LOCUS       X76227                  1021 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  H.sapiens TIMP3 mRNA for tissue inhibitor of metalloproteinases-3.
ACCESSION   X76227
VERSION     X76227.1
KEYWORDS    TIMP-3 gene; tissue inhibitor of metalloproteinases.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Lopez-Otin C.
  JOURNAL   Submitted (19-NOV-1993) to the INSDC. C. Lopez-Otin, Universidad de
            Oviedo, Dept. de Biologia Funcional, Area de Bioquimica, Fac. de
            Medicina, C/ Julian Claveria S/N, 33006 Oviedo, SPAIN
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Uria J.A., Ferrando A.A., Velasco G., Freije J.M., Lopez-Otin C.
  TITLE     Structure and expression in breast tumors of human TIMP-3, a new
            member of the metalloproteinase inhibitor family
  JOURNAL   Cancer Res. 54(8), 2091-2094(1994).
   PUBMED   8174111
FEATURES             Location/Qualifiers
     source          1..1021
                     /db_xref="H-InvDB:HIT000323576"
                     /organism="Homo sapiens"
                     /isolate="patient I-9"
                     /mol_type="mRNA"
                     /clone_lib="lambda gt11"
                     /clone="T7-1"
                     /tissue_type="breast carcinoma"
                     /db_xref="taxon:9606"
     CDS             71..706
                     /gene="TIMP3"
                     /product="tissue inhibitor of metalloproteinases-3"
                     /db_xref="GOA:P35625"
                     /db_xref="H-InvDB:HIT000323576.11"
                     /db_xref="HGNC:HGNC:11822"
                     /db_xref="InterPro:IPR001134"
                     /db_xref="InterPro:IPR001820"
                     /db_xref="InterPro:IPR008993"
                     /db_xref="InterPro:IPR015612"
                     /db_xref="InterPro:IPR027465"
                     /db_xref="InterPro:IPR030490"
                     /db_xref="PDB:3CKI"
                     /db_xref="UniProtKB/Swiss-Prot:P35625"
                     /protein_id="CAA53813.1"
                     /translation="MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRA
                     KVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQY
                     LLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSK
                     NECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP"
BASE COUNT          225 a          301 c          266 g          229 t
ORIGIN      
        1 cccgccggcg gcgcgcacgg caactttgga gaggcgagca gcagccccgg cagcggcggc
       61 agcagcggca atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg
      121 ggactggggc gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa
      181 ctccgacatc gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt
      241 cggcacgctg gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc
      301 ccatgtgcag tacatccaca cggaagcttc cgagagtctc tgtggcctta agctggaggt
      361 caacaagtac cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct
      421 gtgcaacttc gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta
      481 tcggtatcac ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt
      541 gacttccaag aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta
      601 ccagtccaaa cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg
      661 atgggccccc ccggataaaa gcatcatcaa tgccacagac ccctgagcgc cagaccctgc
      721 cccacctcac ttccctccct tcccgctgag cttcccttgg acactaactc ttcccagatg
      781 atgacaatga aattagtgcc tgttttcttg caaatttagc acttggaaca tttaaagaaa
      841 ggtctatgct gtcatatggg gtttattggg aactatcctc ctggccccac cctgcccctt
      901 ctttttggtt ttgacatcat tcatttccac ctgggaattt ctggtgccat gccagaaaga
      961 atgaggaacc tgtattcctc ttcttcgtga taatataatc tctatttttt taggaaaaaa
     1021 a
//