LOCUS X77753 2805 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens TROP-2 gene.
ACCESSION X77753
VERSION X77753.1
KEYWORDS gp50 protein; TROP-2 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Fornaro M., Dell' Arciprete R., Stella S., Bucci C., Nutini M.,
Capri M.G., Alberti S.
TITLE Cloning of the gene encoding Trop-2, a cell-surface glycoprotein
expressed by human carcinomas
JOURNAL Int. J. Cancer 62(5), 610-618(1995).
PUBMED 7665234
REFERENCE 2
AUTHORS Alberti S.
JOURNAL Submitted (18-FEB-1994) to the INSDC. S. Alberti, Institute Mario
Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, ITALY
REMARK revised by [3]
REFERENCE 3
AUTHORS Alberti S.
JOURNAL Submitted (14-AUG-1995) to the INSDC. S. Alberti, Institute Mario
Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, ITALY
REMARK revised by [4]
REFERENCE 4 (bases 1 to 2805)
AUTHORS Alberti S.
JOURNAL Submitted (04-SEP-1996) to the INSDC. S. Alberti, Institute Mario
Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro, Chieti, ITALY
FEATURES Location/Qualifiers
source 1..2805
/db_xref="H-InvDB:HIT000323640"
/organism="Homo sapiens"
/chromosome="1"
/map="p32"
/mol_type="mRNA"
/cell_type="epithelial"
/germline
/db_xref="taxon:9606"
sig_peptide 616..794
/gene="TROP-2"
/product="gp50/Trop-2"
CDS 616..1587
/gene="TROP-2"
/product="gp50/Trop-2"
/db_xref="GOA:P09758"
/db_xref="H-InvDB:HIT000323640.15"
/db_xref="HGNC:HGNC:11530"
/db_xref="InterPro:IPR000716"
/db_xref="InterPro:IPR036857"
/db_xref="PDB:2MAE"
/db_xref="PDB:2MVK"
/db_xref="PDB:2MVL"
/db_xref="UniProtKB/Swiss-Prot:P09758"
/protein_id="CAA54799.1"
/translation="MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVC
SPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDG
LYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRH
RPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGEVD
IGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAG
LIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL"
BASE COUNT 618 a 755 c 801 g 631 t
ORIGIN
1 cgggtctgat agtccctacc tgtcaggact ggtgttagga tgagataatg tttgtgaact
61 gtaaacatat ataaacgtgt gctactgtga gaactggaac aaagaagaga gggagtgaga
121 gaaatcaagg gagggctggg gctgggaaag aacgaaaagg gagtcgcgta tagaggagag
181 gcgacagtcg cgagccacac tttgcaatga aactctttag actttctgcc gggagagcgg
241 cccagacgcg ccaggtctgt agcaggaggc cgcgagggcg ggtccccaga agcctacagg
301 tgagtatcgg ttctcccctt cccggctttc ggtccggagg aggcgggagc agcttccctg
361 ttctgatcct atcgcgggcg gcgcagggcc ggcttggcct tccgtgggac ggggaggggg
421 gcgggatgtg tcacccaaat accagtgggg acggtcggtg gtggaaccag ccgggcaggt
481 cgggtagagt ataagagccg gagggagcgg ccggggcgca gacgcctgca gaccatccca
541 gacgccggag cccgagcccc gacgagtccc cgcgcctcat ccgcccgcgt ccggtccgcg
601 ttcctccgcc ccaccatggc tcggggcccc ggcctcgcgc cgccaccgct gcggctgccg
661 ctgctgctgc tggtgctggc ggcggtgacc ggccacacgg ccgcgcagga caactgcacg
721 tgtcccacca acaagatgac cgtgtgcagc cccgacggcc ccggcggccg ctgccagtgc
781 cgcgcgctgg gctcgggcat ggcggtcgac tgctccacgc tgacctccaa gtgtctgctg
841 ctcaaggcgc gcatgagcgc ccccaagaac gcccgcacgc tggtgcggcc gagtgagcac
901 gcgctcgtgg acaacgatgg cctctacgac cccgactgcg accccgaggg ccgcttcaag
961 gcgcgccagt gcaaccagac gtcggtgtgc tggtgcgtga actcggtggg cgtgcgccgc
1021 acggacaagg gcgacctgag cctacgctgc gatgagctgg tgcgcaccca ccacatcctc
1081 attgacctgc gccaccgccc caccgccggc gccttcaacc actcagacct ggacgccgag
1141 ctgaggcggc tcttccgcga gcgctatcgg ctgcacccca agttcgtggc ggccgtgcac
1201 tacgagcagc ccaccatcca gatcgagctg cggcagaaca cgtctcagaa ggccgccggt
1261 gaagtggata tcggcgatgc cgcctactac ttcgagaggg acatcaaggg cgagtctcta
1321 ttccagggcc gcggcggcct ggacttgcgc gtgcgcggag aacccctgca ggtggagcgc
1381 acgctcatct attacctgga cgagattccc ccgaagttct ccatgaagcg cctcaccgcc
1441 ggcctcatcg ccgtcatcgt ggtggtcgtg gtggccctcg tcgccggcat ggccgtcctg
1501 gtgatcacca accggagaaa gtcggggaag tacaagaagg tggagatcaa ggaactgggg
1561 gagttgagaa aggaaccgag cttgtaggta cccggcgggg caggggatgg ggtggggtac
1621 cggatttcgg tatcgtccca gacccaagtg agtcacgctt cctgattcct cggcgcaaag
1681 gagacgttta tcctttcaaa ttcctgcctt ccccctccct tttgcgcaca caccaggttt
1741 aatagatcct ggcctcaggg tctcctttct ttctcacttc tgtcttgagg gaagcatttc
1801 taaaatgtat cccctttcgg tccaacaaca ggaaacctga ctggggcagt gaaggaaggg
1861 atggcacagc gttatgtgta aaaaacaagt atctgtatga caacccggga tcgtttgcaa
1921 gtaactgaat ccattgcgac attgtgaagg cttaaatgag tttagatggg aaatagcgtt
1981 gttatcgcct tgggtttaaa ttatttgatg agttccactt gtatcatggc ctacccgagg
2041 agaagaggag tttgttaact gggcctatgt agtagcctca tttaccatcg tttgtattac
2101 tgaccacata tgcttgtcac tgggaaagaa gcctgtttca gctgcctgaa cgcagtttgg
2161 atgtctttga ggacagacat tgcccggaaa ctcagtctat ttattcttca gcttgccctt
2221 actgccactg atattggtaa tgttcttttt tgtaaaatgt ttgtacatat gttgtctttg
2281 ataatgttgc tgtaattttt taaaataaaa cacgaattta ataaaatatg ggaaaggcac
2341 aaaccagaag tcggcatttg tgaaaagtcc ctccagattt ctatcacttt ggtctctaat
2401 ttcccaagac ttgtattttt tttttatttc aaattataac actttttttt cccccagaag
2461 tgggtgtttc atgttgctac tctggtgtgt cccaagatat cctaactggc cagtgtaaat
2521 gctattcttt ctaaataaga ttatttggaa acttccttca aactgcagga gggcgagctc
2581 tgagggcacg agaagctaaa actagctgct tttgatgaaa aagagtgcca gtctttggtc
2641 atctctaaac aaggcttatc accaatggag acagaaaact ctagttcaag agctgtacct
2701 cctttgaatc ccagccctac tcgaaataag tggtactatt tccatttagc ctttgagcaa
2761 atcacttaac tcaaaggcgt tgtggctcta agattaaacg acttt
//