LOCUS X80289 8043 bp mRNA linear HUM 23-OCT-2008
DEFINITION H.sapiens PTPL1 mRNA for protein tyrosine phosphatase.
ACCESSION X80289
VERSION X80289.1
KEYWORDS protein tyrosine phophatase; protein tyrosine phophatase 1; PTPL1
gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Saras J., Claesson-Welsh L., Heldin C.H., Gonez J.L.
TITLE Cloning and characterization of PTPL1, a protein tyrosine
phosphatase with similarities to cytoskeletal-associated proteins
JOURNAL J Biol Chem 269(39), 24082-24089(1994).
PUBMED 7929060
REFERENCE 2 (bases 1 to 8043)
AUTHORS Saras J.
JOURNAL Submitted (14-JUL-1994) to the INSDC. J. Saras, Ludwig Institute
for Cancer, Research, Box 595 BMC, Husargatan 3, S-75124 Uppsala,
SWEDEN
FEATURES Location/Qualifiers
source 1..8043
/db_xref="H-InvDB:HIT000323803"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="AG1518"
/cell_type="foreskin fibroblast"
/db_xref="taxon:9606"
CDS 78..7478
/gene="PTPL1"
/product="protein-tyrosine-phosphatase"
/EC_number="3.1.3.48"
/db_xref="GOA:Q12923"
/db_xref="H-InvDB:HIT000323803.14"
/db_xref="HGNC:HGNC:9646"
/db_xref="InterPro:IPR000242"
/db_xref="InterPro:IPR000299"
/db_xref="InterPro:IPR000387"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR003595"
/db_xref="InterPro:IPR011019"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR012153"
/db_xref="InterPro:IPR014352"
/db_xref="InterPro:IPR018979"
/db_xref="InterPro:IPR018980"
/db_xref="InterPro:IPR019748"
/db_xref="InterPro:IPR019749"
/db_xref="InterPro:IPR029021"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR035963"
/db_xref="InterPro:IPR036034"
/db_xref="PDB:1D5G"
/db_xref="PDB:1Q7X"
/db_xref="PDB:1WCH"
/db_xref="PDB:2M0Z"
/db_xref="PDB:2M10"
/db_xref="PDB:3LNX"
/db_xref="PDB:3LNY"
/db_xref="PDB:3PDZ"
/db_xref="PDB:5GLJ"
/db_xref="UniProtKB/Swiss-Prot:Q12923"
/protein_id="CAA56563.1"
/translation="MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADP
AALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIY
SLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNS
NCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSD
VLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQ
FKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTS
TTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLR
EAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVD
ETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDT
IKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGK
NEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYF
FVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQ
LRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDL
SYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVC
SKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQY
LLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS
STLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHD
LSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASL
NRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQ
IIGGEKMGRLDLGIFISSVAPGGPADFHGCLKPGDRLISVNSVSLEGVSHHAAIEILQ
NAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRG
TLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGS
PSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQ
ESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYV
KAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSP
TSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGF
SFSREDNLIPEQINASIVRVKKLFAGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI
SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTS
SDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMV
SQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESA
SSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKASLGFTV
TKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTV
RLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVA
AIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSA
VSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNL
TLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK
LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITW
GNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLD
QGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASF
IKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN
ILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPS
QPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVR
CMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK"
misc_feature 1493..1582
/note="leucine zipper motif"
misc_feature 1790..2699
/note="band 4,1 homology region"
repeat_region 3315..3545
/note="GLGF repeat1"
repeat_region 4137..4367
/note="GLGF repeat2"
repeat_region 4533..4775
/note="GLGF repeat 3"
repeat_region 5401..5615
/note="GLGF repeat 4"
repeat_region 5682..5906
/note="GLGF repeat 5"
BASE COUNT 2560 a 1668 c 1732 g 2082 t
ORIGIN
1 cccgccccga cgccgcgtcc ctgcagccct gcccggcgct ccagtagcag gacccggtct
61 cgggaccagc cggtaatatg cacgtgtcac tagctgaggc cctggaggtt cggggtggac
121 cacttcagga ggaagaaata tgggctgtat taaatcaaag tgctgaaagt ctccaagaat
181 tattcagaaa agtaagccta gctgatcctg ctgcccttgg cttcatcatt tctccatggt
241 ctctgctgtt gctgccatct ggtagtgtgt catttacaga tgaaaatatt tccaatcagg
301 atcttcgagc attcactgca ccagaggttc ttcaaaatca gtcactaact tctctctcag
361 atgttgaaaa gatccacatt tattctcttg gaatgacact gtattggggg gctgattatg
421 aagtgcctca gagccaacct attaagcttg gagatcatct caacagcata ctgcttggaa
481 tgtgtgagga tgttatttac gctcgagttt ctgttcggac tgtgctggat gcttgcagtg
541 cccacattag gaatagcaat tgtgcaccct cattttccta cgtgaaacac ttggtaaaac
601 tggttctggg aaatctttct gggacagatc agctttcctg taacagtgaa caaaagcctg
661 atcgaagcca ggctattcga gatcgattgc gaggaaaagg attaccaaca ggaagaagct
721 ctacttctga tgtactagac atacaaaagc ctccactctc tcatcagacc tttcttaaca
781 aagggcttag taaatctatg ggatttctgt ccatcaaaga tacacaagat gagaattatt
841 tcaaggacat tttatcagat aattctggac gtgaagattc tgaaaataca ttctcccctt
901 accagttcaa aactagtggc ccagaaaaaa aacccatccc tggcattgat gtgctttcta
961 agaagaagat ctgggcttca tccatggact tgctttgtac agctgacaga gacttctctt
1021 caggagagac tgccacatat cgtcgttgtc accctgaggc agtaacagtg cggacttcaa
1081 ctacgcctag aaaaaaggag gcaagatact cagatggaag tatagccttg gatatctttg
1141 gccctcagaa aatggatcca atatatcaca ctcgagaatt gcccacctcc tcagcaatat
1201 caagtgcttt ggaccgaatc cgagagagac aaaagaaact tcaggttctg agggaagcca
1261 tgaatgtaga agaaccagtt cgaagataca aaacttatca tggtgatgtc tttagtacct
1321 ccagtgaaag tccatctatt atttcctctg aatcagattt cagacaagtg agaagaagtg
1381 aagcctcaaa gaggtttgaa tccagcagtg gtctcccagg ggtagatgaa accttaagtc
1441 aaggccagtc acagagaccg agcagacaat atgaaacacc ctttgaaggc aacttaatta
1501 atcaagagat catgctaaaa cggcaagagg aagaactgat gcagctacaa gccaaaatgg
1561 cccttagaca gtctcggttg agcctatatc caggagacac aatcaaagcg tccatgcttg
1621 acatcaccag ggatccgtta agagaaattg ccctagaaac agccatgact caaagaaaac
1681 tgaggaattt ctttggccct gagtttgtga aaatgacaat tgaaccattt atatctttgg
1741 atttgccacg gtctattctt actaagaaag ggaagaatga ggataaccga aggaaagtaa
1801 acataatgct tctgaacggg caaagactgg aactgacctg tgataccaaa actatatgta
1861 aagatgtgtt tgatatggtt gtggcacata ttggcttagt agagcatcat ttgtttgctt
1921 tagctaccct caaagataat gaatatttct ttgttgatcc tgacttaaaa ttaaccaaag
1981 tggccccaga gggatggaaa gaagaaccaa agaaaaagac caaagccact gttaatttta
2041 ctttgttttt cagaattaaa ttttttatgg atgatgttag tctaatacaa catactctga
2101 cgtgtcatca gtattacctt cagcttcgaa aagatatttt ggaggaaagg atgcactgtg
2161 atgatgagac ttccttattg ctggcatcct tggctctcca ggctgagtat ggagattatc
2221 aaccagaggt tcatggtgtg tcttacttta gaatggagca ctatttgccc gccagagtga
2281 tggagaaact tgatttatcc tatatcaaag aagagttacc caaattgcat aatacctatg
2341 tgggagcttc tgaaaaagag acagagttag aatttttaaa ggtctgccaa agactgacag
2401 aatatggagt tcattttcac cgagtgcacc ctgagaagaa gtcacaaaca ggaatattgc
2461 ttggagtctg ttctaaaggt gtccttgtgt ttgaagttca caatggagtg cgcacattgg
2521 tccttcgctt tccatggagg gaaaccaaga aaatatcttt ttctaaaaag aaaatcacat
2581 tgcaaaatac atcagatgga ataaaacatg gcttccagac agacaacagt aagatatgcc
2641 agtacctgct gcacctctgc tcttaccagc ataagttcca gctacagatg agagcaagac
2701 agagcaacca agatgcccaa gatattgaga gagcttcgtt taggagcctg aatctccaag
2761 cagagtctgt tagaggattt aatatgggac gagcaatcag cactggcagt ctggccagca
2821 gcaccctcaa caaacttgct gttcgacctt tatcagttca agctgagatt ctgaagaggc
2881 tatcctgctc agagctgtcg ctttaccagc cattgcaaaa cagttcaaaa gagaagaatg
2941 acaaagcttc atgggaggaa aagcctagag agatgagtaa atcataccat gatctcagtc
3001 aggcctctct ctatccacat cggaaaaatg tcattgttaa catggaaccc ccaccacaaa
3061 ccgttgcaga gttggtggga aaaccttctc accagatgtc aagatctgat gcagaatctt
3121 tggcaggagt gacaaaactt aataattcaa agtctgttgc gagtttaaat agaagtcctg
3181 aaaggaggaa acatgaatca gactcctcat ccattgaaga ccctgggcaa gcatatgttc
3241 tagatgtgct acacaaaaga tggagcatag tatcttcacc agaaagggag atcaccttag
3301 tgaacctgaa aaaagatgca aagtatggct tgggatttca aattattggt ggggagaaga
3361 tgggaagact ggacctaggc atatttatca gctcagttgc ccctggagga ccagctgact
3421 tccatggatg cttgaagcca ggagaccgtt tgatatctgt gaatagtgtg agtctggagg
3481 gagtcagcca ccatgctgca attgaaattt tgcaaaatgc acctgaagat gtgacacttg
3541 ttatctctca gccaaaagaa aagatatcca aagtgccttc tactcctgtg catctcacca
3601 atgagatgaa aaactacatg aagaaatctt cctacatgca agacagtgct atagattctt
3661 cttccaagga tcaccactgg tcacgtggta ccctgaggca catctcggag aactcctttg
3721 ggccgtctgg gggcctgcgg gaaggaagcc tgagttctca agattccagg actgagagtg
3781 ccagcttgtc tcaaagccag gtcaatggtt tctttgccag ccatttaggt gaccaaacct
3841 ggcaggaatc acagcatggc agcccttccc catctgtaat atccaaagcc accgagaaag
3901 agactttcac tgatagtaac caaagcaaaa ctaaaaagcc aggcatttct gatgtaactg
3961 attactcaga ccgtggagat tcagacatgg atgaagccac ttactccagc agtcaggatc
4021 atcaaacacc aaaacaggaa tcttcctctt cagtgaatac atccaacaag atgaatttta
4081 aaactttttc ttcatcacct cctaagcctg gagatatctt tgaggttgaa ctggctaaaa
4141 atgataacag cttggggata agtgtcacgg gaggtgtgaa tacgagtgtc agacatggtg
4201 gcatttatgt gaaagctgtt attccccagg gagcagcaga gtctgatggt agaattcaca
4261 aaggtgatcg cgtcctagct gtcaatggag ttagtctaga aggagccacc cataagcaag
4321 ctgtggaaac actgagaaat acaggacagg tggttcatct gttattagaa aagggacaat
4381 ctccaacatc taaagaacat gtcccggtaa ccccacagtg taccctttca gatcagaatg
4441 cccaaggtca aggcccagaa aaagtgaaga aaacaactca ggtcaaagac tacagctttg
4501 tcactgaaga aaatacattt gaggtaaaat tatttaaaaa tagctcaggt ctaggattca
4561 gtttttctcg agaagataat cttataccgg agcaaattaa tgccagcata gtaagggtta
4621 aaaagctctt tgctggacag ccagcagcag aaagtggaaa aattgatgta ggagatgtta
4681 tcttgaaagt gaatggagcc tctttgaaag gactatctca gcaggaagtc atatctgctc
4741 tcaggggaac tgctccagaa gtattcttgc ttctctgcag acctccacct ggtgtgctac
4801 cggaaattga tactgcgctt ttgaccccac ttcagtctcc agcacaagta cttccaaaca
4861 gcagtaaaga ctcttctcag ccatcatgtg tggagcaaag caccagctca gatgaaaatg
4921 aaatgtcaga caaaagcaaa aaacagtgca agtccccatc cagaagagac agttacagtg
4981 acagcagtgg gagtggagaa gatgacttag tcacagctcc agcaaacata tcaaattcga
5041 cctggagttc agctttgcat cagactctaa gcaacatggt atcacaggca cagagtcatc
5101 atgaagcacc caagagtcaa gaagatacca tttgtaccat gttttactat cctcagaaaa
5161 ttcccaataa accagagttt gaggacagta atccttcccc tctaccaccg gatatggctc
5221 ctgggcagag ttatcaaccc caatcagaat ctgcttcctc tagttcgatg gataagtatc
5281 atatacatca catttctgaa ccaactagac aagaaaactg gacacctttg aaaaatgact
5341 tggaaaatca ccttgaagac tttgaactgg aagtagaact cctcattacc ctaattaaat
5401 cagaaaaagc aagcctgggt tttacagtaa ccaaaggcaa tcagagaatt ggttgttatg
5461 ttcatgatgt catacaggat ccagccaaaa gtgatggaag gctaaaacct ggggaccggc
5521 tcataaaggt taatgataca gatgttacta atatgactca tacagatgca gttaatctgc
5581 tccgggctgc atccaaaaca gtcagattag ttattggacg agttctagaa ttacccagaa
5641 taccaatgtt gcctcatttg ctaccggaca taacactaac gtgcaacaaa gaggagttgg
5701 gtttttcctt atgtggaggt catgacagcc tttatcaagt ggtatatatt agtgatatta
5761 atccaaggtc cgtcgcagcc attgagggta atctccagct attagatgtc atccattatg
5821 tgaacggagt cagcacacaa ggaatgacct tggaggaagt taacagagca ttagacatgt
5881 cacttccttc attggtattg aaagcaacaa gaaatgatct tccagtggtt cccagctcaa
5941 agaggtctgc tgtttcagct ccaaagtcaa ccaaaggcaa tggttcctac agtgtggggt
6001 cttgcagcca gcctgccctc actcctaatg attcattctc cacggttgct ggggaagaaa
6061 taaatgaaat atcgtacccc aaaggaaaat gttctactta tcagataaag ggatcaccaa
6121 acttgactct gcccaaagaa tcttatatac aagaagatga catttatgat gattcccaag
6181 aagctgaagt tatccagtct ctgctggatg ttgttgatga ggaagcccag aatcttttaa
6241 acgaaaataa tgcagcagga tactcctgtg gtccaggtac attaaagatg aatgggaagt
6301 tatcagaaga gagaacagaa gatacagact gcgatggttc acctttacct gagtatttta
6361 ctgaggccac caaaatgaat ggctgtgaag aatattgtga agaaaaagta aaaagtgaaa
6421 gcttaattca gaagccacaa gaaaagaaga ctgatgatga tgaaataaca tggggaaatg
6481 atgagttgcc aatagagaga acaaaccatg aagattctga taaagatcat tcctttctga
6541 caaacgatga gctcgctgta ctccctgtcg tcaaagtgct tccctctggt aaatacacgg
6601 gtgccaactt aaaatcagtc attcgagtcc tgcggggttt gctagatcaa ggaattcctt
6661 ctaaggagct ggagaatctt caagaattaa aacctttgga tcagtgtcta attgggcaaa
6721 ctaaggaaaa cagaaggaag aacagatata aaaatatact tccctatgat gctacaagag
6781 tgcctcttgg agatgaaggt ggctatatca atgccagctt cattaagata ccagttggga
6841 aagaagagtt cgtttacatt gcctgccaag gaccactgcc tacaactgtt ggagacttct
6901 ggcagatgat ttgggagcaa aaatccacag tgatagccat gatgactcaa gaagtagaag
6961 gagaaaaaat caaatgccag cgctattggc ccaacatcct aggcaaaaca acaatggtca
7021 gcaacagact tcgactggct cttgtgagaa tgcagcagct gaagggcttt gtggtgaggg
7081 caatgaccct tgaagatatt cagaccagag aggtgcgcca tatttctcat ctgaatttca
7141 ctgcctggcc agaccatgat acaccttctc aaccagatga tctgcttact tttatctcct
7201 acatgagaca catccacaga tcaggcccaa tcattacgca ctgcagtgct ggcattggac
7261 gttcagggac cctgatttgc atagatgtgg ttctgggatt aatcagtcag gatcttgatt
7321 ttgacatctc tgatttggtg cgctgcatga gactacaaag acacggaatg gttcagacag
7381 aggatcaata tattttctgc tatcaagtca tcctttatgt cctgacacgt cttcaagcag
7441 aagaagagca aaaacagcag cctcagcttc tgaagtgaca tgaaaagagc ctctggatgc
7501 atttccattt ctctccttaa cctccagcag actcctgctc tctatccaaa taaagatcac
7561 agagcagnaa gttcatacaa catgcatgtt ctcctctatc ttagaggggt attcttcttg
7621 aaaataaaaa atattgaaat gctgtatttt tacagctact ttaacctatg ataattattt
7681 acaaaatttt aacactaacc aaacaatgca gatcttaggg atgattaaag gcagcattga
7741 tgatagcaag acattgttac aaggacatgg tgagtctatt tttaatgcac caatcttgtt
7801 tatagcaaaa atgttttcca atattttaat aaagtagtta ttttataggg catacttgaa
7861 accagtattt aagctttaaa tgacagtaat attggcatag aaaaaagtag caaatgttta
7921 ctgtatcaat ttctaatgtt tactatatag aatttcctgt aatatattta tatacttttt
7981 catgaaaatg gagttatcag ttatctgttt gttactgcat catctgtttg taatcattat
8041 ctc
//