LOCUS X82835 6371 bp mRNA linear HUM 24-SEP-2008
DEFINITION H.sapiens mRNA for voltage-activated sodium channel.
ACCESSION X82835
VERSION X82835.1
KEYWORDS sodium channel alpha subunit; voltage-activated sodium channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Klugbauer N., Lacinova L., Flockerzi V., Hofmann F.
TITLE Structure and functional expression of a new member of the
tetrodotoxin-sensitive voltage-activated sodium channel family from
human neuroendocrine cells
JOURNAL EMBO J. 14(6), 1084-1090(1995).
PUBMED 7720699
REFERENCE 2 (bases 1 to 6371)
AUTHORS Hofmann F.
JOURNAL Submitted (21-NOV-1994) to the INSDC. F. Hofmann, Institut fuer
Pharmakologie und Toxikologie, Technische Univ. Muenchen,
Biedersteiner Str. 29, 80802 Muenchen, FRG
FEATURES Location/Qualifiers
source 1..6371
/db_xref="H-InvDB:HIT000323933"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="pcDNA3 (Invitrogen)"
/cell_line="medullary thyroid carcinoma"
/cell_type="medullary thryroid carcinoma"
/tissue_type="thyroid"
/db_xref="taxon:9606"
CDS 49..5982
/gene="hNE-Na"
/product="sodium channel alpha subunit"
/note="voltage-activated sodium channel"
/db_xref="GOA:Q15858"
/db_xref="H-InvDB:HIT000323933.14"
/db_xref="HGNC:HGNC:10597"
/db_xref="InterPro:IPR000048"
/db_xref="InterPro:IPR001696"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR010526"
/db_xref="InterPro:IPR024583"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR028803"
/db_xref="PDB:5EK0"
/db_xref="PDB:6J8G"
/db_xref="PDB:6J8H"
/db_xref="PDB:6J8I"
/db_xref="PDB:6J8J"
/db_xref="PDB:6N4Q"
/db_xref="PDB:6N4R"
/db_xref="PDB:6NT3"
/db_xref="PDB:6NT4"
/db_xref="UniProtKB/Swiss-Prot:Q15858"
/protein_id="CAA58042.1"
/translation="MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDE
EAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNA
TPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFT
GIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRV
LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCF
RNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG
RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFY
LINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSI
RRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDS
IRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGS
ETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDC
NGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRA
SILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAIT
ICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN
IFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLC
GEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDP
DANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNH
TLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE
NMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTD
GCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY
IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTL
VANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNF
DNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFF
TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ
GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV
LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRIL
RLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMF
NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI
FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQ
FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES
GEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKN
ISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKY
EQDRTEKEDKGKDSKESKK"
BASE COUNT 1948 a 1231 c 1374 g 1818 t
ORIGIN
1 ctcttatgtg aggagctgaa gaggaattaa aatatacagg atgaaaagat ggcaatgttg
61 cctcccccag gacctcagag ctttgtccat ttcacaaaac agtctcttgc cctcattgaa
121 caacgcattg ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga tgatgatgaa
181 gaagccccaa agccaagcag tgacttggaa gctggcaaac aactgccctt catctatggg
241 gacattcctc ccggcatggt gtcagagccc ctggaggact tggaccccta ctatgcagac
301 aaaaagactt tcatagtatt gaacaaaggg aaaacaatct tccgtttcaa tgccacacct
361 gctttatata tgctttctcc tttcagtcct ctaagaagaa tatctattaa gattttagta
421 cactccttat tcagcatgct catcatgtgc actattctga caaactgcat atttatgacc
481 atgaataacc cgccggactg gaccaaaaat gtcgagtaca cttttactgg aatatatact
541 tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg taggagaatt cacttttctt
601 cgtgacccgt ggaactggct ggattttgtc gtcattgttt ttgcgtattt aacagaattt
661 gtaaacctag gcaatgtttc agctcttcga actttcagag tattgagagc tttgaaaact
721 atttctgtaa tcccaggcct gaagacaatt gtaggggctt tgatccagtc agtgaagaag
781 ctttctgatg tcatgatcct gactgtgttc tgtctgagtg tgtttgcact aattggacta
841 cagctgttca tgggaaacct gaagcataaa tgttttcgaa attcacttga aaataatgaa
901 acattagaaa gcataatgaa taccctagag agtgaagaag actttagaaa atatttttat
961 tacttggaag gatccaaaga tgctctcctt tgtggtttca gcacagattc aggtcagtgt
1021 ccagaggggt acacctgtgt gaaaattggc agaaaccctg attatggcta cacgagcttt
1081 gacactttca gctgggcctt cttagccttg tttaggctaa tgacccaaga ttactgggaa
1141 aacctttacc aacagacgct gcgtgctgct ggcaaaacct acatgatctt ctttgtcgta
1201 gtgattttcc tgggctcctt ttatctaata aacttgatcc tggctgtggt tgccatggca
1261 tatgaagaac agaaccaggc aaacattgaa gaagctaaac agaaagaatt agaatttcaa
1321 cagatgttag accgtcttaa aaaagagcaa gaagaagctg aggcaattgc agcggcagcg
1381 gctgaatata caagtattag gagaagcaga attatgggcc tctcagagag ttcttctgaa
1441 acatccaaac tgagctctaa aagtgctaaa gaaagaagaa acagaagaaa gaaaaagaat
1501 caaaagaagc tctccagtgg agaggaaaag ggagatgctg agaaattgtc gaaatcagaa
1561 tcagaggaca gcatcagaag aaaaagtttc caccttggtg tcgaagggca taggcgagca
1621 catgaaaaga ggttgtctac ccccaatcag tcaccactca gcattcgtgg ctccttgttt
1681 tctgcaaggc gaagcagcag aacaagtctt tttagtttca aaggcagagg aagagatata
1741 ggatctgaga ctgaatttgc cgatgatgag cacagcattt ttggagacaa tgagagcaga
1801 aggggctcac tgtttgtgcc ccacagaccc caggagcgac gcagcagtaa catcagccaa
1861 gccagtaggt ccccaccaat gctgccggtg aacgggaaaa tgcacagtgc tgtggactgc
1921 aacggtgtgg tctccctggt tgatggacgc tcagccctca tgctccccaa tggacagctt
1981 ctgccagagg gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc ctatctcctt
2041 tcagaggata tgctgaatga tcccaacctc agacagagag caatgagtag agcaagcata
2101 ttaacaaaca ctgtggaaga acttgaagag tccagacaaa aatgtccacc ttggtggtac
2161 agatttgcac acaaattctt gatctggaat tgctctccat attggataaa attcaaaaag
2221 tgtatctatt ttattgtaat ggatcctttt gtagatcttg caattaccat ttgcatagtt
2281 ttaaacacat tatttatggc tatggaacac cacccaatga ctgaggaatt caaaaatgta
2341 cttgctatag gaaatttggt ctttactgga atctttgcag ctgaaatggt attaaaactg
2401 attgccatgg atccatatga gtatttccaa gtaggctgga atatttttga cagccttatt
2461 gtgactttaa gtttagtgga gctctttcta gcagatgtgg aaggattgtc agttctgcga
2521 tcattcagac tgctccgagt cttcaagttg gcaaaatcct ggccaacatt gaacatgctg
2581 attaagatca ttggtaactc agtaggggct ctaggtaacc tcaccttagt gttggccatc
2641 atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta caaagaatgt
2701 gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc acatgaacga cttcttccac
2761 tccttcctga ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat gtgggactgt
2821 atggaggtcg ctggtcaagc tatgtgcctt attgtttaca tgatggtcat ggtcattgga
2881 aacctggtgg tcctaaacct atttctggcc ttattattga gctcatttag ttcagacaat
2941 cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt gactagaatt
3001 aaaaagggaa taaattatgt gaaacaaacc ttacgtgaat ttattctaaa agcattttcc
3061 aaaaagccaa agatttccag ggagataaga caagcagaag atctgaatac taagaaggaa
3121 aactatattt ctaaccatac acttgctgaa atgagcaaag gtcacaattt cctcaaggaa
3181 aaagataaaa tcagtggttt tggaagcagc gtggacaaac acttgatgga agacagtgat
3241 ggtcaatcat ttattcacaa tcccagcctc acagtgacag tgccaattgc acctggggaa
3301 tccgatttgg aaaatatgaa tgctgaggaa cttagcagtg attcggatag tgaatacagc
3361 aaagtgagat taaaccggtc aagctcctca gagtgcagca cagttgataa ccctttgcct
3421 ggagaaggag aagaagcaga ggctgaacct atgaattccg atgagccaga ggcctgtttc
3481 acagatggtt gtgtacggag gttctcatgc tgccaagtta acatagagtc agggaaagga
3541 aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag ttggtttgaa
3601 agcttcattg tcctcatgat cctgctcagc agtggtgccc tggcttttga agatatttat
3661 attgaaagga aaaagaccat taagattatc ctggagtatg cagacaagat cttcacttac
3721 atcttcattc tggaaatgct tctaaaatgg atagcatatg gttataaaac atatttcacc
3781 aatgcctggt gttggctgga tttcctaatt gttgatgttt ctttggttac tttagtggca
3841 aacactcttg gctactcaga tcttggcccc attaaatccc ttcggacact gagagcttta
3901 agacctctaa gagccttatc tagatttgaa ggaatgaggg tcgttgtgaa tgcactcata
3961 ggagcaattc cttccatcat gaatgtgcta cttgtgtgtc ttatattctg gctgatattc
4021 agcatcatgg gagtaaattt gtttgctggc aagttctatg agtgtattaa caccacagat
4081 gggtcacggt ttcctgcaag tcaagttcca aatcgttccg aatgttttgc ccttatgaat
4141 gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt cggacttggt
4201 tacctatctc tgcttcaagt tgcaactttt aagggatgga cgattattat gtatgcagca
4261 gtggattctg ttaatgtaga caagcagccc aaatatgaat atagcctcta catgtatatt
4321 tattttgtcg tctttatcat ctttgggtca ttcttcactt tgaacttgtt cattggtgtc
4381 atcatagata atttcaacca acagaaaaag aagcttggag gtcaagacat ctttatgaca
4441 gaagaacaga agaaatacta taatgcaatg aaaaagctgg ggtccaagaa gccacaaaag
4501 ccaattcctc gaccagggaa caaaatccaa ggatgtatat ttgacctagt gacaaatcaa
4561 gcctttgata ttagtatcat ggttcttatc tgtctcaaca tggtaaccat gatggtagaa
4621 aaggagggtc aaagtcaaca tatgactgaa gttttatatt ggataaatgt ggtttttata
4681 atccttttca ctggagaatg tgtgctaaaa ctgatctccc tcagacacta ctacttcact
4741 gtaggatgga atatttttga ttttgtggtt gtgattatct ccattgtagg tatgtttcta
4801 gctgatttga ttgaaacgta ttttgtgtcc cctaccctgt tccgagtgat ccgtcttgcc
4861 aggattggcc gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac gctgctcttt
4921 gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tcctgctctt cctggtcatg
4981 ttcatctacg ccatctttgg aatgtccaac tttgcctatg ttaaaaagga agatggaatt
5041 aatgacatgt tcaattttga gacctttggc aacagtatga tttgcctgtt ccaaattaca
5101 acctctgctg gctgggatgg attgctagca cctattctta acagtaagcc acccgactgt
5161 gacccaaaaa aagttcatcc tggaagttca gttgaaggag actgtggtaa cccatctgtt
5221 ggaatattct actttgttag ttatatcatc atatccttcc tggttgtggt gaacatgtac
5281 attgcagtca tactggagaa ttttagtgtt gccactgaag aaagtactga acctctgagt
5341 gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga tgcgacccag
5401 tttatagagt tctctaaact ctctgatttt gcagctgccc tggatcctcc tcttctcata
5461 gcaaaaccca acaaagtcca gctcattgcc atggatctgc ccatggttag tggtgaccgg
5521 atccattgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga gagtggggag
5581 atggattctc ttcgttcaca gatggaagaa aggttcatgt ctgcaaatcc ttccaaagtg
5641 tcctatgaac ccatcacaac cacactaaaa cggaaacaag aggatgtgtc tgctactgtc
5701 attcagcgtg cttatagacg ttaccgctta aggcaaaatg tcaaaaatat atcaagtata
5761 tacataaaag atggagacag agatgatgat ttactcaata aaaaagatat ggcttttgat
5821 aatgttaatg agaactcaag tccagaaaaa acagatgcca cttcatccac cacctctcca
5881 ccttcatatg atagtgtaac aaagccagac aaagagaaat atgaacaaga cagaacagaa
5941 aaggaagaca aagggaaaga cagcaaggaa agcaaaaaat agagcttcat ttttgatata
6001 ttgtttacag cctgtgaaag tgatttattt gtgttaataa aactcttttg aggaagtcta
6061 tgccaaaatc ctttttatca aaatattctc gaaggcagtg cagtcactaa ctctgatttc
6121 ctaagaaagg tgggcagcat tagcagatgg ttatttttgc actgatgatt ctttaagaat
6181 cgtaagagaa ctctgtagga attattgatt atagcataca aaagtgattg attcagtttt
6241 ttggttttta ataaatcaga agaccatgta gaaaactttt acatctgcct tgtcatcttt
6301 tcacaggatt gtaattagtc ttgtttccca tgtaaataaa caacacacgc atacagaaaa
6361 aaaaaaaaaa a
//