LOCUS X75208 3805 bp mRNA linear HUM 18-APR-2005
DEFINITION H.sapiens HEK2 mRNA for protein tyrosine kinase receptor.
ACCESSION X75208
VERSION X75208.1
KEYWORDS protein tyrosine kinase receptor; receptor protein tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Bohme B., Holtrich U., Wolf G., Luzius H., Grzeschik K.H.,
Strebhardt K., Rubsamen-Waigmann H.
TITLE PCR mediated detection of a new human receptor-tyrosine-kinase, HEK
2
JOURNAL Oncogene 8(10), 2857-2862(1993).
PUBMED 8397371
REFERENCE 2 (bases 1 to 3805)
AUTHORS Boehme B.
JOURNAL Submitted (23-SEP-1993) to the INSDC. B. Boehme, Georg-Speyer-Haus,
Paul-Ehrlich-Str. 42-44, D60596 Frankfurt, FRG
FEATURES Location/Qualifiers
source 1..3805
/db_xref="H-InvDB:HIT000323513"
/organism="Homo sapiens"
/chromosome="3"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 28..3024
/gene="HEK2"
/product="protein tyrosine kinase-receptor"
/EC_number="2.7.1.112"
/db_xref="GOA:P54753"
/db_xref="H-InvDB:HIT000323513.13"
/db_xref="HGNC:HGNC:3394"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001090"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001426"
/db_xref="InterPro:IPR001660"
/db_xref="InterPro:IPR003961"
/db_xref="InterPro:IPR008266"
/db_xref="InterPro:IPR008979"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR011641"
/db_xref="InterPro:IPR013761"
/db_xref="InterPro:IPR013783"
/db_xref="InterPro:IPR016257"
/db_xref="InterPro:IPR017441"
/db_xref="InterPro:IPR020635"
/db_xref="InterPro:IPR027936"
/db_xref="InterPro:IPR034245"
/db_xref="InterPro:IPR036116"
/db_xref="PDB:3P1I"
/db_xref="PDB:3ZFY"
/db_xref="PDB:5L6O"
/db_xref="PDB:5L6P"
/db_xref="UniProtKB/Swiss-Prot:P54753"
/protein_id="CAA53021.1"
/translation="MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMD
TKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDV
QRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTI
APDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAG
FALFPETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHE
PAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADS
ACTTVPSPPRGVISNVNETSLILEWSEPRDLGVRDDLLYNVICKKCHGAGGASACSRC
DDNVEFVPRQLGLSEPRVHTSHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQ
AAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSV
QLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATA
GLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREF
AKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSE
ASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLR
GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGG
KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYR
LPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQ
PLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTL
AGHQKKILSSIQDMRLQMNQTLPVQV"
sig_peptide 28..126
/gene="HEK2"
/note="putative"
mat_peptide 127..3021
/product="protein tyrosine kinase-receptor"
/EC_number="2.7.1.112"
misc_feature 1695..1773
/note="transmembrane region"
BASE COUNT 743 a 1175 c 1143 g 744 t
ORIGIN
1 ggctcggctc ctagagctgc cacggccatg gccagagccc gcccgccgcc gccgccgtcg
61 ccgccgccgg ggcttctgcc gctgctccct ccgctgctgc tgctgccgct gctgctgctg
121 cccgccggct gccgggcgct ggaagagacc ctcatggaca caaaatgggt aacatctgag
181 ttggcgtgga catctcatcc agaaagtggg tgggaagagg tgagtggcta cgatgaggcc
241 atgaatccca tccgcacata ccaggtgtgt aatgtgcgcg agtcaagcca gaacaactgg
301 cttcgcacgg ggttcatctg gcggcgggat gtgcagcggg tctacgtgga gctcaagttc
361 actgtgcgtg actgcaacag catccccaac atccccggct cctgcaagga gaccttcaac
421 ctcttctact acgaggctga cagcgatgtg gcctcagcct cctccccctt ctggatggag
481 aacccctacg tgaaagtgga caccattgca cccgatgaga gcttctcgcg gctggatgcc
541 ggccgtgtca acaccaaggt gcgcagcttt gggccacttt ccaaggctgg cttctacctg
601 gccttccagg accagggcgc ctgcatgtcg ctcatctccg tgcgcgcctt ctacaagaag
661 tgtgcatcca ccaccgcagg cttcgcactc ttccccgaga ccctcactgg ggcggagccc
721 acctcgctgg tcattgctcc tggcacctgc atccctaacg ccgtggaggt gtcggtgcca
781 ctcaagctct actgcaacgg cgatggggag tggatggtgc ctgtgggtgc ctgcacctgt
841 gccaccggcc atgagccagc tgccaaggag tcccagtgcc gcccctgtcc ccctgggagc
901 tacaaggcga agcagggaga ggggccctgc ctcccatgtc cccccaacag ccgtaccacc
961 tccccagccg ccagcatctg cacctgccac aataacttct accgtgcaga ctcggactct
1021 gcggacagtg cctgtaccac cgtgccatct ccaccccgag gtgtgatctc caatgtgaat
1081 gaaacctcac tgatcctcga gtggagtgag ccccgggacc tgggtgtccg ggatgacctc
1141 ctgtacaatg tcatctgcaa gaagtgccat ggggctggag gggcctcagc ctgctcacgc
1201 tgtgatgaca acgtggagtt tgtgcctcgg cagctgggcc tgtcggagcc ccgggtccac
1261 accagccatc tgctggccca cacgcgctac acctttgagg tgcaggcggt caacggtgtc
1321 tcgggcaaga gccctctgcc gcctcgttat gcggccgtga atatcaccac aaaccaggct
1381 gccccgtctg aagtgcccac actacgcctg cacagcagct caggcagcag cctcacccta
1441 tcctgggcac ccccagagcg gcccaacgga gtcatcctgg actacgagat gaagtacttt
1501 gagaagagcg agggcatcgc ctccacagtg accagccaga tgaactccgt gcagctggac
1561 gggcttcggc ctgacgcccg ctatgtggtc caggtccgtg cccgcacagt agctggctat
1621 gggcagtaca gccgccctgc cgagtttgag accacaagtg agagaggctc tggggcccag
1681 cagctccagg agcagcttcc cctcatcgtg ggctccgcta cagctgggct tgtcttcgtg
1741 gtggctgtcg tggtcatcgc tatcgtctgc ctcaggaagc agcgacacgg ctctgattcg
1801 gagtacacgg agaagctgca gcagtacatt gctcctggaa tgaaggttta tattgaccct
1861 tttacctacg aggaccctaa tgaggctgtt cgggagtttg ccaaggagat cgacgtgtcc
1921 tgcgtcaaga tcgaggaggt gatcggagct ggggaatttg gggaagtgtg ccgtggtcga
1981 ctgaaacagc ctggccgccg agaggtgttt gtggccatca agacgctgaa ggtgggctac
2041 accgagaggc agcggcggga cttcctaagc gaggcctcca tcatgggtca gtttgatcac
2101 cccaatataa tccggctcga gggcgtggtc accaaaagtc ggccagttat gatcctcact
2161 gagttcatgg aaaactgcgc cctggactcc ttcctccggc tcaacgatgg gcagttcacg
2221 gtcatccagc tggtgggcat gttgcggggc attgctgccg gcatgaagta cctgtccgag
2281 atgaactatg tgcaccgcga cctggctgct cgcaacatcc ttgtcaacag caacctggtc
2341 tgcaaagtct cagactttgg cctctcccgc ttcctggagg atgacccctc cgatcctacc
2401 tacaccagtt ccctgggcgg gaagatcccc atccgctgga ctgccccaga ggccatagcc
2461 tatcggaagt tcacttctgc tagtgatgtc tggagctacg gaattgtcat gtgggaggtc
2521 atgagctatg gagagcgacc ctactgggac atgagcaacc aggatgtcat caatgccgtg
2581 gagcaggatt accggctgcc accacccatg gactgtccca cagcactgca ccagctcatg
2641 ctggactgct gggtgcggga ccggaacctc aggcccaaat tctcccagat tgtcaatacc
2701 ctggacaagc tcatccgcaa tgctgccagc ctcaaggtca ttgccagcgc tcagtctggc
2761 atgtcacagc ccctcctgga ccgcacggtc ccagattaca caaccttcac gacagttggt
2821 gattggctgg atgccatcaa gatggggcgg tacaaggaga gcttcgtcag tgcggggttt
2881 gcatcttttg acctggtggc ccagatgacg gcagaagacc tgctccgtat tggggtcacc
2941 ctggccggcc accagaagaa gatcctgagc agtatccagg acatgcggct gcagatgaac
3001 cagacgctgc ctgtgcaggt ctgacaccgg ctcccacggg gaccctgagg accgtgcagg
3061 gatgccaagc agccggctgg actttcggac tcttggactt ttggatgcct ggccttaggc
3121 tgtggcccag aagctggaag tttgggaaag gcccaagctg ggacttctcc aggcctgtgt
3181 tccctcccca ggaagtgcgc cccaaacctc ttcatattga agatggatta ggagaggggg
3241 tgatgacccc tccccaagcc cctcagggcc cagaccttcc tgctctccag caggggatcc
3301 ccacaacctc acacttgtct gttcttcagt gctggaggtc ctggcagggt caggctgggg
3361 taagccgggg ttccacaggg cccagccctg gcaggggtct ggccccccag gtaggcggag
3421 agcagtccct ccctcaggaa ctggaggagg ggactccagg aatggggaaa tgtgacacca
3481 ccatcctgaa gccagcttgc acctccagtt tgcacaggga tttgtcctgg gggctgaggg
3541 ccctgtcccc acccccgccc ttggtgctgt cataaaaggg caggcagggg caggctgagg
3601 agttgcccgt tgccccccag agactgactc tcagagccag agatgggatg tgtgagtgtg
3661 tgtgtgtgtg tgtgcgcgcg cgcgcgcgtg tgtgtgtgca cgcactggcc tgcacagaga
3721 gcatgggtga gcgtgtaaaa gcttggccct gtgccctaca gtggggacag ctgggccgac
3781 agcagaataa aggcaataag atgaa
//