LOCUS X77244 2058 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens NADP+ dependent cytoplasmic malic enzyme mRNA.
ACCESSION X77244
VERSION X77244.1
KEYWORDS malic enzyme; NADP-dependent malic enzyme.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Loeber G., Dworkin M.B., Infante A., Ahorn H.
TITLE Characterization of cytosolic malic enzyme in human tumor cells
JOURNAL FEBS Lett. 344(2-3), 181-186(1994).
PUBMED 8187880
REFERENCE 2 (bases 1 to 2058)
AUTHORS Loeber G.
JOURNAL Submitted (25-JAN-1994) to the INSDC. G. Loeber, Ernst Boehringer
Institut, Bender & Co., Dr. Boehringergasse 5 - 11, 1121 Vienna,
AUSTRIA
FEATURES Location/Qualifiers
source 1..2058
/db_xref="H-InvDB:HIT000323614"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="white adipose tissue"
/db_xref="taxon:9606"
CDS 1..1719
/product="malate dehydrogenase (oxaloacetate
decarboxylating) (NADP+)"
/EC_number="1.1.1.40"
/db_xref="GOA:P48163"
/db_xref="H-InvDB:HIT000323614.13"
/db_xref="HGNC:HGNC:6983"
/db_xref="InterPro:IPR001891"
/db_xref="InterPro:IPR012301"
/db_xref="InterPro:IPR012302"
/db_xref="InterPro:IPR015884"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR037062"
/db_xref="PDB:2AW5"
/db_xref="PDB:3WJA"
/db_xref="UniProtKB/Swiss-Prot:P48163"
/protein_id="CAA54460.1"
/translation="MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLL
PPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVY
TPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLG
DLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRG
SEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASV
AVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLV
DSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILK
DMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPG
QGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRD
VSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKI
QTKVDQ"
polyA_site 2045..2050
BASE COUNT 628 a 407 c 437 g 586 t
ORIGIN
1 atggagcccg aagccccccg tcgccgccac acccatcagc gcggctacct gctgacacgg
61 aaccctcacc tcaacaagga cttggccttt accctggaag agagacagca attgaacatt
121 catggattgt tgccaccttc cttcaacagt caggagatcc aggttcttag agtagtaaaa
181 aatttcgagc atctgaactc tgactttgac aggtatcttc tcttaatgga tctccaagat
241 agaaatgaaa aactctttta tagagtgctg acatctgaca ttgagaaatt catgcctatt
301 gtttatactc ccactgtggg tctggcttgc caacaatata gtttggtgtt tcggaagcca
361 agaggtctct ttattactat ccacgatcga gggcatattg cttcagttct caatgcatgg
421 ccagaagatg tcatcaaggc cattgtggtg actgatggag agcgtattct tggcttggga
481 gaccttggct gtaatggaat gggcatccct gtgggtaaat tggctctata tacagcttgc
541 ggagggatga atcctcaaga atgtctgcct gtcattctgg atgtgggaac cgaaaatgag
601 gagttactta aagatccact ctacattgga ctacggcaga gaagagtaag aggttctgaa
661 tatgatgatt ttttggacga attcatggag gcagtttctt ccaagtatgg catgaattgc
721 cttattcagt ttgaagattt tgccaatgtg aatgcatttc gtctcctgaa caagtatcga
781 aaccagtatt gcacattcaa tgatgatatt caaggaacag catctgttgc agttgcaggt
841 ctccttgcag ctcttcgaat aaccaagaac aaactgtctg atcaaacaat actattccaa
901 ggagctggag aggctgccct agggattgca cacctgattg tgatggcctt ggaaaaagaa
961 ggtttaccaa aagagaaagc catcaaaaag atatggctgg ttgattcaaa aggattaata
1021 gttaagggac gtgcttcctt aacacaagag aaagagaagt ttgcccatga acatgaagaa
1081 atgaagaacc tagaagccat tgttcaagaa ataaaaccaa ctgccctcat aggagttgct
1141 gcaattggtg gtgcattctc agaacaaatt ctcaaagata tggctgcctt caatgaacgg
1201 cctattattt ttgctttgag taatccaact agcaaagcag aatgttctgc agagcagtgc
1261 tacaaaataa ccaagggacg tgcaattttt gccagtggca gtccttttga tccagtcact
1321 cttccaaatg gacagaccct atatcctggc caaggcaaca attcctacgt gttccctgga
1381 gttgctcttg gtgttgtggc gtgtggattg aggcagatca cagataatat tttcctcact
1441 actgctgagg ttatagctca gcaagtgtca gataaacact tggaagaggg tcggctttat
1501 cctcctttga ataccattag agatgtttct ctgaaaattg cagaaaagat tgtgaaagat
1561 gcataccaag aaaagacagc cacagtttat cctgaaccgc aaaacaaaga agcatttgtc
1621 cgctcccaga tgtatagtac tgattatgac cagattctac ctgattgtta ttcttggcct
1681 gaagaggtgc agaaaataca gaccaaagtt gaccagtagg ataatagcaa acatttctaa
1741 ctctattaat gaggtcttta aacctttcat aatttttaaa ggttggaatc ttttataatg
1801 attcataaga cacttagatt aagattttac tttaacagtc taaaaattga tagaagaata
1861 tcgatataaa ttgggataaa catcacatga gacaattttg cttcactttg ccttctggtt
1921 atttatggtt tctgtctgaa ttattctgcc tacgttctct ttaaaagctg ttgtacgtac
1981 tacggagaaa ctcatcattt ttatacagga cactaatggg aagaccaaaa ttactaataa
2041 attgaaataa ccaacatt
//