LOCUS X76132 4608 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens DCC mRNA.
ACCESSION X76132
VERSION X76132.1
KEYWORDS cell adhesion molecule; DCC gene; immunoglobulin gene superfamily;
transmembrane protein; tumor suppressor gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4608)
AUTHORS Cho K.
JOURNAL Submitted (15-NOV-1993) to the INSDC. K. Cho, The J. Hopkins Univ.
School of Medicine, Dept. of Pathology, Room 656, Ross Research
Bldg., 720 Rutland Ave., Baltimore Maryland 21205-2196, USA
REFERENCE 2 (bases 1 to 4608)
AUTHORS Hedrick L., Cho K.R., Fearon E.R., Wu T.C., Kinzler K.W.,
Vogelstein B.
TITLE The DCC gene product in cellular differentiation and colorectal
tumorigenesis
JOURNAL Genes Dev. 8(10), 1174-1183(1994).
PUBMED 7926722
REFERENCE 3 (bases 1 to 4608)
AUTHORS Cho K.R., Oliner, Simons, Hedrick L., Fearon E.R.
TITLE The DCC gene: structural analysis and mutations in colorectal
carcinomas
JOURNAL Genomics 19(3), 525-531(1994).
PUBMED 8188295
COMMENT Related sequence: M32292
FEATURES Location/Qualifiers
source 1..4608
/db_xref="H-InvDB:HIT000323571"
/organism="Homo sapiens"
/chromosome="18q21.1"
/mol_type="mRNA"
/clone_lib="Clontech cDNA libraries CAT #HL1065b, HL1003b"
/cell_line="normal adult and fetal brain"
/tissue_type="brain"
/db_xref="taxon:9606"
mRNA join(<1..91,92..412,413..697,698..848,849..985,986..1140,
1141..1261,1262..1418,1419..1573,1574..1722,1723..1861,
1862..1911,1912..2053,2054..2164,2165..2359,2360..2455,
2456..2688,2689..2827,2828..2935,2936..3130,3131..3163,
3164..3229,3230..3392,3393..3619,3620..3736,3737..3898,
3899..4111,4112..4254,4255..>4608)
CDS join(1..91,92..412,413..697,698..848,849..985,986..1140,
1141..1261,1262..1418,1419..1573,1574..1722,1723..1861,
1862..1911,1912..2053,2054..2164,2165..2359,2360..2455,
2456..2688,2689..2827,2828..2935,2936..3130,3131..3163,
3164..3229,3230..3392,3393..3619,3620..3736,3737..3898,
3899..4111,4112..4254,4255..4344)
/gene="DCC"
/product="tumour suppressor"
/db_xref="GOA:P43146"
/db_xref="H-InvDB:HIT000323571.14"
/db_xref="HGNC:HGNC:2701"
/db_xref="InterPro:IPR003598"
/db_xref="InterPro:IPR003599"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR007110"
/db_xref="InterPro:IPR010560"
/db_xref="InterPro:IPR013098"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR033012"
/db_xref="InterPro:IPR036116"
/db_xref="InterPro:IPR036179"
/db_xref="PDB:2ED7"
/db_xref="PDB:2ED8"
/db_xref="PDB:2ED9"
/db_xref="PDB:2EDB"
/db_xref="PDB:2EDD"
/db_xref="PDB:2EDE"
/db_xref="PDB:3AU4"
/db_xref="PDB:4URT"
/db_xref="PDB:5X83"
/db_xref="UniProtKB/Swiss-Prot:P43146"
/protein_id="CAA53735.1"
/translation="MENSLRCVWVPKLAFVLFGASLLSAHLQVTGFQIKAFTALRFLS
EPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNI
LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK
CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPA
SSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRG
EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL
NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVK
SDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR
PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEW
GPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCT
EVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA
PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL
FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNC
IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA
FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT
HDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT
MYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDFTVITREGKPRAVIVSWQPPLE
ANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGV
GPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHG
SVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQK
DLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTS
HSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYP
GILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH
SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTH
VKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLM
KQLNAITGSAF"
exon <1..91
/number=1
exon 92..412
/number=2
exon 413..697
/number=3
exon 698..848
/number=4
exon 849..985
/number=5
exon 986..1140
/number=6
exon 1141..1261
/number=7
exon 1262..1418
/number=8
exon 1419..1573
/number=9
exon 1574..1722
/number=10
exon 1723..1861
/number=11
exon 1862..1911
/number=12
exon 1912..2053
/number=13
exon 2054..2164
/number=14
exon 2165..2359
/number=15
exon 2360..2455
/number=16
exon 2456..2688
/number=17
exon 2689..2827
/number=18
exon 2828..2935
/number=19
exon 2936..3130
/number=20
exon 3131..3163
/number=21
exon 3164..3229
/number=22
exon 3230..3392
/number=23
exon 3393..3619
/number=24
exon 3620..3736
/number=25
exon 3737..3898
/number=26
exon 3899..4111
/number=27
exon 4112..4254
/number=28
exon 4255..>4608
/number=29
BASE COUNT 1282 a 1179 c 1058 g 1089 t
ORIGIN
1 atggagaata gtcttagatg tgtttgggta cccaagctgg cttttgtact cttcggagct
61 tccttgctca gcgcgcatct tcaagtaacc ggttttcaaa ttaaagcttt cacagcactg
121 cgcttcctct cagaaccttc tgatgccgtc acaatgcggg gaggaaatgt cctcctcgac
181 tgctccgcgg agtccgaccg aggagttcca gtgatcaagt ggaagaaaga tggcattcat
241 ctggccttgg gaatggatga aaggaagcag caactttcaa atgggtctct gctgatacaa
301 aacatacttc attccagaca ccacaagcca gatgagggac tttaccaatg tgaggcatct
361 ttaggagatt ctggctcaat tattagtcgg acagcaaaag ttgcagtagc aggaccactg
421 aggttccttt cacagacaga atctgtcaca gccttcatgg gagacacagt gctactcaag
481 tgtgaagtca ttggggagcc catgccaaca atccactggc agaagaacca acaagacctg
541 actccaatcc caggtgactc ccgagtggtg gtcttgccct ctggagcatt gcagatcagc
601 cgactccaac cgggggacat tggaatttac cgatgctcag ctcgaaatcc agccagctca
661 agaacaggaa atgaagcaga agtcagaatt ttatcagatc caggactgca tagacagctg
721 tattttctgc aaagaccatc caatgtagta gccattgaag gaaaagatgc tgtcctggaa
781 tgttgtgttt ctggctatcc tccaccaagt tttacctggt tacgaggcga ggaagtcatc
841 caactcaggt ctaaaaagta ttctttattg ggtggaagca acttgcttat ctccaatgtg
901 acagatgatg acagtggaat gtatacctgt gttgtcacat ataaaaatga gaatattagt
961 gcctctgcag agctcacagt cttggttccg ccatggtttt taaatcatcc ttccaacctg
1021 tatgcctatg aaagcatgga tattgagttt gaatgtacag tctctggaaa gcctgtgccc
1081 actgtgaatt ggatgaagaa tggagatgtg gtcattccta gtgattattt tcagatagtg
1141 ggaggaagca acttacggat acttggggtg gtgaagtcag atgaaggctt ttatcaatgt
1201 gtggctgaaa atgaggctgg aaatgcccag accagtgcac agctcattgt ccctaagcct
1261 gcaatcccaa gctccagtgt cctcccttcg gctcccagag atgtggtccc tgtcttggtt
1321 tccagccgat ttgtccgtct cagctggcgc ccacctgcag aagcgaaagg gaacattcaa
1381 actttcacgg tctttttctc cagagaaggt gacaacaggg aacgagcatt gaatacaaca
1441 cagcctgggt cccttcagct cactgtggga aacctgaagc cagaagccat gtacaccttt
1501 cgagttgtgg cttacaatga atggggaccg ggagagagtt ctcaacccat caaggtggcc
1561 acacagcctg agttgcaagt tccagggcca gtagaaaacc tgcaagctgt atctacctca
1621 cctacctcaa ttcttattac ctgggaaccc cctgcctatg caaacggtcc agtccaaggt
1681 tacagattgt tctgcactga ggtgtccaca ggaaaagaac agaatataga ggttgatgga
1741 ctatcttata aactggaagg cctgaaaaaa ttcaccgaat atagtcttcg attcttagct
1801 tataatcgct atggtccggg cgtctctact gatgatataa cagtggttac actttctgac
1861 gtgccaagtg ccccgcctca gaacgtctcc ctggaagtgg tcaattcaag aagtatcaaa
1921 gttagctggc tgcctcctcc atcaggaaca caaaatggat ttattaccgg ctataaaatt
1981 cgacacagaa agacgacccg caggggtgag atggaaacac tggagccaaa caacctctgg
2041 tacctattca caggactgga gaaaggaagt cagtacagtt tccaggtgtc agccatgaca
2101 gtcaatggta ctggaccacc ttccaactgg tatactgcag agactccaga gaatgatcta
2161 gatgaatctc aagttcctga tcaaccaagc tctcttcatg tgaggcccca gactaactgc
2221 atcatcatga gttggactcc tcccttgaac ccaaacatcg tggtgcgagg ttatattatc
2281 ggttatggcg ttgggagccc ttacgctgag acagtgcgtg tggacagcaa gcagcgatat
2341 tattccattg agaggttaga gtcaagttcc cattatgtaa tctccctaaa agcttttaac
2401 aatgccggag aaggagttcc tctttatgaa agtgccacca ccaggtctat aaccgatccc
2461 actgacccag ttgattatta tcctttgctt gatgatttcc ccacctcggt cccagatctc
2521 tccaccccca tgctcccacc agtaggtgta caggctgtgg ctcttaccca tgatgctgtg
2581 agggtcagct gggcagacaa ctctgtccct aagaaccaaa agacgtctga ggtgcgactt
2641 tacaccgtcc ggtggagaac cagcttttct gcaagtgcaa aatacaagtc agaagacaca
2701 acatctctaa gttacacagc aacaggcctc aaaccaaaca caatgtatga attctcggtc
2761 atggtaacaa aaaacagaag gtccagtact tggagcatga ctgcacatgc caccacgtat
2821 gaagcagccc ccacctctgc tcccaaggac tttacagtca ttactaggga agggaagcct
2881 cgtgccgtca ttgtgagttg gcagcctccc ttggaagcca atgggaaaat tactgcttac
2941 atcttatttt ataccttgga caagaacatc ccaattgatg actggattat ggaaacaatc
3001 agtggtgata ggcttactca tcaaatcatg gatctcaacc ttgatactat gtattacttt
3061 cgaattcaag cacgaaattc aaaaggagtg gggccactct ctgatcccat cctcttcagg
3121 actctgaaag tggaacaccc tgacaaaatg gctaatgacc aaggtcgtca tggagatgga
3181 ggttattggc cagttgatac taatttgatt gatagaagca ccctaaatga gccgccaatt
3241 ggacaaatgc accccccgca tggcagtgtc actcctcaga agaacagcaa cctgcttgtg
3301 atcattgtgg tcaccgttgg tgtcatcaca gtgctggtag tggtcatcgt ggctgtgatt
3361 tgcacccgac gctcttcagc ccagcagaga aagaaacggg ccacccacag tgctggcaaa
3421 aggaagggca gccagaagga cctccgaccc cctgatcttt ggatccatca tgaagaaatg
3481 gagatgaaaa atattgaaaa gccatctggc actgaccctg caggaaggga ctctcccatc
3541 caaagttgcc aagacctcac accagtcagc cacagccagt cagaaaccca actgggaagc
3601 aaaagcacct ctcattcagg tcaagacact gaggaagcag ggagctctat gtccactctg
3661 gagaggtcgc tggctgcacg ccgagccccc cgggccaagc tcatgattcc catggatgcc
3721 cagtccaaca atcctgctgt cgtgagcgcc atcccggtgc caacgctaga aagtgcccag
3781 tacccaggaa tcctcccgtc tcccacctgt ggatatcccc acccgcagtt cactctccgg
3841 cctgtgccat tcccaacact ctcagtggac cgaggtttcg gagcaggaag aagtcagtca
3901 gtgagtgaag gaccaactac ccaacaacca cctatgctgc ccccatctca gcctgagcat
3961 tctagcagcg aggaggcacc aagcagaacc atccccacag cttgtgttcg accaactcac
4021 ccactccgca gctttgctaa tcctttgcta cctccaccaa tgagtgcaat agaaccgaaa
4081 gtcccttaca caccactttt gtctcagcca gggcccactc ttcctaagac ccatgtgaaa
4141 acagcctccc ttgggttggc tggaaaagca agatcccctt tgcttcctgt gtctgtgcca
4201 acagcccctg aagtgtctga ggagagccac aaaccaacag aggattcagc caatgtgtat
4261 gaacaggatg atctgagtga acaaatggca agtttggaag gactcatgaa gcagcttaat
4321 gccatcacag gctcagcctt ttaacatgta tttctgaatg gatgaggtga attttccggg
4381 aactttgcag cataccaatt acccataaac agcacacctg tgtccaagaa ctctaaccag
4441 tgtacaggtc acccatcagg accactcagt taaggaagat cctgaagcag ttcagaagga
4501 ataagcattc cttctttcac aggcatcagg aattgtcaaa tgatgattat gagttcccta
4561 aacaaaagca aagatgcatt ttcactgcaa tgtcaaagtt tagctgct
//