcgag attgtgaaag acgccacgac aattgccaaa attcagcaaa
     3001 gcacagtggg caacacggga gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa
     3061 aatcccctac tgaagaaaag tttcaggcag cagtggagag atttgtttat tcctgtgcag
     3121 gctactgtgt ggcaaccttt gttcttggaa taggcgacag acacaatgac aatattatga
     3181 tcaccgagac aggaaaccta tttcatattg acttcgggca cattcttggg aattacaaaa
     3241 gtttcctggg cattaataaa gagagagtgc catttgtgct aacccctgac ttcctctttg
     3301 tgatgggaac ttctggaaag aagacaagcc cacacttcca gaaatttcag gacatctgtg
     3361 ttaaggctta tctagccctt cgtcatcaca caaacctact gatcatcctg ttctccatga
     3421 tgctgatgac aggaatgccc cagttaacaa gcaaagaaga cattgaatat atccgggatg
     3481 ccctcacagt ggggaaaaat gaggaggatg ctaaaaagta ttttcttgat cagatcgaag
     3541 tttgcagaga caaaggatgg actgtgcagt ttaattggtt tctacatctt gttcttggca
     3601 tcaaacaagg agagaaacat tcagcctaat actttaggct agaatcaaaa acaagttagt
     3661 gttctatggt ttaaattagc atagcaatca tcgaacttgg atttcaaatg caatagacat
     3721 tgtgaaagct ggcatttcag aagtatagct cttttcctac ctgaactctt ccctggagaa
     3781 aagatgttgg cattgctgat tgtttggtta agcaatgtcc agtgctagga ttatttgcag
     3841 gtttggtttt ttctcatttg tctgtggcat tggagaatat tctcggttta aacagactaa
     3901 tgacttcctt attgtccctg atattttgac tatcttacta ttgagtgctt ctggaaattc
     3961 tttggaataa ttgatgacat ctattttcat ctgggtttag tctcaatttt ggttatcttt
     4021 gtgttcctca agctctttaa agaaaaagat gtaatcgttg taacctttgt ctcattcctt
     4081 aaatgatgct tccaaacatc tccttagtgt ctgcaggtgt tagtggtgtg ctaaaagcaa
     4141 ggaaagcgag ttagtctttt cagtgtcttt tgcaattcaa ttcttttgtc atgtataact
     4201 gagacacaca aacacagcag gagaaatcta aaccgttgtg ccttgacctt cctctgctgg
     4261 tcttgttcca gggttatgaa tatgaaaaaa tagagatgag actttttgtg tcaactctgt
     4321 ccacaagagt gagttatcta gtatgattag tatagctttc tccagcatgg cagcaggaag
     4381 taactacagg gcctctttta tgcctgacat ttcttccctt cctttttccc tgcctccctt
     4441 tttcatcaat tgcaatgctc ccacaactct ttacagactt gtgaaatctt caagaacacc
     4501 tttactctat aactcaaaaa ttagttgaaa aataattact tctcaaggat tattagaatc
     4561 ttaggtactt atttgtaaag atgtttagtg actttttttt caagtatcta taaaggaggc
     4621 agattctaga aaatatgaat tagtttccaa atgccttaat tttaaacttt ggcctgaaca
     4681 gttttttctt tttcttaatg gaagaagata tttaatatct taaaaatatt ccaagttagg
     4741 aagaacacta cttgccttat ccatttccca tttaaaggac ttttaaactt tgacacagtc
     4801 cttcagattt cctgaaaatc cttgaaatat cttactttaa aaatattttc atctctgaaa
     4861 tatctcgtta tttattggag gtattgttta accttagata gaccattaaa ttatttataa
     4921 aatattttgt aattactgta gctaatacat tacatagaaa aaactatgtt aacagtgtct
     4981 ctgtttaagt ataatcagat ataaatatat aacttaattt tttaatttta aaaaatagat
     5041 acctgtttga ctttgaggta gtccaggcct ttttcttttt tttttttttt aatgtgtgca
     5101 aaagcccaaa ggttcctaag cctggctgca aagaagaatc aacagggaca ctttttaaaa
     5161 acactcttat cagcctgggg caacacagtg agactccatc tcttaaaaaa aaaattagct
     5221 gggtatagtg gtatgtgcct gtagtcccag gtactcagga ggctgaggca ggaggattgc
     5281 ctgagcccag gaggtggaaa ctgcagagag tcatgatcat gtccttacac tccagcctgg
     5341 ataacagagc gagaccctgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa actcgag
//